JP2005514192A - 表面にコーティングを供給するための試薬および方法 - Google Patents
表面にコーティングを供給するための試薬および方法 Download PDFInfo
- Publication number
- JP2005514192A JP2005514192A JP2003556180A JP2003556180A JP2005514192A JP 2005514192 A JP2005514192 A JP 2005514192A JP 2003556180 A JP2003556180 A JP 2003556180A JP 2003556180 A JP2003556180 A JP 2003556180A JP 2005514192 A JP2005514192 A JP 2005514192A
- Authority
- JP
- Japan
- Prior art keywords
- poly
- bis
- group
- acid
- benzoylbenzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000576 coating method Methods 0.000 title claims abstract description 106
- 239000011248 coating agent Substances 0.000 title claims abstract description 102
- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 93
- 238000000034 method Methods 0.000 title claims abstract description 84
- 239000000178 monomer Substances 0.000 claims abstract description 90
- 229920000642 polymer Polymers 0.000 claims abstract description 75
- 230000004913 activation Effects 0.000 claims abstract description 23
- 238000006116 polymerization reaction Methods 0.000 claims abstract description 20
- -1 polyoxymethylenes Polymers 0.000 claims description 69
- 150000001875 compounds Chemical class 0.000 claims description 40
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 30
- XHZPRMZZQOIPDS-UHFFFAOYSA-N 2-Methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid Chemical compound OS(=O)(=O)CC(C)(C)NC(=O)C=C XHZPRMZZQOIPDS-UHFFFAOYSA-N 0.000 claims description 28
- 210000004369 blood Anatomy 0.000 claims description 26
- 239000008280 blood Substances 0.000 claims description 26
- 239000002253 acid Substances 0.000 claims description 19
- 150000007513 acids Chemical class 0.000 claims description 19
- 239000004814 polyurethane Substances 0.000 claims description 18
- 229920002379 silicone rubber Polymers 0.000 claims description 18
- 229920002635 polyurethane Polymers 0.000 claims description 17
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 17
- 239000000463 material Substances 0.000 claims description 16
- 238000012360 testing method Methods 0.000 claims description 16
- NIXVAPHNPNMUIX-UHFFFAOYSA-N 6-amino-2-methylhex-2-enamide Chemical compound NC(=O)C(C)=CCCCN NIXVAPHNPNMUIX-UHFFFAOYSA-N 0.000 claims description 15
- WEAQXVDSAUMZHI-UHFFFAOYSA-M 2-methylprop-2-enamide;trimethyl(propyl)azanium;chloride Chemical compound [Cl-].CC(=C)C(N)=O.CCC[N+](C)(C)C WEAQXVDSAUMZHI-UHFFFAOYSA-M 0.000 claims description 14
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 14
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 claims description 14
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 claims description 14
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 14
- 229920001296 polysiloxane Polymers 0.000 claims description 14
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims description 14
- 230000008569 process Effects 0.000 claims description 14
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 14
- 229920000954 Polyglycolide Polymers 0.000 claims description 13
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims description 12
- 230000010065 bacterial adhesion Effects 0.000 claims description 12
- 238000003491 array Methods 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 11
- 229920000052 poly(p-xylylene) Polymers 0.000 claims description 11
- 229920001223 polyethylene glycol Polymers 0.000 claims description 11
- 230000007935 neutral effect Effects 0.000 claims description 9
- 239000005630 Diquat Substances 0.000 claims description 8
- 239000004743 Polypropylene Substances 0.000 claims description 8
- OBTFKRQJZSUBCQ-UHFFFAOYSA-L dipotassium;benzene-1,3-disulfonate Chemical compound [K+].[K+].[O-]S(=O)(=O)C1=CC=CC(S([O-])(=O)=O)=C1 OBTFKRQJZSUBCQ-UHFFFAOYSA-L 0.000 claims description 8
- OUDPZXBEIAQXME-UHFFFAOYSA-L dipotassium;benzene-1,4-disulfonate Chemical compound [K+].[K+].[O-]S(=O)(=O)C1=CC=C(S([O-])(=O)=O)C=C1 OUDPZXBEIAQXME-UHFFFAOYSA-L 0.000 claims description 8
- 150000002734 metacrylic acid derivatives Chemical class 0.000 claims description 8
- 229910052757 nitrogen Inorganic materials 0.000 claims description 8
- 229920001155 polypropylene Polymers 0.000 claims description 8
- 108090000623 proteins and genes Proteins 0.000 claims description 8
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 claims description 7
- QRIMLDXJAPZHJE-UHFFFAOYSA-N 2,3-dihydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(O)CO QRIMLDXJAPZHJE-UHFFFAOYSA-N 0.000 claims description 7
- OWPUOLBODXJOKH-UHFFFAOYSA-N 2,3-dihydroxypropyl prop-2-enoate Chemical compound OCC(O)COC(=O)C=C OWPUOLBODXJOKH-UHFFFAOYSA-N 0.000 claims description 7
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 7
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 claims description 7
- JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 claims description 7
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 7
- KTPVYVIRKFLZRO-UHFFFAOYSA-L 2-[2-(4-benzoylphenyl)ethyl-[2-[(4-benzoylphenyl)methyl-dimethylazaniumyl]ethyl]azaniumyl]ethyl-[(4-benzoylphenyl)methyl]-dimethylazanium;tribromide Chemical compound [Br-].[Br-].[Br-].C=1C=C(C(=O)C=2C=CC=CC=2)C=CC=1C[N+](C)(C)CC[NH+](CC[N+](C)(C)CC=1C=CC(=CC=1)C(=O)C=1C=CC=CC=1)CCC(C=C1)=CC=C1C(=O)C1=CC=CC=C1 KTPVYVIRKFLZRO-UHFFFAOYSA-L 0.000 claims description 7
- XUDBVJCTLZTSDC-UHFFFAOYSA-N 2-ethenylbenzoic acid Chemical compound OC(=O)C1=CC=CC=C1C=C XUDBVJCTLZTSDC-UHFFFAOYSA-N 0.000 claims description 7
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims description 7
- QZPSOSOOLFHYRR-UHFFFAOYSA-N 3-hydroxypropyl prop-2-enoate Chemical compound OCCCOC(=O)C=C QZPSOSOOLFHYRR-UHFFFAOYSA-N 0.000 claims description 7
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 7
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 7
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 7
- 239000004952 Polyamide Substances 0.000 claims description 7
- 239000004642 Polyimide Substances 0.000 claims description 7
- 239000004793 Polystyrene Substances 0.000 claims description 7
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 7
- XNOMWKDAQZCFGK-UHFFFAOYSA-N [4-[(4-benzoylphenyl)methoxymethyl]phenyl]-phenylmethanone Chemical compound C=1C=C(COCC=2C=CC(=CC=2)C(=O)C=2C=CC=CC=2)C=CC=1C(=O)C1=CC=CC=C1 XNOMWKDAQZCFGK-UHFFFAOYSA-N 0.000 claims description 7
- 150000001252 acrylic acid derivatives Chemical class 0.000 claims description 7
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 claims description 7
- 239000003822 epoxy resin Substances 0.000 claims description 7
- 239000001530 fumaric acid Substances 0.000 claims description 7
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 7
- 239000011976 maleic acid Substances 0.000 claims description 7
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 claims description 7
- ZQXSMRAEXCEDJD-UHFFFAOYSA-N n-ethenylformamide Chemical compound C=CNC=O ZQXSMRAEXCEDJD-UHFFFAOYSA-N 0.000 claims description 7
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims description 7
- 239000005011 phenolic resin Substances 0.000 claims description 7
