JP2005502611A5 - - Google Patents
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- Publication number
- JP2005502611A5 JP2005502611A5 JP2003508307A JP2003508307A JP2005502611A5 JP 2005502611 A5 JP2005502611 A5 JP 2005502611A5 JP 2003508307 A JP2003508307 A JP 2003508307A JP 2003508307 A JP2003508307 A JP 2003508307A JP 2005502611 A5 JP2005502611 A5 JP 2005502611A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- oil
- antigen
- hcv
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 39
- 241000711549 Hepacivirus C Species 0.000 claims 33
- 239000000427 antigen Substances 0.000 claims 25
- 102000036639 antigens Human genes 0.000 claims 25
- 108091007433 antigens Proteins 0.000 claims 25
- 239000007764 o/w emulsion Substances 0.000 claims 22
- 239000003995 emulsifying agent Substances 0.000 claims 18
- 108091034117 Oligonucleotide Proteins 0.000 claims 16
- 230000028993 immune response Effects 0.000 claims 13
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 13
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 13
- 229920000053 polysorbate 80 Polymers 0.000 claims 13
- 239000004147 Sorbitan trioleate Substances 0.000 claims 11
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims 11
- 235000019337 sorbitan trioleate Nutrition 0.000 claims 11
- 229960000391 sorbitan trioleate Drugs 0.000 claims 11
- 150000001413 amino acids Chemical class 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 229920001214 Polysorbate 60 Polymers 0.000 claims 9
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 7
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 7
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 7
- 229940031439 squalene Drugs 0.000 claims 7
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 7
- JMUHBNWAORSSBD-WKYWBUFDSA-N mifamurtide Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCC)COP(O)(=O)OCCNC(=O)[C@H](C)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O JMUHBNWAORSSBD-WKYWBUFDSA-N 0.000 claims 6
- 229960005225 mifamurtide Drugs 0.000 claims 6
- -1 sorbitan diester Chemical class 0.000 claims 6
- 230000004936 stimulating effect Effects 0.000 claims 6
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims 5
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 5
- 230000003308 immunostimulating effect Effects 0.000 claims 5
- 150000007523 nucleic acids Chemical group 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 230000002708 enhancing effect Effects 0.000 claims 4
- 150000005690 diesters Chemical class 0.000 claims 3
- 150000005691 triesters Chemical class 0.000 claims 3
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30222701P | 2001-06-29 | 2001-06-29 | |
| PCT/US2002/020676 WO2003002065A2 (en) | 2001-06-29 | 2002-06-28 | Hcv e1e2 vaccine compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005188972A Division JP2005298523A (ja) | 2001-06-29 | 2005-06-28 | Ｈｃｖｅ１ｅ２ワクチン組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005502611A JP2005502611A (ja) | 2005-01-27 |
| JP2005502611A5 true JP2005502611A5 (https=) | 2006-01-12 |
| JP4370161B2 JP4370161B2 (ja) | 2009-11-25 |
Family
ID=23166848
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003508307A Expired - Fee Related JP4370161B2 (ja) | 2001-06-29 | 2002-06-28 | Ｈｃｖｅ１ｅ２ワクチン組成物 |
| JP2005188972A Pending JP2005298523A (ja) | 2001-06-29 | 2005-06-28 | Ｈｃｖｅ１ｅ２ワクチン組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005188972A Pending JP2005298523A (ja) | 2001-06-29 | 2005-06-28 | Ｈｃｖｅ１ｅ２ワクチン組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20030138458A1 (https=) |
| EP (1) | EP1572124A4 (https=) |
| JP (2) | JP4370161B2 (https=) |
| CN (2) | CN1931365A (https=) |
| AU (1) | AU2002322358B2 (https=) |
| CA (1) | CA2451739A1 (https=) |
| CZ (1) | CZ20033515A3 (https=) |
| HU (1) | HUP0400346A2 (https=) |
