AR037233A1 - Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento - Google Patents
Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamentoInfo
- Publication number
- AR037233A1 AR037233A1 ARP020103213A ARP020103213A AR037233A1 AR 037233 A1 AR037233 A1 AR 037233A1 AR P020103213 A ARP020103213 A AR P020103213A AR P020103213 A ARP020103213 A AR P020103213A AR 037233 A1 AR037233 A1 AR 037233A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- group
- alkyl
- formula
- hydrogen
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- -1 substituted aryl pyridine compound Chemical class 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 230000002265 prevention Effects 0.000 abstract 3
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 3
- 208000002193 Pain Diseases 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 150000001356 alkyl thiols Chemical class 0.000 abstract 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- MKRVOXRLAFVYCF-UHFFFAOYSA-N C(#N)NN([N+](=O)[O-])O Chemical compound C(#N)NN([N+](=O)[O-])O MKRVOXRLAFVYCF-UHFFFAOYSA-N 0.000 abstract 1
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 208000005298 acute pain Diseases 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 125000006323 alkenyl amino group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 230000003561 anti-manic effect Effects 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 125000005125 aryl alkyl amino carbonyl group Chemical group 0.000 abstract 1
- 125000001691 aryl alkyl amino group Chemical group 0.000 abstract 1
- 125000005126 aryl alkyl carbonyl amino group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000005015 aryl alkynyl group Chemical group 0.000 abstract 1
- 125000005100 aryl amino carbonyl group Chemical group 0.000 abstract 1
- 125000004658 aryl carbonyl amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 239000003589 local anesthetic agent Substances 0.000 abstract 1
- 229960005015 local anesthetics Drugs 0.000 abstract 1
- 230000000626 neurodegenerative effect Effects 0.000 abstract 1
- 230000003961 neuronal insult Effects 0.000 abstract 1
- SOWBFZRMHSNYGE-UHFFFAOYSA-N oxamic acid Chemical compound NC(=O)C(O)=O SOWBFZRMHSNYGE-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000005415 substituted alkoxy group Chemical group 0.000 abstract 1
- 150000003573 thiols Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31752601P | 2001-09-07 | 2001-09-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR037233A1 true AR037233A1 (es) | 2004-11-03 |
Family
ID=23234074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020103213A AR037233A1 (es) | 2001-09-07 | 2002-08-27 | Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7105549B2 (https=) |
| EP (1) | EP1432419A1 (https=) |
| JP (1) | JP2005506981A (https=) |
| KR (1) | KR20040031053A (https=) |
| AR (1) | AR037233A1 (https=) |
| BR (1) | BR0212338A (https=) |
| CA (1) | CA2459527A1 (https=) |
| HU (1) | HUP0500131A3 (https=) |
| IL (1) | IL160716A0 (https=) |
| MX (1) | MXPA04002171A (https=) |
| RU (1) | RU2004110721A (https=) |
| WO (1) | WO2003022276A1 (https=) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL159765A0 (en) * | 2001-07-16 | 2004-06-20 | Euro Celtique Sa | Aryl substituted thiazolidinone derivatives and pharmaceutical compositions containing the same |