- 229920003366 poly(p-phenylene terephthalamide) Polymers 0.000 claims description 7
- 229920002647 polyamide Polymers 0.000 claims description 7
- 229920000515 polycarbonate Polymers 0.000 claims description 7
- 239000004417 polycarbonate Substances 0.000 claims description 7
- 229920000647 polyepoxide Polymers 0.000 claims description 7
- 229920000728 polyester Polymers 0.000 claims description 7
- 229920001721 polyimide Polymers 0.000 claims description 7
- 229920000098 polyolefin Polymers 0.000 claims description 7
- 229920006324 polyoxymethylene Polymers 0.000 claims description 7
- 229920002223 polystyrene Polymers 0.000 claims description 7
- 229920002689 polyvinyl acetate Polymers 0.000 claims description 7
- 239000011118 polyvinyl acetate Substances 0.000 claims description 7
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 7
- 239000004800 polyvinyl chloride Substances 0.000 claims description 7
- 150000004756 silanes Chemical class 0.000 claims description 7
- 159000000000 sodium salts Chemical class 0.000 claims description 7
- PEQHIRFAKIASBK-UHFFFAOYSA-N tetraphenylmethane Chemical class C1=CC=CC=C1C(C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 PEQHIRFAKIASBK-UHFFFAOYSA-N 0.000 claims description 7
- ZTWTYVWXUKTLCP-UHFFFAOYSA-N vinylphosphonic acid Chemical compound OP(O)(=O)C=C ZTWTYVWXUKTLCP-UHFFFAOYSA-N 0.000 claims description 7
- 230000007774 longterm Effects 0.000 claims description 6
- 229920002627 poly(phosphazenes) Polymers 0.000 claims description 6
- 229920002239 polyacrylonitrile Polymers 0.000 claims description 6
- 230000002792 vascular Effects 0.000 claims description 6
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 6
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 5
- 208000010412 Glaucoma Diseases 0.000 claims description 5
- 108091005804 Peptidases Proteins 0.000 claims description 5
- 102000035195 Peptidases Human genes 0.000 claims description 5
- 239000004365 Protease Substances 0.000 claims description 5
- 230000001154 acute effect Effects 0.000 claims description 5
- 230000003872 anastomosis Effects 0.000 claims description 5
- 210000000170 cell membrane Anatomy 0.000 claims description 5
- 239000000460 chlorine Substances 0.000 claims description 5
- 229910052801 chlorine Inorganic materials 0.000 claims description 5
- 238000004587 chromatography analysis Methods 0.000 claims description 5
- 230000001684 chronic effect Effects 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 5
- 239000004053 dental implant Substances 0.000 claims description 5
- 238000001631 haemodialysis Methods 0.000 claims description 5
- 210000002216 heart Anatomy 0.000 claims description 5
- 210000003709 heart valve Anatomy 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- 230000000322 hemodialysis Effects 0.000 claims description 5
- 239000007943 implant Substances 0.000 claims description 5
- 210000003734 kidney Anatomy 0.000 claims description 5
- 210000004072 lung Anatomy 0.000 claims description 5
- 229920001427 mPEG Polymers 0.000 claims description 5
- 210000000056 organ Anatomy 0.000 claims description 5
- 230000000399 orthopedic effect Effects 0.000 claims description 5
- 230000008439 repair process Effects 0.000 claims description 5
- 210000002435 tendon Anatomy 0.000 claims description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 4
- 238000000018 DNA microarray Methods 0.000 claims description 4
- 230000002965 anti-thrombogenic effect Effects 0.000 claims description 4
- 238000010241 blood sampling Methods 0.000 claims description 4
- 238000004113 cell culture Methods 0.000 claims description 4
- 239000002299 complementary DNA Substances 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 4
- 238000009396 hybridization Methods 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 4
- 238000002493 microarray Methods 0.000 claims description 4
- 239000004005 microsphere Substances 0.000 claims description 4
- 229920002401 polyacrylamide Polymers 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 229920002554 vinyl polymer Polymers 0.000 claims description 4
- 238000002966 oligonucleotide array Methods 0.000 claims description 3
- 230000001012 protector Effects 0.000 claims description 3
- DKBZZUNCOFCQFT-UHFFFAOYSA-L (4-benzoylphenyl)methyl-[2-[(4-benzoylphenyl)methyl-dimethylazaniumyl]ethyl]-dimethylazanium;dibromide Chemical compound [Br-].[Br-].C=1C=C(C(=O)C=2C=CC=CC=2)C=CC=1C[N+](C)(C)CC[N+](C)(C)CC(C=C1)=CC=C1C(=O)C1=CC=CC=C1 DKBZZUNCOFCQFT-UHFFFAOYSA-L 0.000 claims description 2
- 230000006378 damage Effects 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 12
- RCEJLBKBUGIKGA-UHFFFAOYSA-L (4-benzoylphenyl)methyl-[6-[(4-benzoylphenyl)methyl-dimethylazaniumyl]hexyl]-dimethylazanium;dibromide Chemical compound [Br-].[Br-].C=1C=C(C(=O)C=2C=CC=CC=2)C=CC=1C[N+](C)(C)CCCCCC[N+](C)(C)CC(C=C1)=CC=C1C(=O)C1=CC=CC=C1 RCEJLBKBUGIKGA-UHFFFAOYSA-L 0.000 claims 6
- IXPWKHNDQICVPZ-UHFFFAOYSA-N 2-methylhex-1-en-3-yne Chemical compound CCC#CC(C)=C IXPWKHNDQICVPZ-UHFFFAOYSA-N 0.000 claims 6
- IRLPACMLTUPBCL-KQYNXXCUSA-N 5'-adenylyl sulfate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OS(O)(=O)=O)[C@@H](O)[C@H]1O IRLPACMLTUPBCL-KQYNXXCUSA-N 0.000 claims 6
- HUQINXNYZGEGDJ-UHFFFAOYSA-M [4-[[4-[(4-benzoylphenyl)methyl]morpholin-4-ium-4-yl]methyl]phenyl]-phenylmethanone;bromide Chemical compound [Br-].C=1C=C(C[N+]2(CC=3C=CC(=CC=3)C(=O)C=3C=CC=CC=3)CCOCC2)C=CC=1C(=O)C1=CC=CC=C1 HUQINXNYZGEGDJ-UHFFFAOYSA-M 0.000 claims 6
- RQAKESSLMFZVMC-UHFFFAOYSA-N n-ethenylacetamide Chemical compound CC(=O)NC=C RQAKESSLMFZVMC-UHFFFAOYSA-N 0.000 claims 6
- 229960003080 taurine Drugs 0.000 claims 6
- RGJCUEFHZJHTMV-UHFFFAOYSA-N [Br-].[Br-].C(C1=CC=CC=C1)(=O)C1=CC=C(C[NH+](C)C)C=C1.C=C.C(C1=CC=CC=C1)(=O)C1=CC=C(C[NH+](C)C)C=C1 Chemical compound [Br-].[Br-].C(C1=CC=CC=C1)(=O)C1=CC=C(C[NH+](C)C)C=C1.C=C.C(C1=CC=CC=C1)(=O)C1=CC=C(C[NH+](C)C)C=C1 RGJCUEFHZJHTMV-UHFFFAOYSA-N 0.000 claims 5
- WLFQVYGQQKKEMR-UHFFFAOYSA-M [Cl+].[Cl-] Chemical compound [Cl+].[Cl-] WLFQVYGQQKKEMR-UHFFFAOYSA-M 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 238000009534 blood test Methods 0.000 claims 1
- 238000000465 moulding Methods 0.000 claims 1
- 150000002825 nitriles Chemical class 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 229920001568 phenolic resin Polymers 0.000 claims 1
- 230000000379 polymerizing effect Effects 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 238000003325 tomography Methods 0.000 claims 1
- 229920000307 polymer substrate Polymers 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 60
- 239000000523 sample Substances 0.000 description 34
- 239000000758 substrate Substances 0.000 description 28
- 210000002381 plasma Anatomy 0.000 description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 23
- 150000003254 radicals Chemical class 0.000 description 22
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 21
