JP2005512507A - 抗炎症剤としてのｈｍｇフラグメントの使用 - Google Patents

抗炎症剤としてのｈｍｇフラグメントの使用 Download PDF

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Publication number
JP2005512507A
JP2005512507A JP2002588923A JP2002588923A JP2005512507A JP 2005512507 A JP2005512507 A JP 2005512507A JP 2002588923 A JP2002588923 A JP 2002588923A JP 2002588923 A JP2002588923 A JP 2002588923A JP 2005512507 A JP2005512507 A JP 2005512507A
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box
hmg
release
vertebrate
hmg1
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JP2002588923A
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Japanese (ja)
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JP2005512507A5 (https=
JP2005512507A6 (ja
Inventor
トレーシー，ケビン，ジェイ．
ヤン，フアン
ウォレン，ハウランド，ショー，ジュニア
フィンク，ミッチェル，ピー．
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Feinstein Institutes for Medical Research
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North Shore Long Island Jewish Research Institute
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Publication of JP2005512507A6 publication Critical patent/JP2005512507A6/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
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  • Biomedical Technology (AREA)
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  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
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JP2002588923A 2001-05-15 2002-05-15 抗炎症剤としてのｈｍｇフラグメントの使用 Pending JP2005512507A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29103401P 2001-05-15 2001-05-15
US60/291,034 2001-05-15
PCT/US2002/015329 WO2002092004A2 (en) 2001-05-15 2002-05-15 Use of hmg fragment as anti-inflammatory agents

Publications (3)

Publication Number Publication Date
JP2005512507A true JP2005512507A (ja) 2005-05-12
JP2005512507A6 JP2005512507A6 (ja) 2005-08-04
JP2005512507A5 JP2005512507A5 (https=) 2007-08-02

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JP2002588923A Pending JP2005512507A (ja) 2001-05-15 2002-05-15 抗炎症剤としてのｈｍｇフラグメントの使用

Country Status (18)

Country Link
US (2) US20030060410A1 (https=)
EP (1) EP1392844A4 (https=)
JP (1) JP2005512507A (https=)
KR (1) KR20040018370A (https=)
CN (1) CN100447154C (https=)
AU (1) AU2002309829B2 (https=)
BR (1) BR0209689A (https=)
CA (1) CA2447576C (https=)
CZ (1) CZ20033402A3 (https=)
HU (1) HUP0500042A3 (https=)
IL (3) IL158643A0 (https=)
IS (1) IS7037A (https=)
MX (1) MXPA03010449A (https=)
NO (1) NO20035087L (https=)
NZ (1) NZ529423A (https=)
PL (1) PL367132A1 (https=)
SK (1) SK15422003A3 (https=)
WO (1) WO2002092004A2 (https=)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007049468A1 (ja) 2005-10-24 2007-05-03 National University Corporation Okayama University 脳梗塞抑制剤
WO2008099920A1 (ja) 2007-02-15 2008-08-21 Kyushu University, National University Corporation 抗hmgb-1抗体を含む間質性肺疾患治療剤
WO2011037227A1 (ja) 2009-09-28 2011-03-31 国立大学法人岡山大学 アテローム動脈硬化抑制剤
JP2011105745A (ja) * 2002-12-06 2011-06-02 North Shore-Long Island Jewish Research Inst α７受容体結合コリン作動性アゴニストを用いる炎症の阻害
US8071098B2 (en) 2006-05-19 2011-12-06 National University Corporation Okayama University Method of preventing cerebral vasospasm with anti-HMGB1 antibody
WO2014065348A1 (ja) * 2012-10-25 2014-05-01 株式会社ジェノミックス Hmgb1断片を利用した脊髄の損傷に対する新規治療法
WO2014065347A1 (ja) * 2012-10-25 2014-05-01 株式会社ジェノミックス Hmgb1断片を利用した新規心筋梗塞の治療法
US9919010B2 (en) 2008-04-30 2018-03-20 Genomix Co., Ltd. Method for collecting functional cells in vivo with high efficiency
US10364276B2 (en) 2011-04-26 2019-07-30 StemRIM Inc. Peptide for inducing regeneration of tissue and use thereof
US11191786B2 (en) 2009-10-28 2021-12-07 StemRIM Inc. Agents for promoting tissue regeneration by recruiting bone marrow mesenchymal stem cells and/or pluripotent stem cells into blood
US11298403B2 (en) 2017-12-01 2022-04-12 StemRIM Inc. Therapeutic agent for inflammatory bowel disease
US11969459B2 (en) 2017-01-27 2024-04-30 StemRIM Inc. Therapeutic agent for cardiomyopathy, old myocardial infarction and chronic heart failure
US12304933B2 (en) 2018-10-05 2025-05-20 StemRIM Inc. Disease treatment drug based on mesenchymal-stem-cell mobilization
US12421498B2 (en) 2017-12-01 2025-09-23 StemRIM Inc. Ectodermal mesenchymal stem cells and method for producing same
US12428458B2 (en) 2018-02-08 2025-09-30 StemRIM Inc. Therapeutic agent for psoriasis

