CN101100472A - 4-氨基-5,6-取代的噻吩并[2,3-d]嘧啶化合物及其应用 - Google Patents

4-氨基-5,6-取代的噻吩并[2,3-d]嘧啶化合物及其应用 Download PDF

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Publication number
CN101100472A
CN101100472A CNA2007101410179A CN200710141017A CN101100472A CN 101100472 A CN101100472 A CN 101100472A CN A2007101410179 A CNA2007101410179 A CN A2007101410179A CN 200710141017 A CN200710141017 A CN 200710141017A CN 101100472 A CN101100472 A CN 101100472A
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carbon atom
halogen
atom
alkyl
perhalogeno
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Chinese (zh)
Inventor
A·施托勒
D·E·比雷尔
陈元伟
范冬平
B·哈特
M·K·莫纳汉
W·J·斯科特
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Bayer Corp
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Miles Inc
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
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  • Biomedical Technology (AREA)
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  • Otolaryngology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CNA2007101410179A 2001-04-30 2002-04-29 4-氨基-5,6-取代的噻吩并[2,3-d]嘧啶化合物及其应用 Pending CN101100472A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28762901P 2001-04-30 2001-04-30
US60/287,629 2001-04-30

Related Parent Applications (1)

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CNB028133102A Division CN100343258C (zh) 2001-04-30 2002-04-29 新的4－氨基－5,6－取代的噻吩并[2,3－d]嘧啶化合物

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CN101100472A true CN101100472A (zh) 2008-01-09

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CNA2007101410179A Pending CN101100472A (zh) 2001-04-30 2002-04-29 4-氨基-5,6-取代的噻吩并[2,3-d]嘧啶化合物及其应用
CNB028133102A Expired - Fee Related CN100343258C (zh) 2001-04-30 2002-04-29 新的4－氨基－5,6－取代的噻吩并[2,3－d]嘧啶化合物

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Country Status (6)

Country Link
US (1) US6849638B2 (enExample)
EP (1) EP1401840A4 (enExample)
JP (2) JP2005503345A (enExample)
CN (2) CN101100472A (enExample)
MX (1) MXPA03009925A (enExample)
WO (1) WO2002088138A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102532159A (zh) * 2010-11-12 2012-07-04 姚雪彪 动点马达蛋白CENP-E小分子抑制剂Syntelin
CN106061980A (zh) * 2013-11-20 2016-10-26 拜耳制药股份公司 作为mknk1和mknk2抑制剂的噻吩并嘧啶
CN107158003A (zh) * 2017-05-19 2017-09-15 中山大学 4n杂环化合物的衍生物在制备用于治疗自身免疫疾病的药物中的应用

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ES2217956B1 (es) * 2003-01-23 2006-04-01 Almirall Prodesfarma, S.A. Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo.
BRPI0408988A (pt) * 2003-03-31 2006-03-28 Predix Pharmaceuticals Holding composto de piperidinilamino-tieno[2,3-d]pirimidina
JP4712702B2 (ja) * 2003-07-24 2011-06-29 バイエル・シエリング・フアーマ・アクチエンゲゼルシヤフト 高増殖性疾患を処置するために有用な置換されたテトラヒドロベンゾチエノピリミジンアミン化合物
EP1799653B1 (en) * 2004-08-20 2013-03-20 Bayer Intellectual Property GmbH Condensed thienopyrimidine derivatives for the treatment of cancer
JP5070059B2 (ja) * 2004-10-27 2012-11-07 バイエル・ファルマ・アクチェンゲゼルシャフト 新規ピリミドチエノインダゾール類
AU2006261082B2 (en) * 2005-06-22 2012-04-19 Boehringer Ingelheim International Gmbh Thienopyrimidines for pharmaceutical compositions
WO2007067946A2 (en) * 2005-12-07 2007-06-14 The Regents Of The University Of California Diagnosis and treatment of chronic lymphocytic leukemia (cll)
CA2651898A1 (en) * 2006-04-07 2007-10-18 Develogen Aktiengesellschaft Thienopyrimidines having mnk1/mnk2 inhibiting activity for pharmaceutical compositions
EP1889847A1 (en) 2006-07-10 2008-02-20 DeveloGen Aktiengesellschaft Pyrrolopyrimidines for pharmaceutical compositions
MX2009010450A (es) 2007-03-27 2009-11-23 Omeros Corp El uso de inhibidores de la fosfodiesterasa 7 para el tratamiento transtornos del movimiento.
US8637528B2 (en) * 2007-03-27 2014-01-28 Omeros Corporation Use of PDE7 inhibitors for the treatment of movement disorders
US7982035B2 (en) 2007-08-27 2011-07-19 Duquesne University Of The Holy Spirit Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof
CA2699349C (en) 2007-09-14 2016-04-19 Bayer Schering Pharma Aktiengesellschaft Substituted tricyclic heterocyclic compounds for use as egfr inhibitors
RU2500681C2 (ru) 2007-10-19 2013-12-10 Берингер Ингельхайм Интернациональ Гмбх Замещенные гетероциклом пиперазинодигидротиенопиримидины
CA2702447A1 (en) * 2007-10-19 2009-04-30 Boehringer Ingelheim International Gmbh New phenyl-substituted piperazino-dihydrothienopyrimidines
EP2215093B1 (de) 2007-10-19 2011-12-14 Boehringer Ingelheim International GmbH Neue piperazino-dihydrothienopyrimidin-derivate
SI2610258T1 (sl) 2007-10-19 2014-12-31 Boehringer Ingelheim International Gmbh Substituirani piperidino-dihidrotienopirimidini
WO2009104026A1 (en) * 2008-02-19 2009-08-27 Vichem Chemie Kutató Kft Tricyclic benzo[4,5]thieno-[2,3-d]pyrimidine-4-yl-amin derivatives, their salts, process for producing the compounds and their pharmaceutical use
BRPI0918971A2 (pt) 2008-08-26 2015-12-01 Boehringer Ingelheim Int tienopirimidinas para composições farmacêuticas
AU2010289321A1 (en) * 2009-09-04 2012-04-05 The Regents Of The University Of Michigan Compositions and methods for treatment of leukemia
MX2012009735A (es) 2010-02-26 2012-09-12 Boehringer Ingelheim Int 4-[cicloalquiloxi (hetero) arilamino] tieno [2,3-d] pirimidinas que tienen actividad inhibitoria de mnk1/mnk2 para composiciones farmaceuticas.
ES2562959T3 (es) 2010-02-26 2016-03-09 Evotec International Gmbh Tienopirimidinas que contienen un grupo alquilo sustituido para composiciones farmacéuticas
UY33241A (es) 2010-02-26 2011-09-30 Boehringer Ingelheim Int ?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?.
CN103119047B (zh) 2010-07-23 2016-06-15 哈佛大学校长及研究员协会 三环类蛋白酶体活性增强化合物
KR102385359B1 (ko) 2010-11-08 2022-04-11 오메로스 코포레이션 Pde7 억제제를 사용한 중독 및 충동-조절 장애의 치료
US9220715B2 (en) 2010-11-08 2015-12-29 Omeros Corporation Treatment of addiction and impulse-control disorders using PDE7 inhibitors
EP3239154A1 (en) * 2011-01-10 2017-11-01 Nimbus Iris, Inc. Irak inhibitors and uses thereof
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