- DRSHXJFUUPIBHX-UHFFFAOYSA-N COc1ccc(cc1)N1N=CC2C=NC(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)=NC12 Chemical compound COc1ccc(cc1)N1N=CC2C=NC(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)=NC12 DRSHXJFUUPIBHX-UHFFFAOYSA-N 0.000 description 17
- 229920001684 low density polyethylene Polymers 0.000 description 17
- 239000004702 low-density polyethylene Substances 0.000 description 17
- 230000004048 modification Effects 0.000 description 17
- 238000012986 modification Methods 0.000 description 17
- 241000894007 species Species 0.000 description 16
- 238000001994 activation Methods 0.000 description 15
- 239000000047 product Substances 0.000 description 15
- 229920002614 Polyether block amide Polymers 0.000 description 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
- 239000011148 porous material Substances 0.000 description 12
- 239000004945 silicone rubber Substances 0.000 description 12
- 239000000126 substance Substances 0.000 description 11
- 210000004623 platelet-rich plasma Anatomy 0.000 description 10
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 9
- 238000006243 chemical reaction Methods 0.000 description 9
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 9
- 239000002953 phosphate buffered saline Substances 0.000 description 9
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 8
- 108010071241 Factor XIIa Proteins 0.000 description 7
- 102000008946 Fibrinogen Human genes 0.000 description 7
- 108010049003 Fibrinogen Proteins 0.000 description 7
- 239000012965 benzophenone Substances 0.000 description 7
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 description 7
- 229940012952 fibrinogen Drugs 0.000 description 7
- 239000011521 glass Substances 0.000 description 7
- 238000005259 measurement Methods 0.000 description 7
- 239000011780 sodium chloride Substances 0.000 description 7
- 238000013459 approach Methods 0.000 description 6
- 239000008367 deionised water Substances 0.000 description 6
- 229910021641 deionized water Inorganic materials 0.000 description 6
- 230000000977 initiatory effect Effects 0.000 description 6
- 238000010526 radical polymerization reaction Methods 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 229910001873 dinitrogen Inorganic materials 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 239000001257 hydrogen Substances 0.000 description 5
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- 238000005286 illumination Methods 0.000 description 5
- 238000011534 incubation Methods 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000003504 photosensitizing agent Substances 0.000 description 5
- 239000003656 tris buffered saline Substances 0.000 description 5
- IJRKANNOPXMZSG-SSPAHAAFSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.OC(=O)CC(O)(C(O)=O)CC(O)=O IJRKANNOPXMZSG-SSPAHAAFSA-N 0.000 description 4
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Chemical compound CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 description 4
- 238000002835 absorbance Methods 0.000 description 4
- 238000013019 agitation Methods 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 239000007822 coupling agent Substances 0.000 description 4
- 238000010559 graft polymerization reaction Methods 0.000 description 4
- 230000005283 ground state Effects 0.000 description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 4
- 125000001453 quaternary ammonium group Chemical group 0.000 description 4
- VRBFTYUMFJWSJY-UHFFFAOYSA-N 28804-46-8 Chemical compound ClC1CC(C=C2)=CC=C2C(Cl)CC2=CC=C1C=C2 VRBFTYUMFJWSJY-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 239000007983 Tris buffer Substances 0.000 description 3
- 239000003638 chemical reducing agent Substances 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000005284 excitation Effects 0.000 description 3
- 239000004744 fabric Substances 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 238000011065 in-situ storage Methods 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 230000002441 reversible effect Effects 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 125000001424 substituent group Chemical group 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 3
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 2
- PKDBCJSWQUOKDO-UHFFFAOYSA-M 2,3,5-triphenyltetrazolium chloride Chemical compound [Cl-].C1=CC=CC=C1C(N=[N+]1C=2C=CC=CC=2)=NN1C1=CC=CC=C1 PKDBCJSWQUOKDO-UHFFFAOYSA-M 0.000 description 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 2
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 2
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- URLKBWYHVLBVBO-UHFFFAOYSA-N Para-Xylene Chemical group CC1=CC=C(C)C=C1 URLKBWYHVLBVBO-UHFFFAOYSA-N 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 150000003926 acrylamides Chemical class 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 238000005273 aeration Methods 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 2
- 150000004056 anthraquinones Chemical class 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 229920005601 base polymer Polymers 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000005587 bubbling Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 125000003636 chemical group Chemical group 0.000 description 2
- 239000003593 chromogenic compound Substances 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 239000008098 formaldehyde solution Substances 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 229960002897 heparin Drugs 0.000 description 2
- 229920000669 heparin Polymers 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 229920001477 hydrophilic polymer Polymers 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000007373 indentation Methods 0.000 description 2
- 229910052738 indium Inorganic materials 0.000 description 2
- 239000003999 initiator Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
- 125000000468 ketone group Chemical group 0.000 description 2
- 150000002576 ketones Chemical class 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- DCUFMVPCXCSVNP-UHFFFAOYSA-N methacrylic anhydride Chemical compound CC(=C)C(=O)OC(=O)C(C)=C DCUFMVPCXCSVNP-UHFFFAOYSA-N 0.000 description 2
- 229920002113 octoxynol Polymers 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920002523 polyethylene Glycol 1000 Polymers 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 230000037452 priming Effects 0.000 description 2
- 230000007420 reactivation Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 description 2
- 150000003512 tertiary amines Chemical class 0.000 description 2
- YRHRIQCWCFGUEQ-UHFFFAOYSA-N thioxanthen-9-one Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3SC2=C1 YRHRIQCWCFGUEQ-UHFFFAOYSA-N 0.000 description 2
- JNELGWHKGNBSMD-UHFFFAOYSA-N xanthone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3OC2=C1 JNELGWHKGNBSMD-UHFFFAOYSA-N 0.000 description 2
- 150000004057 1,4-benzoquinones Chemical class 0.000 description 1
- VNQXSTWCDUXYEZ-UHFFFAOYSA-N 1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-dione Chemical compound C1CC2(C)C(=O)C(=O)C1C2(C)C VNQXSTWCDUXYEZ-UHFFFAOYSA-N 0.000 description 1
