JP2005509590A5 - - Google Patents
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- Publication number
- JP2005509590A5 JP2005509590A5 JP2003503584A JP2003503584A JP2005509590A5 JP 2005509590 A5 JP2005509590 A5 JP 2005509590A5 JP 2003503584 A JP2003503584 A JP 2003503584A JP 2003503584 A JP2003503584 A JP 2003503584A JP 2005509590 A5 JP2005509590 A5 JP 2005509590A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- methoxy
- phenoxy
- compound
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC1CC(*)CC1 Chemical compound CC1CC(*)CC1 0.000 description 6
- KBUMRZDHHWZVLY-QHCPKHFHSA-N CC(C)CCOc(cc1)ccc1OCCCOc1ccc(C[C@@H](C(O)=O)OC)cc1 Chemical compound CC(C)CCOc(cc1)ccc1OCCCOc1ccc(C[C@@H](C(O)=O)OC)cc1 KBUMRZDHHWZVLY-QHCPKHFHSA-N 0.000 description 1
- ZHTXOZRZDZMDFO-RBPNCNDUSA-N CCO[C@@H](Cc(cc1)ccc1[U]CCCOc1ccc(Cc2ccccc2)cc1)C(O)=O Chemical compound CCO[C@@H](Cc(cc1)ccc1[U]CCCOc1ccc(Cc2ccccc2)cc1)C(O)=O ZHTXOZRZDZMDFO-RBPNCNDUSA-N 0.000 description 1
- MROYGGAYTUSPIQ-AWEZNQCLSA-N CNOc(cccc1)c1-c1cc(C[C@@H](C(O)=O)O)ccc1O Chemical compound CNOc(cccc1)c1-c1cc(C[C@@H](C(O)=O)O)ccc1O MROYGGAYTUSPIQ-AWEZNQCLSA-N 0.000 description 1
- BDKJFRYEWUMYHB-WNMGUVTHSA-N CO[C@@H](Cc(cc1)ccc1OC(CC1)CC1Oc(cc1)ccc1-c1ccccc1)C(O)=O Chemical compound CO[C@@H](Cc(cc1)ccc1OC(CC1)CC1Oc(cc1)ccc1-c1ccccc1)C(O)=O BDKJFRYEWUMYHB-WNMGUVTHSA-N 0.000 description 1
- VRQBRUCGPYEDQT-DEOSSOPVSA-N CO[C@@H](Cc(cc1)ccc1OCCCOc(cc1)ccc1-c(cc1)ccc1O)C(O)=O Chemical compound CO[C@@H](Cc(cc1)ccc1OCCCOc(cc1)ccc1-c(cc1)ccc1O)C(O)=O VRQBRUCGPYEDQT-DEOSSOPVSA-N 0.000 description 1
- JZQPRALNKOORGZ-XMMPIXPASA-N CO[C@H](Cc(ccc(OCCCOc(cc1)ccc1-c1ccccc1)c1)c1F)C(O)=O Chemical compound CO[C@H](Cc(ccc(OCCCOc(cc1)ccc1-c1ccccc1)c1)c1F)C(O)=O JZQPRALNKOORGZ-XMMPIXPASA-N 0.000 description 1
- ZJBQYRLHEYPLEL-VIFPVBQESA-N C[C@@H](Cc1ccc(C)cc1)C(O)=O Chemical compound C[C@@H](Cc1ccc(C)cc1)C(O)=O ZJBQYRLHEYPLEL-VIFPVBQESA-N 0.000 description 1
- NJDSWUXGRSJHKV-UHFFFAOYSA-N C[O]#CC(Cc(cc1)ccc1OCCCOc(cc1)ccc1C(c1c(cccc2)c2ccc1)=O)C(O)=O Chemical compound C[O]#CC(Cc(cc1)ccc1OCCCOc(cc1)ccc1C(c1c(cccc2)c2ccc1)=O)C(O)=O NJDSWUXGRSJHKV-UHFFFAOYSA-N 0.000 description 1
- YXVFYQXJAXKLAK-UHFFFAOYSA-N Oc(cc1)ccc1-c1ccccc1 Chemical compound Oc(cc1)ccc1-c1ccccc1 YXVFYQXJAXKLAK-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29714401P | 2001-06-07 | 2001-06-07 | |
| US60/297,144 | 2001-06-07 | ||
| PCT/US2002/016950 WO2002100813A2 (en) | 2001-06-07 | 2002-05-30 | Modulators of peroxisome proliferator activated receptors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005509590A JP2005509590A (ja) | 2005-04-14 |
| JP2005509590A6 JP2005509590A6 (ja) | 2005-08-04 |
| JP2005509590A5 true JP2005509590A5 (enExample) | 2006-01-05 |
Family
ID=23145037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003503584A Pending JP2005509590A (ja) | 2001-06-07 | 2002-05-30 | ペルオキシソーム増殖因子活性化受容体の調節物質 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7192982B2 (enExample) |
| EP (1) | EP1392637A2 (enExample) |
| JP (1) | JP2005509590A (enExample) |
| KR (1) | KR20040012905A (enExample) |
| CN (1) | CN1543451A (enExample) |
| AR (1) | AR036084A1 (enExample) |
