JP2005502357A - 細胞培養物中のウイルス増殖 - Google Patents

細胞培養物中のウイルス増殖 Download PDF

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Publication number
JP2005502357A
JP2005502357A JP2003527090A JP2003527090A JP2005502357A JP 2005502357 A JP2005502357 A JP 2005502357A JP 2003527090 A JP2003527090 A JP 2003527090A JP 2003527090 A JP2003527090 A JP 2003527090A JP 2005502357 A JP2005502357 A JP 2005502357A
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virus
cells
medium
culture
cell
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Japanese (ja)
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JP2005502357A5 (enrdf_load_stackoverflow
Inventor
ユルゲン フォアロープ，
クリスチャン フレッヒ，
ホルガー リュッベン，
イェンスーペーター グレーゲルゼン，
Original Assignee
カイロン ベーリング ゲーエムベーハー アンド カンパニー
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Publication of JP2005502357A publication Critical patent/JP2005502357A/ja
Publication of JP2005502357A5 publication Critical patent/JP2005502357A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12051—Methods of production or purification of viral material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2003527090A 2001-09-12 2002-09-11 細胞培養物中のウイルス増殖 Pending JP2005502357A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10144903A DE10144903A1 (de) 2001-09-12 2001-09-12 Vermehrung von Viren in Zellkultur
PCT/EP2002/010207 WO2003023025A1 (de) 2001-09-12 2002-09-11 Vermehrung von viren in zellkultur

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010145663A Division JP2010246559A (ja) 2001-09-12 2010-06-25 細胞培養物中のウイルス増殖

Publications (2)

Publication Number Publication Date
JP2005502357A true JP2005502357A (ja) 2005-01-27
JP2005502357A5 JP2005502357A5 (enrdf_load_stackoverflow) 2006-01-05

Family

ID=7698761

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2003527090A Pending JP2005502357A (ja) 2001-09-12 2002-09-11 細胞培養物中のウイルス増殖
JP2010145663A Pending JP2010246559A (ja) 2001-09-12 2010-06-25 細胞培養物中のウイルス増殖

Family Applications After (1)

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JP2010145663A Pending JP2010246559A (ja) 2001-09-12 2010-06-25 細胞培養物中のウイルス増殖

Country Status (16)

Country Link
US (1) US20050118698A1 (enrdf_load_stackoverflow)
EP (1) EP1427817B1 (enrdf_load_stackoverflow)
JP (2) JP2005502357A (enrdf_load_stackoverflow)
KR (1) KR100968141B1 (enrdf_load_stackoverflow)
AT (1) ATE466932T1 (enrdf_load_stackoverflow)
AU (1) AU2002338666B2 (enrdf_load_stackoverflow)
BR (1) BR0212469A (enrdf_load_stackoverflow)
CA (1) CA2456561A1 (enrdf_load_stackoverflow)
CY (1) CY1110716T1 (enrdf_load_stackoverflow)
DE (2) DE10144903A1 (enrdf_load_stackoverflow)
DK (1) DK1427817T3 (enrdf_load_stackoverflow)
ES (1) ES2345606T3 (enrdf_load_stackoverflow)
NZ (1) NZ532203A (enrdf_load_stackoverflow)
PT (1) PT1427817E (enrdf_load_stackoverflow)
SI (1) SI1427817T1 (enrdf_load_stackoverflow)
WO (1) WO2003023025A1 (enrdf_load_stackoverflow)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010502692A (ja) * 2006-09-11 2010-01-28 ノバルティス アーゲー 卵を使用しないインフルエンザウイルスワクチンの作製
JP2013507952A (ja) * 2009-10-20 2013-03-07 ノバルティス アーゲー ウイルスレスキューのための改善された逆遺伝学
JP2014506795A (ja) * 2011-02-17 2014-03-20 ベーリンガー インゲルハイム フェトメディカ ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｒｒｓｖの工業規模の製造方法

