CN103261205A - 动点马达蛋白cenp-e小分子抑制剂syntelin及其应用 - Google Patents
动点马达蛋白cenp-e小分子抑制剂syntelin及其应用 Download PDFInfo
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- A—HUMAN NECESSITIES
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
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- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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Abstract
本发明公开了一种动点马达蛋白CENP-E小分子抑制剂Syntelin及其应用。本发明提供的与CENP-E马达驱动域结合的有机小分子化合物，它与CENP-E结合后可抑制CENP-E马达在微管上的行走，但不影响其与微管的相互作用，当该化合物加入细胞培养基中能够进入细胞抑制CENP-E的功能，导致部分染色体排列错误并长时间维系纺锤体检验点的活性。
Description
PCT国内申请，说明书已公开。
Claims (1)
- PCT国内申请，权利要求书已公开。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201180048379.8A CN103261205B (zh) | 2010-11-12 | 2011-11-11 | 动点马达蛋白cenp-e小分子抑制剂syntelin及其应用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010544018.X | 2010-11-12 | ||
| CN201010544018 | 2010-11-12 | ||
| CN201010544018X | 2010-11-12 | ||
| PCT/CN2011/001897 WO2012062044A1 (zh) | 2010-11-12 | 2011-11-11 | 动点马达蛋白cenp-e小分子抑制剂syntelin及其应用 |
| CN201180048379.8A CN103261205B (zh) | 2010-11-12 | 2011-11-11 | 动点马达蛋白cenp-e小分子抑制剂syntelin及其应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103261205A true CN103261205A (zh) | 2013-08-21 |
| CN103261205B CN103261205B (zh) | 2015-08-19 |
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ID=46050342
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011103567316A Active CN102552274B (zh) | 2010-11-12 | 2011-11-11 | 动点马达蛋白小分子抑制剂在抑制肿瘤细胞增殖中的应用 |
| CN201110356727.XA Active CN102532159B (zh) | 2010-11-12 | 2011-11-11 | 动点马达蛋白CENP-E小分子抑制剂Syntelin |
| CN201180048379.8A Active CN103261205B (zh) | 2010-11-12 | 2011-11-11 | 动点马达蛋白cenp-e小分子抑制剂syntelin及其应用 |
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| CN2011103567316A Active CN102552274B (zh) | 2010-11-12 | 2011-11-11 | 动点马达蛋白小分子抑制剂在抑制肿瘤细胞增殖中的应用 |
| CN201110356727.XA Active CN102532159B (zh) | 2010-11-12 | 2011-11-11 | 动点马达蛋白CENP-E小分子抑制剂Syntelin |
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| Country | Link |
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| CN (3) | CN102552274B (zh) |
| WO (1) | WO2012062044A1 (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2011281015B2 (en) | 2010-07-23 | 2015-09-24 | President And Fellows Of Harvard College | Tricyclic proteasome activity enhancing compounds |
| CA2861464C (en) | 2012-01-25 | 2018-03-06 | Proteostasis Therapeutics, Inc. | Proteasome activity modulating tricyclic compounds |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1192142A (zh) * | 1995-08-03 | 1998-09-02 | 普罗克特和甘保尔公司 | 1h－1,2,4－三唑衍生物用于抑制癌症生长的用途 |
| WO2001007436A2 (en) * | 1999-07-28 | 2001-02-01 | Aventis Pharmaceuticals Inc. | Substituted oxoazaheterocyclyl compounds |
| CN1291892A (zh) * | 1998-01-27 | 2001-04-18 | 阿温蒂斯药物制品公司 | 取代的氧代氮杂杂环基因子Xa抑制剂 |
| CN101100472A (zh) * | 2001-04-30 | 2008-01-09 | 美国拜尔公司 | 4-氨基-5,6-取代的噻吩并[2,3-d]嘧啶化合物及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6710017B2 (en) * | 2000-02-07 | 2004-03-23 | Avecia, Inc. | Compositions and methods for controlling algae in recirculating water systems |
| US7462614B2 (en) * | 2003-04-01 | 2008-12-09 | Smithkline Beecham Corporation | Imidazotriazine compounds |
| CN100391451C (zh) * | 2005-04-08 | 2008-06-04 | 中山大学 | 斑蝥素衍生物在制备抗肿瘤药物中的应用 |
| JP2011507910A (ja) * | 2007-12-21 | 2011-03-10 | ユニバーシティー オブ ロチェスター | 真核生物の寿命を変更するための方法 |
-
2011
- 2011-11-11 WO PCT/CN2011/001897 patent/WO2012062044A1/zh active Application Filing
- 2011-11-11 CN CN2011103567316A patent/CN102552274B/zh active Active
- 2011-11-11 CN CN201110356727.XA patent/CN102532159B/zh active Active
- 2011-11-11 CN CN201180048379.8A patent/CN103261205B/zh active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1192142A (zh) * | 1995-08-03 | 1998-09-02 | 普罗克特和甘保尔公司 | 1h－1,2,4－三唑衍生物用于抑制癌症生长的用途 |
| CN1291892A (zh) * | 1998-01-27 | 2001-04-18 | 阿温蒂斯药物制品公司 | 取代的氧代氮杂杂环基因子Xa抑制剂 |
| WO2001007436A2 (en) * | 1999-07-28 | 2001-02-01 | Aventis Pharmaceuticals Inc. | Substituted oxoazaheterocyclyl compounds |
| CN101100472A (zh) * | 2001-04-30 | 2008-01-09 | 美国拜尔公司 | 4-氨基-5,6-取代的噻吩并[2,3-d]嘧啶化合物及其应用 |
Non-Patent Citations (2)
| Title |
|---|
| CA: "CAS-RN: 438481-33-5", 《STN-REGISTRY数据库》 * |
| CHAMANLAL J. SHISHOO，等: "Design, synthesis and antihistaminic(H1) activity of some condensed 3-aminopyrimidin-4(3H)-ones", 《EUR. J. MED. CHEM.》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012062044A1 (zh) | 2012-05-18 |
| CN102552274B (zh) | 2013-10-23 |
| CN103261205B (zh) | 2015-08-19 |
| CN102552274A (zh) | 2012-07-11 |
| CN102532159A (zh) | 2012-07-04 |
| CN102532159B (zh) | 2015-02-11 |
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