| AR037233A1 (es) * | 2001-09-07 | 2004-11-03 | Euro Celtique Sa | Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento |
| GB0124941D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124936D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124931D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124933D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124939D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124938D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124934D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| ATE375980T1 (de) | 2002-02-12 | 2007-11-15 | Smithkline Beecham Corp | Nicotinamide und deren verwendung als p38 inhibitoren |
| MXPA04008901A (es) * | 2002-03-13 | 2004-11-26 | Euro Celtique Sa | Pirimidinas arilo sustituidas y el uso de las mismas. |
| CA2492305A1 (en) * | 2002-07-31 | 2004-02-05 | Euro-Celtique S.A. | Aryl substituted benzimidazoles and their use as sodium channel blockers |
| GB0217757D0 (en) | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Novel compounds |
| US20050227974A9 (en) * | 2002-08-01 | 2005-10-13 | Euro-Celtique S.A. | Aminoalkyl-substituted aryl compounds and their use as sodium channel blockers |
| US20040152696A1 (en) * | 2002-08-01 | 2004-08-05 | Euro-Celtique S.A. | 2-substituted bicyclic benzoheterocyclic compounds and their use as sodium channel blockers |
| JP2006521357A (ja) * | 2003-03-24 | 2006-09-21 | メルク エンド カムパニー インコーポレーテッド | ナトリウムチャンネル遮断薬としてのビアリール置換６員複素環化合物 |
| GB0308185D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
| CN1922156A (zh) * | 2003-11-10 | 2007-02-28 | 默克公司 | 作为钠通道阻断剂的取代的三唑 |
| GB0402143D0 (en) * | 2004-01-30 | 2004-03-03 | Smithkline Beecham Corp | Novel compounds |
| AU2005266090A1 (en) | 2004-07-23 | 2006-02-02 | Pfizer Inc. | Pyridine derivatives |
| US20080051416A1 (en) * | 2004-10-05 | 2008-02-28 | Smithkline Beecham Corporation | Novel Compounds |
| GB0512429D0 (en) * | 2005-06-17 | 2005-07-27 | Smithkline Beecham Corp | Novel compound |
| WO2007011760A2 (en) * | 2005-07-15 | 2007-01-25 | Kalypsys, Inc. | Inhibitors of mitotic kinesin |
| TW200728258A (en) * | 2005-10-10 | 2007-08-01 | Glaxo Group Ltd | Novel compounds |
| JP4159586B2 (ja) * | 2006-08-03 | 2008-10-01 | エヌイーシーコンピュータテクノ株式会社 | 情報処理装置および情報処理の高速化方法 |
| CA2684105C (en) | 2007-05-03 | 2011-09-06 | Pfizer Limited | Pyridine derivatives |
| KR200451955Y1 (ko) * | 2008-05-09 | 2011-01-25 | 박영주 | 차량진입 방지대 |
| JP5693452B2 (ja) * | 2008-08-04 | 2015-04-01 | シーエイチディーアイ ファウンデーション，インコーポレーテッド | 特定のキヌレニン−３−モノオキシゲナーゼインヒビター、医薬組成物およびそれらの使用方法 |
| CA2787365A1 (en) | 2010-01-25 | 2011-07-28 | Chdi Foundation, Inc. | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| JP2013531687A (ja) | 2010-07-16 | 2013-08-08 | パーデュー、ファーマ、リミテッド、パートナーシップ | ナトリウムチャネル遮断剤としてのピリジン化合物 |
| AU2011303597A1 (en) | 2010-09-17 | 2013-04-11 | Purdue Pharma L.P. | Pyridine compounds and the uses thereof |
| KR20130095772A (ko) | 2010-10-05 | 2013-08-28 | 퍼듀 퍼머 엘피 | 나트륨 채널 차단제로서 퀴나졸린 화합물 |
| EP2655330B1 (en) | 2010-12-22 | 2016-02-10 | Purdue Pharma LP | Substituted pyridines as sodium channel blockers |
