JP2005503345A5 - - Google Patents
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- JP2005503345A5 JP2005503345A5 JP2002585436A JP2002585436A JP2005503345A5 JP 2005503345 A5 JP2005503345 A5 JP 2005503345A5 JP 2002585436 A JP2002585436 A JP 2002585436A JP 2002585436 A JP2002585436 A JP 2002585436A JP 2005503345 A5 JP2005503345 A5 JP 2005503345A5
- Authority
- JP
- Japan
- Prior art keywords
- carbon atoms
- halogen
- atoms
- alkyl
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000004432 carbon atom Chemical group C* 0.000 claims 1001
- 229910052717 sulfur Inorganic materials 0.000 claims 180
- 125000000217 alkyl group Chemical group 0.000 claims 178
- 125000003342 alkenyl group Chemical group 0.000 claims 155
- 229910052757 nitrogen Inorganic materials 0.000 claims 154
- 125000000304 alkynyl group Chemical group 0.000 claims 151
- 125000005843 halogen group Chemical group 0.000 claims 151
- 229910052760 oxygen Inorganic materials 0.000 claims 136
- 125000005842 heteroatom Chemical group 0.000 claims 111
- 125000003118 aryl group Chemical group 0.000 claims 101
- 125000003545 alkoxy group Chemical group 0.000 claims 90
- 229910052736 halogen Inorganic materials 0.000 claims 90
- 150000002367 halogens Chemical class 0.000 claims 90
- 125000001188 haloalkyl group Chemical group 0.000 claims 80
- 125000004438 haloalkoxy group Chemical group 0.000 claims 71
- 229910052739 hydrogen Inorganic materials 0.000 claims 49
- 239000001257 hydrogen Substances 0.000 claims 49
- 125000001072 heteroaryl group Chemical group 0.000 claims 47
- 125000000753 cycloalkyl group Chemical group 0.000 claims 40
- 150000002431 hydrogen Chemical class 0.000 claims 35
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 33
- 229920006395 saturated elastomer Polymers 0.000 claims 31
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 30
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 16
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 14
- 229910052799 carbon Inorganic materials 0.000 claims 11
- 201000010099 disease Diseases 0.000 claims 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 11
- 125000004429 atom Chemical group 0.000 claims 10
- 125000001424 substituent group Chemical group 0.000 claims 9
- PIGFYZPCRLYGLF-UHFFFAOYSA-N Aluminum nitride Chemical compound [Al]#N PIGFYZPCRLYGLF-UHFFFAOYSA-N 0.000 claims 8
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
- 101100407335 Dictyostelium discoideum pde7 gene Proteins 0.000 claims 6
- 230000001404 mediated effect Effects 0.000 claims 6
- -1 piperidin-4-olyl group Chemical group 0.000 claims 6
- 230000002265 prevention Effects 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical group C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims 4
- 125000002619 bicyclic group Chemical group 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 208000001132 Osteoporosis Diseases 0.000 claims 3
- 208000006673 asthma Diseases 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- 125000004434 sulfur atom Chemical group 0.000 claims 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
- 208000029725 Metabolic bone disease Diseases 0.000 claims 2
