JP2005503433A5 - - Google Patents
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- Publication number
- JP2005503433A5 JP2005503433A5 JP2003530652A JP2003530652A JP2005503433A5 JP 2005503433 A5 JP2005503433 A5 JP 2005503433A5 JP 2003530652 A JP2003530652 A JP 2003530652A JP 2003530652 A JP2003530652 A JP 2003530652A JP 2005503433 A5 JP2005503433 A5 JP 2005503433A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkoxy
- alkyl
- halogen
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 9
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 claims description 3
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 claims description 3
- 229910052736 halogen Inorganic materials 0.000 claims 11
- 150000002367 halogens Chemical class 0.000 claims 11
- 125000001424 substituent group Chemical group 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 208000010877 cognitive disease Diseases 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 208000028698 Cognitive impairment Diseases 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 125000005871 1,3-benzodioxolyl group Chemical group 0.000 claims 1
- KAESVJOAVNADME-UHFFFAOYSA-N 1H-pyrrole Natural products C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- PTIASGVLWNOMTD-FIRIVFDPSA-N N-[(1R,2R)-6-[[N-[2-(4-fluorophenyl)ethyl]-C-methylcarbonimidoyl]amino]-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-4-phenylbenzamide Chemical compound FC1=CC=C(CCNC(C)=NC2=CC=C3C[C@H]([C@@H](C3=C2)NC(=O)C2=CC=C(C=C2)C2=CC=CC=C2)O)C=C1 PTIASGVLWNOMTD-FIRIVFDPSA-N 0.000 claims 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000004802 cyanophenyl group Chemical group 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 208000027061 mild cognitive impairment Diseases 0.000 claims 1
- -1 nitro Naphthyl Chemical group 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 150000003233 pyrroles Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 4
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 4
- 239000000556 agonist Substances 0.000 description 4
- 102000017927 CHRM1 Human genes 0.000 description 2
- 101150073075 Chrm1 gene Proteins 0.000 description 2
- 230000003042 antagnostic effect Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32414101P | 2001-09-21 | 2001-09-21 | |
| PCT/US2002/025969 WO2003027061A2 (en) | 2001-09-21 | 2002-09-09 | Muscarinic agonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005503433A JP2005503433A (ja) | 2005-02-03 |
| JP2005503433A5 true JP2005503433A5 (https=) | 2006-01-05 |
| JP4409290B2 JP4409290B2 (ja) | 2010-02-03 |
Family
ID=23262266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003530652A Expired - Fee Related JP4409290B2 (ja) | 2001-09-21 | 2002-09-09 | ムスカリン性アゴニスト |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US7326731B2 (https=) |
| EP (1) | EP1436249B1 (https=) |
| JP (1) | JP4409290B2 (https=) |
| KR (1) | KR20040053130A (https=) |
| CN (1) | CN1556788A (https=) |
| AR (1) | AR036602A1 (https=) |
| AU (1) | AU2002332541B2 (https=) |
| BR (1) | BR0212353A (https=) |
| CA (1) | CA2461218C (https=) |
| CZ (1) | CZ2004397A3 (https=) |
| EA (1) | EA006853B1 (https=) |
| EC (1) | ECSP045027A (https=) |
| EG (1) | EG25796A (https=) |
| ES (1) | ES2439093T3 (https=) |
| HR (1) | HRP20040230B1 (https=) |
| HU (1) | HUP0401883A2 (https=) |
| IL (2) | IL160751A0 (https=) |
| MX (1) | MXPA04002633A (https=) |
| MY (1) | MY142358A (https=) |
| NO (1) | NO20041107L (https=) |
| NZ (1) | NZ531135A (https=) |
| PE (1) | PE20030707A1 (https=) |
| PL (1) | PL205708B1 (https=) |
| SV (1) | SV2004001250A (https=) |
| TW (1) | TWI327997B (https=) |
| UA (1) | UA76492C2 (https=) |
| WO (1) | WO2003027061A2 (https=) |
| ZA (1) | ZA200402191B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60335380D1 (de) * | 2002-08-22 | 2011-01-27 | Lilly Co Eli | Muskarine agonisten |
| ATE384039T1 (de) | 2003-07-03 | 2008-02-15 | Lilly Co Eli | Indanderivate als muscarinrezeptoragonisten |
| AR046078A1 (es) * | 2003-08-06 | 2005-11-23 | Senomyx Inc | Nuevos sabores, modificadores de sabores, sustancias gustativas, mejoradores de gusto, sustancias gustativas y/o mejoradoras del gusto umani o dulce y uso de los mismos. |
