CN101100472A - 4-氨基-5,6-取代的噻吩并[2,3-d]嘧啶化合物及其应用 - Google Patents

4-氨基-5,6-取代的噻吩并[2,3-d]嘧啶化合物及其应用 Download PDF

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Publication number
CN101100472A
CN101100472A CNA2007101410179A CN200710141017A CN101100472A CN 101100472 A CN101100472 A CN 101100472A CN A2007101410179 A CNA2007101410179 A CN A2007101410179A CN 200710141017 A CN200710141017 A CN 200710141017A CN 101100472 A CN101100472 A CN 101100472A
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carbon atom
halogen
atom
alkyl
perhalogeno
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Chinese (zh)
Inventor
A·施托勒
D·E·比雷尔
陈元伟
范冬平
B·哈特
M·K·莫纳汉
W·J·斯科特
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Bayer Corp
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Miles Inc
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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  • Dermatology (AREA)
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  • Hematology (AREA)
  • Endocrinology (AREA)
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  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CNA2007101410179A 2001-04-30 2002-04-29 4-氨基-5,6-取代的噻吩并[2,3-d]嘧啶化合物及其应用 Pending CN101100472A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28762901P 2001-04-30 2001-04-30
US60/287,629 2001-04-30

Related Parent Applications (1)

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CNB028133102A Division CN100343258C (zh) 2001-04-30 2002-04-29 新的4－氨基－5,6－取代的噻吩并[2,3－d]嘧啶化合物

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CN101100472A true CN101100472A (zh) 2008-01-09

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CNA2007101410179A Pending CN101100472A (zh) 2001-04-30 2002-04-29 4-氨基-5,6-取代的噻吩并[2,3-d]嘧啶化合物及其应用
CNB028133102A Expired - Fee Related CN100343258C (zh) 2001-04-30 2002-04-29 新的4－氨基－5,6－取代的噻吩并[2,3－d]嘧啶化合物

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Country Link
US (1) US6849638B2 (enExample)
EP (1) EP1401840A4 (enExample)
JP (2) JP2005503345A (enExample)
CN (2) CN101100472A (enExample)
MX (1) MXPA03009925A (enExample)
WO (1) WO2002088138A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102532159A (zh) * 2010-11-12 2012-07-04 姚雪彪 动点马达蛋白CENP-E小分子抑制剂Syntelin
CN106061980A (zh) * 2013-11-20 2016-10-26 拜耳制药股份公司 作为mknk1和mknk2抑制剂的噻吩并嘧啶
CN107158003A (zh) * 2017-05-19 2017-09-15 中山大学 4n杂环化合物的衍生物在制备用于治疗自身免疫疾病的药物中的应用

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ES2217956B1 (es) * 2003-01-23 2006-04-01 Almirall Prodesfarma, S.A. Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo.
CN1777612A (zh) * 2003-03-31 2006-05-24 普雷迪克医药品控股公司 新的哌啶基氨基－噻吩并[2,3－d]嘧啶化合物
JP4712702B2 (ja) * 2003-07-24 2011-06-29 バイエル・シエリング・フアーマ・アクチエンゲゼルシヤフト 高増殖性疾患を処置するために有用な置換されたテトラヒドロベンゾチエノピリミジンアミン化合物
US8207172B2 (en) * 2004-08-20 2012-06-26 Bayer Intellectual Property Gmbh Pyrimidinothienoindazoles useful for the treatment of hyperproliferative disorders
JP5070059B2 (ja) * 2004-10-27 2012-11-07 バイエル・ファルマ・アクチェンゲゼルシャフト 新規ピリミドチエノインダゾール類
AU2006261082B2 (en) * 2005-06-22 2012-04-19 Boehringer Ingelheim International Gmbh Thienopyrimidines for pharmaceutical compositions
US7846664B2 (en) * 2005-12-07 2010-12-07 The Regents Of The University Of California Diagnosis and treatment of chronic lymphocytic leukemia (CLL)
WO2007115822A1 (en) * 2006-04-07 2007-10-18 Develogen Aktiengesellschaft Thienopyrimidines having mnkl /mnk2 inhibiting activity for pharmaceutical compositions
EP1889847A1 (en) 2006-07-10 2008-02-20 DeveloGen Aktiengesellschaft Pyrrolopyrimidines for pharmaceutical compositions
US8637528B2 (en) 2007-03-27 2014-01-28 Omeros Corporation Use of PDE7 inhibitors for the treatment of movement disorders
NZ580413A (en) 2007-03-27 2012-11-30 Omeros Corp The use of pde7 inhibitors for the treatment of movement disorders
US7982035B2 (en) 2007-08-27 2011-07-19 Duquesne University Of The Holy Spirit Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof
JP5461402B2 (ja) 2007-09-14 2014-04-02 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 置換三環式化合物およびその使用方法
CA2702518A1 (en) 2007-10-19 2009-04-23 Boehringer Ingelheim International Gmbh New piperazino-dihydrothienopyrimidine derivatives
JP2011500621A (ja) * 2007-10-19 2011-01-06 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規フェニル置換ピペラジノ−ジヒドロチエノピリミジン
BRPI0817781A2 (pt) 2007-10-19 2019-09-24 Boehringer Ingelheim Int piperazino-diidroteinopirimidinas substituídas com heterociclo
PT2215092E (pt) 2007-10-19 2012-04-10 Boehringer Ingelheim Int Piperidino-di-hidrotienopirimidinas substituídas
WO2009104026A1 (en) * 2008-02-19 2009-08-27 Vichem Chemie Kutató Kft Tricyclic benzo[4,5]thieno-[2,3-d]pyrimidine-4-yl-amin derivatives, their salts, process for producing the compounds and their pharmaceutical use
CN102186857A (zh) 2008-08-26 2011-09-14 贝林格尔·英格海姆国际有限公司 用于药物组合物的噻吩并嘧啶
WO2011029054A1 (en) 2009-09-04 2011-03-10 The Regents Of The University Of Michigan Compositions and methods for treatment of leukemia
UY33241A (es) 2010-02-26 2011-09-30 Boehringer Ingelheim Int ?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?.
TW201141483A (en) 2010-02-26 2011-12-01 Boehringer Ingelheim Int Thienopyrimidines containing a substituted alkyl group for pharmaceutical compositions
TW201141872A (en) 2010-02-26 2011-12-01 Boehringer Ingelheim Int Cycloalkyl containing thienopyrimidines for pharmaceutical compositions
EP2595993B1 (en) * 2010-07-23 2018-04-18 President and Fellows of Harvard College Tricyclic proteasome activity enhancing compounds
US9220715B2 (en) 2010-11-08 2015-12-29 Omeros Corporation Treatment of addiction and impulse-control disorders using PDE7 inhibitors
MX2013004943A (es) 2010-11-08 2013-09-02 Omeros Corp Tratamiento de trastornos de adicion y control de impulsos usando inhibidores de pde7.
US8703941B2 (en) * 2011-01-10 2014-04-22 Nimbus Iris, Inc. IRAK inhibitors and uses thereof
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