JP2005513165A5 - - Google Patents
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- JP2005513165A5 JP2005513165A5 JP2003557558A JP2003557558A JP2005513165A5 JP 2005513165 A5 JP2005513165 A5 JP 2005513165A5 JP 2003557558 A JP2003557558 A JP 2003557558A JP 2003557558 A JP2003557558 A JP 2003557558A JP 2005513165 A5 JP2005513165 A5 JP 2005513165A5
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- JP
- Japan
- Prior art keywords
- independently
- alkyl
- optionally substituted
- aryl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims 55
- 125000003118 aryl group Chemical group 0.000 claims 46
- 125000001072 heteroaryl group Chemical group 0.000 claims 43
- 125000000753 cycloalkyl group Chemical group 0.000 claims 35
- 125000003342 alkenyl group Chemical group 0.000 claims 20
- 125000000304 alkynyl group Chemical group 0.000 claims 19
- 125000005865 C2-C10alkynyl group Chemical group 0.000 claims 17
- 229910052799 carbon Inorganic materials 0.000 claims 17
- -1 N- (substituted glycyl) -4-cyanopyrrolidine Chemical class 0.000 claims 16
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 15
- 229910052736 halogen Inorganic materials 0.000 claims 13
- 150000002367 halogens Chemical class 0.000 claims 13
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 claims 9
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 claims 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- 102000003729 Neprilysin Human genes 0.000 claims 5
- 108090000028 Neprilysin Proteins 0.000 claims 5
- 239000003603 dipeptidyl peptidase IV inhibitor Substances 0.000 claims 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 5
- 239000000825 pharmaceutical preparation Substances 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 125000002993 cycloalkylene group Chemical group 0.000 claims 4
- 239000002792 enkephalinase inhibitor Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229940124213 Dipeptidyl peptidase 4 (DPP IV) inhibitor Drugs 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000004404 heteroalkyl group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims 2
- 206010016807 Fluid retention Diseases 0.000 claims 2
- 125000004450 alkenylene group Chemical group 0.000 claims 2
- 125000003302 alkenyloxy group Chemical group 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 2
- 125000000732 arylene group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- ZTWZVMIYIIVABD-OEMFJLHTSA-N candoxatril Chemical group C([C@@H](COCCOC)C(=O)OC=1C=C2CCCC2=CC=1)C1(C(=O)N[C@@H]2CC[C@@H](CC2)C(O)=O)CCCC1 ZTWZVMIYIIVABD-OEMFJLHTSA-N 0.000 claims 2
- 229950004548 candoxatril Drugs 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 125000005549 heteroarylene group Chemical group 0.000 claims 2
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 claims 1
- SHERAUCGTHRFCU-UHFFFAOYSA-N 1,3-dimethyl-7-(2-oxopropyl)-8-piperazin-1-ylpurine-2,6-dione Chemical compound N=1C=2N(C)C(=O)N(C)C(=O)C=2N(CC(=O)C)C=1N1CCNCC1 SHERAUCGTHRFCU-UHFFFAOYSA-N 0.000 claims 1
- ARAFEULRMHFMDE-UHFFFAOYSA-N 1,3-oxazolidine-2,5-dione Chemical compound O=C1CNC(=O)O1 ARAFEULRMHFMDE-UHFFFAOYSA-N 0.000 claims 1
- FJJDFWFMTJCZBG-UHFFFAOYSA-N 2-(1,3-dimethyl-2,6-dioxo-8-piperazin-1-ylpurin-7-yl)ethyl 3,4,5-trimethoxybenzoate Chemical compound COC1=C(OC)C(OC)=CC(C(=O)OCCN2C=3C(=O)N(C)C(=O)N(C)C=3N=C2N2CCNCC2)=C1 FJJDFWFMTJCZBG-UHFFFAOYSA-N 0.000 claims 1