- 206010049088 Osteopenia Diseases 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 125000003542 3-methylbutan-2-yl group Chemical group [H]C([H])([H])C([H])(*)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- JEBHUFMDZLZEJP-UHFFFAOYSA-N 4-(3,3-dimethylpiperidin-1-yl)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine Chemical compound C1C(C)(C)CCCN1C1=NC=NC2=C1C(CCCC1)=C1S2 JEBHUFMDZLZEJP-UHFFFAOYSA-N 0.000 claims 1
- ZJZQFDBFPJDURJ-UHFFFAOYSA-N 4-(3,3-dimethylpiperidin-1-yl)-6,8-dihydro-5h-pyrano[4,5]thieno[1,2-c]pyrimidine Chemical compound C1C(C)(C)CCCN1C1=NC=NC2=C1C(CCOC1)=C1S2 ZJZQFDBFPJDURJ-UHFFFAOYSA-N 0.000 claims 1
- 206010006458 Bronchitis chronic Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010022562 Intermittent claudication Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 241001111421 Pannus Species 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 206010006451 bronchitis Diseases 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000007451 chronic bronchitis Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 claims 1
- 208000021156 intermittent vascular claudication Diseases 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- YGWJEMZMNCBCCM-UHFFFAOYSA-N n-(3-methylbutan-2-yl)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-amine Chemical compound C1CCCC2=C1SC1=C2C(NC(C)C(C)C)=NC=N1 YGWJEMZMNCBCCM-UHFFFAOYSA-N 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- DYTQGJLVGDSCLF-UHFFFAOYSA-N thieno[2,3-d]pyrimidin-4-amine Chemical compound NC1=NC=NC2=C1C=CS2 DYTQGJLVGDSCLF-UHFFFAOYSA-N 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28762901P | 2001-04-30 | 2001-04-30 | |
| PCT/US2002/013630 WO2002088138A1 (en) | 2001-04-30 | 2002-04-29 | Novel 4-amino-5,6-substituted thiopheno[2,3-d]pyrimidines |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010030397A Division JP2010155847A (ja) | 2001-04-30 | 2010-02-15 | 新規な４−アミノ−５，６−置換チオフェノ［２，３−ｄ］ピリミジン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005503345A JP2005503345A (ja) | 2005-02-03 |
| JP2005503345A5 true JP2005503345A5 (enExample) | 2005-12-22 |
Family
ID=23103719
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002585436A Withdrawn JP2005503345A (ja) | 2001-04-30 | 2002-04-29 | 新規な４−アミノ−５，６−置換チオフェノ［２，３−ｄ］ピリミジン |
| JP2010030397A Pending JP2010155847A (ja) | 2001-04-30 | 2010-02-15 | 新規な４−アミノ−５，６−置換チオフェノ［２，３−ｄ］ピリミジン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010030397A Pending JP2010155847A (ja) | 2001-04-30 | 2010-02-15 | 新規な４−アミノ−５，６−置換チオフェノ［２，３−ｄ］ピリミジン |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6849638B2 (enExample) |
| EP (1) | EP1401840A4 (enExample) |
| JP (2) | JP2005503345A (enExample) |
| CN (2) | CN100343258C (enExample) |
| MX (1) | MXPA03009925A (enExample) |
| WO (1) | WO2002088138A1 (enExample) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2217956B1 (es) * | 2003-01-23 | 2006-04-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo. |
| WO2004089312A2 (en) * | 2003-03-31 | 2004-10-21 | Predix Pharmaceuticals Holdings, Inc. | New piperidinylamino-thieno[2,3-d] pyrimidine compounds |
| US7238701B2 (en) | 2003-07-24 | 2007-07-03 | Bayer Pharmaceuticals Corporation | Substituted tetrahydrobenzothienopyrimidinamine compounds useful for treating hyper-proliferative disorders |
| EP1799653B1 (en) * | 2004-08-20 | 2013-03-20 | Bayer Intellectual Property GmbH | Condensed thienopyrimidine derivatives for the treatment of cancer |
| EP1819711B1 (en) * | 2004-10-27 | 2010-04-21 | Bayer Schering Pharma Aktiengesellschaft | Pyrimidothienoindazoles capable of inhibiting tyrosine kinases of the epidermal growth factor |
