JP2005513165A

JP2005513165A - 糖尿病、高血圧、慢性心不全および体液貯留状態の治療のための方法および組成物

糖尿病、高血圧、慢性心不全および体液貯留状態の治療のための方法および組成物 Download PDF

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Publication number: JP2005513165A
Authority: JP; Japan
Prior art keywords: independently; alkyl; optionally substituted; aryl; heteroaryl
Prior art date: 2002-01-11
Legal status : Withdrawn

Application number

JP2003557558A

Other languages

English (en)

Japanese (ja)

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JP2005513165A5 (https=

Inventor

カー、リチャード・デイビッド

Current Assignee

Novo Nordisk AS

Original Assignee

Novo Nordisk AS

Priority date

2002-01-11

Filing date

2003-01-13

Publication date

2005-05-12

2003-01-13 Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS

2005-05-12 Publication of JP2005513165A publication Critical patent/JP2005513165A/ja

2006-03-02 Publication of JP2005513165A5 publication Critical patent/JP2005513165A5/ja

Status Withdrawn legal-status Critical Current

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238000000034 method Methods 0.000 title claims abstract description 119
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238000011282 treatment Methods 0.000 title abstract description 20
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206010007558 Cardiac failure chronic Diseases 0.000 title abstract description 7
208000024891 symptom Diseases 0.000 claims abstract description 31
230000005764 inhibitory process Effects 0.000 claims abstract description 17
150000001875 compounds Chemical class 0.000 claims description 169
125000000217 alkyl group Chemical group 0.000 claims description 159
-1 N- (substituted glycyl) -4-cyanopyrrolidine Chemical class 0.000 claims description 148
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125000001072 heteroaryl group Chemical group 0.000 claims description 110
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150000003839 salts Chemical class 0.000 claims description 28
SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims description 25
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 15
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229950004548 candoxatril Drugs 0.000 claims description 8
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ARAFEULRMHFMDE-UHFFFAOYSA-N 1,3-oxazolidine-2,5-dione Chemical compound O=C1CNC(=O)O1 ARAFEULRMHFMDE-UHFFFAOYSA-N 0.000 claims description 3
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125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims description 2
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NUQFSJZWLOJBLL-UHFFFAOYSA-N 7-[(4-chlorophenyl)methyl]-3-methyl-8-piperazin-1-ylpurine-2,6-dione Chemical compound C=1C=C(Cl)C=CC=1CN1C=2C(=O)NC(=O)N(C)C=2N=C1N1CCNCC1 NUQFSJZWLOJBLL-UHFFFAOYSA-N 0.000 claims description 2
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