JP2005506527A5 - - Google Patents
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- JP2005506527A5 JP2005506527A5 JP2003534911A JP2003534911A JP2005506527A5 JP 2005506527 A5 JP2005506527 A5 JP 2005506527A5 JP 2003534911 A JP2003534911 A JP 2003534911A JP 2003534911 A JP2003534911 A JP 2003534911A JP 2005506527 A5 JP2005506527 A5 JP 2005506527A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- probe
- support
- microparticles
- array
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000011859 microparticle Substances 0.000 claims description 55
- 239000000523 sample Substances 0.000 claims description 43
- 238000000034 method Methods 0.000 claims description 40
- 239000000463 material Substances 0.000 claims description 28
- -1 aryl ketone Chemical class 0.000 claims description 24
- 108090000623 proteins and genes Proteins 0.000 claims description 22
- 102000004169 proteins and genes Human genes 0.000 claims description 22
- 150000001875 compounds Chemical class 0.000 claims description 11
- 125000003277 amino group Chemical group 0.000 claims description 9
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 8
- 125000003396 thiol group Chemical group [H]S* 0.000 claims description 8
- 239000010419 fine particle Substances 0.000 claims description 6
- 108010090804 Streptavidin Proteins 0.000 claims description 5
- 125000003172 aldehyde group Chemical group 0.000 claims description 4
- 229960002685 biotin Drugs 0.000 claims description 4
- 235000020958 biotin Nutrition 0.000 claims description 4
- 239000011616 biotin Substances 0.000 claims description 4
- 150000001720 carbohydrates Chemical class 0.000 claims description 4
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 4
- 125000003700 epoxy group Chemical group 0.000 claims description 4
- 239000003550 marker Substances 0.000 claims 25
- 229920013730 reactive polymer Polymers 0.000 claims 21
- 239000002245 particle Substances 0.000 claims 12
- 229920000642 polymer Polymers 0.000 claims 9
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 6
- 229920001577 copolymer Polymers 0.000 claims 6
- 239000011248 coating agent Substances 0.000 claims 5
- 238000000576 coating method Methods 0.000 claims 5
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims 4
- 239000002853 nucleic acid probe Substances 0.000 claims 4
- KKGFAULLJCULTN-UHFFFAOYSA-N 4-benzoyl-n-[3-(2-methylprop-2-enoylamino)propyl]benzamide Chemical compound C1=CC(C(=O)NCCCNC(=O)C(=C)C)=CC=C1C(=O)C1=CC=CC=C1 KKGFAULLJCULTN-UHFFFAOYSA-N 0.000 claims 3
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 3
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 3
- 102100026735 Coagulation factor VIII Human genes 0.000 claims 3
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 3
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims 3
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims 3
- 102000004856 Lectins Human genes 0.000 claims 3
- 108090001090 Lectins Proteins 0.000 claims 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 3
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 3
- 229920002125 Sokalan® Polymers 0.000 claims 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- XXTZHYXQVWRADW-UHFFFAOYSA-N diazomethanone Chemical compound [N]N=C=O XXTZHYXQVWRADW-UHFFFAOYSA-N 0.000 claims 3
- CCGKOQOJPYTBIH-UHFFFAOYSA-N ethenone Chemical compound C=C=O CCGKOQOJPYTBIH-UHFFFAOYSA-N 0.000 claims 3
- 150000004676 glycans Chemical class 0.000 claims 3
- 230000003100 immobilizing effect Effects 0.000 claims 3
- 239000002523 lectin Substances 0.000 claims 3
- 239000006249 magnetic particle Substances 0.000 claims 3
- CPGRMGOILBSUQC-UHFFFAOYSA-N phosphoryl azide Chemical compound [N-]=[N+]=NP(=O)(N=[N+]=[N-])N=[N+]=[N-] CPGRMGOILBSUQC-UHFFFAOYSA-N 0.000 claims 3
- 229920002401 polyacrylamide Polymers 0.000 claims 3
- 239000004584 polyacrylic acid Substances 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 229920001282 polysaccharide Polymers 0.000 claims 3
- 239000005017 polysaccharide Substances 0.000 claims 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 239000002096 quantum dot Substances 0.000 claims 3
- HSVFKFNNMLUVEY-UHFFFAOYSA-N sulfuryl diazide Chemical compound [N-]=[N+]=NS(=O)(=O)N=[N+]=[N-] HSVFKFNNMLUVEY-UHFFFAOYSA-N 0.000 claims 3
- BXEFQPCKQSTMKA-UHFFFAOYSA-N OC(=O)C=[N+]=[N-] Chemical compound OC(=O)C=[N+]=[N-] BXEFQPCKQSTMKA-UHFFFAOYSA-N 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 238000000059 patterning Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 description 6
- 150000001412 amines Chemical class 0.000 description 5
- 239000003431 cross linking reagent Substances 0.000 description 5
- 108091034117 Oligonucleotide Proteins 0.000 description 4
- 239000004971 Cross linker Substances 0.000 description 3
- 239000003068 molecular probe Substances 0.000 description 3
- 108090001008 Avidin Proteins 0.000 description 2
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 2
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 2
- 230000001588 bifunctional effect Effects 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 150000001735 carboxylic acids Chemical group 0.000 description 2
- 239000005090 green fluorescent protein Substances 0.000 description 2
- 150000002540 isothiocyanates Chemical class 0.000 description 2
