JP2005507365A5 - - Google Patents
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- Publication number
- JP2005507365A5 JP2005507365A5 JP2002573735A JP2002573735A JP2005507365A5 JP 2005507365 A5 JP2005507365 A5 JP 2005507365A5 JP 2002573735 A JP2002573735 A JP 2002573735A JP 2002573735 A JP2002573735 A JP 2002573735A JP 2005507365 A5 JP2005507365 A5 JP 2005507365A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- carbon atoms
- halogen
- substituted
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26265101P | 2001-01-22 | 2001-01-22 | |
| US26719601P | 2001-02-08 | 2001-02-08 | |
| US30614001P | 2001-07-19 | 2001-07-19 | |
| PCT/US2002/001508 WO2002074726A2 (en) | 2001-01-22 | 2002-01-22 | Aniline derivatives useful as phosphodiesterase 4 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005507365A JP2005507365A (ja) | 2005-03-17 |
| JP2005507365A5 true JP2005507365A5 (enrdf_load_stackoverflow) | 2008-02-21 |
| JP4223287B2 JP4223287B2 (ja) | 2009-02-12 |
Family
ID=27401532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002573735A Expired - Fee Related JP4223287B2 (ja) | 2001-01-22 | 2002-01-22 | 新規な化合物及び製薬上許容し得るそれらの塩並びにそれらを用いた薬剤組成物 |
Country Status (23)
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7153871B2 (en) | 2001-01-22 | 2006-12-26 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs |
| ATE437853T1 (de) * | 2001-02-14 | 2009-08-15 | Karobio Ab | Glucocorticoid-rezeptoren-modulatoren |
| NZ537724A (en) | 2002-07-19 | 2006-10-27 | Memory Pharm Corp | Phosphodiesterase 4 inhibitors, including N-substituted aniline and diphenylamine analogs |
| HRP20050082A2 (en) | 2002-07-19 | 2005-06-30 | Memory Pharmaceuticals Corporation | 6-amino-1h-indazole and 4-aminobenzofuran compounds as phosphodiesterase 4 inhibitors |
| AU2003295656B2 (en) | 2002-11-19 | 2010-11-11 | Memory Pharmaceuticals Corporation | Pyridine N-oxide compounds as phosphodiesterase 4 inhibitors |
| US20060040981A1 (en) * | 2002-11-22 | 2006-02-23 | Daniel Dube | Use of phosphodiesterase-4 inhibitors as enhancers of cognition |
| CA2511502A1 (en) * | 2002-12-27 | 2004-07-15 | H. Lundbeck A/S | 1,2,4-triaminobenzene derivatives,useful for treating disorders of the central nervous system |
| FR2856595B1 (fr) * | 2003-06-27 | 2008-05-30 | Exonhit Therapeutics Sa | Methodes et compositions pour le traitement de deficits cognitifs. |
| US7776893B2 (en) | 2003-09-05 | 2010-08-17 | Nycomed Gmbh | Use of PDE4 inhibitors for the treatment of diabetes mellitus |
| MY141255A (en) * | 2003-12-11 | 2010-03-31 | Memory Pharm Corp | Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs |
| BRPI0513286A (pt) | 2004-07-15 | 2008-05-06 | Japan Tobacco Inc | compostos de benzamida condensada e inibidores de atividade de receptor vanilóide subtipo (vr1), suas composições farmacêuticas, pacote comercial, fármaco e respectivos usos |
| EP1809608A4 (en) * | 2004-10-28 | 2009-11-04 | Merck & Co Inc | PYRIMIDINES AND CHINOLINES THAT ACTIVATE AS REINFORCING SUBSTANCES OF METABOTROPIC GLUTAMATE RECEPTORS |
| AU2006222060B2 (en) | 2005-03-08 | 2011-09-01 | Takeda Gmbh | Roflumilast for the treatment of diabetes mellitus |
| AU2006257863A1 (en) * | 2005-06-10 | 2006-12-21 | F. Hoffmann-La Roche Ag | Trisubstituted amines as phosphodiesterase 4 inhibitors |
| AR057455A1 (es) * | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
| US7906508B2 (en) | 2005-12-28 | 2011-03-15 | Japan Tobacco Inc. | 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity |
| AU2008215948A1 (en) | 2007-02-12 | 2008-08-21 | Merck & Co., Inc. | Piperazine derivatives for treatment of AD and related conditions |
| EP2110375A1 (en) | 2008-04-14 | 2009-10-21 | CHIESI FARMACEUTICI S.p.A. | Phosphodiesterase-4 inhibitors belonging to the tertiary amine class |
| WO2009128057A2 (en) | 2008-04-18 | 2009-10-22 | UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al | Psycho-pharmaceuticals |
| JP5542059B2 (ja) * | 2008-10-09 | 2014-07-09 | 国立大学法人 岡山大学 | Ｒｘｒ作動性物質を有効成分とする抗アレルギー剤 |
| FI2440546T3 (fi) | 2009-06-12 | 2023-03-30 | Abivax | Ennenaikaisen vanhenemisen ja erityisesti progerian hoitamiseen hyödyllisiä yhdisteitä |
| HRP20191460T1 (hr) * | 2009-06-12 | 2019-11-15 | Abivax | Spojevi korisni za liječenje raka |
| US10253020B2 (en) | 2009-06-12 | 2019-04-09 | Abivax | Compounds for preventing, inhibiting, or treating cancer, AIDS and/or premature aging |
| BR112012020060B8 (pt) | 2010-02-12 | 2021-05-25 | Askat Inc | uso de n-((1-((4-hidroxitetrahidro-2h-piran-4-il)metil)piperidin-4-il)metil)-3-isopropil-2-oxo-2,3-dihidro-1h-benzo[d]imidazol-1-carboxamida para tratar doença de alzheimer e demência |
| JP6124351B2 (ja) | 2012-02-09 | 2017-05-10 | 塩野義製薬株式会社 | 複素環および炭素環誘導体 |
| CN102603676B (zh) * | 2012-02-20 | 2014-02-12 | 徐江平 | 一种能避免呕吐反应的磷酸二酯酶4抑制剂 |
| JP5959670B2 (ja) * | 2012-03-14 | 2016-08-02 | シノケム・コーポレーションＳｉｎｏｃｈｅｍ Ｃｏｒｐｏｒａｔｉｏｎ | 抗腫瘍薬の調製における置換ジフェニルアミン化合物の使用 |
| EP2757161A1 (en) | 2013-01-17 | 2014-07-23 | Splicos | miRNA-124 as a biomarker of viral infection |
| CN105530938B (zh) | 2013-07-05 | 2019-10-22 | Abivax公司 | 用于治疗由逆转录病毒引起的疾病的化合物 |
| DK3033082T3 (da) | 2013-08-16 | 2021-09-20 | Univ Maastricht | Behandling af kognitiv svækkelse med pde4-hæmmer |
| EP2974729A1 (en) | 2014-07-17 | 2016-01-20 | Abivax | Quinoline derivatives for use in the treatment of inflammatory diseases |
| EP3669873A1 (en) | 2018-12-20 | 2020-06-24 | Abivax | Quinoline derivatives for use ine the traeatment of inflammation diseases |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6971894A (en) * | 1993-05-27 | 1994-12-20 | Smithkline Beecham Laboratoires Pharmaceutiques | Anti-arrhythmic n-substituted 3-benzazepines or isoquinolines |
| JPH07206789A (ja) * | 1993-09-01 | 1995-08-08 | Taisho Pharmaceut Co Ltd | コンブレタスタチン類縁化合物 |
| US5591776A (en) * | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
| FR2729142A1 (fr) * | 1995-01-06 | 1996-07-12 | Smithkline Beecham Lab | Nouvelles amines heterocycliques, leur procede de preparation et leur utilisation en tant que medicaments et notamment en tant qu'agents anti-arythmiques |
| CA2295106C (en) * | 1997-06-24 | 2007-03-13 | Nikken Chemicals Co., Ltd. | 3-anilino-2-cycloalkenone derivatives |
| MXPA01011832A (es) * | 1999-05-21 | 2002-06-21 | Squibb Bristol Myers Co | Inhibidores de cinasas, de pirrolotriazina. |
| DE50011851D1 (de) * | 1999-12-18 | 2006-01-19 | Wella Ag | 2-Aminoalkyl-1,4-diaminobenzol-Derivate und diese Verbindungen enthaltende Färbemittel |
-
2002
- 2002-01-22 HR HR20030662A patent/HRP20030662A2/hr not_active Application Discontinuation
- 2002-01-22 YU YU57603A patent/YU57603A/sh unknown
- 2002-01-22 CZ CZ20031986A patent/CZ20031986A3/cs unknown
- 2002-01-22 HU HU0302793A patent/HUP0302793A3/hu unknown
- 2002-01-22 WO PCT/US2002/001508 patent/WO2002074726A2/en active Application Filing
- 2002-01-22 EP EP02731078A patent/EP1353907A2/en not_active Withdrawn
- 2002-01-22 AU AU2002303078A patent/AU2002303078B2/en not_active Ceased
- 2002-01-22 BR BR0206943-1A patent/BR0206943A/pt not_active Application Discontinuation
- 2002-01-22 EE EEP200300347A patent/EE05362B1/xx not_active IP Right Cessation
- 2002-01-22 KR KR1020037009624A patent/KR100856622B1/ko not_active Expired - Fee Related
- 2002-01-22 MX MXPA03006519A patent/MXPA03006519A/es active IP Right Grant
- 2002-01-22 NZ NZ527081A patent/NZ527081A/xx unknown
- 2002-01-22 CN CNB028070100A patent/CN100378075C/zh not_active Expired - Fee Related
- 2002-01-22 JP JP2002573735A patent/JP4223287B2/ja not_active Expired - Fee Related
- 2002-01-22 CA CA002435847A patent/CA2435847A1/en not_active Abandoned
- 2002-01-22 IL IL15695802A patent/IL156958A0/xx unknown
- 2002-01-22 PL PL02373301A patent/PL373301A1/xx not_active Application Discontinuation
- 2002-01-22 SK SK915-2003A patent/SK9152003A3/sk unknown
-
2003
- 2003-07-18 BG BG108003A patent/BG108003A/bg unknown
- 2003-07-21 NO NO20033288A patent/NO329548B1/no not_active IP Right Cessation
- 2003-07-21 ZA ZA2003/05623A patent/ZA200305623B/en unknown
- 2003-07-22 MA MA27246A patent/MA25996A1/fr unknown
-
2004
- 2004-05-20 CL CL200401165A patent/CL2004001165A1/es unknown
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