- IKQCSJBQLWJEPU-UHFFFAOYSA-N 2,5-dihydroxybenzenesulfonic acid Chemical class OC1=CC=C(O)C(S(O)(=O)=O)=C1 IKQCSJBQLWJEPU-UHFFFAOYSA-N 0.000 description 1
- YICILWNDMQTUIY-UHFFFAOYSA-N 2-methylidenepentanamide Chemical compound CCCC(=C)C(N)=O YICILWNDMQTUIY-UHFFFAOYSA-N 0.000 description 1
- YRNWIFYIFSBPAU-UHFFFAOYSA-N 4-[4-(dimethylamino)phenyl]-n,n-dimethylaniline Chemical compound C1=CC(N(C)C)=CC=C1C1=CC=C(N(C)C)C=C1 YRNWIFYIFSBPAU-UHFFFAOYSA-N 0.000 description 1
- IFQUPKAISSPFTE-UHFFFAOYSA-M 4-benzoylbenzoate Chemical compound C1=CC(C(=O)[O-])=CC=C1C(=O)C1=CC=CC=C1 IFQUPKAISSPFTE-UHFFFAOYSA-M 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- JAJIPIAHCFBEPI-UHFFFAOYSA-M 9,10-dioxoanthracene-1-sulfonate Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C=CC=C2S(=O)(=O)[O-] JAJIPIAHCFBEPI-UHFFFAOYSA-M 0.000 description 1
- GDALETGZDYOOGB-UHFFFAOYSA-N Acridone Natural products C1=C(O)C=C2N(C)C3=CC=CC=C3C(=O)C2=C1O GDALETGZDYOOGB-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 108010039627 Aprotinin Proteins 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- RYECOJGRJDOGPP-UHFFFAOYSA-N Ethylurea Chemical compound CCNC(N)=O RYECOJGRJDOGPP-UHFFFAOYSA-N 0.000 description 1
- 108010080865 Factor XII Proteins 0.000 description 1
- 102000000429 Factor XII Human genes 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 101000635799 Homo sapiens Run domain Beclin-1-interacting and cysteine-rich domain-containing protein Proteins 0.000 description 1
- 108060005987 Kallikrein Proteins 0.000 description 1
- 102000001399 Kallikrein Human genes 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- 241000219470 Mirabilis Species 0.000 description 1
- 229930192627 Naphthoquinone Natural products 0.000 description 1
- 238000010546 Norrish type I reaction Methods 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 229920003082 Povidone K 90 Polymers 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 102100030852 Run domain Beclin-1-interacting and cysteine-rich domain-containing protein Human genes 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 238000003848 UV Light-Curing Methods 0.000 description 1
- AUYXSAVQMSZYEY-UHFFFAOYSA-N [4-(morpholin-4-ylmethyl)phenyl]-phenylmethanone Chemical compound C=1C=C(CN2CCOCC2)C=CC=1C(=O)C1=CC=CC=C1 AUYXSAVQMSZYEY-UHFFFAOYSA-N 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- FZEYVTFCMJSGMP-UHFFFAOYSA-N acridone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3NC2=C1 FZEYVTFCMJSGMP-UHFFFAOYSA-N 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- RJGDLRCDCYRQOQ-UHFFFAOYSA-N anthrone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3CC2=C1 RJGDLRCDCYRQOQ-UHFFFAOYSA-N 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 229960004405 aprotinin Drugs 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 238000004630 atomic force microscopy Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- BMUAWSFTBCUPQS-UHFFFAOYSA-N benzoyl-benzyl-dimethylazanium Chemical compound C=1C=CC=CC=1C(=O)[N+](C)(C)CC1=CC=CC=C1 BMUAWSFTBCUPQS-UHFFFAOYSA-N 0.000 description 1
- 108010055000 benzyloxycarbonyl-lysyl-phenylalanyl-arginine-4-nitroanilide Proteins 0.000 description 1
- 230000005266 beta plus decay Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 238000006664 bond formation reaction Methods 0.000 description 1
- 229930006711 bornane-2,3-dione Natural products 0.000 description 1
- 150000001634 bornane-2,3-dione derivatives Chemical class 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 150000001793 charged compounds Chemical class 0.000 description 1
- 238000012412 chemical coupling Methods 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 229920001688 coating polymer Polymers 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 238000010908 decantation Methods 0.000 description 1
- 238000006356 dehydrogenation reaction Methods 0.000 description 1
- 238000006392 deoxygenation reaction Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000001212 derivatisation Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 125000005594 diketone group Chemical group 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
- 238000007323 disproportionation reaction Methods 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 125000003700 epoxy group Chemical group 0.000 description 1
- 230000005281 excited state Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000002073 fluorescence micrograph Methods 0.000 description 1
- 238000000799 fluorescence microscopy Methods 0.000 description 1
- 210000005224 forefinger Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- VOZRXNHHFUQHIL-UHFFFAOYSA-N glycidyl methacrylate Chemical compound CC(=C)C(=O)OCC1CO1 VOZRXNHHFUQHIL-UHFFFAOYSA-N 0.000 description 1
- 125000003827 glycol group Chemical group 0.000 description 1
- 229920000578 graft copolymer Polymers 0.000 description 1
- 238000002615 hemofiltration Methods 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000005661 hydrophobic surface Effects 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 229940127121 immunoconjugate Drugs 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 description 1
- 238000013152 interventional procedure Methods 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- VHRYZQNGTZXDNX-UHFFFAOYSA-N methacryloyl chloride Chemical compound CC(=C)C(Cl)=O VHRYZQNGTZXDNX-UHFFFAOYSA-N 0.000 description 1
- 239000003068 molecular probe Substances 0.000 description 1
- 229940088644 n,n-dimethylacrylamide Drugs 0.000 description 1
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 description 1
- 150000002791 naphthoquinones Chemical class 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 229920002114 octoxynol-9 Polymers 0.000 description 1
- 150000004010 onium ions Chemical class 0.000 description 1
- RPQRDASANLAFCM-UHFFFAOYSA-N oxiran-2-ylmethyl prop-2-enoate Chemical compound C=CC(=O)OCC1CO1 RPQRDASANLAFCM-UHFFFAOYSA-N 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 125000005496 phosphonium group Chemical group 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 239000002296 pyrolytic carbon Substances 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 150000005838 radical anions Chemical class 0.000 description 1
- 150000005839 radical cations Chemical class 0.000 description 1
- 239000012048 reactive intermediate Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000007761 roller coating Methods 0.000 description 1
- 238000010079 rubber tapping Methods 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 238000004626 scanning electron microscopy Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- HQORTWNIGOCVPP-UHFFFAOYSA-M sodium 2-[bis[2-[(4-benzoylphenyl)methoxy]ethyl]amino]ethanesulfonate Chemical compound [Na+].C(C1=CC=CC=C1)(=O)C1=CC=C(COCCN(CCS(=O)(=O)[O-])CCOCC2=CC=C(C=C2)C(C2=CC=CC=C2)=O)C=C1 HQORTWNIGOCVPP-UHFFFAOYSA-M 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-O sulfonium Chemical compound [SH3+] RWSOTUBLDIXVET-UHFFFAOYSA-O 0.000 description 1