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303321B1 (en) 1999-02-11 2001-10-16 North Shore-Long Island Jewish Research Institute Methods for diagnosing sepsis
US7151082B2 (en) 1999-02-11 2006-12-19 The Feinstein Institute For Medical Research Antagonists of HMG1 for treating inflammatory conditions
US7754217B2 (en) * 2001-03-16 2010-07-13 Bio3 Research Srl HMGB1 protein inhibitors and/or antagonists for the treatment of vascular diseases
US7220723B2 (en) * 2001-05-15 2007-05-22 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
US7304034B2 (en) 2001-05-15 2007-12-04 The Feinstein Institute For Medical Research Use of HMGB fragments as anti-inflammatory agents
AU2003228099A1 (en) * 2002-07-03 2004-01-23 Centro Cardiologico Monzino S.P.A.-Irccs Use of hmgb1 in the treatment of tissue damage and/or to promote tissue repair
US20060121047A1 (en) * 2002-11-20 2006-06-08 Tracey Kevin J Use of hmgb polypetides for increasing immune responses
US20040141948A1 (en) * 2002-11-20 2004-07-22 Critical Therapeutics, Inc. Use of HMGB fragments as anti-inflammatory agents
US20040156851A1 (en) * 2002-11-20 2004-08-12 Critical Therapeutics, Inc. HMGB1 combination therapies
US20090069227A9 (en) * 2003-04-29 2009-03-12 Capogrossi Maurizio C Use of HMGB1 to promote stem cell migration and/or proliferation
US7696169B2 (en) * 2003-06-06 2010-04-13 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
WO2005025604A2 (en) * 2003-09-10 2005-03-24 The General Hospital Corporation Use of hmgb and hmgb fragments to decrease specific immune response
AU2004272607B2 (en) * 2003-09-11 2008-11-06 Cornerstone Therapeutics Inc. Monoclonal antibodies against HMGB1
US20080305120A1 (en) 2004-06-17 2008-12-11 Medimmune, Inc. Immunogenic Compositions Comprising Hmgb 1 Polypeptides
EP1771565B1 (en) 2004-07-20 2012-09-05 The Feinstein Institute for Medical Research Rage protein derivatives
WO2006012373A2 (en) * 2004-07-20 2006-02-02 Critical Therapeutics, Inc. Combination therapies of hmgb and complement inhibitors against inflammation
JP5622351B2 (ja) * 2004-09-03 2014-11-12 クレアビリス・セラピューティクス・エスピーエー プロテアーゼ抵抗性ヒトおよび非ヒトＨＭＧＢ１Ｂｏｘ−Ａ変異体、ならびにそれらの治療／診断への使用
WO2007001422A2 (en) 2004-10-22 2007-01-04 Medimmune, Inc. High affinity antibodies against hmgb1 and methods of use thereof
US8129130B2 (en) 2004-10-22 2012-03-06 The Feinstein Institute For Medical Research High affinity antibodies against HMGB1 and methods of use thereof
EP1899376A2 (en) 2005-06-16 2008-03-19 The Feinstein Institute for Medical Research Antibodies against hmgb1 and fragments thereof
WO2007011606A2 (en) * 2005-07-18 2007-01-25 Critical Therapeutics, Inc. USE OF HMGBl ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY SKIN CONDITIONS
US20100172909A1 (en) * 2005-10-24 2010-07-08 Masahiro Nishibori Cerebral edema suppressant
WO2007076200A2 (en) 2005-11-28 2007-07-05 Medimmune, Inc. Antagonists of hmgb1 and/or rage and methods of use thereof
US7829097B2 (en) * 2006-02-06 2010-11-09 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Use of HMGB1 for protection against ischemia reperfusion injury
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