JP2005509412A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005509412A5 JP2005509412A5 JP2003523491A JP2003523491A JP2005509412A5 JP 2005509412 A5 JP2005509412 A5 JP 2005509412A5 JP 2003523491 A JP2003523491 A JP 2003523491A JP 2003523491 A JP2003523491 A JP 2003523491A JP 2005509412 A5 JP2005509412 A5 JP 2005509412A5
- Authority
- JP
- Japan
- Prior art keywords
- tsh receptor
- subject
- polypeptide sequence
- response
- tsh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000003911 Thyrotropin Receptors Human genes 0.000 claims 35
- 108090000253 Thyrotropin Receptors Proteins 0.000 claims 35
- 108090000765 processed proteins & peptides Proteins 0.000 claims 17
- 229920001184 polypeptide Polymers 0.000 claims 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims 16
- 208000023275 Autoimmune disease Diseases 0.000 claims 11
- 210000004698 lymphocyte Anatomy 0.000 claims 11
- 150000001413 amino acids Chemical class 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 10
- 230000028993 immune response Effects 0.000 claims 10
- 230000004044 response Effects 0.000 claims 10
- 229940124597 therapeutic agent Drugs 0.000 claims 10
- 239000012634 fragment Substances 0.000 claims 8
- 238000000034 method Methods 0.000 claims 6
- 230000000890 antigenic effect Effects 0.000 claims 5
- 239000000032 diagnostic agent Substances 0.000 claims 5
- 229940039227 diagnostic agent Drugs 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 210000001124 body fluid Anatomy 0.000 claims 3
- 239000010839 body fluid Substances 0.000 claims 3
- 230000003993 interaction Effects 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 238000003745 diagnosis Methods 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000005784 autoimmunity Effects 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 230000008105 immune reaction Effects 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0120649A GB0120649D0 (en) | 2001-08-23 | 2001-08-23 | Epitope regions of a thyrotrophin (TSH) receptor and uses thereof |
| GB0215212A GB0215212D0 (en) | 2002-07-01 | 2002-07-01 | Epitope regions of a thyrotrophin (TSH) receptor, uses thereof and antibodies thereto |
| PCT/GB2002/003831 WO2003018632A2 (en) | 2001-08-23 | 2002-08-21 | Epitope regions of a thyrotrophin (tsh) receptor, uses thereof and antibodies thereto |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009171358A Division JP5576072B2 (ja) | 2001-08-23 | 2009-07-22 | チロトロフィン（ｔｓｈ）受容体の抗原決定領域、その使用およびその抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005509412A JP2005509412A (ja) | 2005-04-14 |
| JP2005509412A5 true JP2005509412A5 (https=) | 2006-01-05 |
Family
ID=26246470
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003523491A Pending JP2005509412A (ja) | 2001-08-23 | 2002-08-21 | チロトロフィン（ｔｓｈ）受容体の抗原決定領域、その使用およびその抗体 |
| JP2009171358A Expired - Lifetime JP5576072B2 (ja) | 2001-08-23 | 2009-07-22 | チロトロフィン（ｔｓｈ）受容体の抗原決定領域、その使用およびその抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009171358A Expired - Lifetime JP5576072B2 (ja) | 2001-08-23 | 2009-07-22 | チロトロフィン（ｔｓｈ）受容体の抗原決定領域、その使用およびその抗体 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US8298769B2 (https=) |
| EP (3) | EP2383291B1 (https=) |
| JP (2) | JP2005509412A (https=) |
| CN (3) | CN103224562B (https=) |
| ES (3) | ES2736165T3 (https=) |
| WO (1) | WO2003018632A2 (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2736165T3 (es) | 2001-08-23 | 2019-12-26 | Rsr Ltd | Regiones epítopo de un receptor de tirotropina (TSH), sus usos y anticuerpos para las mismas |
| WO2004050708A2 (en) * | 2002-11-29 | 2004-06-17 | Rsr Limited | Antibody for the thyrotropin receptor and uses thereof |
| ES2382627T3 (es) | 2004-06-29 | 2012-06-12 | B.R.A.H.M.S Gmbh | Nuevos anticuerpos monoclonales estimuladores o bloqueadores de la tiroides, secuencias peptídicas que corresponden a sus regiones variables, y sus usos en medicina diagnóstica, preventiva y terapéutica |
| GB0418181D0 (en) | 2004-08-13 | 2004-09-15 | Rsr Ltd | Thyrotrophin receptor preparations,thyrotrophin receptor epitopes,antibody and hormone interactions therewith,and uses thereof |
| EP1951753A2 (en) * | 2005-11-21 | 2008-08-06 | Dr. Fenning Biomed GmbH | Recombinant polypeptides and methods for detecting and/or quantifying autoantibodies against tsh receptor |
| JP5165672B2 (ja) * | 2006-03-29 | 2013-03-21 | キングス カレッジ ロンドン | Ｔｓｈｒに対するアゴニスト抗体 |
| ES2550158T3 (es) * | 2007-08-06 | 2015-11-04 | Chugai Seiyaku Kabushiki Kaisha | Método para medir la actividad inhibidora sobre la unión ligando-receptor |
| JP5784504B2 (ja) * | 2008-12-24 | 2015-09-24 | アールエスアール リミテッド | ヒト抗ｔｓｈｒ抗体 |
| ES2702315T3 (es) | 2012-08-24 | 2019-02-28 | Univ California | Anticuerpos y vacunas para su uso en tratar cánceres ROR1 e inhibir metástasis |
| US20170335281A1 (en) | 2014-03-15 | 2017-11-23 | Novartis Ag | Treatment of cancer using chimeric antigen receptor |
| JP2017528433A (ja) | 2014-07-21 | 2017-09-28 | ノバルティス アーゲー | 低い免疫増強用量のｍＴＯＲ阻害剤とＣＡＲの組み合わせ |
| ES2996234T3 (en) | 2014-12-24 | 2025-02-12 | Worg Pharmaceuticals Zhejiang Co Ltd | Composition |
| WO2016126608A1 (en) | 2015-02-02 | 2016-08-11 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| EP3286211A1 (en) | 2015-04-23 | 2018-02-28 | Novartis AG | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
| US11667691B2 (en) | 2015-08-07 | 2023-06-06 | Novartis Ag | Treatment of cancer using chimeric CD3 receptor proteins |
| FI3380620T3 (fi) | 2015-11-23 | 2024-08-01 | Novartis Ag | Optimoituja lentiviruksen siirtovektoreita ja niiden käyttötapoja |
| RU2018127657A (ru) | 2015-12-30 | 2020-01-31 | Новартис Аг | Виды терапии на основе иммуноэффекторных клеток с улучшенной эффективностью |
| EP3432924A1 (en) | 2016-03-23 | 2019-01-30 | Novartis AG | Cell secreted minibodies and uses thereof |
| TWI767915B (zh) | 2016-06-27 | 2022-06-21 | 加州大學董事會 | Ror-1與btk拮抗劑的組合 |
| WO2018111340A1 (en) | 2016-12-16 | 2018-06-21 | Novartis Ag | Methods for determining potency and proliferative function of chimeric antigen receptor (car)-t cells |
| ES2912408T3 (es) | 2017-01-26 | 2022-05-25 | Novartis Ag | Composiciones de CD28 y métodos para terapia con receptores quiméricos para antígenos |
| CN110582509A (zh) | 2017-01-31 | 2019-12-17 | 诺华股份有限公司 | 使用具有多特异性的嵌合t细胞受体蛋白治疗癌症 |
| WO2018229715A1 (en) | 2017-06-16 | 2018-12-20 | Novartis Ag | Compositions comprising anti-cd32b antibodies and methods of use thereof |
| RU2020116579A (ru) | 2017-10-25 | 2021-11-25 | Новартис Аг | Способы получения клеток, экспрессирующих химерный антигенный рецептор |
| WO2019081983A1 (en) | 2017-10-25 | 2019-05-02 | Novartis Ag | CD32B TARGETING ANTIBODIES AND METHODS OF USE |
| WO2019210153A1 (en) | 2018-04-27 | 2019-10-31 | Novartis Ag | Car t cell therapies with enhanced efficacy |
| EP3788369A1 (en) | 2018-05-01 | 2021-03-10 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
| EP3801769A1 (en) | 2018-05-25 | 2021-04-14 | Novartis AG | Combination therapy with chimeric antigen receptor (car) therapies |
| WO2019237035A1 (en) | 2018-06-08 | 2019-12-12 | Intellia Therapeutics, Inc. | Compositions and methods for immunooncology |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| WO2020092928A1 (en) * | 2018-11-02 | 2020-05-07 | The Regents Of The University Of California | Compositions and methods for diagnosis of cardiovascular disease |
| KR20210106437A (ko) | 2018-12-20 | 2021-08-30 | 노파르티스 아게 | 3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체를 포함하는 투약 요법 및 약학적 조합물 |
| CA3123519A1 (en) | 2019-02-15 | 2020-08-20 | Novartis Ag | Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| CN113490528B (zh) | 2019-02-15 | 2024-12-03 | 诺华股份有限公司 | 3-(1-氧代-5-(哌啶-4-基)异吲哚啉-2-基)哌啶-2,6-二酮衍生物及其用途 |
| BR112022011902A2 (pt) | 2019-12-20 | 2022-09-06 | Novartis Ag | Terapias de combinação |
| JP2023529211A (ja) | 2020-06-11 | 2023-07-07 | ノバルティス アーゲー | Ｚｂｔｂ３２阻害剤及びその使用 |
| KR20230027056A (ko) | 2020-06-23 | 2023-02-27 | 노파르티스 아게 | 3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체를 포함하는 투약 요법 |
| JP7819176B2 (ja) | 2020-08-03 | 2026-02-24 | ノバルティス アーゲー | ヘテロアリール置換３－（１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオン誘導体及びその使用 |
| TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途 |
| WO2022229853A1 (en) | 2021-04-27 | 2022-11-03 | Novartis Ag | Viral vector production system |
| WO2023214325A1 (en) | 2022-05-05 | 2023-11-09 | Novartis Ag | Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors |
| WO2024046384A1 (zh) * | 2022-08-31 | 2024-03-07 | 长春金赛药业有限责任公司 | 结合促甲状腺激素受体的抗体及其用途 |
| AU2023369684A1 (en) | 2022-10-26 | 2025-04-17 | Novartis Ag | Lentiviral formulations |
| PE20252789A1 (es) | 2023-05-24 | 2025-12-22 | Kumquat Biosciences Inc | Compuestos heterociclicos y usos de estos |
| CN119930815A (zh) * | 2023-10-27 | 2025-05-06 | 上海交通大学医学院附属第九人民医院 | 一种全人源tsh受体阻断性单克隆抗体及其制备和应用 |
| CN119086939B (zh) * | 2024-10-10 | 2026-04-07 | 深圳市新产业生物医学工程股份有限公司 | 四碘甲状腺素自身抗体作为癌症治疗过程中的甲状腺功能异常标志物的应用 |
| CN119510769B (zh) * | 2024-10-10 | 2026-03-31 | 深圳市新产业生物医学工程股份有限公司 | 三碘甲状腺素自身抗体作为癌症治疗过程中的甲状腺功能异常标志物的应用 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4244940A (en) | 1978-09-05 | 1981-01-13 | Bio-Rad Laboratories, Inc. | Single-incubation two-site immunoassay |
| US4514498A (en) | 1982-05-26 | 1985-04-30 | The Board Of Regents, The University Of Texas System | Hybrid cell lines producing monoclonal antibodies directed against Treponema |
| US4472508A (en) | 1982-12-30 | 1984-09-18 | The Beth Israel Hospital Association | Test for detecting and measuring the graves' disease-specific immunoglobulins |
| EP0139676B1 (en) | 1983-02-04 | 1992-11-25 | Cytoclonal Pharmaceutics Inc. | Production and characterization of hybridoma antibodies directed specifically against common determinant(s) present among closely related, but distinct proteins |
| US4609622A (en) | 1983-05-31 | 1986-09-02 | Interthyr Research Foundation Inc. | Clinical determination and/or quantification of thyrotropin and a variety of thyroid stimulatory or inhibitory factors performed in vitro with an improved thyroid cell line, FRTL-5 |
| US4753894A (en) | 1984-02-08 | 1988-06-28 | Cetus Corporation | Monoclonal anti-human breast cancer antibodies |
| US4661446A (en) | 1985-02-19 | 1987-04-28 | Dana-Farber Cancer Institute, Inc. | Monoclonal antibodies and method of immunizing therewith |
| WO1990008528A1 (en) | 1989-01-11 | 1990-08-09 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Biologically active synthetic thyrotropin and cloned gene for producing same |
| US6261800B1 (en) | 1989-05-05 | 2001-07-17 | Genentech, Inc. | Luteinizing hormone/choriogonadotropin (LH/CG) receptor |
| EP1199361A3 (en) | 1989-05-05 | 2004-03-10 | Genentech Inc. | Glycoprotein hormone receptor molecules. Their uses |
| US5744348A (en) | 1989-09-08 | 1998-04-28 | New England Medical Center Hospitals, Inc. | TSH receptor |
| US5614363A (en) | 1990-01-25 | 1997-03-25 | New England Medical Center Hospitals, Inc. | TSH receptor |
| EP0433509B1 (en) * | 1989-12-14 | 1996-11-13 | B.R.A.H.M.S Diagnostica GmbH | Polypeptides having thyrotropin receptor activity, nucleic acid sequences coding for such receptors and polypeptides, and applications of these polypeptides |
| EP0506890A4 (en) | 1989-12-20 | 1993-06-30 | Nichols Institute Diagnostics | Recombinant thyrotropin receptor |
| JPH04149197A (ja) | 1990-10-12 | 1992-05-22 | Tanabe Seiyaku Co Ltd | 新規ペプチド |
| EP0482598A3 (en) | 1990-10-24 | 1993-05-19 | Ishihara Sangyo Kaisha, Ltd. | Peptide analog of human tsh receptor affective against autoimmune hyperthyroidism |
| US5578496A (en) | 1991-12-19 | 1996-11-26 | Board Of Regents, Baylor College Of Medicine | Detection of autoantibodies associated with the disease myasthenia gravis |
| JPH07506810A (ja) | 1992-02-10 | 1995-07-27 | デューク・ユニバーシティ | 自己抗原である病原性のｔ細胞エピトープおよびｂ細胞エピトープに対する寛容性を誘導するための合成ペプチドの使用 |
| US5705400A (en) | 1992-03-07 | 1998-01-06 | Rsr Limited | Assay for adrenal autoantigen |
| US5195860A (en) | 1992-07-20 | 1993-03-23 | Trw Inc. | Push-on type fastener for automatic feed and installation equipment |
| JPH06220089A (ja) | 1993-01-27 | 1994-08-09 | Ishihara Sangyo Kaisha Ltd | ペプチド又はその塩並びにそれらを含有する自己免疫性甲状腺疾患の診断薬又は治療薬 |
| EP0683396A1 (en) | 1993-02-04 | 1995-11-22 | Sumitomo Pharmaceuticals Company, Limited | Method of assaying specific antibody |
| DE4328070C1 (de) | 1993-08-20 | 1994-11-24 | Henning Berlin Gmbh | Verfahren zur Bestimmung eines Analyten in einem Volumen einer flüssigen Probe sowie seine Anwendung zur Bestimmung von anti-TSH-Rezeptor-Autoantikörpern in einem Patientenserum |
| JPH0789991A (ja) | 1993-09-28 | 1995-04-04 | Mitsubishi Chem Corp | 新規なポリペプチドおよびそれを用いるｔｓｈ受容体抗体の測定法 |
| EP0719858A3 (en) | 1994-12-27 | 1997-12-29 | Tosoh Corporation | Myeloma cell line expressing recombinant human thyroid stimulating hormone receptor |
| DE19505266C1 (de) | 1995-02-16 | 1996-10-02 | Brahms Diagnostica Gmbh | Verwendung von polyklonalen humanen anti-hTg-Autoantikörpern als Reagenz für die klinische Diagnostik von Schilddrüsen-Autoimmunerkrankungen sowie Reagenziensatz für eine Bestimmung von anti-hTg-Autoantikörpern in Patientenseren |
| DE19522171C1 (de) | 1995-06-19 | 1996-08-22 | Brahms Diagnostica Gmbh | Verfahren zur Bestimmung von Anti-TSH-Rezeptor-Autoantikörpern |