- UGWULZWUXSCWPX-UHFFFAOYSA-N 2-sulfanylideneimidazolidin-4-one Chemical compound O=C1CNC(=S)N1 UGWULZWUXSCWPX-UHFFFAOYSA-N 0.000 claims 1
- OZJASCJKXWVJDK-UHFFFAOYSA-N 3-methyl-7-(1-phenylethyl)-8-piperazin-1-ylpurine-2,6-dione Chemical compound C1CNCCN1C1=NC=2N(C)C(=O)NC(=O)C=2N1C(C)C1=CC=CC=C1 OZJASCJKXWVJDK-UHFFFAOYSA-N 0.000 claims 1
- ZRSJKBZMIQCRAV-UHFFFAOYSA-N 3-methyl-7-(3-methylbutyl)-8-piperazin-1-ylpurine-2,6-dione Chemical compound N=1C=2N(C)C(=O)NC(=O)C=2N(CCC(C)C)C=1N1CCNCC1 ZRSJKBZMIQCRAV-UHFFFAOYSA-N 0.000 claims 1
- URWZRCBFOLIMBX-UHFFFAOYSA-N 3-methyl-7-(3-phenylpropyl)-8-piperazin-1-ylpurine-2,6-dione Chemical compound C=1C=CC=CC=1CCCN1C=2C(=O)NC(=O)N(C)C=2N=C1N1CCNCC1 URWZRCBFOLIMBX-UHFFFAOYSA-N 0.000 claims 1
- NCBQWTNHQFIYCS-UHFFFAOYSA-N 3-methyl-7-[(3-methylphenyl)methyl]-8-piperazin-1-ylpurine-2,6-dione Chemical compound CC1=CC=CC(CN2C=3C(=O)NC(=O)N(C)C=3N=C2N2CCNCC2)=C1 NCBQWTNHQFIYCS-UHFFFAOYSA-N 0.000 claims 1
- UTGRHIJKSXXDBN-UHFFFAOYSA-N 3-methyl-8-piperazin-1-yl-1,7-dipropylpurine-2,6-dione Chemical compound N=1C=2N(C)C(=O)N(CCC)C(=O)C=2N(CCC)C=1N1CCNCC1 UTGRHIJKSXXDBN-UHFFFAOYSA-N 0.000 claims 1
- PSTDNERGQHJGIB-UHFFFAOYSA-N 3-methyl-8-piperazin-1-yl-7-propylpurine-2,6-dione Chemical compound N=1C=2N(C)C(=O)NC(=O)C=2N(CCC)C=1N1CCNCC1 PSTDNERGQHJGIB-UHFFFAOYSA-N 0.000 claims 1
- 125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 1
- ZGZLYKUHYXFIIO-UHFFFAOYSA-N 5-nitro-2h-tetrazole Chemical compound [O-][N+](=O)C=1N=NNN=1 ZGZLYKUHYXFIIO-UHFFFAOYSA-N 0.000 claims 1
- WMQWNGOCKCYSAY-UHFFFAOYSA-N 7-[(2-chlorophenyl)methyl]-3-methyl-8-piperazin-1-ylpurine-2,6-dione Chemical compound C=1C=CC=C(Cl)C=1CN1C=2C(=O)NC(=O)N(C)C=2N=C1N1CCNCC1 WMQWNGOCKCYSAY-UHFFFAOYSA-N 0.000 claims 1
- NUQFSJZWLOJBLL-UHFFFAOYSA-N 7-[(4-chlorophenyl)methyl]-3-methyl-8-piperazin-1-ylpurine-2,6-dione Chemical compound C=1C=C(Cl)C=CC=1CN1C=2C(=O)NC(=O)N(C)C=2N=C1N1CCNCC1 NUQFSJZWLOJBLL-UHFFFAOYSA-N 0.000 claims 1
- DJABCRUQDNAHBQ-YCRREMRBSA-N 7-[(e)-3-chlorobut-2-enyl]-3-methyl-8-piperazin-1-ylpurine-2,6-dione Chemical compound N=1C=2N(C)C(=O)NC(=O)C=2N(C\C=C(Cl)/C)C=1N1CCNCC1 DJABCRUQDNAHBQ-YCRREMRBSA-N 0.000 claims 1
- YOZCVGNKCHWWJJ-ONEGZZNKSA-N 7-[(e)-but-2-enyl]-3-methyl-8-piperazin-1-ylpurine-2,6-dione Chemical compound N=1C=2N(C)C(=O)NC(=O)C=2N(C/C=C/C)C=1N1CCNCC1 YOZCVGNKCHWWJJ-ONEGZZNKSA-N 0.000 claims 1
- WNVROUIPADYYDI-UHFFFAOYSA-N 7-[2-hydroxy-2-(4-nitrophenyl)ethyl]-3-methyl-8-piperazin-1-yl-8,9-dihydropurine-2,6-dione Chemical compound C1=2C(=O)NC(=O)N(C)C=2NC(N2CCNCC2)N1CC(O)C1=CC=C([N+]([O-])=O)C=C1 WNVROUIPADYYDI-UHFFFAOYSA-N 0.000 claims 1
- LRUXRWIHRNWCMG-UHFFFAOYSA-N 7-[2-hydroxy-3-(4-methoxyphenoxy)propyl]-3-methyl-8-piperazin-1-ylpurine-2,6-dione Chemical compound C1=CC(OC)=CC=C1OCC(O)CN1C(C(=O)NC(=O)N2C)=C2N=C1N1CCNCC1 LRUXRWIHRNWCMG-UHFFFAOYSA-N 0.000 claims 1
- OSWQQKHGTFZUND-UHFFFAOYSA-N 7-benzyl-3-methyl-8-piperazin-1-ylpurine-2,6-dione Chemical compound C=1C=CC=CC=1CN1C=2C(=O)NC(=O)N(C)C=2N=C1N1CCNCC1 OSWQQKHGTFZUND-UHFFFAOYSA-N 0.000 claims 1
- XARYHVKQXCTWDU-UHFFFAOYSA-N 7-butyl-3-methyl-8-piperazin-1-ylpurine-2,6-dione Chemical compound N=1C=2N(C)C(=O)NC(=O)C=2N(CCCC)C=1N1CCNCC1 XARYHVKQXCTWDU-UHFFFAOYSA-N 0.000 claims 1
- FDYKRGIGKFPKEU-UHFFFAOYSA-N 7-ethyl-3-methyl-8-piperazin-1-ylpurine-2,6-dione Chemical compound N=1C=2N(C)C(=O)NC(=O)C=2N(CC)C=1N1CCNCC1 FDYKRGIGKFPKEU-UHFFFAOYSA-N 0.000 claims 1