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NZ551640A (en) * 2004-05-20 2010-05-28 Id Biomedical Corp Process for the production of an influenza vaccine
DE602005024827D1 (de) 2004-09-09 2010-12-30 Novartis Vaccines & Diagnostic Verminderung von potentiellen iatrogenen risiken in verbindung mit influenza impfstoffen
US10655108B2 (en) 2005-11-01 2020-05-19 Seqirus UK Limited Cell-derived viral vaccines with low levels of residual cell DNA
EP2368572B1 (en) 2005-11-04 2020-03-04 Seqirus UK Limited Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture
US8697087B2 (en) 2005-11-04 2014-04-15 Novartis Ag Influenza vaccines including combinations of particulate adjuvants and immunopotentiators
WO2007052056A1 (en) 2005-11-04 2007-05-10 Novartis Vaccines And Diagnostics Srl Adjuvanted influenza vaccines including cytokine-inducing agents
DE202006021242U1 (de) 2005-11-04 2014-01-29 Novartis Vaccines And Diagnostics S.R.L. Emulsionen mit freiem wässrigen Phasen Tensid als Adjuvans für Spalt-Grippeimpfstoffe
EP2377552A3 (en) 2005-11-04 2013-05-15 Novartis Vaccines and Diagnostics S.r.l. Influenza vaccines with reduced amount of emulsion adjuvant
EP2004226A1 (en) 2006-03-24 2008-12-24 Novartis Vaccines and Diagnostics GmbH & Co. KG Storage of influenza vaccines without refrigeration
GB0614460D0 (en) 2006-07-20 2006-08-30 Novartis Ag Vaccines
CN103361319A (zh) 2006-09-15 2013-10-23 米迪缪尼有限公司 支持病毒生长到高效价的mdck细胞系和采用该细胞系的生物反应器方法
KR20100045437A (ko) 2007-06-27 2010-05-03 노파르티스 아게 첨가물이 적은 인플루엔자 백신
GB0810305D0 (en) 2008-06-05 2008-07-09 Novartis Ag Influenza vaccination
EP2334328A4 (en) 2008-09-24 2012-08-29 Medimmune Llc METHOD FOR CLEANING VIRUSES
US8202726B2 (en) 2008-09-24 2012-06-19 Medimmune, Llc Methods for cultivating cells, propagating and purifying viruses
JP2012507272A (ja) 2008-11-05 2012-03-29 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 新規な方法
DE102010018462A1 (de) 2009-04-27 2011-04-07 Novartis Ag Impfstoffe zum Schutz gegen Influenza
KR101549296B1 (ko) 2010-04-14 2015-09-01 이엠디 밀리포어 코포레이션 고역가 고순도 바이러스 스톡의 생산 방법 및 이의 사용 방법
EP2566323A2 (en) 2010-05-06 2013-03-13 Novartis AG Organic peroxide compounds for microorganism inactivation
CN103025350A (zh) 2010-05-21 2013-04-03 诺华有限公司 流感病毒的重配方法
CN102939104A (zh) 2010-06-01 2013-02-20 诺华有限公司 用冻干浓缩疫苗抗原
EP2575872B1 (en) 2010-06-01 2020-08-19 Seqirus UK Limited Concentration of influenza vaccine antigens without lyophilization
EP2605792B1 (en) 2010-08-20 2014-12-10 Novartis AG Soluble needle arrays for delivery of influenza vaccines
CA2829774C (en) 2011-03-14 2019-09-24 National Research Council Of Canada Method of viral production in cells
GB201216121D0 (en) 2012-09-10 2012-10-24 Novartis Ag Sample quantification by disc centrifugation
JP5918870B2 (ja) 2012-03-06 2016-05-18 クルセル ホランド ベー ヴェー インフルエンザに対する改善されたワクチン接種
AU2013306080B2 (en) * 2012-08-24 2019-01-31 Global Life Sciences Solutions Usa Llc Virus purification and formulation process
KR101370512B1 (ko) * 2013-06-07 2014-03-06 재단법인 목암생명공학연구소 무단백 배지에서 부유 배양되는 mdck 유래 세포주 및 상기 세포주를 이용하여 바이러스를 증식시키는 방법
BR112017028011A2 (pt) 2015-06-26 2018-08-28 Seqirus Uk Ltd vacinas de gripe correspondentes antigenicamente
US10416171B2 (en) 2015-07-07 2019-09-17 Seqirus UK Limited Influenza potency assays
CN105561317B (zh) * 2015-12-22 2018-03-20 肇庆大华农生物药品有限公司 重组伪狂犬病病毒疫苗耐热冻干保护剂及其制备方法
CN108239619A (zh) * 2016-12-23 2018-07-03 甘肃健顺生物科技有限公司 悬浮mdck细胞相关疫苗生产的二阶培养工艺技术
CN108570454A (zh) * 2017-11-09 2018-09-25 甘肃健顺生物科技有限公司 Mdbk驯化悬浮方法和二阶病毒生产工艺
CN108570444A (zh) * 2017-11-09 2018-09-25 甘肃健顺生物科技有限公司 St细胞驯化悬浮方法和二阶病毒生产工艺
CN108570445A (zh) * 2017-11-09 2018-09-25 甘肃健顺生物科技有限公司 Pk15细胞驯化悬浮方法和二阶病毒生产工艺
KR20220128613A (ko) 2019-11-18 2022-09-21 세퀴러스 피티와이 리미티드 재배열 인플루엔자 바이러스의 제조 방법
KR102444684B1 (ko) * 2020-04-29 2022-09-16 에스케이바이오사이언스(주) 일회용 배양 공정 시스템을 이용한 인플루엔자 바이러스 생산 방법