- 230000003746 surface roughness Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 238000010345 tape casting Methods 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
- 229950003937 tolonium Drugs 0.000 description 1
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 239000006150 trypticase soy agar Substances 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
- 238000001429 visible spectrum Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D4/00—Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond ; Coating compositions, based on monomers of macromolecular compounds of groups C09D183/00 - C09D183/16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S522/00—Synthetic resins or natural rubbers -- part of the class 520 series
- Y10S522/904—Monomer or polymer contains initiating group
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/249921—Web or sheet containing structurally defined element or component
- Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
- Y10T428/249987—With nonvoid component of specified composition
- Y10T428/249991—Synthetic resin or natural rubbers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/249921—Web or sheet containing structurally defined element or component
- Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
- Y10T428/249987—With nonvoid component of specified composition
- Y10T428/249991—Synthetic resin or natural rubbers
- Y10T428/249992—Linear or thermoplastic
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Nanotechnology (AREA)
- Materials Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Wood Science & Technology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Composite Materials (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Coating Of Shaped Articles Made Of Macromolecular Substances (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
- Prostheses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Paints Or Removers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/028,518 US7348055B2 (en) | 2001-12-21 | 2001-12-21 | Reagent and method for providing coatings on surfaces |
| PCT/US2002/041143 WO2003055611A1 (en) | 2001-12-21 | 2002-12-20 | Reagent and method for providing coatings on surfaces |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005514192A true JP2005514192A (ja) | 2005-05-19 |
| JP2005514192A5 JP2005514192A5 (enExample) | 2006-02-16 |
Family
ID=21843895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003556180A Pending JP2005514192A (ja) | 2001-12-21 | 2002-12-20 | 表面にコーティングを供給するための試薬および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US7348055B2 (enExample) |
| EP (1) | EP1465740A4 (enExample) |
| JP (1) | JP2005514192A (enExample) |
| AU (1) | AU2002360736A1 (enExample) |
| CA (1) | CA2471103A1 (enExample) |
| WO (1) | WO2003055611A1 (enExample) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006504451A (ja) * | 2002-08-22 | 2006-02-09 | フレセニウス メディカル ケア ドイチェランド ゲーエムベーハー | ポリマー支持体表面にハイドロゲル形成ポリマーを固定化するための方法 |
| JP2007130194A (ja) * | 2005-11-10 | 2007-05-31 | Osaka Organic Chem Ind Ltd | 医療用材料 |
| JP2011500894A (ja) * | 2007-10-11 | 2011-01-06 | スリーエム イノベイティブ プロパティズ カンパニー | 親水性多孔質基材 |
| JP2015502221A (ja) * | 2011-12-14 | 2015-01-22 | センプラス・バイオサイエンシーズ・コーポレイションSemprus Biosciences Corp. | 複数の材料から構成されたカテーテルのための表面修飾 |
| WO2015098764A1 (ja) * | 2013-12-27 | 2015-07-02 | テルモ株式会社 | 抗血栓性医療材料、および該医療材料を利用した医療用具 |
| JP2016074755A (ja) * | 2014-10-02 | 2016-05-12 | 住友ゴム工業株式会社 | 表面改質方法及び表面改質弾性体 |
| JP2018153441A (ja) * | 2017-03-17 | 2018-10-04 | 株式会社日本触媒 | 人工関節用材料 |
| JP2019022885A (ja) * | 2010-03-30 | 2019-02-14 | サーモディクス,インコーポレイテッド | 分解性光架橋剤 |
| KR20190049530A (ko) * | 2017-10-31 | 2019-05-09 | 도오꾜오까고오교 가부시끼가이샤 | 표면 처리 방법, 표면 처리액, 및 표면 처리된 물품 |
Families Citing this family (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7846202B2 (en) * | 1995-06-07 | 2010-12-07 | Cook Incorporated | Coated implantable medical device |
| AU2002235694B2 (en) * | 2001-02-28 | 2007-06-14 | Covalon Technologies Inc. | Method of making anti-microbial polymeric surfaces |
| US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
| KR100529209B1 (ko) * | 2002-08-28 | 2005-11-17 | 한국과학기술연구원 | 세포 친화성이 향상된 생분해성의 조직 공학용 다공성고분자 지지체의 제조방법 |
| US20040208983A1 (en) * | 2003-04-16 | 2004-10-21 | Hill Gregory A. | Antimicrobial coatings for ophthalmic devices |
| US8246974B2 (en) | 2003-05-02 | 2012-08-21 | Surmodics, Inc. | Medical devices and methods for producing the same |
| WO2005037338A1 (en) * | 2003-10-14 | 2005-04-28 | Cook Incorporated | Hydrophilic coated medical device |
| US7550443B2 (en) * | 2004-03-26 | 2009-06-23 | Surmodics, Inc. | Process and systems for biocompatible surfaces |
| CA2560507C (en) * | 2004-03-26 | 2011-08-16 | Surmodics, Inc. | Composition and method for preparing biocompatible surfaces |
| US8696564B2 (en) | 2004-07-09 | 2014-04-15 | Cardiac Pacemakers, Inc. | Implantable sensor with biocompatible coating for controlling or inhibiting tissue growth |
| JP2008518667A (ja) | 2004-10-28 | 2008-06-05 | サーモディクス,インコーポレイティド | 向線維性コーティング |
| WO2006063181A1 (en) * | 2004-12-06 | 2006-06-15 | Surmodics, Inc. | Multifunctional medical articles |
| JP5155146B2 (ja) | 2005-03-15 | 2013-02-27 | サーモディクス,インコーポレイティド | 挿入可能な医療器具用の柔軟性ポリマー被膜 |
| US7772393B2 (en) * | 2005-06-13 | 2010-08-10 | Innovative Surface Technologies, Inc. | Photochemical crosslinkers for polymer coatings and substrate tie-layer |
| US20070228606A1 (en) * | 2005-07-07 | 2007-10-04 | Specialty Coating Systems, Inc. | Nanoscale structures and methods of preparation |
| US7387813B2 (en) * | 2005-07-07 | 2008-06-17 | Specialty Coating Systems, Inc. | Methods of preparation of hollow microstructures and nanostructures |
| DE102005033520B4 (de) * | 2005-07-14 | 2007-12-20 | Schwan-Stabilo Cosmetics Gmbh & Co. Kg | Zubereitung, insbesondere kosmetische Zubereitung, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US7989619B2 (en) * | 2005-07-14 | 2011-08-02 | Innovative Surface Technoloiges, Inc. | Nanotextured surfaces |
| JP2009502242A (ja) * | 2005-07-20 | 2009-01-29 | サーモディクス,インコーポレイティド | ポリマーがコーティングされたナノフィブリル構造体、並びに細胞維持及び分化のための方法 |
| WO2007012051A1 (en) * | 2005-07-20 | 2007-01-25 | Surmodics, Inc. | Polymeric coatings and methods for cell attachment |
| US7994372B2 (en) * | 2005-10-31 | 2011-08-09 | Specialty Coating Systems, Inc. | Parylene variants and methods of synthesis and use |
| US20070148390A1 (en) * | 2005-12-27 | 2007-06-28 | Specialty Coating Systems, Inc. | Fluorinated coatings |
| US7652178B2 (en) * | 2007-02-26 | 2010-01-26 | Specialty Coating Systems, Inc. | Perfluoroparacyclophane and methods of synthesis and use thereof |
| WO2009002869A2 (en) | 2007-06-22 | 2008-12-31 | Innovative Surface Technologies, Inc. | Nanofibers containing latent reactive groups |
| WO2009002858A2 (en) | 2007-06-22 | 2008-12-31 | Innovative Surface Technologies, Inc. | Stimuli responsive nanofibers |
| JP5766127B2 (ja) * | 2009-02-20 | 2015-08-19 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | エステル結合したポリ(エステル−ブロック−アミド)上における粒子発生を低減する親水性コーティング |
| US8691983B2 (en) * | 2009-03-03 | 2014-04-08 | Innovative Surface Technologies, Inc. | Brush polymer coating by in situ polymerization from photoreactive surface |
| MX342897B (es) | 2009-04-28 | 2016-10-18 | Surmodics Inc | Dispositivos y metodos para suministrar agentes bioactivos. |
| DK2251454T3 (da) | 2009-05-13 | 2014-10-13 | Sio2 Medical Products Inc | Coating og inspektion af beholder |
| JP5937004B2 (ja) | 2009-05-18 | 2016-06-22 | ドーズ メディカル コーポレーションDose Medical Corporation | 薬剤溶出眼内インプラント |
| US12478503B2 (en) | 2009-05-18 | 2025-11-25 | Glaukos Corporation | Implants with controlled drug delivery features and methods of using same |
| WO2012071476A2 (en) | 2010-11-24 | 2012-05-31 | David Haffner | Drug eluting ocular implant |
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| US9458536B2 (en) | 2009-07-02 | 2016-10-04 | Sio2 Medical Products, Inc. | PECVD coating methods for capped syringes, cartridges and other articles |
| US20110105990A1 (en) * | 2009-11-04 | 2011-05-05 | Silvestrini Thomas A | Zonal drug delivery device and method |
| WO2011072199A2 (en) * | 2009-12-10 | 2011-06-16 | Surmodics, Inc. | Water-soluble degradable photo-crosslinker |
| WO2011079062A1 (en) * | 2009-12-21 | 2011-06-30 | Siemens Industry, Inc. | Charged porous polymeric membranes and their preparation |
| US20120258313A1 (en) | 2009-12-21 | 2012-10-11 | Jie Wen | Coating agents and coated articles |
| US8529492B2 (en) | 2009-12-23 | 2013-09-10 | Trascend Medical, Inc. | Drug delivery devices and methods |
| EP2519270B1 (en) | 2009-12-31 | 2017-02-15 | Surmodics, Inc. | Silyl ether-modified hydrophilic polymers and uses for medical articles |
| US11624115B2 (en) | 2010-05-12 | 2023-04-11 | Sio2 Medical Products, Inc. | Syringe with PECVD lubrication |
| US8932694B2 (en) | 2010-06-29 | 2015-01-13 | Surmodics, Inc. | Fluorinated polymers and lubricious coatings |
| US9878101B2 (en) | 2010-11-12 | 2018-01-30 | Sio2 Medical Products, Inc. | Cyclic olefin polymer vessels and vessel coating methods |
| US10315987B2 (en) | 2010-12-13 | 2019-06-11 | Surmodics, Inc. | Photo-crosslinker |
| US9272095B2 (en) | 2011-04-01 | 2016-03-01 | Sio2 Medical Products, Inc. | Vessels, contact surfaces, and coating and inspection apparatus and methods |
| US9861727B2 (en) | 2011-05-20 | 2018-01-09 | Surmodics, Inc. | Delivery of hydrophobic active agent particles |
| US9757497B2 (en) | 2011-05-20 | 2017-09-12 | Surmodics, Inc. | Delivery of coated hydrophobic active agent particles |
| US10213529B2 (en) | 2011-05-20 | 2019-02-26 | Surmodics, Inc. | Delivery of coated hydrophobic active agent particles |
| EP2716669B1 (en) | 2011-06-03 | 2018-11-07 | Sumitomo Rubber Industries, Ltd. | Tire and gasket for syringes |
| US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
| US11116695B2 (en) | 2011-11-11 | 2021-09-14 | Sio2 Medical Products, Inc. | Blood sample collection tube |
| AU2012318242A1 (en) | 2011-11-11 | 2013-05-30 | Sio2 Medical Products, Inc. | Passivation, pH protective or lubricity coating for pharmaceutical package, coating process and apparatus |
| EP3012301B1 (en) * | 2012-01-18 | 2023-08-16 | SurModics, Inc. | Lubricious medical device coating with low particulates |
| EP2846755A1 (en) | 2012-05-09 | 2015-03-18 | SiO2 Medical Products, Inc. | Saccharide protective coating for pharmaceutical package |
| JP5812935B2 (ja) * | 2012-05-16 | 2015-11-17 | 住友ゴム工業株式会社 | 表面改質方法及び表面改質弾性体 |
| MX351261B (es) | 2012-06-01 | 2017-10-06 | Surmodics Inc | Aparato y método para recubrir catéteres con globo. |
| US9827401B2 (en) | 2012-06-01 | 2017-11-28 | Surmodics, Inc. | Apparatus and methods for coating medical devices |
| US20150297800A1 (en) | 2012-07-03 | 2015-10-22 | Sio2 Medical Products, Inc. | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS |
| WO2014038688A1 (ja) | 2012-09-10 | 2014-03-13 | 住友ゴム工業株式会社 | 表面改質方法及び表面改質弾性体 |
| CA2890066C (en) | 2012-11-01 | 2021-11-09 | Sio2 Medical Products, Inc. | Coating inspection method |
| WO2014071387A1 (en) | 2012-11-05 | 2014-05-08 | Surmodics, Inc. | Composition and method for delivery of hydrophobic active agents |
| US11246963B2 (en) | 2012-11-05 | 2022-02-15 | Surmodics, Inc. | Compositions and methods for delivery of hydrophobic active agents |
| TWI512103B (zh) | 2012-11-12 | 2015-12-11 | Ind Tech Res Inst | 細胞培養系統、以及無血清細胞培養方法 |
| WO2014078666A1 (en) | 2012-11-16 | 2014-05-22 | Sio2 Medical Products, Inc. | Method and apparatus for detecting rapid barrier coating integrity characteristics |
| JP5620456B2 (ja) | 2012-11-20 | 2014-11-05 | 住友ゴム工業株式会社 | 表面改質方法及び表面改質弾性体 |
| JP6053482B2 (ja) | 2012-11-30 | 2016-12-27 | 住友ゴム工業株式会社 | 注射器用ガスケットの製造方法 |
| US9764093B2 (en) | 2012-11-30 | 2017-09-19 | Sio2 Medical Products, Inc. | Controlling the uniformity of PECVD deposition |
| EP2925903B1 (en) | 2012-11-30 | 2022-04-13 | Si02 Medical Products, Inc. | Controlling the uniformity of pecvd deposition on medical syringes, cartridges, and the like |
| EP2941279B1 (en) | 2013-01-04 | 2023-05-17 | SurModics, Inc. | Low particulate lubricious coating with vinyl pyrrolidone and acidic polymer-containing layers |
| JP6105292B2 (ja) | 2013-01-07 | 2017-03-29 | 住友ゴム工業株式会社 | 表面改質方法及び表面改質弾性体 |
| WO2014110407A2 (en) | 2013-01-11 | 2014-07-17 | Surmodics, Inc. | Conductive polymers and uses |
| EP2961858B1 (en) | 2013-03-01 | 2022-09-07 | Si02 Medical Products, Inc. | Coated syringe. |
| US9937099B2 (en) | 2013-03-11 | 2018-04-10 | Sio2 Medical Products, Inc. | Trilayer coated pharmaceutical packaging with low oxygen transmission rate |
| CN105392916B (zh) | 2013-03-11 | 2019-03-08 | Sio2医药产品公司 | 涂布包装材料 |
| EP2971227B1 (en) | 2013-03-15 | 2017-11-15 | Si02 Medical Products, Inc. | Coating method. |
| JP5816222B2 (ja) | 2013-04-25 | 2015-11-18 | 住友ゴム工業株式会社 | 表面改質方法及び表面改質弾性体 |
| US10543175B1 (en) * | 2013-05-17 | 2020-01-28 | Degama Berrier Ltd. | Film composition and methods for producing the same |
| CN103289499B (zh) * | 2013-06-05 | 2015-12-02 | 中山大学 | 一种可光固化亲水润滑性涂层及其制备方法和使用方法 |
| JP5797239B2 (ja) | 2013-06-11 | 2015-10-21 | 住友ゴム工業株式会社 | 立体形状物の表面改質方法及び注射器用ガスケット |
| WO2014203668A1 (ja) | 2013-06-20 | 2014-12-24 | 住友ゴム工業株式会社 | 表面改質方法及び表面改質体 |
| JP5820489B2 (ja) | 2014-01-06 | 2015-11-24 | 住友ゴム工業株式会社 | 表面改質方法及び表面改質弾性体 |
| JP6018237B2 (ja) | 2014-02-14 | 2016-11-02 | アークレイ株式会社 | マイクロ流路を備えるチップの製造方法及びそれにより製造されるチップ |
| EP3693493A1 (en) | 2014-03-28 | 2020-08-12 | SiO2 Medical Products, Inc. | Antistatic coatings for plastic vessels |
| EP3148491B1 (en) | 2014-05-29 | 2020-07-01 | Glaukos Corporation | Implants with controlled drug delivery features and manufacturing method for said implants |
| US10124088B2 (en) | 2014-09-29 | 2018-11-13 | Surmodics, Inc. | Lubricious medical device elements |
| CN120114655A (zh) | 2015-01-29 | 2025-06-10 | 苏尔莫迪克斯公司 | 疏水性活性剂颗粒的递送 |
| JP6551022B2 (ja) | 2015-08-03 | 2019-07-31 | 住友ゴム工業株式会社 | 表面改質方法及び表面改質体 |
| JP6613692B2 (ja) | 2015-08-03 | 2019-12-04 | 住友ゴム工業株式会社 | 表面改質方法及び表面改質弾性体 |
| US11077233B2 (en) | 2015-08-18 | 2021-08-03 | Sio2 Medical Products, Inc. | Pharmaceutical and other packaging with low oxygen transmission rate |