| SI2750677T1 (sl) | 2011-08-30 | 2017-10-30 | Chdi Foundation, Inc. | Inhibitorji kinurenin-3-monooksigenaze, farmacevtski sestavki in postopki njihove uporabe |
| KR20140072037A (ko) | 2011-08-30 | 2014-06-12 | 씨에이치디아이 파운데이션, 인코포레이티드 | 키뉴레닌-3-모노옥시게나제 억제제, 약학적 조성물 및 이의 사용 방법 |
| EP3255041A1 (en) | 2011-09-02 | 2017-12-13 | Purdue Pharma L.P. | Pyrimidines as sodium channel blockers |
| WO2013064884A1 (en) * | 2011-10-31 | 2013-05-10 | Purdue Pharma L.P. | Quaternized amines as sodium channel blockers |
| WO2013064883A1 (en) | 2011-10-31 | 2013-05-10 | Purdue Pharma L.P. | Heteroaryl compounds as sodium channel blockers |
| US9133131B2 (en) | 2011-11-15 | 2015-09-15 | Purdue Pharma L.P. | Pyrimidine diol amides as sodium channel blockers |
| WO2013136170A1 (en) | 2012-03-16 | 2013-09-19 | Purdue Pharma L.P. | Substituted pyridines as sodium channel blockers |
| US9143309B2 (en) * | 2012-04-13 | 2015-09-22 | Dominant Technologies, LLC | Hopping master in wireless conference |
| EP2935257B1 (en) | 2012-12-20 | 2018-02-07 | Purdue Pharma LP | Cyclic sulfonamides as sodium channel blockers |
| WO2014135955A1 (en) | 2013-03-04 | 2014-09-12 | Purdue Pharma L.P. | Pyrimidine carboxamides as sodium channel blockers |
| US9120786B2 (en) | 2013-03-04 | 2015-09-01 | Purdue Pharma, L.P. | Triazine carboxamides as sodium channel blockers |
| CA2939549C (en) | 2013-03-15 | 2020-08-18 | Purdue Pharma L.P. | Carboxamide derivatives and use thereof |
| CN105612152A (zh) | 2013-08-26 | 2016-05-25 | 普渡制药公司 | 氮杂螺[4.5]癸烷衍生物及其用途 |
| KR102272792B1 (ko) * | 2013-09-30 | 2021-07-05 | 광저우 이노케어 파마 테크 씨오., 엘티디. | Ｂｔｋ의 치환된 니코틴이미드 저해제 및 그의 제조 방법 및 암, 염증 및 자가면역 질환에의 용도 |
| US9340504B2 (en) | 2013-11-21 | 2016-05-17 | Purdue Pharma L.P. | Pyridine and piperidine derivatives as novel sodium channel blockers |
| US9745287B2 (en) | 2013-12-20 | 2017-08-29 | Purdue Pharma L.P. | Pyrimidines and use thereof |
| US9695144B2 (en) | 2013-12-23 | 2017-07-04 | Purdue Pharma L.P. | Dibenzazepine derivatives and use thereof |
| JP6337124B2 (ja) | 2013-12-23 | 2018-06-06 | パーデュー、ファーマ、リミテッド、パートナーシップ | インダゾール及びその使用 |
| EP3089978B1 (en) | 2013-12-30 | 2018-08-29 | Purdue Pharma L.P. | Pyridone-sulfone morphinan analogs as opioid receptor ligands |
| JP6526023B2 (ja) | 2014-01-24 | 2019-06-05 | パーデュー、ファーマ、リミテッド、パートナーシップ | ピリジン類及びピリミジン類並びにその使用 |
| AU2015217185B2 (en) | 2014-02-12 | 2018-04-05 | Purdue Pharma L.P. | Isoquinoline derivatives and use thereof |
| US10730866B2 (en) | 2014-04-07 | 2020-08-04 | Purdue Pharma L.P. | Indole derivatives and use thereof |
| CA2948144A1 (en) | 2014-05-06 | 2015-11-12 | Purdue Pharma L.P. | Benzomorphan analogs and use thereof |
| MA40171A (fr) | 2014-06-13 | 2017-04-19 | Purdue Pharma Lp | Dérivés d'azamophinan et leur utilisation |
| WO2015192039A1 (en) | 2014-06-13 | 2015-12-17 | Purdue Pharma L.P. | Heterocyclic morphinan derivatives and use thereof |
| AU2015289492B2 (en) | 2014-07-17 | 2020-02-20 | Chdi Foundation, Inc. | Methods and compositions for treating HIV-related disorders |
| WO2016033150A1 (en) * | 2014-08-28 | 2016-03-03 | X-Chem, Inc. | Soluble epoxide hydrolase inhibitors and uses thereof |
| WO2018125716A1 (en) | 2017-01-02 | 2018-07-05 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