- UUVBVONAGUSCCH-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 4',5'-dichloro-3',6'-dihydroxy-2',7'-dimethoxy-1-oxospiro[2-benzofuran-3,9'-xanthene]-5-carboxylate Chemical compound ClC1=C(O)C(OC)=CC2=C1OC1=C(Cl)C(O)=C(OC)C=C1C2(C1=C2)OC(=O)C1=CC=C2C(=O)ON1C(=O)CCC1=O UUVBVONAGUSCCH-UHFFFAOYSA-N 0.000 description 1
- RBAFCMJBDZWZIV-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 4-azido-2-hydroxybenzoate Chemical compound OC1=CC(N=[N+]=[N-])=CC=C1C(=O)ON1C(=O)CCC1=O RBAFCMJBDZWZIV-UHFFFAOYSA-N 0.000 description 1
- WXXSHAKLDCERGU-UHFFFAOYSA-N 1-[4-(2,5-dioxopyrrol-1-yl)butyl]pyrrole-2,5-dione Chemical compound O=C1C=CC(=O)N1CCCCN1C(=O)C=CC1=O WXXSHAKLDCERGU-UHFFFAOYSA-N 0.000 description 1
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 1
- IHDBZCJYSHDCKF-UHFFFAOYSA-N 4,6-dichlorotriazine Chemical class ClC1=CC(Cl)=NN=N1 IHDBZCJYSHDCKF-UHFFFAOYSA-N 0.000 description 1
- 239000012099 Alexa Fluor family Substances 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 239000004158 L-cystine Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 150000001502 aryl halides Chemical class 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 229960003067 cystine Drugs 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000012954 diazonium Substances 0.000 description 1
- ZWIBGKZDAWNIFC-UHFFFAOYSA-N disuccinimidyl suberate Chemical compound O=C1CCC(=O)N1OC(=O)CCCCCCC(=O)ON1C(=O)CCC1=O ZWIBGKZDAWNIFC-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 108091006047 fluorescent proteins Proteins 0.000 description 1
- 102000034287 fluorescent proteins Human genes 0.000 description 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine group Chemical group NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000000269 nucleophilic effect Effects 0.000 description 1
- 150000003009 phosphonic acids Chemical group 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 150000003016 phosphoric acids Chemical group 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003460 sulfonic acids Chemical group 0.000 description 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical class ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/972,687 US7195913B2 (en) | 2001-10-05 | 2001-10-05 | Randomly ordered arrays and methods of making and using |
| PCT/US2002/031740 WO2003031979A1 (en) | 2001-10-05 | 2002-10-04 | Randomly ordered arrays and methods of making and using |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005506527A JP2005506527A (ja) | 2005-03-03 |
| JP2005506527A5 true JP2005506527A5 (https=) | 2006-01-05 |
| JP4464132B2 JP4464132B2 (ja) | 2010-05-19 |
Family
ID=25520000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003534911A Expired - Fee Related JP4464132B2 (ja) | 2001-10-05 | 2002-10-04 | ランダムに配置されたアレイ群、ならびにその製造方法と使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7195913B2 (https=) |
| EP (1) | EP1432989B1 (https=) |
| JP (1) | JP4464132B2 (https=) |
| AT (1) | ATE450795T1 (https=) |
| CA (1) | CA2462736A1 (https=) |
| DE (1) | DE60234614D1 (https=) |
| MX (1) | MXPA04003184A (https=) |
| WO (1) | WO2003031979A1 (https=) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2255599C (en) | 1996-04-25 | 2006-09-05 | Bioarray Solutions, Llc | Light-controlled electrokinetic assembly of particles near surfaces |
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| US9709559B2 (en) | 2000-06-21 | 2017-07-18 | Bioarray Solutions, Ltd. | Multianalyte molecular analysis using application-specific random particle arrays |
| US7262063B2 (en) | 2001-06-21 | 2007-08-28 | Bio Array Solutions, Ltd. | Directed assembly of functional heterostructures |
| US8158106B2 (en) * | 2001-10-05 | 2012-04-17 | Surmodics, Inc. | Particle immobilized coatings and uses thereof |
| CA2497740C (en) | 2001-10-15 | 2011-06-21 | Bioarray Solutions, Ltd. | Multiplexed analysis of polymorphic loci by probe elongation-mediated detection |
| US7108891B2 (en) * | 2002-03-07 | 2006-09-19 | Eastman Kodak Company | Random array of microspheres |
| AU2003298655A1 (en) | 2002-11-15 | 2004-06-15 | Bioarray Solutions, Ltd. | Analysis, secure access to, and transmission of array images |
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| US20050019745A1 (en) * | 2003-07-23 | 2005-01-27 | Eastman Kodak Company | Random array of microspheres |
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2001
- 2001-10-05 US US09/972,687 patent/US7195913B2/en not_active Expired - Fee Related
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2002
- 2002-10-04 MX MXPA04003184A patent/MXPA04003184A/es unknown
- 2002-10-04 JP JP2003534911A patent/JP4464132B2/ja not_active Expired - Fee Related
- 2002-10-04 AT AT02800906T patent/ATE450795T1/de not_active IP Right Cessation
- 2002-10-04 CA CA002462736A patent/CA2462736A1/en not_active Abandoned
- 2002-10-04 EP EP02800906A patent/EP1432989B1/en not_active Expired - Lifetime
- 2002-10-04 WO PCT/US2002/031740 patent/WO2003031979A1/en not_active Ceased
- 2002-10-04 DE DE60234614T patent/DE60234614D1/de not_active Expired - Lifetime
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2007
- 2007-03-06 US US11/682,526 patent/US20080039343A1/en not_active Abandoned
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