| BR (1) | BR0210190A (enExample) |
| CA (1) | CA2449256A1 (enExample) |
| CO (1) | CO5640097A2 (enExample) |
| CZ (1) | CZ20033309A3 (enExample) |
| EA (1) | EA200400010A1 (enExample) |
| EC (1) | ECSP034877A (enExample) |
| EE (1) | EE200400001A (enExample) |
| HR (1) | HRP20031001A2 (enExample) |
| HU (1) | HUP0400280A3 (enExample) |
| IL (1) | IL158873A0 (enExample) |
| MX (1) | MXPA03011201A (enExample) |
| NO (1) | NO20035439D0 (enExample) |
| NZ (1) | NZ529351A (enExample) |
| PE (1) | PE20030099A1 (enExample) |
| PL (1) | PL368051A1 (enExample) |
| SK (1) | SK14912003A3 (enExample) |
| WO (1) | WO2002100813A2 (enExample) |
| ZA (1) | ZA200308863B (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL158873A0 (en) * | 2001-06-07 | 2004-05-12 | Lilly Co Eli | Modulators of peroxisome proliferator activated receptors |
| IL159002A0 (en) | 2001-06-07 | 2004-05-12 | Lilly Co Eli | Modulators of peroxisome proliferator activated receptors (ppar) |
| KR101059776B1 (ko) * | 2001-06-12 | 2011-08-26 | 웰스테트 테라퓨틱스 코포레이션 | 대사 질환의 치료용 화합물 |
| ITRM20020016A1 (it) * | 2002-01-15 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Derivati di acidi fenil(alchil)carbossilici e derivati fenilalchileterociclici dionici, loro uso come medicamenti ad attivita' ipoglicemizza |
| WO2004048351A2 (en) * | 2002-11-25 | 2004-06-10 | Galderma Research & Development, S.N.C. | Biphenyl compounds which activate ppar-gamma type receptors and use thereof in cosmetic or pharmaceutical compositions |
| FR2847580B1 (fr) * | 2002-11-25 | 2006-03-03 | Galderma Res & Dev | NOUVEAUX COMPOSES BI-AROMATIQUES ACTIVATEURS DES RECEPTEURS DE TYPE PPARy ET LEUR UTILISATION DANS DES COMPOSITIONS COSMETIQUES OU PHARMACEUTIQUES |
| US7192970B2 (en) * | 2002-11-26 | 2007-03-20 | Chipscreen Biosciences, Ltd. | Noncyclic 1,3-dicarbonyl compounds as dual PPAR agonists with potent antihyperglycemic and antihyperlipidemic activity |
| BRPI0407180A (pt) | 2003-02-14 | 2006-02-07 | Lilly Co Eli | Composto, composição farmacêutica, métodos para modular um receptor ativado pelo proliferador de peroxissoma, para tratar ou prevenir uma doença ou condição, para diminuir a glicose no sangue em um mamìfero, para tratar ou prevenir diabetes mellitus, doença cardiovascular e sìndrome x em um mamìfero, e, uso de um composto |
| GB0314075D0 (en) * | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
| WO2005009104A2 (en) * | 2003-07-16 | 2005-02-03 | Ligand Pharmacueticals Incorporated | Benzoic and phenyl acetic acid derivatives as hnf-4 modulators |
| WO2005019151A1 (en) * | 2003-08-20 | 2005-03-03 | Eli Lilly And Company | Ppar modulators |
| SG145752A1 (en) | 2003-09-19 | 2008-09-29 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| CA2541751A1 (en) * | 2003-10-14 | 2005-04-28 | Eli Lilly And Company | Phenoxyether derivatives as ppar modulators |
| CA2551610A1 (en) | 2003-12-25 | 2005-07-14 | Takeda Pharmaceutical Company Limited | 3-(4-benzyloxyphenyl)propanoic acid derivatives |
| JP4074616B2 (ja) * | 2003-12-25 | 2008-04-09 | 武田薬品工業株式会社 | ３−（４−ベンジルオキシフェニル）プロパン酸誘導体 |
| US7262318B2 (en) * | 2004-03-10 | 2007-08-28 | Pfizer, Inc. | Substituted heteroaryl- and phenylsulfamoyl compounds |
| CA2566090C (en) * | 2004-05-12 | 2013-07-23 | Alan D. Snow | Substituted n-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies |
| FR2872159B1 (fr) * | 2004-06-28 | 2007-10-05 | Merck Sante Soc Par Actions Si | Nouveaux derives acides carboxyliques phenyliques et leur utilisation dans le traitement du diabete |
| US20050288340A1 (en) * | 2004-06-29 | 2005-12-29 | Pfizer Inc | Substituted heteroaryl- and phenylsulfamoyl compounds |
| TW200608967A (en) | 2004-07-29 | 2006-03-16 | Sankyo Co | Pharmaceutical compositions containing with diabetic agent |
| US7622491B2 (en) * | 2004-08-13 | 2009-11-24 | Metabolex Inc. | Modulators of PPAR and methods of their preparation |
| US7405236B2 (en) * | 2004-08-16 | 2008-07-29 | Hoffman-La Roche Inc. | Indole derivatives comprising an acetylene group |
| US20080070958A1 (en) * | 2004-09-13 | 2008-03-20 | Santen Pharmaceutical Co., Ltd. | Therapeutic Agent for Keratoconjunctival Disorder |
| MY145712A (en) | 2004-09-15 | 2012-03-30 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| MY147518A (en) * | 2004-09-15 | 2012-12-31 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| US7635779B2 (en) * | 2004-10-15 | 2009-12-22 | Council Of Scientific & Industrial Research | Oxy substituted flavones as antihyperglycemic and antidyslipidemic agents |
| FR2882359A1 (fr) * | 2005-02-24 | 2006-08-25 | Negma Lerads Soc Par Actions S | Derives activateurs de ppar, procede de preparation et application en therapeutique |
| JO3006B1 (ar) * | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
| CA2647258A1 (en) * | 2006-03-31 | 2007-10-18 | Wellstat Therapeutics Corporation | Combination treatment of metabolic disorders |
| PE20080188A1 (es) | 2006-04-18 | 2008-03-10 | Janssen Pharmaceutica Nv | Derivados del acido benzoazepin-oxi-acetico como agonistas de ppar-delta usados para aumentar hdl-c, reducir ldl-c y reducir colesterol |
| AU2007293885A1 (en) | 2006-09-07 | 2008-03-13 | Takeda Gmbh | Combination treatment for diabetes mellitus |
| CN102114076B (zh) * | 2006-10-25 | 2013-04-10 | 中国科学院上海生命科学研究院 | 肉桂提取物的制备方法、肉桂提取物、其组合物以及用途 |
| PL2152663T3 (pl) | 2007-06-04 | 2014-09-30 | Ben Gurion Univ Of The Negev Research And Development Authority | Związki triarylowe oraz kompozycje zawierające te związki |
| US8481595B2 (en) * | 2008-01-15 | 2013-07-09 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| US20090238900A1 (en) * | 2008-03-24 | 2009-09-24 | Himalaya Global Holdings Limited | Novel anti-diabetic herbal composition, method for preparing the same and use thereof |
| JP5436941B2 (ja) * | 2009-06-03 | 2014-03-05 | あすか製薬株式会社 | ラクタム化合物又はその塩及びｐｐａｒ活性化剤 |
| CN103228622B (zh) * | 2010-07-23 | 2016-01-20 | 康内克斯生命科学私人有限公司 | Gpr40的激动剂 |
| JP2016516004A (ja) | 2013-02-22 | 2016-06-02 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | 抗糖尿病二環式化合物 |
| CR20160207A (es) | 2013-11-05 | 2016-08-10 | Ben Gurion Univ Of The Negev Res And Dev Authority | Compuestos para el tratamiento de la diabetes y las complicaciones que surgen de la misma enfermedad |
| CN104974103A (zh) * | 2015-07-14 | 2015-10-14 | 佛山市赛维斯医药科技有限公司 | 一类含苯并异恶唑和烷氧苯基类结构的化合物及其用途 |
| CN104926743A (zh) * | 2015-07-14 | 2015-09-23 | 佛山市赛维斯医药科技有限公司 | 含苯并异恶唑和末端苄基类结构的化合物及其用途 |
| CN105037290A (zh) * | 2015-07-14 | 2015-11-11 | 佛山市赛维斯医药科技有限公司 | 一类含苯并异恶唑和腈基苯类结构化合物及其用途 |
| CN104987314A (zh) * | 2015-07-14 | 2015-10-21 | 佛山市赛维斯医药科技有限公司 | 含苯并异恶唑和末端硝基苄基类结构的化合物及其用途 |
| CN104945344A (zh) * | 2015-07-14 | 2015-09-30 | 佛山市赛维斯医药科技有限公司 | 一类含苯并异恶唑和末端胺基结构化合物及其用途 |
| CN104926744A (zh) * | 2015-07-14 | 2015-09-23 | 佛山市赛维斯医药科技有限公司 | 一类含苯并异恶唑和末端苄基类结构的化合物及其用途 |
| CN104926746A (zh) * | 2015-07-14 | 2015-09-23 | 佛山市赛维斯医药科技有限公司 | 含苯并异恶唑和末端胺基苄基类结构的化合物及其用途 |
| CN104961702A (zh) * | 2015-07-14 | 2015-10-07 | 佛山市赛维斯医药科技有限公司 | 苯并异恶唑类11β-HSD1抑制剂、制备方法及其用途 |
| CN105001174A (zh) * | 2015-07-14 | 2015-10-28 | 佛山市赛维斯医药科技有限公司 | 含苯并异恶唑和末端腈基苄基类结构的化合物及其用途 |
| CN104961703A (zh) * | 2015-07-14 | 2015-10-07 | 佛山市赛维斯医药科技有限公司 | 一类苯并异恶唑类11β-HSD1抑制剂、制备方法及其用途 |
| CN104926742A (zh) * | 2015-07-14 | 2015-09-23 | 佛山市赛维斯医药科技有限公司 | 一类含苯并异恶唑和硝基苯基类结构的化合物及其用途 |
| CN104926745A (zh) * | 2015-07-14 | 2015-09-23 | 佛山市赛维斯医药科技有限公司 | 含苯并异恶唑和末端卤代苄基类结构的化合物及其用途 |
| CN111108105B (zh) | 2017-09-22 | 2023-03-31 | 朱比兰特埃皮帕德有限公司 | 作为pad抑制剂的杂环化合物 |
| KR102782563B1 (ko) | 2017-10-18 | 2025-03-14 | 주빌런트 에피파드 엘엘씨 | Pad 억제제로서의 이미다조-피리딘 화합물 |
| AU2018362046B2 (en) | 2017-11-06 | 2023-04-13 | Jubilant Prodel LLC | Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation |
| HUE067265T2 (hu) | 2017-11-24 | 2024-10-28 | Jubilant Episcribe Llc | Heterociklusos vegyületek mint PRMT5 inhibitorok |
| EP3765453A1 (en) | 2018-03-13 | 2021-01-20 | Jubilant Prodel LLC | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation |
| WO2025079680A1 (ja) * | 2023-10-13 | 2025-04-17 | 国立研究開発法人国立精神・神経医療研究センター | 神経保護剤 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089514A (en) | 1990-06-14 | 1992-02-18 | Pfizer Inc. | 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents |
| PH30449A (en) * | 1991-11-25 | 1997-05-28 | Lilly Co Eli | Substituted phenyl phenol leukotriene antagonists |
| US5232945A (en) | 1992-07-20 | 1993-08-03 | Pfizer Inc. | 3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives |
| US5387672A (en) * | 1993-03-02 | 1995-02-07 | The University Of Maryland At Baltimore | Hemoglobin intramolecularly cross-linked withlong chain divalent reagents |
| EP0743064A1 (en) * | 1995-05-17 | 1996-11-20 | Eli Lilly And Company | Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease |
| JP3964478B2 (ja) | 1995-06-30 | 2007-08-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ヘテロ環含有カルボン酸誘導体及びそれを含有する医薬 |
| GB9604242D0 (en) * | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| EP0903343B1 (en) | 1997-09-19 | 2003-05-28 | SSP Co., Ltd. | Alpha-Substituted phenylpropionic acid derivative and medicine containing the same |
| GB2364304B (en) | 1997-10-27 | 2003-04-23 | Reddy Research Foundation | Novel tricyclic compounds and their use in medicine process for their preparation and pharmaceutical compositions containing them |
| KR100620337B1 (ko) | 1998-03-10 | 2006-09-13 | 오노 야꾸힝 고교 가부시키가이샤 | 카르복실산 유도체와 그 유도체를 유효 성분으로서함유하는 약제 |