Family Cites Families (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3149109A (en) | 1962-02-20 | 1964-09-15 | Searle & Co | Certain 4-trifluoromethyl-2-(oxy/thio) pyrimidines |
| FR1477021A (fr) | 1965-04-21 | 1967-04-14 | Ilford Ltd | Matières photographiques |
| GB1121922A (en) | 1966-06-17 | 1968-07-31 | Ici Ltd | Pyrimidine derivatives |
| FR1536093A (fr) | 1966-09-10 | 1968-08-09 | Basf Ag | Nouvelles amino-4-alcoylmercapto-6-triazines-s |
| US3631036A (en) | 1969-11-04 | 1971-12-28 | American Home Prod | 5-amino-2 6-substituted-7h-pyrrolo(2 3-d) pyrimidines and related compounds |
| US3709888A (en) | 1970-06-01 | 1973-01-09 | Sandoz Ag | Aryl-substituted-pyrido(2,3-d)pyrimidin-2-ones |
| US3660414A (en) | 1970-06-01 | 1972-05-02 | Sandoz Ag | Certain 5-aryl-2-amino-nicotinonitriles |
| US3886167A (en) | 1974-03-06 | 1975-05-27 | Us Army | 2-Aryl-6-trifluoromethyl-4-pyridylcarbinolamine antimalarials |
| US3940404A (en) | 1974-03-06 | 1976-02-24 | The United States Of America As Represented By The Secretary Of The Army | 2-Substituted phenyl-6-trifluoromethyl-4-pyridyl-carbinolamines |
| DE2643753A1 (de) | 1976-09-29 | 1978-04-06 | Thomae Gmbh Dr K | Neue 1h-pyrazolo eckige klammer auf 3,4-b eckige klammer zu pyridine |
| US4133956A (en) | 1977-07-27 | 1979-01-09 | Eli Lilly And Company | Preparation of benzoylureas |
| US4293552A (en) | 1978-02-27 | 1981-10-06 | Eli Lilly And Company | Novel 1-(mono-o-substituted benzoyl)-3-(substituted pyrazinyl) ureas |
| ES8104268A1 (es) | 1979-04-05 | 1981-04-01 | Lilly Industries Ltd | Procedimiento para preparar piranonas 5-sustituidas |
| JPS56104883A (en) | 1980-01-25 | 1981-08-20 | Tanabe Seiyaku Co Ltd | Novel pyridinecarboxamide derivative and its preparation |
| JPS56115784A (en) | 1980-02-15 | 1981-09-11 | Tanabe Seiyaku Co Ltd | Novel pyridinecarboxamide derivative and its preparation |
| US4769462A (en) | 1980-06-02 | 1988-09-06 | American Cyanamid Co. | Novel 2-carbamoylnicotinic and 3-quinolinecarboxylic acids and esters |
| GB2095240A (en) | 1981-03-05 | 1982-09-29 | Fujisawa Pharmaceutical Co | Dihydropyrimidine derivatives, processes for preparation thereof and pharmaceutical composition comprising the same |
| DE3239573A1 (de) | 1981-10-28 | 1983-05-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Substituierte picolinsaeuren, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende arzneimittel |
| DE3245950A1 (de) | 1981-12-24 | 1983-07-07 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Verfahren zur herstellung substituierter pyridine |
| FR2527206B1 (fr) | 1982-05-18 | 1986-12-05 | Sandoz Sa | Nouveaux derives de la 2(1h)-pyridinone, leur preparation et leur utilisation comme medicaments |
| DE3379544D1 (en) | 1982-06-08 | 1989-05-11 | Ciba Geigy Ag | 2-phenyl-2-naphthyl and 2-heterocyclic pyrimidines as antidotes for protecting cultured plants before phytotoxic damages caused by herbicides |
| FR2531948B1 (fr) * | 1982-06-28 | 1986-05-09 | Nat Res Dev | Pesticide et procedes pour sa preparation et pour son utilisation |
| EP0123700A1 (de) | 1983-04-27 | 1984-11-07 | Byk Gulden Lomberg Chemische Fabrik GmbH | Substituierte Picolinsäuren, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende Arzneimittel |