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KR19990072201A (ko) * 1996-10-18 1999-09-27 무타이 마사히꼬 로타바이러스 항원, 로타바이러스 감염증에 대한백신 및 진단제와 항원 제조방법
GB9915413D0 (en) * 1999-07-01 1999-09-01 Glaxo Group Ltd Propagation method

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010502692A (ja) * 2006-09-11 2010-01-28 ノバルティス アーゲー 卵を使用しないインフルエンザウイルスワクチンの作製
JP2016074747A (ja) * 2006-09-11 2016-05-12 ノバルティス アーゲー 卵を使用しないインフルエンザウイルスワクチンの作製
JP2019011344A (ja) * 2006-09-11 2019-01-24 セキラス ユーケー リミテッドＳｅｑｉｒｕｓ ＵＫ Ｌｉｍｉｔｅｄ 卵を使用しないインフルエンザウイルスワクチンの作製
JP2022034076A (ja) * 2006-09-11 2022-03-02 セキラス ユーケー リミテッド 卵を使用しないインフルエンザウイルスワクチンの作製
JP7260270B2 (ja) 2006-09-11 2023-04-18 セキラス ユーケー リミテッド 卵を使用しないインフルエンザウイルスワクチンの作製
JP2023093728A (ja) * 2006-09-11 2023-07-04 セキラス ユーケー リミテッド 卵を使用しないインフルエンザウイルスワクチンの作製
JP7427648B2 (ja) 2006-09-11 2024-02-05 セキラス ユーケー リミテッド 卵を使用しないインフルエンザウイルスワクチンの作製
JP2013507952A (ja) * 2009-10-20 2013-03-07 ノバルティス アーゲー ウイルスレスキューのための改善された逆遺伝学
JP2014506795A (ja) * 2011-02-17 2014-03-20 ベーリンガー インゲルハイム フェトメディカ ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｒｒｓｖの工業規模の製造方法

Also Published As

Publication number Publication date
BR0212469A (pt) 2004-08-24
ES2345606T3 (es) 2010-09-28
EP1427817B1 (de) 2010-05-05
DE10144903A1 (de) 2003-03-27
KR20050027164A (ko) 2005-03-17
US20050118698A1 (en) 2005-06-02
NZ532203A (en) 2005-04-29
JP2010246559A (ja) 2010-11-04
KR100968141B1 (ko) 2010-07-06
HK1062029A1 (zh) 2004-10-15
CY1110716T1 (el) 2015-06-10
CA2456561A1 (en) 2003-03-20
AU2002338666B2 (en) 2008-11-20
SI1427817T1 (sl) 2010-08-31
DK1427817T3 (da) 2010-08-23
PT1427817E (pt) 2010-08-10
WO2003023025A1 (de) 2003-03-20
ATE466932T1 (de) 2010-05-15
DE50214416D1 (de) 2010-06-17
EP1427817A1 (de) 2004-06-16

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