| US20100143341A1 (en) * | 2005-06-22 | 2010-06-10 | Develogen Aktiengesellschaft | Thienopyrimidines for pharmaceutical compositions |
| US7846664B2 (en) * | 2005-12-07 | 2010-12-07 | The Regents Of The University Of California | Diagnosis and treatment of chronic lymphocytic leukemia (CLL) |
| EP2004656B1 (en) | 2006-04-07 | 2013-07-10 | Boehringer Ingelheim International GmbH | Thienopyrimidines having mnk1 /mnk2 inhibiting activity for pharmaceutical compositions |
| EP1889847A1 (en) | 2006-07-10 | 2008-02-20 | DeveloGen Aktiengesellschaft | Pyrrolopyrimidines for pharmaceutical compositions |
| AU2008230710B2 (en) * | 2007-03-27 | 2014-04-10 | Omeros Corporation | The use of PDE7 inhibitors for the treatment of movement disorders |
| US8637528B2 (en) * | 2007-03-27 | 2014-01-28 | Omeros Corporation | Use of PDE7 inhibitors for the treatment of movement disorders |
| US7982035B2 (en) | 2007-08-27 | 2011-07-19 | Duquesne University Of The Holy Spirit | Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof |
| WO2009033581A1 (en) | 2007-09-14 | 2009-03-19 | Bayer Schering Pharma Aktiengesellschaft | Substituted tricyclic compounds and methods of use thereof |
| WO2009053268A1 (de) * | 2007-10-19 | 2009-04-30 | Boehringer Ingelheim International Gmbh | Neue phenyl-substituierte piperazino-dihydrothienopyrimidine |
| EP2205609B1 (de) | 2007-10-19 | 2017-03-29 | Boehringer Ingelheim International GmbH | Heterocyclus-substituierte piperazino-dihydrothienopyrimidine |
| BRPI0818006B8 (pt) | 2007-10-19 | 2021-05-25 | Boehringer Ingelheim Int | compostos de piperidino-di-hidrotienopirimidinas substituídas, uso dos mesmos e formulações farmacêuticas |
| JP5563466B2 (ja) * | 2007-10-19 | 2014-07-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ピペラジノ−ジヒドロチエノピリミジン誘導体 |
| WO2009104026A1 (en) * | 2008-02-19 | 2009-08-27 | Vichem Chemie Kutató Kft | Tricyclic benzo[4,5]thieno-[2,3-d]pyrimidine-4-yl-amin derivatives, their salts, process for producing the compounds and their pharmaceutical use |
| AU2009286734A1 (en) | 2008-08-26 | 2010-03-04 | Boehringer Ingelheim International Gmbh | Thienopyrimidines for pharmaceutical compositions |
| CA2773131C (en) * | 2009-09-04 | 2015-07-14 | The Regents Of The University Of Michigan | Compositions and methods for treatment of leukemia |
| US8754079B2 (en) | 2010-02-26 | 2014-06-17 | Boehringer Ingelheim International Gmbh | Cycloalkyl containing thienopyrimidines for pharmaceutical compositions |
| UY33245A (es) | 2010-02-26 | 2011-09-30 | Boehringer Ingelheim Int | Tienopirimidinas que contienen un grupo alquilo sustituido para composiciones farmacéuticas |
| UY33241A (es) | 2010-02-26 | 2011-09-30 | Boehringer Ingelheim Int | ?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?. |
| WO2012012712A2 (en) | 2010-07-23 | 2012-01-26 | President And Fellows Of Harvard College | Tricyclic proteasome activity enhancing compounds |
| KR20220047894A (ko) | 2010-11-08 | 2022-04-19 | 오메로스 코포레이션 | Pde7 억제제를 사용한 중독 및 충동-조절 장애의 치료 |
| US9220715B2 (en) | 2010-11-08 | 2015-12-29 | Omeros Corporation | Treatment of addiction and impulse-control disorders using PDE7 inhibitors |
| CN102552274B (zh) * | 2010-11-12 | 2013-10-23 | 姚雪彪 | 动点马达蛋白小分子抑制剂在抑制肿瘤细胞增殖中的应用 |
| WO2012097013A1 (en) * | 2011-01-10 | 2012-07-19 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| US20130059866A1 (en) | 2011-08-24 | 2013-03-07 | Boehringer Ingelheim International Gmbh | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma |
| US9802954B2 (en) | 2011-08-24 | 2017-10-31 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
| AU2013207972B2 (en) * | 2012-01-10 | 2017-06-15 | Nimbus Iris, Inc. | IRAK inhibitors and uses thereof |
| AU2013202373B2 (en) * | 2012-01-25 | 2016-04-14 | Proteostasis Therapeutics, Inc. | Proteasome activity enhancing compounds |
| CA2861464C (en) | 2012-01-25 | 2018-03-06 | Proteostasis Therapeutics, Inc. | Proteasome activity modulating tricyclic compounds |
| CA2873967A1 (en) * | 2012-05-21 | 2013-11-28 | Bayer Pharma Aktiengesellschaft | Substituted benzothienopyrimidines |
| CA2873975A1 (en) | 2012-05-21 | 2013-11-28 | Bayer Pharma Aktiengesellschaft | Thienopyrimidines |
| AU2013290080A1 (en) | 2012-07-11 | 2015-01-29 | Nimbus Iris, Inc. | IRAK inhibitors and uses thereof |
| EP2872144A4 (en) | 2012-07-11 | 2015-12-02 | Nimbus Iris Inc | IRAQ INHIBITOR AND USES THEREOF |
| TW201412740A (zh) | 2012-09-20 | 2014-04-01 | Bayer Pharma AG | 經取代之吡咯并嘧啶胺基苯并噻唑酮 |
| CN105142639A (zh) * | 2013-01-10 | 2015-12-09 | 林伯士艾瑞斯公司 | Irak抑制剂和其用途 |
| US8778365B1 (en) | 2013-01-31 | 2014-07-15 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| EP2951187A1 (en) | 2013-02-01 | 2015-12-09 | Bayer Pharma Aktiengesellschaft | Substituted thienopyrimidines and pharmaceutical use thereof |
| US10208023B2 (en) | 2013-03-01 | 2019-02-19 | Mark G. DeGiacomo | Heterocyclic inhibitors of the sodium channel |
| US9675612B2 (en) | 2013-03-06 | 2017-06-13 | Bayer Pharma Aktiengesellschaft | Substituted thiazolopyrimidines |
| BR112016006319A2 (pt) | 2013-09-27 | 2017-08-01 | Nimbus Iris Inc | inibidores de irak e usos dos mesmos |
| TW201605867A (zh) * | 2013-11-20 | 2016-02-16 | 拜耳製藥公司 | 噻吩并嘧啶 |
| CA2940897A1 (en) * | 2014-02-27 | 2015-09-03 | Epirus Biopharmaceuticals, Inc. | Heterocyclic inhibitors of the sodium channel |
| WO2015181063A1 (en) * | 2014-05-26 | 2015-12-03 | Bayer Pharma Aktiengesellschaft | Substituted tetrahydropyridothienopyrimidines |
| WO2016040330A1 (en) | 2014-09-09 | 2016-03-17 | The Regents Of The University Of Michigan | Thienopyrimidine and thienopyridine compounds and methods of use thereof |
| AR104020A1 (es) | 2015-06-04 | 2017-06-21 | Kura Oncology Inc | Métodos y composiciones para inhibir la interacción de menina con proteínas mill |
| HK1246593A1 (zh) | 2015-06-04 | 2018-09-14 | Kura Oncology, Inc. | 用於抑制menin蛋白与mll蛋白的相互作用的方法及组合物 |
| RS64261B1 (sr) | 2016-03-16 | 2023-07-31 | Kura Oncology Inc | Supstituisani derivati tieno[2,3-d]pirimidina kao inhibitori menin-mll i načini upotrebe |
| AU2017235462B2 (en) | 2016-03-16 | 2021-07-01 | Kura Oncology, Inc. | Bridged bicyclic inhibitors of menin-MLL and methods of use |
| EP3601249A4 (en) | 2017-03-24 | 2020-12-16 | Kura Oncology, Inc. | METHODS OF TREATMENT OF MALIGNANT HEMOPATHIES AND EWING'S SARCOMA |
| CN107158003B (zh) * | 2017-05-19 | 2020-10-30 | 中山大学 | 4n杂环化合物的衍生物在制备用于治疗自身免疫疾病的药物中的应用 |
| US11542248B2 (en) | 2017-06-08 | 2023-01-03 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with MLL proteins |
| US11649251B2 (en) | 2017-09-20 | 2023-05-16 | Kura Oncology, Inc. | Substituted inhibitors of menin-MLL and methods of use |