| NZ (1) | NZ530632A (https=) |
| RU (1) | RU2316347C2 (https=) |
| SK (1) | SK15762003A3 (https=) |
| WO (1) | WO2003002065A2 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| CZ20033515A3 (cs) * | 2001-06-29 | 2005-01-12 | Chiron Corporation | Kompozice vakcíny HCV E1E2 |
| CA2388049A1 (en) | 2002-05-30 | 2003-11-30 | Immunotech S.A. | Immunostimulatory oligonucleotides and uses thereof |
| PT2241325E (pt) * | 2002-10-29 | 2012-04-12 | Coley Pharm Gmbh | Utilização de oligonucleótidos cpg no tratamento de infecção com vírus da hepatite c |
| EP1578954A4 (en) | 2002-12-11 | 2010-08-11 | Coley Pharm Group Inc | 5'-CPG NUCLEIC ACIDS AND USE METHOD |
| US20050191358A1 (en) * | 2003-01-14 | 2005-09-01 | Derek O' Hagan | Microparticles with adsorbed polynucleotide-containing species |
| CA2523266A1 (en) * | 2003-04-25 | 2004-11-11 | Chiron Corporation | Compositions comprising cationic microparticles and hcv e1e2 dna and methods of use thereof |
| EP1631264B8 (en) * | 2003-06-02 | 2017-05-24 | GlaxoSmithKline Biologicals SA | Immunogenic compositions based on microparticles comprising adsorbed toxoid and a polysaccharide-containing antigen |
| NZ551319A (en) * | 2004-05-17 | 2010-07-30 | Novartis Vaccines & Diagnostic | Truncated Hepatitis C virus NS5 domain and fusion proteins comprising same |
| FR2878746B1 (fr) | 2004-12-02 | 2007-02-23 | Vetoquinol Sa Sa | Nouvelle composition pharmaceutique utilisable dans le domaine des vaccins |
| CA2646539A1 (en) | 2006-03-23 | 2007-09-27 | Novartis Ag | Imidazoquinoxaline compounds as immunomodulators |
| AU2015234338C1 (en) * | 2006-07-28 | 2017-07-20 | The Trustees Of The University Of Pennsylvania | Improved vaccines and methods for using the same |
| US8324369B2 (en) * | 2007-11-30 | 2012-12-04 | Baylor College Of Medicine | Dendritic cell vaccine compositions and uses of same |
| RU2572826C2 (ru) | 2008-12-02 | 2016-01-20 | Чиралджен, Лтд. | Способ синтеза модифицированных по атому фосфора нуклеиновых кислот |
| CA2767253A1 (en) | 2009-07-06 | 2011-01-13 | Ontorii, Inc. | Novel nucleic acid prodrugs and methods of use thereof |
| WO2011040535A1 (ja) | 2009-09-30 | 2011-04-07 | 東レ株式会社 | Ｃ型肝炎ウイルスワクチン組成物 |
| JP5868324B2 (ja) | 2010-09-24 | 2016-02-24 | 株式会社Wave Life Sciences Japan | 不斉補助基 |
| AU2012284265B2 (en) | 2011-07-19 | 2017-08-17 | Wave Life Sciences Ltd. | Methods for the synthesis of functionalized nucleic acids |
| JP6453212B2 (ja) | 2012-07-13 | 2019-01-16 | ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | キラル制御 |
| CN104684923B (zh) | 2012-07-13 | 2018-09-28 | 株式会社新日本科学 | 手性核酸佐剂 |
| SG11201500239VA (en) | 2012-07-13 | 2015-03-30 | Wave Life Sciences Japan | Asymmetric auxiliary group |
| JP2016520077A (ja) * | 2013-05-15 | 2016-07-11 | ザ ガバナーズ オブ ザ ユニバーシティ オブ アルバータ | Ｅ１ｅ２ｈｃｖワクチン及び使用方法 |
| JPWO2015108046A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
| WO2015108047A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| WO2015108048A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| ES2917473T3 (es) | 2014-01-16 | 2022-07-08 | Wave Life Sciences Ltd | Diseño quiral |
| AU2017341735B2 (en) | 2016-10-11 | 2022-01-13 | Helmholtz Center for Infection Research | Hepatitis C virus immunogenic compositions comprising as an adjuvant a cyclic dinucleotide or an archaeosome and methods of use thereof |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU212924B (en) * | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
| US6274148B1 (en) * | 1990-11-08 | 2001-08-14 | Chiron Corporation | Hepatitis C virus asialoglycoproteins |
| WO1993006126A1 (en) * | 1991-09-13 | 1993-04-01 | Chiron Corporation | Immunoreactive hepatitis c virus polypeptide compositions |
| ATE509102T1 (de) * | 1994-07-15 | 2011-05-15 | Univ Iowa Res Found | Immunomodulatorische oligonukleotide |