| US7662821B2 (en) | 2003-10-08 | 2010-02-16 | Bayer Schering Pharma Ag | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
| US7638515B2 (en) | 2003-10-08 | 2009-12-29 | Bayer Schering Pharma Aktiengesellschaft | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
| PT1670458E (pt) | 2003-10-08 | 2007-03-30 | Schering Ag | Derivados de tetra-hidronaftaleno, processo para a sua preparação e utilização como inibidor de inflamação |
| US20080153859A1 (en) | 2004-04-05 | 2008-06-26 | Hartmut Rehwinkel | Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
| DE102004029325A1 (de) * | 2004-06-10 | 2006-01-05 | Universität Leipzig | Arzneitmittel zur Behandlung des fetalen Alkoholsyndroms |
| DE102005017316A1 (de) * | 2005-04-14 | 2006-10-19 | Schering Ag | Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
| CN101374836A (zh) * | 2005-12-27 | 2009-02-25 | 托莱多大学 | 毒蕈碱激动剂及其使用方法 |
| EP1834948A1 (de) | 2006-03-15 | 2007-09-19 | Bayer Schering Pharma Aktiengesellschaft | Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
| ES2640453T3 (es) | 2006-04-21 | 2017-11-03 | Senomyx, Inc. | Procesos para preparar composiciones saborizantes sólidas |
| WO2009140483A1 (en) | 2008-05-15 | 2009-11-19 | University Of Toledo | Muscarinic agonists as cognitive enhancers |
| JP5670325B2 (ja) * | 2008-06-19 | 2015-02-18 | エックスカバリー ホールディング カンパニー エルエルシー | キナーゼ阻害化合物としての置換されたピリダジンカルボキサミド化合物 |
| JP2013523679A (ja) | 2010-03-29 | 2013-06-17 | ビーエーエスエフ ソシエタス・ヨーロピア | 殺菌性イミノ誘導体 |
| TWI402072B (zh) | 2010-10-19 | 2013-07-21 | Lilly Co Eli | 組織蛋白酶ｓ抑制劑化合物 |
| US9549928B2 (en) | 2011-04-29 | 2017-01-24 | The University Of Toledo | Muscarinic agonists as enhancers of cognitive flexibility |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0874625B1 (en) * | 1996-01-22 | 2005-03-16 | Eli Lilly And Company | Indane derivatives for antipsychotic compositions |
| CA2278424A1 (en) * | 1997-01-22 | 1998-07-23 | Bret Eugene Huff | Process for preparing indane-like compounds |
| JP2001510797A (ja) * | 1997-07-22 | 2001-08-07 | イーライ・リリー・アンド・カンパニー | 医薬化合物 |
-
2002
- 2002-09-09 UA UA2004032068A patent/UA76492C2/uk unknown
- 2002-09-09 JP JP2003530652A patent/JP4409290B2/ja not_active Expired - Fee Related
- 2002-09-09 EP EP02799555.4A patent/EP1436249B1/en not_active Expired - Lifetime
- 2002-09-09 ES ES02799555.4T patent/ES2439093T3/es not_active Expired - Lifetime
- 2002-09-09 WO PCT/US2002/025969 patent/WO2003027061A2/en not_active Ceased
- 2002-09-09 HU HU0401883A patent/HUP0401883A2/hu unknown
- 2002-09-09 EA EA200400454A patent/EA006853B1/ru not_active IP Right Cessation
- 2002-09-09 KR KR10-2004-7004057A patent/KR20040053130A/ko not_active Ceased
- 2002-09-09 AU AU2002332541A patent/AU2002332541B2/en not_active Ceased
- 2002-09-09 IL IL16075102A patent/IL160751A0/xx unknown
- 2002-09-09 CN CNA028185501A patent/CN1556788A/zh active Pending
- 2002-09-09 MX MXPA04002633A patent/MXPA04002633A/es active IP Right Grant
- 2002-09-09 PL PL368272A patent/PL205708B1/pl not_active IP Right Cessation
- 2002-09-09 CA CA2461218A patent/CA2461218C/en not_active Expired - Fee Related
- 2002-09-09 NZ NZ531135A patent/NZ531135A/en not_active IP Right Cessation
- 2002-09-09 HR HR20040230A patent/HRP20040230B1/xx not_active IP Right Cessation
- 2002-09-09 CZ CZ2004397A patent/CZ2004397A3/cs unknown
- 2002-09-09 US US10/488,519 patent/US7326731B2/en not_active Expired - Fee Related
- 2002-09-09 BR BR0212353-3A patent/BR0212353A/pt active Search and Examination
- 2002-09-18 EG EG2002091034A patent/EG25796A/xx active
- 2002-09-19 MY MYPI20023487A patent/MY142358A/en unknown
- 2002-09-19 TW TW091121495A patent/TWI327997B/zh not_active IP Right Cessation
- 2002-09-20 PE PE2002000926A patent/PE20030707A1/es not_active Application Discontinuation
- 2002-09-20 SV SV2002001250A patent/SV2004001250A/es unknown
- 2002-09-20 AR ARP020103544A patent/AR036602A1/es unknown
-
2004
- 2004-03-04 IL IL160751A patent/IL160751A/en not_active IP Right Cessation
- 2004-03-15 NO NO20041107A patent/NO20041107L/no not_active Application Discontinuation
- 2004-03-18 ZA ZA200402191A patent/ZA200402191B/en unknown
- 2004-03-19 EC EC2004005027A patent/ECSP045027A/es unknown
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