- GHMYMBNVKKTJGK-UHFFFAOYSA-N 7-heptyl-3-methyl-8-piperazin-1-ylpurine-2,6-dione Chemical compound N=1C=2N(C)C(=O)NC(=O)C=2N(CCCCCCC)C=1N1CCNCC1 GHMYMBNVKKTJGK-UHFFFAOYSA-N 0.000 claims 1
- 239000005541 ACE inhibitor Substances 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000002330 Congenital Heart Defects Diseases 0.000 claims 1
- 208000000059 Dyspnea Diseases 0.000 claims 1
- 206010013975 Dyspnoeas Diseases 0.000 claims 1
- 206010014561 Emphysema Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010022562 Intermittent claudication Diseases 0.000 claims 1
- 206010030124 Oedema peripheral Diseases 0.000 claims 1
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 1
- 206010037423 Pulmonary oedema Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010042674 Swelling Diseases 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 125000005133 alkynyloxy group Chemical group 0.000 claims 1
- 239000003472 antidiabetic agent Substances 0.000 claims 1
- 229940125708 antidiabetic agent Drugs 0.000 claims 1
- 210000000544 articulatio talocruralis Anatomy 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- SFZULDYEOVSIKM-UHFFFAOYSA-N chembl321317 Chemical compound C1=CC(C(=N)NO)=CC=C1C1=CC=C(C=2C=CC(=CC=2)C(=N)NO)O1 SFZULDYEOVSIKM-UHFFFAOYSA-N 0.000 claims 1
- 208000028831 congenital heart disease Diseases 0.000 claims 1
- 210000004351 coronary vessel Anatomy 0.000 claims 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 239000002934 diuretic Substances 0.000 claims 1
- 229940030606 diuretics Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 206010016256 fatigue Diseases 0.000 claims 1
- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 claims 1
- 208000018578 heart valve disease Diseases 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 208000014471 histiocytoid cardiomyopathy Diseases 0.000 claims 1
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical compound O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 claims 1
- 229940091173 hydantoin Drugs 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 208000021156 intermittent vascular claudication Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000004458 methylaminocarbonyl group Chemical group [H]N(C(*)=O)C([H])([H])[H] 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 208000031225 myocardial ischemia Diseases 0.000 claims 1
- 125000000538 pentafluorophenyl group Chemical group FC1=C(F)C(F)=C(*)C(F)=C1F 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 208000005333 pulmonary edema Diseases 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 125000003003 spiro group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 230000008961 swelling Effects 0.000 claims 1
- 125000004571 thiomorpholin-4-yl group Chemical group N1(CCSCC1)* 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200200047 | 2002-01-11 | ||
| US34833202P | 2002-01-14 | 2002-01-14 | |
| PCT/DK2003/000017 WO2003057200A2 (en) | 2002-01-11 | 2003-01-13 | Compositions comprising inhibitors of dpp-iv and nep enzymes for the treatment of diabetes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005513165A JP2005513165A (ja) | 2005-05-12 |
| JP2005513165A5 true JP2005513165A5 (https=) | 2006-03-02 |
Family
ID=26069126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003557558A Withdrawn JP2005513165A (ja) | 2002-01-11 | 2003-01-13 | 糖尿病、高血圧、慢性心不全および体液貯留状態の治療のための方法および組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20030236272A1 (https=) |