| US11925578B2 (en) | 2015-09-02 | 2024-03-12 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
| US10478546B2 (en) | 2015-09-15 | 2019-11-19 | Surmodics, Inc. | Hemodialysis catheter sleeve |
| US11564833B2 (en) | 2015-09-25 | 2023-01-31 | Glaukos Corporation | Punctal implants with controlled drug delivery features and methods of using same |
| US11174447B2 (en) | 2015-12-29 | 2021-11-16 | Surmodics, Inc. | Lubricious coatings with surface salt groups |
| US10342898B2 (en) | 2015-12-29 | 2019-07-09 | Surmodics, Inc. | Lubricious coatings with surface salt groups |
| US20170281914A1 (en) | 2016-03-31 | 2017-10-05 | Surmodics, Inc. | Localized treatment of tissues through transcatheter delivery of active agents |
| US10918835B2 (en) | 2016-03-31 | 2021-02-16 | Surmodics, Inc. | Delivery system for active agent coated balloon |
| US10806904B2 (en) | 2016-03-31 | 2020-10-20 | Surmodics, Inc. | Two-part insertion tool and methods |
| WO2017173114A1 (en) | 2016-03-31 | 2017-10-05 | Surmodics, Inc. | Lubricious coating for medical device |
| JP7003110B2 (ja) | 2016-04-20 | 2022-01-20 | ドーズ メディカル コーポレーション | 生体吸収性眼球薬物送達デバイス |
| US9778103B1 (en) * | 2016-05-13 | 2017-10-03 | Eit, Llc | UV radiometry instruments and methods |
| US10391292B2 (en) | 2016-06-15 | 2019-08-27 | Surmodics, Inc. | Hemostasis sealing device with constriction ring |
| US11150219B2 (en) | 2016-08-03 | 2021-10-19 | Basf Se | Bio-recognition elements |
| JP2019532695A (ja) | 2016-09-16 | 2019-11-14 | サーモディクス,インコーポレイティド | 医療デバイス用の潤滑性挿入具および使用方法 |
| US10758719B2 (en) | 2016-12-15 | 2020-09-01 | Surmodics, Inc. | Low-friction sealing devices |
| US11123459B2 (en) | 2016-12-16 | 2021-09-21 | Surmodics, Inc. | Hydrophobic active agent particle coatings and methods for treatment |
| US10898446B2 (en) | 2016-12-20 | 2021-01-26 | Surmodics, Inc. | Delivery of hydrophobic active agents from hydrophilic polyether block amide copolymer surfaces |
| RU2020110828A (ru) * | 2017-08-17 | 2021-09-17 | Колопласт А/С | Полимерные покрытия |
| US11433359B1 (en) | 2018-01-29 | 2022-09-06 | Arrowhead Center, Inc. | Antimicrobial filtration membranes |
| DE102018129483B4 (de) * | 2018-11-22 | 2020-09-10 | Carl Zeiss Meditec Ag | Ophthalmologisches Implantat mit superhydrophiler Oberfläche und Verfahren zum Herstellen eines solchen ophthalmologischen Implantats |
| US11628466B2 (en) | 2018-11-29 | 2023-04-18 | Surmodics, Inc. | Apparatus and methods for coating medical devices |
| US11819590B2 (en) | 2019-05-13 | 2023-11-21 | Surmodics, Inc. | Apparatus and methods for coating medical devices |
| US12226552B2 (en) | 2019-09-30 | 2025-02-18 | Surmodics, Inc. | Active agent depots formed in situ |
| WO2023211937A1 (en) | 2022-04-25 | 2023-11-02 | Surmodics, Inc. | Medical device coatings with microcrystalline active agents |
| CN116003692B (zh) * | 2022-05-12 | 2024-02-09 | 天津大学 | 一种表面接枝交联的两性离子聚合物涂层及其制备方法与应用 |
| CN115433327B (zh) * | 2022-11-08 | 2023-03-03 | 四川兴泰普乐医疗科技有限公司 | 一种人工晶体材料及其制备方法和应用 |
| CN115677983A (zh) * | 2022-11-10 | 2023-02-03 | 上海派拉纶生物技术股份有限公司 | 对聚对二甲苯的改性方法、聚对二甲苯改性材料以及防水涂料 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08505839A (ja) * | 1992-11-06 | 1996-06-25 | ビーエスアイ コーポレイション | 表面改質用の拘束された多官能性試薬 |
| JPH1180393A (ja) * | 1997-06-28 | 1999-03-26 | Huels Ag | ポリマー支持体の表面の親水性化法、このように処理された支持体からなる製品、およびその使用 |
| WO1999038546A1 (en) * | 1998-01-30 | 1999-08-05 | Advanced Cardiovascular Systems, Inc. | Hydrophilic coating for an intracorporeal medical device |
| JP2000500440A (ja) * | 1995-11-03 | 2000-01-18 | ビーエスアイ コーポレイション | 水溶性架橋剤 |
| WO2001021326A1 (en) * | 1999-09-22 | 2001-03-29 | Surmodics, Inc. | Water-soluble coating agents bearing initiator groups and coating process |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US666994A (en) * | 1900-06-20 | 1901-01-29 | Frans Oskar Zeinwoldt | Frame or bracket for bearings. |
| US4207287A (en) * | 1977-07-27 | 1980-06-10 | Chevron Research Company | Contact lens sterilizer apparatus |
| US4725279A (en) * | 1979-01-22 | 1988-02-16 | Sterling Drug Inc. | Bio compatible and blood compatible materials and methods |
| US5073484A (en) | 1982-03-09 | 1991-12-17 | Bio-Metric Systems, Inc. | Quantitative analysis apparatus and method |
| US4973493A (en) | 1982-09-29 | 1990-11-27 | Bio-Metric Systems, Inc. | Method of improving the biocompatibility of solid surfaces |
| US5002582A (en) | 1982-09-29 | 1991-03-26 | Bio-Metric Systems, Inc. | Preparation of polymeric surfaces via covalently attaching polymers |
| US5258041A (en) | 1982-09-29 | 1993-11-02 | Bio-Metric Systems, Inc. | Method of biomolecule attachment to hydrophobic surfaces |
| US4722906A (en) | 1982-09-29 | 1988-02-02 | Bio-Metric Systems, Inc. | Binding reagents and methods |
| US5512329A (en) | 1982-09-29 | 1996-04-30 | Bsi Corporation | Substrate surface preparation |
| US5217492A (en) | 1982-09-29 | 1993-06-08 | Bio-Metric Systems, Inc. | Biomolecule attachment to hydrophobic surfaces |
| US4578536A (en) | 1983-10-19 | 1986-03-25 | International Teldata Corp | Centerpoint automatic meter reading system |
| US4826759A (en) | 1984-10-04 | 1989-05-02 | Bio-Metric Systems, Inc. | Field assay for ligands |
| US4603904A (en) | 1985-08-12 | 1986-08-05 | Shelby Williams Industries, Inc. | Chair with articulated, flexible spring backrest |
| FI872890L (fi) | 1985-11-01 | 1987-06-30 | Pfizer | Polypeptider innehaollande difluorcyklostatin. |
| WO1987006708A1 (en) | 1986-04-28 | 1987-11-05 | Bio-Metric Systems, Inc. | Rapid assay involving solid phase receptors |
| US5263992A (en) | 1986-10-17 | 1993-11-23 | Bio-Metric Systems, Inc. | Biocompatible device with covalently bonded biocompatible agent |
| ATE116863T1 (de) | 1986-10-17 | 1995-01-15 | Bio Metric Systems Inc | Bioverträglichkeit harter flächen. |
| US4979959A (en) | 1986-10-17 | 1990-12-25 | Bio-Metric Systems, Inc. | Biocompatible coating for solid surfaces |
| WO1988004487A1 (en) | 1986-12-05 | 1988-06-16 | Domus International Pty. Ltd. | Adjustable closure means |
| SE8605266L (sv) | 1986-12-09 | 1988-06-10 | Ragnar Jonsson | Switch-koppling |
| CA1335721C (en) | 1987-12-24 | 1995-05-30 | Patrick E. Guire | Biomolecule attached to a solid surface by means of a spacer and methods of attaching biomolecules to surfaces |
| WO1990000251A1 (en) | 1988-06-30 | 1990-01-11 | Bio-Metric Systems, Inc. | Pressure-assisted analytical apparatus and method |
| DE3856430T2 (de) | 1988-07-22 | 2001-05-03 | Surmodics, Inc. | Herstellung von polymeren oberflächen |
| JPH0259029A (ja) * | 1988-08-25 | 1990-02-28 | Tosoh Corp | 親水性表面を有する多孔質膜及びその製造方法 |
| BR9007643A (pt) | 1989-09-15 | 1992-08-18 | Chiron Ophthalmics Inc | Metodo para se conseguir a epitelizacao de lentes sinteticas |
| WO1991007485A1 (en) | 1989-11-09 | 1991-05-30 | Bio-Metric Systems, Inc. | Improved bioreactor surfaces and methods of making same |
| CA2107683C (en) | 1992-02-13 | 2004-07-20 | Dale G. Swan | Immobilization of chemical species in crosslinked matrices |