| US5723343A (en) | 1995-08-28 | 1998-03-03 | University Of Florida | Autoantibodies in patients with acquired hypoparathyroidism and assay method therefor |
| DE59712916D1 (de) | 1996-11-06 | 2008-03-20 | Bosch Gmbh Robert | Elektrochemischer messfühler |
| US5734464A (en) | 1996-11-06 | 1998-03-31 | Cobe Laboratories, Inc. | Red blood cell spillover detection technique |
| DE19728991A1 (de) | 1996-11-06 | 1999-02-11 | Brahms Diagnostica Gmbh | Rezeptorbindungsassay, für den Rezeptorbindungsassay geeigneter rekombinanter Fusionsrezeptor, Vektor zu dessen Herstellung sowie Reagenziensatz für die Durchführung des Rezeptorbindungsassays |
| DE19651093C2 (de) * | 1996-12-09 | 1999-06-10 | Brahms Diagnostica Gmbh | Rezeptorbindungsassay zum Nachweis von TSH-Rezeptor-Autoantikörpern sowie Reagenziensatz für die Durchführung eines solchen Rezeptorbindungsassays |
| IL123888A0 (en) | 1997-04-01 | 1998-10-30 | Sankyo Co | Anti-fas antibodies |
| GB9909661D0 (en) * | 1998-06-06 | 1999-06-23 | Rsr Ltd | Assays for TSH receptor autoantibodies |
| WO2000005345A1 (en) * | 1998-07-21 | 2000-02-03 | Basil Rapoport | Human thyrotropin receptor compositions and use thereof |
| GB9823397D0 (en) * | 1998-10-27 | 1998-12-23 | Rsr Ltd | Assays for thyroid autoantibodies |
| JP4427878B2 (ja) * | 1999-08-20 | 2010-03-10 | 味の素株式会社 | 析出を伴う発酵法によるｌ−グルタミン酸の製造法 |
| EP1078986B1 (en) * | 1999-08-24 | 2007-02-28 | Tosoh Corporation | Secretory thyroid stimulating hormone receptor (TSHR), and method for assaying anti-TSHR antibody using the same |
| EP1224473B1 (de) | 1999-10-12 | 2005-08-17 | Ulrich Loos | Verfahren zur bestimmung von autoantikörpern gegen den tsh-rezeptor |
| WO2001044300A2 (en) | 1999-12-13 | 2001-06-21 | Cambridge Antibody Technology Limited | Brain specific binding members |
| WO2001063296A2 (de) | 2000-02-21 | 2001-08-30 | Milo Gmbh | Verfahren zur differentialdiagnostischen bestimmung von gegen den tsh-rezeptor gebildeten autoantikörpern in einer serum- oder plasmaprobe eines patienten |
| ATE414151T1 (de) | 2000-03-03 | 2008-11-15 | Cambridge Antibody Tech | Antikörper gegen eotaxin und deren verwendung |
| CA2409991A1 (en) | 2000-05-24 | 2001-11-29 | Imclone Systems Incorporated | Bispecific immunoglobulin-like antigen binding proteins and method of production |
| DE10126968A1 (de) | 2001-06-01 | 2002-12-12 | Ivoclar Vivadent Ag | Farbstoffzusammensetzung zum individuellen Einfärben von Prothesenkunststoffen |
| ES2736165T3 (es) | 2001-08-23 | 2019-12-26 | Rsr Ltd | Regiones epítopo de un receptor de tirotropina (TSH), sus usos y anticuerpos para las mismas |
| WO2004050708A2 (en) | 2002-11-29 | 2004-06-17 | Rsr Limited | Antibody for the thyrotropin receptor and uses thereof |
| PL2121758T3 (pl) * | 2007-02-15 | 2015-02-27 | R S R Ltd | Ludzkie przeciwciała monoklonalne przeciwko receptorowi tyreotropiny, które działają jako antagoniści |
| JP5784504B2 (ja) * | 2008-12-24 | 2015-09-24 | アールエスアール リミテッド | ヒト抗ｔｓｈｒ抗体 |
-
2002
- 2002-08-21 ES ES11158927T patent/ES2736165T3/es not_active Expired - Lifetime
- 2002-08-21 CN CN201310075812.8A patent/CN103224562B/zh not_active Expired - Lifetime
- 2002-08-21 JP JP2003523491A patent/JP2005509412A/ja active Pending
- 2002-08-21 CN CN2010101273436A patent/CN101799476B/zh not_active Expired - Lifetime
- 2002-08-21 EP EP11158929.7A patent/EP2383291B1/en not_active Expired - Lifetime