| AR125044A1 (es) | 2021-03-09 | 2023-05-31 | Fmc Corp | Amidas bicíclicas para controlar plagas de invertebrados |
| KR20250048344A (ko) | 2022-08-18 | 2025-04-08 | 미토디큐어 게엠베하 | 만성 피로, 탈진 및/또는 운동 불내성과 연관된 질환의 치료 및 예방을 위한 포스포디에스테라제-7 억제 활성을 갖는 치료제의 용도 |
| WO2023097341A2 (en) | 2023-03-20 | 2023-06-01 | Fmc Corporation | Bicyclic amides and esters for controlling invertebrate pests |
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| US4879309A (en) * | 1988-09-27 | 1989-11-07 | Schering Corporation | Mercapto-acylamino acids as antihypertensives |
| CA2039411A1 (en) * | 1990-03-30 | 1991-10-01 | Ronnie Gerald Edie | Thienopyrimidine derivatives |
| PT100905A (pt) * | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
| US5356903A (en) * | 1993-04-22 | 1994-10-18 | Sterling Winthrop Inc. | 1-cyclopropyl-4-pyridyl-quinolines |
| JPH07126255A (ja) * | 1993-09-10 | 1995-05-16 | Eisai Co Ltd | キナゾリン系化合物 |
| US6316439B1 (en) * | 1993-10-15 | 2001-11-13 | Aventis Pharamaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
| DE19632423A1 (de) * | 1996-08-12 | 1998-02-19 | Merck Patent Gmbh | Thienopyrimidine |
| DE19644228A1 (de) * | 1996-10-24 | 1998-04-30 | Merck Patent Gmbh | Thienopyrimidine |
| JP3919272B2 (ja) * | 1996-12-18 | 2007-05-23 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | キナゾリン系化合物 |
| RU2116309C1 (ru) * | 1997-02-13 | 1998-07-27 | Институт медицинской паразитологии и тропической медицины им.Е.И.Марциновского | 4-[(бензо-2,1,3-тиадиазолил-4)амино]-5,6,7,8-тетрагидробензотиено [2,3-d]пиримидин, обладающий противогельминтной активностью при ларвальном альвеолярном эхинококкозе |
| DE19752952A1 (de) * | 1997-11-28 | 1999-06-02 | Merck Patent Gmbh | Thienopyrimidine |
| AU2641199A (en) * | 1998-02-27 | 1999-09-15 | Kyowa Hakko Kogyo Co. Ltd. | Remedies for erectile dysfunction |
| WO1999046267A1 (en) | 1998-03-12 | 1999-09-16 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases (ptpases) |
| WO1999051582A1 (en) * | 1998-03-31 | 1999-10-14 | Kyowa Hakko Kogyo Co., Ltd. | Nitrogenous heterocyclic compounds |
| CZ27399A3 (cs) * | 1999-01-26 | 2000-08-16 | Ústav Experimentální Botaniky Av Čr | Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv |
| EP1167367A4 (en) | 1999-03-30 | 2002-04-24 | Nippon Soda Co | THIENOPYRIMIDINE COMPOUNDS AND SALTS THEREOF, AND PROCESS FOR THE PREPARATION THEREOF |
| AU7738000A (en) * | 1999-09-30 | 2001-04-30 | Neurogen Corporation | Certain alkylene diamine-substituted heterocycles |
| DE10042997A1 (de) * | 2000-09-01 | 2002-03-14 | Merck Patent Gmbh | Thienopyrimidine |
| DE10064994A1 (de) * | 2000-12-23 | 2002-07-04 | Merck Patent Gmbh | Sulfamidothienopyrimidine |
-
2002
- 2002-04-29 WO PCT/US2002/013630 patent/WO2002088138A1/en not_active Ceased
- 2002-04-29 US US10/136,575 patent/US6849638B2/en not_active Expired - Fee Related
- 2002-04-29 MX MXPA03009925A patent/MXPA03009925A/es active IP Right Grant
- 2002-04-29 JP JP2002585436A patent/JP2005503345A/ja not_active Withdrawn
- 2002-04-29 CN CNB028133102A patent/CN100343258C/zh not_active Expired - Fee Related
- 2002-04-29 EP EP02734103A patent/EP1401840A4/en not_active Withdrawn
- 2002-04-29 CN CNA2007101410179A patent/CN101100472A/zh active Pending
-
2010
- 2010-02-15 JP JP2010030397A patent/JP2010155847A/ja active Pending
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