JP2006528199A5 - - Google Patents
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- Publication number
- JP2006528199A5 JP2006528199A5 JP2006521248A JP2006521248A JP2006528199A5 JP 2006528199 A5 JP2006528199 A5 JP 2006528199A5 JP 2006521248 A JP2006521248 A JP 2006521248A JP 2006521248 A JP2006521248 A JP 2006521248A JP 2006528199 A5 JP2006528199 A5 JP 2006528199A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- ethyl
- composition according
- formula
- purine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
- -1 hydroxy, amino Chemical group 0.000 claims 5
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 4
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 4
- 239000005977 Ethylene Chemical group 0.000 claims 4
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 2
- 125000004176 4-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])* 0.000 claims 2
- 102000009346 Adenosine receptors Human genes 0.000 claims 2
- 108050000203 Adenosine receptors Proteins 0.000 claims 2
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 230000003042 antagnostic effect Effects 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 150000004985 diamines Chemical class 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 230000004217 heart function Effects 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 201000008383 nephritis Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 230000008085 renal dysfunction Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48946903P | 2003-07-22 | 2003-07-22 | |
| PCT/US2004/023632 WO2005009445A1 (en) | 2003-07-22 | 2004-07-22 | A1 adenosine receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006528199A JP2006528199A (ja) | 2006-12-14 |
| JP2006528199A5 true JP2006528199A5 (https=) | 2007-08-02 |
Family
ID=34102883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006521248A Pending JP2006528199A (ja) | 2003-07-22 | 2004-07-22 | Ａ１アデノシン受容体拮抗薬 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7022710B2 (https=) |
| EP (1) | EP1646390B1 (https=) |
| JP (1) | JP2006528199A (https=) |
| KR (1) | KR20060037383A (https=) |
| AT (1) | ATE410168T1 (https=) |
| CA (1) | CA2533402A1 (https=) |
| DE (1) | DE602004017005D1 (https=) |
| WO (1) | WO2005009445A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8455489B2 (en) * | 2003-11-10 | 2013-06-04 | Exelixis, Inc. | Substituted pyrimidine compositions and methods of use |
| US20080280926A1 (en) * | 2003-12-16 | 2008-11-13 | Palle Venkata P | Phosphodiesterase Inhibitors |
| WO2007095161A2 (en) * | 2006-02-14 | 2007-08-23 | New York University | Methods and compositions for treating disorders associated with increased bone turnover and osteopenia |
| US7906518B2 (en) * | 2006-06-27 | 2011-03-15 | Cbt Development Limited | Therapeutic compounds |
| WO2009052310A1 (en) * | 2007-10-16 | 2009-04-23 | Cv Therapeutics, Inc | A3 adenosine receptor antagonists |
| JP5460690B2 (ja) * | 2008-03-26 | 2014-04-02 | アドヴィナス・セラピューティックス・リミテッド | アデノシンレセプターアンタゴニストとしてのヘテロ環化合物 |
| DE102008039083A1 (de) * | 2008-08-21 | 2010-02-25 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 5-Aminopyrazole und ihre Verwendung |
| WO2011123518A1 (en) | 2010-03-31 | 2011-10-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adenosine receptor agonists for the treatment and prevention of vascular or joint capsule calcification disorders |
| DE102011005232A1 (de) | 2011-03-08 | 2012-09-13 | AristoCon GmbH & Co. KG | Adenosin und seine Derivate zur Verwendung in der Schmerztherapie |
| KR20230007369A (ko) * | 2020-04-07 | 2023-01-12 | 아이테오스 벨지움 에스에이 | 암의 치료를 위한 ent 저해제로서의 거대환식 다이아민 유도체 및 이와 아데노신 수용체 길항제와의 조합물 |
| WO2024105159A1 (en) * | 2022-11-16 | 2024-05-23 | University Of Zurich | Ligands of the m6a-rna readers |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19816857A1 (de) * | 1998-04-16 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue unsymmetrisch substituierte Xanthin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US6545002B1 (en) | 1999-06-01 | 2003-04-08 | University Of Virginia Patent Foundation | Substituted 8-phenylxanthines useful as antagonists of A2B adenosine receptors |
| DE60001969T2 (de) * | 1999-08-31 | 2004-02-05 | Vanderbilt University, Nashville | Selektive antagonisten von a2b adenosinrezeptoren |
| KR20020042248A (ko) * | 2000-11-30 | 2002-06-05 | 한가람 | 문장으로부터의 감정 인식 및 표시 방법과 시스템 |
| DK1401837T3 (da) | 2001-06-29 | 2005-11-07 | Cv Therapeutics Inc | Purinderivater som A2B-adenosinreceptorantagonister |
| WO2003006465A1 (en) * | 2001-07-13 | 2003-01-23 | Cv Therapeutics, Inc. | Partial and full agonist of a adenosine receptors |
| US7968523B2 (en) | 2001-07-23 | 2011-06-28 | Senesco Technologies, Inc. | Method for inducing apoptosis using apoptosis-specific EIF5-A |
| US20050107611A1 (en) * | 2001-12-21 | 2005-05-19 | Barbara Matuszczak | Pyrazolyl-substituted triazoloquinoxalines |
-
2004
- 2004-07-22 EP EP04778924A patent/EP1646390B1/en not_active Expired - Lifetime
- 2004-07-22 JP JP2006521248A patent/JP2006528199A/ja active Pending
- 2004-07-22 CA CA002533402A patent/CA2533402A1/en not_active Abandoned
- 2004-07-22 AT AT04778924T patent/ATE410168T1/de not_active IP Right Cessation
- 2004-07-22 WO PCT/US2004/023632 patent/WO2005009445A1/en not_active Ceased
- 2004-07-22 KR KR1020067001373A patent/KR20060037383A/ko not_active Ceased
- 2004-07-22 DE DE602004017005T patent/DE602004017005D1/de not_active Expired - Lifetime
- 2004-07-22 US US10/897,047 patent/US7022710B2/en not_active Expired - Fee Related
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