- 2002-08-21 ES ES02755210.8T patent/ES2466377T3/es not_active Expired - Lifetime
- 2002-08-21 CN CN028164229A patent/CN1622958B/zh not_active Expired - Lifetime
- 2002-08-21 US US10/488,074 patent/US8298769B2/en not_active Expired - Fee Related
- 2002-08-21 ES ES11158929T patent/ES2732276T3/es not_active Expired - Lifetime
- 2002-08-21 WO PCT/GB2002/003831 patent/WO2003018632A2/en not_active Ceased
- 2002-08-21 EP EP11158927.1A patent/EP2383290B1/en not_active Expired - Lifetime
- 2002-08-21 EP EP02755210.8A patent/EP1456234B1/en not_active Expired - Lifetime
-
2008
- 2008-12-12 US US12/333,740 patent/US8298771B2/en not_active Expired - Fee Related
- 2008-12-12 US US12/333,714 patent/US8309693B2/en not_active Expired - Fee Related
-
2009
- 2009-07-22 JP JP2009171358A patent/JP5576072B2/ja not_active Expired - Lifetime
-
2012
- 2012-11-09 US US13/673,878 patent/US9751940B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005509412A5 (https=) | ||
| JP3204510B2 (ja) | 勃起不全の診断および治療 | |
| Bagnasco et al. | Pharmacokinetics of an allergen and a monomeric allergoid for oromucosal immunotherapy in allergic volunteers | |
| Ortiz-Ortiz et al. | Cellular events in the induction of experimental allergic encephalomyelitis in rats. | |
| Lamanna et al. | The botulinal, tetanal, and enterostaphylococcal toxins: a review | |
| Lördal et al. | A novel tachykinin NK2 receptor antagonist prevents motility-stimulating effects of neurokinin A in small intestine | |
| Van Ree et al. | Involvement of neurohypophyseal peptides in drug-mediated adaptive responses | |
| Hartung et al. | Shorter infusion time of ocrelizumab: results from the randomized, double-blind ENSEMBLE PLUS substudy in patients with relapsing-remitting multiple sclerosis | |
| EP0690914B1 (en) | Allergenic protein and peptides from house dust mite and uses therefor | |
| Trotman et al. | Bloated irritable bowel syndrome defined by dynamic 99mTc bran scan | |
| JP2010202653A (ja) | 抗梗塞分子 | |
| JPH09505282A (ja) | レトロウイルススーパー抗原、スーパー抗原ペプチド及び使用方法 | |
| JP2001501579A (ja) | 抗体の産生、及び抗体を含む医療的使用 | |
| JPH02479A (ja) | ｓｎＲＮＰ−Ａ抗原及びそのフラグメント | |
| AU2001285427B2 (en) | Stress proteins and peptides and methods of use thereof | |
| SHOELSON et al. | Antiinsulin Receptor Antibodies in an Insulin-Dependent Diabetic May Ariseas Autoantiidiotypes | |
| WO2008127642A1 (en) | Myelin specific ige unencumbered by corresponding blocking antibodies as a causative factor in multiple sclerosis | |
| Galin et al. | Possible therapeutic vaccines for canine myasthenia gravis: implications for the human disease and associated fatigue | |
| JP4218987B2 (ja) | ペプチド免疫療法治療剤 | |
| Kalman et al. | Effects of staphylococcal enterotoxin B on T cell receptor Vβ utilization and clinical manifestations of experimental allergic encephalomyelitis | |
| Mayer et al. | Corticotropin Releasing Factor (CRF) increases post‐prandial duodenal motor activity in humans | |
| Perrild et al. | The differential diagnostic problems in unilateral euthyroid Graves’ ophthalmopathy | |
| HAKAMATA et al. | Insulin autoimmune syndrome after the third therapy with methimazole | |
| JP3349513B2 (ja) | ２，６−ジ−ヨードフェノール−４−イルを少なくとも２ケ含む化合物とヨードアレルギー診断薬 | |
| Takahashi et al. | Drug-induced inhibition of insulin recognition by T-cells: the antirheumatic drug aurothiomalate inhibits MHC binding of insulin peptide |