| SE9801990D0 (sv) | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl propionic acid derivatives and analogs |
| SE9801992D0 (sv) | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl-2-hydroxypropionic acid derivative I |
| AU7073400A (en) * | 1999-08-27 | 2001-03-26 | Eli Lilly And Company | Biaryl-oxa(thia)zole derivatives and their use as ppars modulators |
| TWI262185B (en) * | 1999-10-01 | 2006-09-21 | Eisai Co Ltd | Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives |
| EP1276710A1 (en) * | 2000-04-17 | 2003-01-22 | Novo Nordisk A/S | New compounds, their preparation and use |
| US7176224B2 (en) * | 2000-08-23 | 2007-02-13 | Eli Lilly And Company | Oxazolyl-aryloxyacetic acid derivatives and their use as PPAR agonists |
| EP1316549A4 (en) | 2000-09-01 | 2005-01-12 | Eisai Co Ltd | 1-BENZYL-4 - [(5,6-DIMETHOXY-2-FLUORO-1-INDANONE) -2-YL] METHYLPIPERIDIN |
| WO2002080899A1 (fr) * | 2001-03-30 | 2002-10-17 | Eisai Co., Ltd. | Agent de traitement de maladie digestive |
| TWI311133B (en) * | 2001-04-20 | 2009-06-21 | Eisai R&D Man Co Ltd | Carboxylic acid derivativeand the salt thereof |
| IL158873A0 (en) * | 2001-06-07 | 2004-05-12 | Lilly Co Eli | Modulators of peroxisome proliferator activated receptors |
-
2002
- 2002-05-30 IL IL15887302A patent/IL158873A0/xx unknown
- 2002-05-30 EE EEP200400001A patent/EE200400001A/xx unknown
- 2002-05-30 WO PCT/US2002/016950 patent/WO2002100813A2/en not_active Ceased
- 2002-05-30 CZ CZ20033309A patent/CZ20033309A3/cs unknown
- 2002-05-30 NZ NZ529351A patent/NZ529351A/en unknown
- 2002-05-30 CA CA002449256A patent/CA2449256A1/en not_active Abandoned
- 2002-05-30 MX MXPA03011201A patent/MXPA03011201A/es unknown
- 2002-05-30 EA EA200400010A patent/EA200400010A1/ru unknown
- 2002-05-30 HR HR20031001A patent/HRP20031001A2/hr not_active Application Discontinuation
- 2002-05-30 HU HU0400280A patent/HUP0400280A3/hu unknown
- 2002-05-30 JP JP2003503584A patent/JP2005509590A/ja active Pending
- 2002-05-30 BR BR0210190-4A patent/BR0210190A/pt not_active IP Right Cessation
- 2002-05-30 EP EP02739503A patent/EP1392637A2/en not_active Withdrawn
- 2002-05-30 US US10/479,262 patent/US7192982B2/en not_active Expired - Fee Related
- 2002-05-30 CN CNA028115309A patent/CN1543451A/zh active Pending
- 2002-05-30 SK SK1491-2003A patent/SK14912003A3/sk not_active Application Discontinuation
- 2002-05-30 PL PL02368051A patent/PL368051A1/xx not_active Application Discontinuation
- 2002-05-30 KR KR10-2003-7016050A patent/KR20040012905A/ko not_active Withdrawn
- 2002-06-06 AR ARP020102096A patent/AR036084A1/es not_active Application Discontinuation
- 2002-06-07 PE PE2002000484A patent/PE20030099A1/es not_active Application Discontinuation
-
2003
- 2003-11-13 ZA ZA200308863A patent/ZA200308863B/en unknown
- 2003-12-04 EC EC2003004877A patent/ECSP034877A/es unknown
- 2003-12-05 CO CO03107407A patent/CO5640097A2/es not_active Application Discontinuation
- 2003-12-05 NO NO20035439A patent/NO20035439D0/no not_active Application Discontinuation
-
2006
- 2006-12-11 US US11/637,223 patent/US20070276138A1/en not_active Abandoned
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