| US5512474A (en) | 1992-05-29 | 1996-04-30 | Bsi Corporation | Cell culture support containing a cell adhesion factor and a positively-charged molecule |
| TW328535B (en) * | 1993-07-02 | 1998-03-21 | Novartis Ag | Functional photoinitiators and their manufacture |
| WO1995012420A1 (en) | 1993-11-04 | 1995-05-11 | Bsi Corporation | Barrier coatings for surfaces |
| US5803925A (en) * | 1995-01-17 | 1998-09-08 | Allergan | IOL insertion apparatus with covalently bonded lubricant |
| AU720963B2 (en) | 1995-05-26 | 2000-06-15 | Surmodics, Inc. | Method and implantable article for promoting endothelialization |
| US5783502A (en) | 1995-06-07 | 1998-07-21 | Bsi Corporation | Virus inactivating coatings |
| US5942555A (en) | 1996-03-21 | 1999-08-24 | Surmodics, Inc. | Photoactivatable chain transfer agents and semi-telechelic photoactivatable polymers prepared therefrom |
| US5814064A (en) | 1997-03-06 | 1998-09-29 | Scimed Life Systems, Inc. | Distal protection device |
| US6121027A (en) | 1997-08-15 | 2000-09-19 | Surmodics, Inc. | Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups |
| US6506895B2 (en) | 1997-08-15 | 2003-01-14 | Surmodics, Inc. | Photoactivatable nucleic acids |
| WO1999015917A1 (en) | 1997-09-23 | 1999-04-01 | Novartis Ag | Method for hydrogel surface treatment and article formed therefrom |
| US5858653A (en) | 1997-09-30 | 1999-01-12 | Surmodics, Inc. | Reagent and method for attaching target molecules to a surface |
| GB9720693D0 (en) | 1997-09-30 | 1997-11-26 | Univ Wales Medicine | Assay |
| US6465178B2 (en) | 1997-09-30 | 2002-10-15 | Surmodics, Inc. | Target molecule attachment to surfaces |
| US6465525B1 (en) | 1998-03-18 | 2002-10-15 | Surmodics, Inc. | Latent reactive blood compatible agents |
| US6007833A (en) | 1998-03-19 | 1999-12-28 | Surmodics, Inc. | Crosslinkable macromers bearing initiator groups |
| ATE466603T1 (de) | 1998-04-27 | 2010-05-15 | Surmodics Inc | Bioaktive wirkstoffe freisetzende beschichtungen |
| US6254634B1 (en) | 1998-06-10 | 2001-07-03 | Surmodics, Inc. | Coating compositions |
| DE59914221D1 (de) * | 1998-08-28 | 2007-04-12 | Poly An Ges Zur Herstellung Vo | Verfahren zur herstellung polymerer festphasenträger |
| US6514768B1 (en) | 1999-01-29 | 2003-02-04 | Surmodics, Inc. | Replicable probe array |
| US6358557B1 (en) | 1999-09-10 | 2002-03-19 | Sts Biopolymers, Inc. | Graft polymerization of substrate surfaces |
| US6278018B1 (en) | 1999-12-14 | 2001-08-21 | Surmodics, Inc. | Surface coating agents |
| US7220276B1 (en) | 2000-03-06 | 2007-05-22 | Surmodics, Inc. | Endovascular graft coatings |
| US6706408B2 (en) * | 2002-05-16 | 2004-03-16 | Surmodics, Inc. | Silane coating composition |
-
2001
- 2001-12-21 US US10/028,518 patent/US7348055B2/en not_active Expired - Lifetime
-
2002
- 2002-12-20 WO PCT/US2002/041143 patent/WO2003055611A1/en not_active Ceased
- 2002-12-20 JP JP2003556180A patent/JP2005514192A/ja active Pending
- 2002-12-20 AU AU2002360736A patent/AU2002360736A1/en not_active Abandoned
- 2002-12-20 CA CA002471103A patent/CA2471103A1/en not_active Abandoned
- 2002-12-20 EP EP02796018A patent/EP1465740A4/en not_active Withdrawn
-
2007
- 2007-08-29 US US11/846,955 patent/US7736689B2/en not_active Expired - Lifetime
-
2010
- 2010-05-20 US US12/783,907 patent/US8039524B2/en not_active Expired - Fee Related
-
2011
- 2011-09-16 US US13/234,270 patent/US20120004339A1/en not_active Abandoned
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08505839A (ja) * | 1992-11-06 | 1996-06-25 | ビーエスアイ コーポレイション | 表面改質用の拘束された多官能性試薬 |
| JP2000500440A (ja) * | 1995-11-03 | 2000-01-18 | ビーエスアイ コーポレイション | 水溶性架橋剤 |
| JPH1180393A (ja) * | 1997-06-28 | 1999-03-26 | Huels Ag | ポリマー支持体の表面の親水性化法、このように処理された支持体からなる製品、およびその使用 |
| WO1999038546A1 (en) * | 1998-01-30 | 1999-08-05 | Advanced Cardiovascular Systems, Inc. | Hydrophilic coating for an intracorporeal medical device |
| WO2001021326A1 (en) * | 1999-09-22 | 2001-03-29 | Surmodics, Inc. | Water-soluble coating agents bearing initiator groups and coating process |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006504451A (ja) * | 2002-08-22 | 2006-02-09 | フレセニウス メディカル ケア ドイチェランド ゲーエムベーハー | ポリマー支持体表面にハイドロゲル形成ポリマーを固定化するための方法 |
| JP2007130194A (ja) * | 2005-11-10 | 2007-05-31 | Osaka Organic Chem Ind Ltd | 医療用材料 |
| JP2011500894A (ja) * | 2007-10-11 | 2011-01-06 | スリーエム イノベイティブ プロパティズ カンパニー | 親水性多孔質基材 |
| KR101546551B1 (ko) * | 2007-10-11 | 2015-08-21 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 친수성 다공성 기판 |
| JP2019022885A (ja) * | 2010-03-30 | 2019-02-14 | サーモディクス,インコーポレイテッド | 分解性光架橋剤 |
| JP2015502221A (ja) * | 2011-12-14 | 2015-01-22 | センプラス・バイオサイエンシーズ・コーポレイションSemprus Biosciences Corp. | 複数の材料から構成されたカテーテルのための表面修飾 |
| JP2017038946A (ja) * | 2011-12-14 | 2017-02-23 | アロー インターナショナル インコーポレイテッド | 複数の材料から構成されたカテーテルのための表面修飾 |
| WO2015098764A1 (ja) * | 2013-12-27 | 2015-07-02 | テルモ株式会社 | 抗血栓性医療材料、および該医療材料を利用した医療用具 |
| JPWO2015098764A1 (ja) * | 2013-12-27 | 2017-03-23 | テルモ株式会社 | 抗血栓性医療材料、および該医療材料を利用した医療用具 |
| JP2016074755A (ja) * | 2014-10-02 | 2016-05-12 | 住友ゴム工業株式会社 | 表面改質方法及び表面改質弾性体 |
| JP2018153441A (ja) * | 2017-03-17 | 2018-10-04 | 株式会社日本触媒 | 人工関節用材料 |
| KR20190049530A (ko) * | 2017-10-31 | 2019-05-09 | 도오꾜오까고오교 가부시끼가이샤 | 표면 처리 방법, 표면 처리액, 및 표면 처리된 물품 |
| KR102693590B1 (ko) * | 2017-10-31 | 2024-08-08 | 도오꾜오까고오교 가부시끼가이샤 | 표면 처리 방법, 표면 처리액, 및 표면 처리된 물품 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1465740A1 (en) | 2004-10-13 |
| AU2002360736A1 (en) | 2003-07-15 |
| US8039524B2 (en) | 2011-10-18 |
| CA2471103A1 (en) | 2003-07-10 |
| US20070292596A1 (en) | 2007-12-20 |
| WO2003055611A1 (en) | 2003-07-10 |
| EP1465740A4 (en) | 2006-06-07 |
| US20030165613A1 (en) | 2003-09-04 |
| US7736689B2 (en) | 2010-06-15 |
| US20120004339A1 (en) | 2012-01-05 |
| US7348055B2 (en) | 2008-03-25 |
| US20100240789A1 (en) | 2010-09-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005514192A (ja) | 表面にコーティングを供給するための試薬および方法 | |
| JP4782338B2 (ja) | 開始剤基を有する水溶性コーティング剤およびコーティング方法 | |
| US6706408B2 (en) | Silane coating composition | |
| CA2625638C (en) | Ultra-thin photo-polymer coatings and uses thereof | |
| CZ2003523A3 (cs) | Způsob povrchové modifikace substrátů a takto získané modifikované substráty | |
| JP2013514841A (ja) | コーティング剤およびコーティングされた物品 | |
| JP5607486B2 (ja) | 開始剤基を有する水溶性コーティング剤およびコーティング方法 | |
| MXPA01004369A (es) | Agentes de revestimiento solubles en agua que contienen grupos iniciadores y procedimiento de revestimiento |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20051220 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20051220 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20080610 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20080909 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20080917 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20081209 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20100112 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20100409 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20100416 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20101109 |