| EP (1) | EP1496877B1 (https=) |
| JP (1) | JP2005513165A (https=) |
| AT (1) | ATE409466T1 (https=) |
| AU (1) | AU2003201274A1 (https=) |
| DE (1) | DE60323823D1 (https=) |
| WO (1) | WO2003057200A2 (https=) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6821978B2 (en) * | 2000-09-19 | 2004-11-23 | Schering Corporation | Xanthine phosphodiesterase V inhibitors |
| KR100926247B1 (ko) * | 2001-02-24 | 2009-11-12 | 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 | 크산틴 유도체를 포함하는 약제학적 조성물 및 이의제조방법 |
| US7524635B2 (en) * | 2003-04-17 | 2009-04-28 | Biosite Incorporated | Methods and compositions for measuring natriuretic peptides and uses thereof |
| EP1463727A2 (en) * | 2001-09-19 | 2004-10-06 | Novo Nordisk A/S | Heterocyclic compounds that are inhibitors of the enzyme dpp-iv |
| WO2003084563A1 (en) * | 2002-04-04 | 2003-10-16 | Novo Nordisk A/S | Glp-1 agonist and cardiovascular complications |
| WO2003101992A1 (en) * | 2002-05-31 | 2003-12-11 | Schering Corporation | Process for preparing xanthine phosphodiesterase v inhibitors and precursors thereof |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| EP1532149B9 (de) * | 2002-08-21 | 2011-04-20 | Boehringer Ingelheim Pharma GmbH & Co. KG | 8-[3-amino-piperidin-1-yl] -xanthine, deren herstellung und deren verwendung als arzneimittel |
| US7495005B2 (en) | 2002-08-22 | 2009-02-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthine derivatives, their preparation and their use in pharmaceutical compositions |
| DE10238470A1 (de) * | 2002-08-22 | 2004-03-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Xanthinderivate, deren Herstellung und deren Verwendung als Arzneimittel |
| US7569574B2 (en) | 2002-08-22 | 2009-08-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Purine derivatives, the preparation thereof and their use as pharmaceutical compositions |
| US7482337B2 (en) | 2002-11-08 | 2009-01-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions |
| DE10254304A1 (de) | 2002-11-21 | 2004-06-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Xanthinderivate, deren Herstellung und deren Verwendung als Arzneimittel |
| US7550590B2 (en) | 2003-03-25 | 2009-06-23 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| WO2004103993A1 (en) | 2003-05-14 | 2004-12-02 | Syrrx, Inc. | Dipeptidyl peptidase inhibitors |
| US7566707B2 (en) | 2003-06-18 | 2009-07-28 | Boehringer Ingelheim International Gmbh | Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions |
| KR20060041309A (ko) | 2003-08-13 | 2006-05-11 | 다케다 야쿠힌 고교 가부시키가이샤 | ４-피리미돈 유도체 및 펩티딜 펩티다제 저해제로서의 그의용도 |
| US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US7790734B2 (en) | 2003-09-08 | 2010-09-07 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| DE10348022A1 (de) * | 2003-10-15 | 2005-05-25 | Imtm Gmbh | Neue Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
| KR20120008093A (ko) | 2003-11-17 | 2012-01-25 | 노파르티스 아게 | 디펩티딜 펩티다제 ⅳ 억제제의 용도 |
| DE10355304A1 (de) | 2003-11-27 | 2005-06-23 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 8-(Piperazin-1-yl)-und 8-([1,4]Diazepan-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| DK1715893T3 (da) | 2004-01-20 | 2009-11-09 | Novartis Pharma Ag | Direkte kompressionsformulering og fremgangsmåde |
| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| DE102004009039A1 (de) | 2004-02-23 | 2005-09-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-[3-Amino-piperidin-1-yl]-xanthine, deren Herstellung und Verwendung als Arzneimittel |
| US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US7393847B2 (en) | 2004-03-13 | 2008-07-01 | Boehringer Ingleheim International Gmbh | Imidazopyridazinediones, their preparation and their use as pharmaceutical compositions |
| CN102127057A (zh) | 2004-03-15 | 2011-07-20 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
| US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
| US7179809B2 (en) * | 2004-04-10 | 2007-02-20 | Boehringer Ingelheim International Gmbh | 2-Amino-imidazo[4,5-d]pyridazin-4-ones, their preparation and their use as pharmaceutical compositions |
| US7439370B2 (en) | 2004-05-10 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Imidazole derivatives, their preparation and their use as intermediates for the preparation of pharmaceutical compositions and pesticides |
| JP2008501714A (ja) | 2004-06-04 | 2008-01-24 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼインヒビター |
| DE102004030502A1 (de) | 2004-06-24 | 2006-01-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Imidazole und Triazole, deren Herstellung und Verwendung als Arzneimittel |
| WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| ATE553077T1 (de) | 2004-07-23 | 2012-04-15 | Nuada Llc | Peptidaseinhibitoren |
| AU2005271403A1 (en) * | 2004-08-03 | 2006-02-16 | Biorexis Pharmaceutical Corporation | Combination therapy using transferrin fusion proteins comprising GLP-1 |
| DE102004043944A1 (de) | 2004-09-11 | 2006-03-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 8-(3-Amino-piperidin-1-yl)-7-(but-2-inyl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US202560A (en) * | 1878-04-16 | Improvement in combined carriage and chair | ||
| KR880007441A (ko) * | 1986-12-11 | 1988-08-27 | 알렌 제이.스피겔 | 스피로-치환된 글루타르아미드 이뇨제 |
| US5508272A (en) * | 1993-06-15 | 1996-04-16 | Bristol-Myers Squibb Company | Compounds containing a fused bicycle ring and processes therefor |
| US6569832B1 (en) * | 1999-11-12 | 2003-05-27 | Novo Nordisk A/S | Inhibition of beta cell degeneration |
| US6380398B2 (en) * | 2000-01-04 | 2002-04-30 | Novo Nordisk A/S | Therapeutically active and selective heterocyclic compounds that are inhibitors of the enzyme DPP-IV |
| US6509330B2 (en) * | 2000-02-17 | 2003-01-21 | Bristol-Myers Squibb Company | Hydroxamic acid containing compounds useful as ACE inhibitors and/or NEP inhibotors |
| WO2002059343A2 (en) * | 2000-10-31 | 2002-08-01 | Vanderbilt University | Biological markers and diagnostic tests for angiotensin converting enzyme inhibitor- and vasopeptidase inhibitor-associated angioedema |
-
2003
- 2003-01-13 JP JP2003557558A patent/JP2005513165A/ja not_active Withdrawn
- 2003-01-13 EP EP03729217A patent/EP1496877B1/en not_active Expired - Lifetime
- 2003-01-13 WO PCT/DK2003/000017 patent/WO2003057200A2/en not_active Ceased
- 2003-01-13 DE DE60323823T patent/DE60323823D1/de not_active Expired - Fee Related
- 2003-01-13 AT AT03729217T patent/ATE409466T1/de not_active IP Right Cessation
- 2003-01-13 AU AU2003201274A patent/AU2003201274A1/en not_active Abandoned
- 2003-04-23 US US10/421,465 patent/US20030236272A1/en not_active Abandoned
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