| US4701208A (en) | 1983-08-02 | 1987-10-20 | American Cyanamid Company | Dihydroimidazopyrrolopyridine, quinoline, thieno- and furo[2,3-b]pyridine, dihydrothieno- and furo[2,3-b]-pyridine, thieno- and furo[3,2-b]pyridine and dihydrothieno- and furo[3,2-b]pyridine herbicides and method for preparation thereof |
| SU1790172A1 (ru) | 1984-05-17 | 1995-05-10 | Всесоюзный Государственный Научно-Исследовательский И Проектный Институт Химико-Фотографической Промышленности | Бисчетвертичные соли пиридина в качестве активаторов спектральной сенсибилизации фотографических бромйодсеребряных эмульсий, содержащих анионные или катион-анионные цианины |
| DE3685840D1 (de) | 1985-04-30 | 1992-08-06 | Dresden Arzneimittel | 3-cyan-pyridine, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung. |
| US4962109A (en) | 1985-12-23 | 1990-10-09 | Imperial Chemical Industries Plc | Insecticidally and acaricidally active pyrimidine esters and intermediates therefor |
| GB8531637D0 (en) | 1985-12-23 | 1986-02-05 | Ici Plc | Pyrimidine derivatives |
| JPS6320234A (ja) | 1986-07-11 | 1988-01-27 | Daihatsu Motor Co Ltd | 自動車の２輪・４輪駆動切換装置 |
| PH23565A (en) | 1986-09-05 | 1989-08-25 | Sumitomo Chemical Co | Novel pyrimidinylpyrimidine derivatives and a plant disease protectant containing them as the active ingredient |
| GB8627059D0 (en) | 1986-11-12 | 1986-12-10 | Cookson Group Plc | Substituted trialine derivatives |
| ZW21687A1 (en) | 1986-12-12 | 1988-07-20 | Hoffmann La Roche | Triazine derivatives |
| US5116989A (en) | 1987-11-06 | 1992-05-26 | Baxter Diagnostics Inc. | Fluorescent poly(arylpyridine) rare earth chelates |
| US5084462A (en) | 1988-04-26 | 1992-01-28 | The Du Pont Merck Pharmaceutical Company | 4-quinoline carboxylic acid derivatives useful as immunosuppressive agents |
| DE68905884T2 (de) | 1988-07-13 | 1993-08-12 | Canon Kk | Ferroelektrische, chirale, smektische fluessigkristall-zusammensetzung und vorrichtung zu deren anwendung. |
| JPH0252360A (ja) | 1988-08-15 | 1990-02-21 | Fujitsu Ltd | 電子写真感光体 |
| EP0362578A1 (en) | 1988-09-14 | 1990-04-11 | E.I. Du Pont De Nemours And Company | Treatment of cancer in mammals by concurrent administration of 4-quinoline carboxylic acid derivatives and interleukin-2 |
| FI895821A7 (fi) | 1988-12-07 | 1990-06-08 | The Wellcome Foundation Ltd | Farmaseuttisesti aktivisia CNS-yhdisteitä |
| GB8918893D0 (en) | 1989-08-18 | 1989-09-27 | Wellcome Found | Pharmacologically active cns compounds |
| US4968702A (en) | 1989-01-17 | 1990-11-06 | American Cyanamid Company | Substituted quinolinecarboxylic acids |
| GB8906470D0 (en) | 1989-03-21 | 1989-05-04 | Cookson Group Plc | Photopolymerisable composition |
| DE4134467A1 (de) | 1991-10-18 | 1993-04-22 | Thomae Gmbh Dr K | Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| WO1990015673A1 (en) * | 1989-06-12 | 1990-12-27 | General Electric Company | A laminar impressor for coating flat substrates |
| DE3940476A1 (de) | 1989-12-07 | 1991-06-13 | Bayer Ag | Pyridinylpyrimidin-derivate |
| GB8923131D0 (en) | 1989-10-13 | 1989-11-29 | Smith Kline French Lab | Chemical compounds |
| US5136080A (en) | 1989-12-04 | 1992-08-04 | Burroughs Wellcome Co. | Nitrile compounds |
| US5403934A (en) | 1990-03-12 | 1995-04-04 | Burroughs Wellcome Co. | Heterocyclic compounds |
