JP2005506981A5 - - Google Patents
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- JP2005506981A5 JP2005506981A5 JP2003526405A JP2003526405A JP2005506981A5 JP 2005506981 A5 JP2005506981 A5 JP 2005506981A5 JP 2003526405 A JP2003526405 A JP 2003526405A JP 2003526405 A JP2003526405 A JP 2003526405A JP 2005506981 A5 JP2005506981 A5 JP 2005506981A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- group
- alkyl
- hydrogen
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 58
- 229910052739 hydrogen Inorganic materials 0.000 claims 52
- 239000001257 hydrogen Substances 0.000 claims 52
- -1 2-imidazolinyl Chemical group 0.000 claims 46
- 150000001875 compounds Chemical class 0.000 claims 40
- 150000002431 hydrogen Chemical class 0.000 claims 37
- 125000000217 alkyl group Chemical group 0.000 claims 32
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 30
- 125000000547 substituted alkyl group Chemical group 0.000 claims 27
- 229910052736 halogen Inorganic materials 0.000 claims 23
- 150000002367 halogens Chemical class 0.000 claims 23
- 125000003342 alkenyl group Chemical group 0.000 claims 22
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 22
- 125000003545 alkoxy group Chemical group 0.000 claims 21
- 125000000304 alkynyl group Chemical group 0.000 claims 20
- 229910052760 oxygen Inorganic materials 0.000 claims 19
- 229910052717 sulfur Inorganic materials 0.000 claims 19
- 125000003282 alkyl amino group Chemical group 0.000 claims 16
- 125000004663 dialkyl amino group Chemical group 0.000 claims 16
- 239000000651 prodrug Substances 0.000 claims 16
- 229940002612 prodrug Drugs 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 16
- 239000012453 solvate Substances 0.000 claims 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 15
- 150000001356 alkyl thiols Chemical class 0.000 claims 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims 14
- 125000001188 haloalkyl group Chemical group 0.000 claims 13
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 11
- 125000004076 pyridyl group Chemical group 0.000 claims 11
- 125000006323 alkenyl amino group Chemical group 0.000 claims 9
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 9
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 9
- 125000005125 aryl alkyl amino carbonyl group Chemical group 0.000 claims 9
- 125000005126 aryl alkyl carbonyl amino group Chemical group 0.000 claims 9
- 125000005100 aryl amino carbonyl group Chemical group 0.000 claims 9
- 125000004658 aryl carbonyl amino group Chemical group 0.000 claims 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims 9
- MKRVOXRLAFVYCF-UHFFFAOYSA-N C(#N)NN([N+](=O)[O-])O Chemical compound C(#N)NN([N+](=O)[O-])O MKRVOXRLAFVYCF-UHFFFAOYSA-N 0.000 claims 7
- 125000004442 acylamino group Chemical group 0.000 claims 7
- 125000004423 acyloxy group Chemical group 0.000 claims 7
- 229910052783 alkali metal Inorganic materials 0.000 claims 7
- 150000001340 alkali metals Chemical class 0.000 claims 7
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 7
- 125000005018 aryl alkenyl group Chemical group 0.000 claims 7
- 125000001691 aryl alkyl amino group Chemical group 0.000 claims 7
- 125000003710 aryl alkyl group Chemical group 0.000 claims 7
- 125000005015 aryl alkynyl group Chemical group 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 7
- 150000001540 azides Chemical class 0.000 claims 7
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 claims 7
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 7
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 7
- 125000000842 isoxazolyl group Chemical group 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- SOWBFZRMHSNYGE-UHFFFAOYSA-N oxamic acid Chemical compound NC(=O)C(O)=O SOWBFZRMHSNYGE-UHFFFAOYSA-N 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 150000003573 thiols Chemical class 0.000 claims 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 6
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 6
- 208000002193 Pain Diseases 0.000 claims 5
- 125000004103 aminoalkyl group Chemical group 0.000 claims 5
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 4
- 125000004864 4-thiomethylphenyl group Chemical group 0.000 claims 2
- 206010010904 Convulsion Diseases 0.000 claims 2
- 108010052164 Sodium Channels Proteins 0.000 claims 2
- 102000018674 Sodium Channels Human genes 0.000 claims 2
- 150000005840 aryl radicals Chemical class 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 208000028867 ischemia Diseases 0.000 claims 2
- 235000005152 nicotinamide Nutrition 0.000 claims 2
- 239000011570 nicotinamide Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 2
- WLRQGJFLMSNZAK-UHFFFAOYSA-N 2-(4-phenoxyphenyl)pyridine-4-carboxamide Chemical compound NC(=O)C1=CC=NC(C=2C=CC(OC=3C=CC=CC=3)=CC=2)=C1 WLRQGJFLMSNZAK-UHFFFAOYSA-N 0.000 claims 1
- VNPFVKSKEFHPRR-UHFFFAOYSA-N 2-(4-phenylphenyl)pyridine-4-carboxamide Chemical compound NC(=O)C1=CC=NC(C=2C=CC(=CC=2)C=2C=CC=CC=2)=C1 VNPFVKSKEFHPRR-UHFFFAOYSA-N 0.000 claims 1
- UTHASJFQCPZOKF-UHFFFAOYSA-N 2-(4-tert-butylphenyl)pyridine-4-carboxamide Chemical compound C1=CC(C(C)(C)C)=CC=C1C1=CC(C(N)=O)=CC=N1 UTHASJFQCPZOKF-UHFFFAOYSA-N 0.000 claims 1
- XAFONVMAPPEAIT-UHFFFAOYSA-N 2-[4-(4-fluorophenoxy)phenyl]pyridine-3-carboxamide Chemical compound NC(=O)C1=CC=CN=C1C(C=C1)=CC=C1OC1=CC=C(F)C=C1 XAFONVMAPPEAIT-UHFFFAOYSA-N 0.000 claims 1
- FHYAIJCEEYITHI-UHFFFAOYSA-N 2-[4-(4-fluorophenoxy)phenyl]pyridine-4-carboxamide Chemical compound NC(=O)C1=CC=NC(C=2C=CC(OC=3C=CC(F)=CC=3)=CC=2)=C1 FHYAIJCEEYITHI-UHFFFAOYSA-N 0.000 claims 1
- CJNRGSHEMCMUOE-UHFFFAOYSA-N 2-piperidin-1-ylethanamine Chemical compound NCCN1CCCCC1 CJNRGSHEMCMUOE-UHFFFAOYSA-N 0.000 claims 1
- RHODAQXTNFLOAE-UHFFFAOYSA-N 5-(4-phenoxyphenyl)pyridine-3-carboxamide Chemical compound NC(=O)C1=CN=CC(C=2C=CC(OC=3C=CC=CC=3)=CC=2)=C1 RHODAQXTNFLOAE-UHFFFAOYSA-N 0.000 claims 1
- GRKCWUVREMQJCO-UHFFFAOYSA-N 5-(4-tert-butylphenyl)pyridine-3-carboxamide Chemical compound C1=CC(C(C)(C)C)=CC=C1C1=CN=CC(C(N)=O)=C1 GRKCWUVREMQJCO-UHFFFAOYSA-N 0.000 claims 1
- MNOULQLXILYKNV-UHFFFAOYSA-N 5-[4-(trifluoromethyl)phenyl]-1h-pyrazole Chemical group C1=CC(C(F)(F)F)=CC=C1C1=CC=NN1 MNOULQLXILYKNV-UHFFFAOYSA-N 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- FNVGBCQVTXYPPL-UHFFFAOYSA-N NCCN1CCCCC1.OC(C(C=C1)=CN=C1C(C=C1)=CC=C1OC(C=C1)=CC=C1F)=O Chemical compound NCCN1CCCCC1.OC(C(C=C1)=CN=C1C(C=C1)=CC=C1OC(C=C1)=CC=C1F)=O FNVGBCQVTXYPPL-UHFFFAOYSA-N 0.000 claims 1
- MERFVOREMSEJAU-UHFFFAOYSA-N NCCN1CCCCC1.OC(C1=CC(C(C=C2)=CC=C2OC(C=C2)=CC=C2F)=CN=C1)=O Chemical compound NCCN1CCCCC1.OC(C1=CC(C(C=C2)=CC=C2OC(C=C2)=CC=C2F)=CN=C1)=O MERFVOREMSEJAU-UHFFFAOYSA-N 0.000 claims 1
- 208000009205 Tinnitus Diseases 0.000 claims 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 208000028683 bipolar I disease Diseases 0.000 claims 1
- 230000036461 convulsion Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000003589 local anesthetic agent Substances 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 230000000626 neurodegenerative effect Effects 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000002287 radioligand Substances 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000004055 thiomethyl group Chemical group [H]SC([H])([H])* 0.000 claims 1
- 231100000886 tinnitus Toxicity 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31752601P | 2001-09-07 | 2001-09-07 | |
| PCT/US2002/028298 WO2003022276A1 (en) | 2001-09-07 | 2002-09-06 | Aryl substituted pyridinecarboxamides and their use as sodium channel blockers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005506981A JP2005506981A (ja) | 2005-03-10 |
| JP2005506981A5 true JP2005506981A5 (https=) | 2005-12-08 |
Family
ID=23234074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003526405A Withdrawn JP2005506981A (ja) | 2001-09-07 | 2002-09-06 | アリール置換ピリジンカルボキサミドおよびナトリウムチャンネル遮断薬としてのそれらの使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7105549B2 (https=) |
| EP (1) | EP1432419A1 (https=) |
| JP (1) | JP2005506981A (https=) |
| KR (1) | KR20040031053A (https=) |
| AR (1) | AR037233A1 (https=) |
| BR (1) | BR0212338A (https=) |
| CA (1) | CA2459527A1 (https=) |
| HU (1) | HUP0500131A3 (https=) |
| IL (1) | IL160716A0 (https=) |
| MX (1) | MXPA04002171A (https=) |
| RU (1) | RU2004110721A (https=) |
| WO (1) | WO2003022276A1 (https=) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA04000411A (es) * | 2001-07-16 | 2004-03-18 | Euro Celtique Sa | Tiazolidinonas arilo sustituidas y uso de las mismas. |
| AR037233A1 (es) * | 2001-09-07 | 2004-11-03 | Euro Celtique Sa | Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento |
| GB0124933D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124938D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124931D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124936D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124939D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124934D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124941D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| EP2258687B1 (en) | 2002-02-12 | 2012-12-26 | Glaxosmithkline LLC | Nicotinamide derivates useful as P38 inhibitors |
| DK1483247T3 (da) * | 2002-03-13 | 2009-08-17 | Euro Celtique Sa | Arylsubstituerede pyrimidiner og anvendelsen deraf |
| JP2006504660A (ja) * | 2002-07-31 | 2006-02-09 | ユーロ−セルティーク エス．エイ． | アリール置換ベンゾイミダゾール類およびナトリウムチャネルブロッカーとしてのそれらの使用 |
| GB0217757D0 (en) | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Novel compounds |
| US20050227974A9 (en) * | 2002-08-01 | 2005-10-13 | Euro-Celtique S.A. | Aminoalkyl-substituted aryl compounds and their use as sodium channel blockers |
| US20040152696A1 (en) * | 2002-08-01 | 2004-08-05 | Euro-Celtique S.A. | 2-substituted bicyclic benzoheterocyclic compounds and their use as sodium channel blockers |
| WO2004084824A2 (en) * | 2003-03-24 | 2004-10-07 | Merck & Co., Inc. | Biaryl substituted 6-membered heterocyles as sodium channel blockers |
| GB0308185D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
| ATE500234T1 (de) * | 2003-11-10 | 2011-03-15 | Merck Sharp & Dohme | Substituierte trialzole als blocker des natriumkanals |
| GB0402143D0 (en) * | 2004-01-30 | 2004-03-03 | Smithkline Beecham Corp | Novel compounds |
| AU2005266090A1 (en) | 2004-07-23 | 2006-02-02 | Pfizer Inc. | Pyridine derivatives |
| US20080051416A1 (en) * | 2004-10-05 | 2008-02-28 | Smithkline Beecham Corporation | Novel Compounds |
| GB0512429D0 (en) * | 2005-06-17 | 2005-07-27 | Smithkline Beecham Corp | Novel compound |
| WO2007011760A2 (en) * | 2005-07-15 | 2007-01-25 | Kalypsys, Inc. | Inhibitors of mitotic kinesin |
| TW200728258A (en) * | 2005-10-10 | 2007-08-01 | Glaxo Group Ltd | Novel compounds |
| JP4159586B2 (ja) * | 2006-08-03 | 2008-10-01 | エヌイーシーコンピュータテクノ株式会社 | 情報処理装置および情報処理の高速化方法 |
| GEP20125379B (en) | 2007-05-03 | 2012-01-10 | Pfizer Ltd | 2 -pyridine carboxamide derivatives as sodium channel modulators |
| KR200451955Y1 (ko) * | 2008-05-09 | 2011-01-25 | 박영주 | 차량진입 방지대 |
| JP5693452B2 (ja) * | 2008-08-04 | 2015-04-01 | シーエイチディーアイ ファウンデーション，インコーポレーテッド | 特定のキヌレニン−３−モノオキシゲナーゼインヒビター、医薬組成物およびそれらの使用方法 |
| MX2012008346A (es) | 2010-01-25 | 2012-11-12 | Chdi Foundation Inc | Determinados inhibidores de cinurenina-3-monooxigenasa, composiciones farmceuticas y metodos de uso de los mismos. |
| JP2013531687A (ja) | 2010-07-16 | 2013-08-08 | パーデュー、ファーマ、リミテッド、パートナーシップ | ナトリウムチャネル遮断剤としてのピリジン化合物 |
| EP2616441B1 (en) * | 2010-09-17 | 2019-08-07 | Purdue Pharma L.P. | Pyridine compounds and the uses thereof |
| EP2625169B1 (en) | 2010-10-05 | 2015-03-25 | Purdue Pharma L.P. | Quinazoline compounds as sodium channel blockers |
| CN103429571A (zh) | 2010-12-22 | 2013-12-04 | 普渡制药公司 | 作为钠通道阻断剂的取代吡啶 |
| SI2750677T1 (sl) | 2011-08-30 | 2017-10-30 | Chdi Foundation, Inc. | Inhibitorji kinurenin-3-monooksigenaze, farmacevtski sestavki in postopki njihove uporabe |
| MX2014002459A (es) | 2011-08-30 | 2014-04-10 | Chdi Foundation Inc | Inhibidores de quinurenina-3-monooxigenasa, composiciones farmaceuticas y metodos de uso de los mismos. |
| WO2013030665A1 (en) | 2011-09-02 | 2013-03-07 | Purdue Pharma L.P. | Pyrimidines as sodium channel blockers |
| WO2013064883A1 (en) * | 2011-10-31 | 2013-05-10 | Purdue Pharma L.P. | Heteroaryl compounds as sodium channel blockers |
| AU2012321111A1 (en) * | 2011-10-31 | 2013-05-16 | Purdue Pharma L.P. | Quaternized amines as sodium channel blockers |
| US9133131B2 (en) | 2011-11-15 | 2015-09-15 | Purdue Pharma L.P. | Pyrimidine diol amides as sodium channel blockers |
| WO2013136170A1 (en) | 2012-03-16 | 2013-09-19 | Purdue Pharma L.P. | Substituted pyridines as sodium channel blockers |
| US9143309B2 (en) * | 2012-04-13 | 2015-09-22 | Dominant Technologies, LLC | Hopping master in wireless conference |
| WO2014096941A1 (en) | 2012-12-20 | 2014-06-26 | Purdue Pharma L.P. | Cyclic sulfonamides as sodium channel blockers |
| US9120786B2 (en) | 2013-03-04 | 2015-09-01 | Purdue Pharma, L.P. | Triazine carboxamides as sodium channel blockers |
| US9637458B2 (en) | 2013-03-04 | 2017-05-02 | Jeffrey Lockman | Pyrimidine carboxamides as sodium channel blockers |
| CA3082427A1 (en) * | 2013-03-15 | 2014-09-25 | Purdue Pharma L.P. | Carboxamide derivatives and use thereof |
| WO2015031036A1 (en) | 2013-08-26 | 2015-03-05 | Purdue Pharma L.P. | Azaspiro[4.5] decane derivatives and use thereof |
| JP6615752B2 (ja) * | 2013-09-30 | 2019-12-04 | グアンジョウ・イノケア・ファーマ・テク・カンパニー・リミテッド | Ｂｔｋの置換ニコチンイミド阻害剤およびそれらの調製、ならびにがん、炎症および自己免疫疾患の治療における使用 |
| US9340504B2 (en) | 2013-11-21 | 2016-05-17 | Purdue Pharma L.P. | Pyridine and piperidine derivatives as novel sodium channel blockers |
| US9745287B2 (en) | 2013-12-20 | 2017-08-29 | Purdue Pharma L.P. | Pyrimidines and use thereof |
| AU2014370407B2 (en) | 2013-12-23 | 2018-03-29 | Purdue Pharma L.P. | Indazoles and use thereof |
| US9695144B2 (en) | 2013-12-23 | 2017-07-04 | Purdue Pharma L.P. | Dibenzazepine derivatives and use thereof |
| EP3089978B1 (en) | 2013-12-30 | 2018-08-29 | Purdue Pharma L.P. | Pyridone-sulfone morphinan analogs as opioid receptor ligands |
| US10047075B2 (en) | 2014-01-24 | 2018-08-14 | Purdue Pharma L.P. | Pyridines and pyrimidines and use thereof |
| US10738026B2 (en) | 2014-02-12 | 2020-08-11 | Purdue Pharma L.P. | Isoquinoline derivatives and use thereof |
| US10730866B2 (en) | 2014-04-07 | 2020-08-04 | Purdue Pharma L.P. | Indole derivatives and use thereof |
| CA2948144A1 (en) | 2014-05-06 | 2015-11-12 | Purdue Pharma L.P. | Benzomorphan analogs and use thereof |
| WO2015192039A1 (en) | 2014-06-13 | 2015-12-17 | Purdue Pharma L.P. | Heterocyclic morphinan derivatives and use thereof |
| EP3154972A4 (en) | 2014-06-13 | 2017-11-22 | Purdue Pharma L.P. | Azamophinan derivatives and use thereof |
| CN106715421A (zh) | 2014-07-17 | 2017-05-24 | Chdi基金会股份有限公司 | 用于治疗hiv相关病症的方法和组合物 |
| WO2016033150A1 (en) * | 2014-08-28 | 2016-03-03 | X-Chem, Inc. | Soluble epoxide hydrolase inhibitors and uses thereof |
| WO2018125716A1 (en) | 2017-01-02 | 2018-07-05 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
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-
2002
- 2002-08-27 AR ARP020103213A patent/AR037233A1/es unknown
- 2002-09-06 IL IL16071602A patent/IL160716A0/xx unknown
- 2002-09-06 RU RU2004110721/04A patent/RU2004110721A/ru not_active Application Discontinuation
- 2002-09-06 HU HU0500131A patent/HUP0500131A3/hu unknown
- 2002-09-06 CA CA002459527A patent/CA2459527A1/en not_active Abandoned
- 2002-09-06 KR KR10-2004-7003314A patent/KR20040031053A/ko not_active Withdrawn
- 2002-09-06 JP JP2003526405A patent/JP2005506981A/ja not_active Withdrawn
- 2002-09-06 EP EP02773292A patent/EP1432419A1/en not_active Withdrawn
- 2002-09-06 US US10/235,673 patent/US7105549B2/en not_active Expired - Lifetime
- 2002-09-06 BR BR0212338-0A patent/BR0212338A/pt not_active Application Discontinuation
- 2002-09-06 MX MXPA04002171A patent/MXPA04002171A/es unknown
- 2002-09-06 WO PCT/US2002/028298 patent/WO2003022276A1/en not_active Ceased
-
2006
- 2006-09-11 US US11/518,448 patent/US7579367B2/en not_active Expired - Fee Related
-
2009
- 2009-08-24 US US12/546,572 patent/US7943643B2/en not_active Expired - Fee Related
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