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| AU3241095A (en) * | 1994-07-29 | 1996-03-04 | Chiron Corporation | Novel hepatitis c e1 and e2 truncated polypeptides and methods of obtaining the same |
| BR9506059A (pt) * | 1994-07-29 | 1997-10-28 | Innogenetics Nv | Proteinas envelopes purificadas de virus c para uso de diagnóstico e terapêutico |
| GB9703406D0 (en) * | 1997-02-19 | 1997-04-09 | Chiron Spa | Expression of heterologous proteins |
| WO1998037919A1 (en) * | 1997-02-28 | 1998-09-03 | University Of Iowa Research Foundation | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS |
| US6406705B1 (en) * | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| GB9712347D0 (en) | 1997-06-14 | 1997-08-13 | Smithkline Beecham Biolog | Vaccine |
| ES2298316T3 (es) | 1997-09-05 | 2008-05-16 | Glaxosmithkline Biologicals S.A. | Emulsiones de aceite en agua que contienen saponinas. |
| ES2175668T3 (es) * | 1997-12-16 | 2002-11-16 | Chiron Corp | Uso de microparticulas combinadas con emulsiones de aceite en agua submicronicas. |
| ATE356630T1 (de) * | 1998-04-03 | 2007-04-15 | Univ Iowa Res Found | Verfahren und produkte zur stimulierung des immunsystems mittels immunotherapeutischer oligonukleotide und zytokine |
| IL138000A0 (en) | 1998-04-09 | 2001-10-31 | Smithkline Beecham Biolog | Adjuvant compositions |
| DE69935606T9 (de) | 1998-10-16 | 2021-03-11 | Glaxosmithkline Biologicals S.A. | Adjuvanzsysteme und impfstoffe |
| DE60014076T2 (de) | 1999-04-19 | 2005-10-13 | Glaxosmithkline Biologicals S.A. | Adjuvans-zusammensetzung, enthaltend saponin und ein immunstimulatorisches oligonukleotid |
| SK287400B6 (sk) * | 1999-09-25 | 2010-08-09 | University Of Iowa Research Foundation | Prostriedok s obsahom imunostimulačnej nukleovej kyseliny a jeho použitie na stimuláciu imunitnej reakcie |
| DE60043708D1 (de) * | 1999-10-13 | 2010-03-04 | Novartis Vaccines & Diagnostic | Verfahren zur erhaltung zellimmuneantworten gegen proteinen |
| EP1239876B1 (en) * | 1999-11-19 | 2008-07-30 | Csl Limited | Hcv vaccine compositions |
| JP2004500366A (ja) * | 1999-12-01 | 2004-01-08 | カイロン コーポレイション | Ｃ型肝炎ウイルス（ｈｃｖ）について特異的な抗体を誘発すること |
| ATE350015T1 (de) * | 2000-09-28 | 2007-01-15 | Novartis Vaccines & Diagnostic | Mikropartikelzusammensetzungen und verfahren zu ihrer herstellung |
| CZ20033515A3 (cs) * | 2001-06-29 | 2005-01-12 | Chiron Corporation | Kompozice vakcíny HCV E1E2 |
| AU2003299994A1 (en) * | 2002-12-27 | 2004-07-29 | Chiron Corporation | Immunogenic compositions containing phospholpid |
-
2002
- 2002-06-28 CZ CZ20033515A patent/CZ20033515A3/cs unknown
- 2002-06-28 HU HU0400346A patent/HUP0400346A2/hu unknown
- 2002-06-28 CN CNA2006101395992A patent/CN1931365A/zh active Pending
- 2002-06-28 NZ NZ530632A patent/NZ530632A/en not_active IP Right Cessation
- 2002-06-28 SK SK1576-2003A patent/SK15762003A3/sk unknown
- 2002-06-28 JP JP2003508307A patent/JP4370161B2/ja not_active Expired - Fee Related
- 2002-06-28 AU AU2002322358A patent/AU2002322358B2/en not_active Ceased
- 2002-06-28 CN CNA028128192A patent/CN1636015A/zh active Pending
- 2002-06-28 CA CA002451739A patent/CA2451739A1/en not_active Abandoned
- 2002-06-28 RU RU2004102520/13A patent/RU2316347C2/ru not_active IP Right Cessation
- 2002-06-28 WO PCT/US2002/020676 patent/WO2003002065A2/en not_active Ceased
- 2002-06-28 EP EP02756345A patent/EP1572124A4/en not_active Withdrawn
- 2002-06-28 US US10/187,257 patent/US20030138458A1/en not_active Abandoned
-
2005
- 2005-06-16 US US11/154,324 patent/US20050255124A1/en not_active Abandoned
- 2005-06-28 JP JP2005188972A patent/JP2005298523A/ja active Pending
-
2009
- 2009-05-12 US US12/454,074 patent/US20090258033A1/en not_active Abandoned
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