| EP0446604A3 (en) | 1990-03-16 | 1992-02-19 | American Cyanamid Company | Pyridine and related aza heterocycle derivatives as cardiovascular agents |
| JPH06501254A (ja) | 1990-09-28 | 1994-02-10 | スミス・クライン・アンド・フレンチ・ラボラトリース・リミテッド | 医薬用フェニルピリジノール誘導体 |
| DE4032147A1 (de) | 1990-10-10 | 1992-04-16 | Bayer Ag | Verwendung von substituierten 2-mercaptonicotinsaeurederivaten zur bekaempfung von endoparasiten, neue substituierte 2-mercaptonicotinsaeurederivate und verfahren zu ihrer herstellung |
| DE69132635T2 (de) | 1990-10-25 | 2001-09-20 | Ihara Chemical Industry Co., Ltd. | Picolinsäurederivat, seine herstellung und verwendung als herbizid |
| JPH0597706A (ja) | 1991-04-09 | 1993-04-20 | Chemex Block Drug Jv | アフタ性潰瘍および他の粘膜皮膚障害の処置方法 |
| GB9124578D0 (en) | 1991-11-20 | 1992-01-08 | Smithkline Beecham Plc | Chemical compounds |
| DE4200323A1 (de) | 1992-01-09 | 1993-07-15 | Bayer Ag | Herbizide und pflanzennematizide mittel auf basis von mercaptonicotinsaeurederivaten |
| US5389632A (en) | 1992-02-24 | 1995-02-14 | Laboratoires Upsa | Pyrazolopyrimidine derivatives which are angiotensin II receptor antagonists |
| TW237456B (https=) | 1992-04-09 | 1995-01-01 | Ciba Geigy | |
| JPH0776542A (ja) | 1993-09-06 | 1995-03-20 | Canon Inc | 液晶性化合物、これを含む液晶組成物、それを有する液晶素子、それらを用いた表示方法および表示装置 |
| US5602156A (en) | 1993-09-17 | 1997-02-11 | The United States Of America As Represented By The Department Of Health And Human Services | Method for inhibiting metalloproteinase expression |
| US5744492A (en) | 1993-09-17 | 1998-04-28 | United States Of America | Method for inhibiting angiogenesis |
| IL112290A (en) | 1994-01-12 | 1999-01-26 | Novartis Ag | Transformed aryl and the troiryl pyrimidines and herbicides containing them |
| GB9405347D0 (en) | 1994-03-18 | 1994-05-04 | Agrevo Uk Ltd | Fungicides |
| US5563143A (en) | 1994-09-21 | 1996-10-08 | Pfizer Inc. | Catechol diether compounds as inhibitors of TNF release |
| US6057346A (en) | 1994-12-12 | 2000-05-02 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of retroviral LTR promoters by calcium response modifiers |
| US5849758A (en) | 1995-05-30 | 1998-12-15 | American Cyanamid Company | Herbicidal 2, 6-disubstituted pyridines and 2, 4-disubstituted pyrimidines |
| CZ290330B6 (cs) | 1995-01-26 | 2002-07-17 | American Cyanamid Company | 2,6-Disubstituované pyridinové a 2,4-disubstituované pyrimidinové deriváty, způsob a meziprodukty pro jejich výrobu, jejich pouľití a herbicidní prostředky na jejich bázi a způsob potlačování růstu neľádoucích rostlin |
| US6008161A (en) | 1995-05-30 | 1999-12-28 | American Cyanamid Company | Herbicidal 2-(hetero)aryloxy-6-arylpyridines and 2-aryl-4-(hetero) aryloxypyrimidines |
| US5741818A (en) | 1995-06-07 | 1998-04-21 | University Of Saskatchewan | Semicarbazones having CNS activity and pharmaceutical preparations containing same |
| DE69616364T2 (de) | 1995-08-02 | 2002-07-11 | Smithkline Beecham Corp., Philadelphia | Endothelinrezeptorantagonisten |
| AU6320998A (en) * | 1997-02-21 | 1998-09-09 | Bristol-Myers Squibb Company | Benzoic acid derivatives and related compounds as antiarrhythmic agents |
| NZ500590A (en) | 1997-04-22 | 2001-11-30 | Cocensys Inc | Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof |
| DE69814151T2 (de) | 1997-12-12 | 2004-03-25 | Abbott Laboratories, Abbott Park | Triazin angiogenese-inhibitoren |
| AU1504599A (en) | 1997-12-17 | 1999-07-05 | Shionogi & Co., Ltd. | Novel pyridine compounds |
| WO1999032468A1 (en) | 1997-12-19 | 1999-07-01 | Takeda Chemical Industries, Ltd. | Anilide derivative, production and use thereof |
| ID24959A (id) | 1998-01-28 | 2000-08-31 | Shionogi & Co | Senyawa-senyawa trisiklik yang baru |
| CA2352612A1 (en) | 1998-11-27 | 2000-06-08 | Hideo Fukui | Pharmaceuticals |
| CA2358047A1 (en) | 1998-12-24 | 2000-07-06 | Francis A. Volz | Substituted (aminoiminomethyl or aminomethyl)benzoheteroaryl compounds |
| TW502019B (en) | 1999-03-26 | 2002-09-11 | Cocensys Inc | Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof |
| MXPA02003436A (es) | 1999-10-07 | 2002-08-20 | Amgen Inc | Inhibidores de triazina cinasa. |
| DOP2000000109A (es) * | 1999-12-23 | 2002-08-30 | Gerald Kleymann | Derivados de tiazolilamida |
| BR0107732A (pt) | 2000-01-20 | 2003-03-11 | Eisai Ltd | Método para prevenir ou tratar uma doença |
| AR029489A1 (es) * | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
| AU4589701A (en) | 2000-03-24 | 2001-10-08 | Cocensys Inc | Aryl substituted pyrazoles, triazoles and tetrazoles, and the use thereof |
| AU4961001A (en) | 2000-03-31 | 2001-10-15 | Cocensys Inc | Aminopyridines and their use as anticonvulsants and sodium channel blockers |
| JP4272338B2 (ja) | 2000-09-22 | 2009-06-03 | バイエル アクチェンゲゼルシャフト | ピリジン誘導体 |
| US6394753B1 (en) * | 2001-02-07 | 2002-05-28 | Hypro Corporation | Flexible impeller removal and installation method |
| US6552188B2 (en) * | 2001-06-29 | 2003-04-22 | Kowa Co., Ltd. | Unsymmetrical cyclic diamine compound |
| US6395753B1 (en) * | 2001-08-30 | 2002-05-28 | Kowa Co., Ltd. | Cyclic amine compounds and pharmaceutical composition containing the same |
| AR037233A1 (es) * | 2001-09-07 | 2004-11-03 | Euro Celtique Sa | Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento |
| MXPA04008901A (es) | 2002-03-13 | 2004-11-26 | Euro Celtique Sa | Pirimidinas arilo sustituidas y el uso de las mismas. |
-
2002
- 2002-08-27 AR ARP020103213A patent/AR037233A1/es unknown
- 2002-09-06 IL IL16071602A patent/IL160716A0/xx unknown
- 2002-09-06 BR BR0212338-0A patent/BR0212338A/pt not_active Application Discontinuation
- 2002-09-06 JP JP2003526405A patent/JP2005506981A/ja not_active Withdrawn
- 2002-09-06 US US10/235,673 patent/US7105549B2/en not_active Expired - Lifetime
- 2002-09-06 CA CA002459527A patent/CA2459527A1/en not_active Abandoned
- 2002-09-06 EP EP02773292A patent/EP1432419A1/en not_active Withdrawn
- 2002-09-06 HU HU0500131A patent/HUP0500131A3/hu unknown
- 2002-09-06 MX MXPA04002171A patent/MXPA04002171A/es unknown
- 2002-09-06 RU RU2004110721/04A patent/RU2004110721A/ru not_active Application Discontinuation
- 2002-09-06 WO PCT/US2002/028298 patent/WO2003022276A1/en not_active Ceased
- 2002-09-06 KR KR10-2004-7003314A patent/KR20040031053A/ko not_active Withdrawn
-
2006
- 2006-09-11 US US11/518,448 patent/US7579367B2/en not_active Expired - Fee Related
-
2009
- 2009-08-24 US US12/546,572 patent/US7943643B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7943643B2 (en) | 2011-05-17 |
| US20080194627A9 (en) | 2008-08-14 |
| WO2003022276A1 (en) | 2003-03-20 |
| IL160716A0 (en) | 2004-08-31 |
| BR0212338A (pt) | 2004-09-21 |
| HUP0500131A3 (en) | 2005-07-28 |
| US7579367B2 (en) | 2009-08-25 |
| EP1432419A1 (en) | 2004-06-30 |
| US20030055088A1 (en) | 2003-03-20 |
| KR20040031053A (ko) | 2004-04-09 |
| MXPA04002171A (es) | 2004-07-23 |
| US7105549B2 (en) | 2006-09-12 |
| HUP0500131A2 (hu) | 2005-05-30 |
| JP2005506981A (ja) | 2005-03-10 |
| US20100048626A1 (en) | 2010-02-25 |
| RU2004110721A (ru) | 2005-10-10 |
| US20070010554A1 (en) | 2007-01-11 |
| CA2459527A1 (en) | 2003-03-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR037233A1 (es) | Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento | |
| AR036873A1 (es) | Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento | |
| AR029489A1 (es) | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento | |
| CA2400778A1 (en) | Aryl substituted pyrazoles, triazoles and tetrazoles, and the use thereof | |
| PH12022553603A1 (en) | Triazine derivative having virus propagation inhibitory effect, and pharmaceutical composition containing same | |
| PH12021500049A1 (en) | 2,3-dihydroquinazolin compounds as nav1.8 inhibitors | |
| AR060545A1 (es) | Compuestos de benzoaxol y benzotiazol 6-0- sustituidos y metodos de inhibicion de la senalizacion de csf-1r. composiciones farmaceuticas | |
| AR083339A1 (es) | Compuestos de quinazolina como bloqueadores de los canales de sodio | |
| FI811897L (fi) | Foerfarande foer framstaellning av aryloxipropanolaminer | |
| IL108562A (en) | 7, 8-diaryl-1,2,3,4- terahydropyrazolo- £5,1-c| £1,2,4| triazine derivatives, methods for the preparation thereof and pharmaceutical compositions containing them | |
| LV12209A (lv) | Ar fenilgrupu aizvietoti heterocikli ka ciklooksigenazes-2 inhibitori | |
| MXPA01009655A (es) | Pirazoles, imidazoles, oxazoles, tiazoles y pirroles substituidos con arilo y uso de los mismos. | |
| LTIP846A (en) | N-(4-piperidinyl)(dihydrobenzofuran or dihydro-2h-benzopyran)carboxamide derivatives,processes for the preparation thereof and pharmaceutical compositions | |
| BG105666A (en) | Complex of ras-farnesyltransferase inhibitor and sulfobutylether-7-beta-cyclodextrin or 2-hydroxypropyl-beta-cyclodextrin and method for forming the complex | |
| SI20744B (sl) | Derivati karboksilne kisline, ki inhibirajo vezavo integrinov na njihove receptorje | |
| RU2006147307A (ru) | Производные 3-карбамоил-2-пиридона | |
| TNSN06377A1 (en) | Combinations of glycopyrrolate and beta2 adrenoceptor agonists | |
| ME03800B (me) | Heteroaril amidi kao inhibitori proteinske agregacije | |
| IL79841A0 (en) | Heterocyclic compounds,their production and pharmaceutical compositions containing them | |
| BG104717A (en) | Water soluble azoles as broad-spectrum antifungals | |
| HRP20120257T1 (hr) | Antagonisti receptora 5-ht7 | |
| MX2023000926A (es) | Nuevo derivado de pirazol. | |
| MXPA05010651A (es) | Compuestos de pirazol. | |
| MXPA05010986A (es) | Compuestos de n-[(piperazinil)hetaril]arilsulfonamida con afinidad para el receptor d3 de la dopamina. | |
| AR044175A1 (es) | Compuestos de cefemo |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |