JP2005501035A5 - - Google Patents
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- JP2005501035A5 JP2005501035A5 JP2003511809A JP2003511809A JP2005501035A5 JP 2005501035 A5 JP2005501035 A5 JP 2005501035A5 JP 2003511809 A JP2003511809 A JP 2003511809A JP 2003511809 A JP2003511809 A JP 2003511809A JP 2005501035 A5 JP2005501035 A5 JP 2005501035A5
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- Prior art keywords
- alkyl
- hydrogen
- pharmaceutical composition
- aralkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 59
- 239000001257 hydrogen Substances 0.000 claims description 59
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 42
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 39
- 150000001875 compounds Chemical class 0.000 claims description 37
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 34
- 150000002431 hydrogen Chemical class 0.000 claims description 19
- 125000001589 carboacyl group Chemical group 0.000 claims description 18
- 125000001424 substituent group Chemical group 0.000 claims description 18
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 15
- 125000003282 alkyl amino group Chemical group 0.000 claims description 15
- 125000003435 aroyl group Chemical group 0.000 claims description 10
- 125000003118 aryl group Chemical group 0.000 claims description 10
- 229910052736 halogen Inorganic materials 0.000 claims description 10
- 150000002367 halogens Chemical class 0.000 claims description 10
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims description 8
- 125000001475 halogen functional group Chemical group 0.000 claims description 8
- 125000001072 heteroaryl group Chemical group 0.000 claims description 8
- -1 hydroxy, amino Chemical group 0.000 claims description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 30
- 208000024891 symptom Diseases 0.000 claims 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 208000027866 inflammatory disease Diseases 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 9
- 239000012453 solvate Substances 0.000 claims 9
- 201000010099 disease Diseases 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 201000001320 Atherosclerosis Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 3
- JHHQMABPKJQTQI-ZEWCDIPDSA-N (Z)-4-[[(1S,2S)-2-[amino(methyl)amino]-2,3-dihydro-1H-inden-1-yl]oxy]-4-oxobut-2-enoic acid Chemical compound C1=CC=C2[C@H](OC(=O)\C=C/C(O)=O)[C@@H](N(N)C)CC2=C1 JHHQMABPKJQTQI-ZEWCDIPDSA-N 0.000 claims 2
- 208000017189 Gastrointestinal inflammatory disease Diseases 0.000 claims 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 206010035664 Pneumonia Diseases 0.000 claims 2
- 208000017442 Retinal disease Diseases 0.000 claims 2
- 206010038923 Retinopathy Diseases 0.000 claims 2
- 206010047115 Vasculitis Diseases 0.000 claims 2
- 230000005856 abnormality Effects 0.000 claims 2
- 210000001789 adipocyte Anatomy 0.000 claims 2
- 150000001414 amino alcohols Chemical class 0.000 claims 2
- 230000023852 carbohydrate metabolic process Effects 0.000 claims 2
- 235000021256 carbohydrate metabolism Nutrition 0.000 claims 2
- 230000003915 cell function Effects 0.000 claims 2
- 210000002808 connective tissue Anatomy 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 230000006870 function Effects 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 201000001119 neuropathy Diseases 0.000 claims 2
- 230000007823 neuropathy Effects 0.000 claims 2
- 230000002093 peripheral effect Effects 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- 201000006292 polyarteritis nodosa Diseases 0.000 claims 2
- 208000005987 polymyositis Diseases 0.000 claims 2
- 210000000329 smooth muscle myocyte Anatomy 0.000 claims 2
- 208000003265 stomatitis Diseases 0.000 claims 2
- 208000019553 vascular disease Diseases 0.000 claims 2
- RKQMIKZYIWURLN-BZALSJTCSA-N (1r,2r)-2-[amino(methyl)amino]-2,3-dihydro-1h-inden-1-ol;(e)-but-2-enedioic acid Chemical compound OC(=O)\C=C\C(O)=O.C1=CC=C2[C@@H](O)[C@H](N(N)C)CC2=C1 RKQMIKZYIWURLN-BZALSJTCSA-N 0.000 claims 1
- UAQZOFLSGATPKL-DHTOPLTISA-N (1r,2r)-2-[amino(methyl)amino]-2,3-dihydro-1h-inden-1-ol;butanedioic acid Chemical compound OC(=O)CCC(O)=O.C1=CC=C2[C@@H](O)[C@H](N(N)C)CC2=C1 UAQZOFLSGATPKL-DHTOPLTISA-N 0.000 claims 1
- RKQMIKZYIWURLN-UOVKAEDESA-N (1s,2s)-2-[amino(methyl)amino]-2,3-dihydro-1h-inden-1-ol;(e)-but-2-enedioic acid Chemical compound OC(=O)\C=C\C(O)=O.C1=CC=C2[C@H](O)[C@@H](N(N)C)CC2=C1 RKQMIKZYIWURLN-UOVKAEDESA-N 0.000 claims 1
- UAQZOFLSGATPKL-IYPAPVHQSA-N (1s,2s)-2-[amino(methyl)amino]-2,3-dihydro-1h-inden-1-ol;butanedioic acid Chemical compound OC(=O)CCC(O)=O.C1=CC=C2[C@H](O)[C@@H](N(N)C)CC2=C1 UAQZOFLSGATPKL-IYPAPVHQSA-N 0.000 claims 1
- JHHQMABPKJQTQI-LOYNQKGGSA-N (Z)-4-[[(1R,2R)-2-[amino(methyl)amino]-2,3-dihydro-1H-inden-1-yl]oxy]-4-oxobut-2-enoic acid Chemical compound C1=CC=C2[C@@H](OC(=O)\C=C/C(O)=O)[C@H](N(N)C)CC2=C1 JHHQMABPKJQTQI-LOYNQKGGSA-N 0.000 claims 1
- QMEQBOSUJUOXMX-UHFFFAOYSA-N 2h-oxadiazine Chemical compound N1OC=CC=N1 QMEQBOSUJUOXMX-UHFFFAOYSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 102000016893 Amine Oxidase (Copper-Containing) Human genes 0.000 claims 1
- 108010028700 Amine Oxidase (Copper-Containing) Proteins 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 208000031104 Arterial Occlusive disease Diseases 0.000 claims 1
- 206010061666 Autonomic neuropathy Diseases 0.000 claims 1
- 208000027496 Behcet disease Diseases 0.000 claims 1
- 208000009137 Behcet syndrome Diseases 0.000 claims 1
- 208000025985 Central nervous system inflammatory disease Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010012442 Dermatitis contact Diseases 0.000 claims 1
- 208000006926 Discoid Lupus Erythematosus Diseases 0.000 claims 1
- 206010014954 Eosinophilic fasciitis Diseases 0.000 claims 1
- 206010015150 Erythema Diseases 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 208000003790 Foot Ulcer Diseases 0.000 claims 1
- 208000032382 Ischaemic stroke Diseases 0.000 claims 1
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
- 208000003250 Mixed connective tissue disease Diseases 0.000 claims 1
- 206010029164 Nephrotic syndrome Diseases 0.000 claims 1
- FRXWUNIBLAKANP-NNUSTRKZSA-N O[C@@H]([C@H](O)C(O)=O)C(O)=O.CN(N)[C@@H]1Cc2ccccc2[C@H]1O Chemical compound O[C@@H]([C@H](O)C(O)=O)C(O)=O.CN(N)[C@@H]1Cc2ccccc2[C@H]1O FRXWUNIBLAKANP-NNUSTRKZSA-N 0.000 claims 1
- FRXWUNIBLAKANP-AZOAGKATSA-N O[C@@H]([C@H](O)C(O)=O)C(O)=O.CN(N)[C@H]1Cc2ccccc2[C@@H]1O Chemical compound O[C@@H]([C@H](O)C(O)=O)C(O)=O.CN(N)[C@H]1Cc2ccccc2[C@@H]1O FRXWUNIBLAKANP-AZOAGKATSA-N 0.000 claims 1
- FRXWUNIBLAKANP-SVSJBQMCSA-N O[C@H]([C@@H](O)C(O)=O)C(O)=O.CN(N)[C@@H]1Cc2ccccc2[C@H]1O Chemical compound O[C@H]([C@@H](O)C(O)=O)C(O)=O.CN(N)[C@@H]1Cc2ccccc2[C@H]1O FRXWUNIBLAKANP-SVSJBQMCSA-N 0.000 claims 1
- FRXWUNIBLAKANP-IHCRGVPVSA-N O[C@H]([C@@H](O)C(O)=O)C(O)=O.CN(N)[C@H]1Cc2ccccc2[C@@H]1O Chemical compound O[C@H]([C@@H](O)C(O)=O)C(O)=O.CN(N)[C@H]1Cc2ccccc2[C@@H]1O FRXWUNIBLAKANP-IHCRGVPVSA-N 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 102000004316 Oxidoreductases Human genes 0.000 claims 1
- 108090000854 Oxidoreductases Proteins 0.000 claims 1
- 206010065159 Polychondritis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 208000012322 Raynaud phenomenon Diseases 0.000 claims 1
- 208000033464 Reiter syndrome Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 claims 1
- 208000025747 Rheumatic disease Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
- 206010042953 Systemic sclerosis Diseases 0.000 claims 1
- 206010043540 Thromboangiitis obliterans Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 208000024780 Urticaria Diseases 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 208000021328 arterial occlusion Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 150000001721 carbon Chemical class 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 208000019069 chronic childhood arthritis Diseases 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 208000010247 contact dermatitis Diseases 0.000 claims 1
- 230000002920 convulsive effect Effects 0.000 claims 1
- 208000004921 cutaneous lupus erythematosus Diseases 0.000 claims 1
- 201000001981 dermatomyositis Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 231100000321 erythema Toxicity 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 201000011486 lichen planus Diseases 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000002200 mouth mucosa Anatomy 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000031225 myocardial ischemia Diseases 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 208000002574 reactive arthritis Diseases 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 201000004193 respiratory failure Diseases 0.000 claims 1
- 230000000552 rheumatic effect Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 230000001732 thrombotic effect Effects 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- 201000008757 transient arthritis Diseases 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 2
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000006201 3-phenylpropyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000006283 4-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])* 0.000 description 1
- 0 CC(C(*)([C@@]1(*)**)N(*)*)(c2c1c(*)c(*)c(*)c2*)O* Chemical compound CC(C(*)([C@@]1(*)**)N(*)*)(c2c1c(*)c(*)c(*)c2*)O* 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 125000002950 monocyclic group Chemical group 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/902,789 US6982286B2 (en) | 2001-07-12 | 2001-07-12 | Carbocyclic hydrazino inhibitors of copper-containing amine oxidases |
| PCT/FI2002/000630 WO2003006003A1 (en) | 2001-07-12 | 2002-07-11 | Carbocyclic hydrazino inhibitors of copper-containing amine oxidases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005501035A JP2005501035A (ja) | 2005-01-13 |
| JP2005501035A5 true JP2005501035A5 (enExample) | 2009-05-14 |
| JP4377221B2 JP4377221B2 (ja) | 2009-12-02 |
Family
ID=25416395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003511809A Expired - Fee Related JP4377221B2 (ja) | 2001-07-12 | 2002-07-11 | 銅含有アミン・オキシダーゼの炭素環ヒドラジノ阻害剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6982286B2 (enExample) |
| EP (1) | EP1414426B1 (enExample) |
| JP (1) | JP4377221B2 (enExample) |
| KR (1) | KR20040017289A (enExample) |
| CN (1) | CN1520290A (enExample) |
| AT (1) | ATE318589T1 (enExample) |
| CA (1) | CA2451569A1 (enExample) |
| DE (1) | DE60209504T2 (enExample) |
| ES (1) | ES2259379T3 (enExample) |
| HU (1) | HUP0401097A3 (enExample) |
| IL (1) | IL159205A0 (enExample) |
| NO (1) | NO20035139D0 (enExample) |
| RU (1) | RU2004103869A (enExample) |
| WO (1) | WO2003006003A1 (enExample) |
| ZA (1) | ZA200309112B (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6982286B2 (en) * | 2001-07-12 | 2006-01-03 | Biotie Therapies Corp. | Carbocyclic hydrazino inhibitors of copper-containing amine oxidases |
| FI20022007A0 (fi) * | 2002-11-08 | 2002-11-08 | Juvantia Pharma Ltd Oy | Oromukosaalinen valmiste ja menetelmä sen valmistamiseksi |
| AR042941A1 (es) * | 2003-01-27 | 2005-07-06 | Fujisawa Pharmaceutical Co | Derivados de tiazol, su preparacion, composiciones farmaceuticas que los contienen y su uso en la fabricacion de medicamentos inhibidores de la proteina-1 de adhesion vascular (vap-1) |
| CN1794988B (zh) * | 2003-03-31 | 2010-07-28 | 株式会社·R-技术上野 | 用于治疗血管渗透性过高疾病的组合物 |
| JP2007509605A (ja) * | 2003-05-26 | 2007-04-19 | バイオティ セラピーズ コーポレイション | 結晶性タンパク質ｖａｐ−１その用途 |
| FI20031927A0 (fi) * | 2003-12-31 | 2003-12-31 | Faron Pharmaceuticals Oy | Terapeuttisesti vaikuttavia aineita ja niiden käyttö |
| US8119651B2 (en) * | 2004-01-30 | 2012-02-21 | Biotie Therapies Corp. | Compositions useful especially for treatment or prevention of metabolic syndrome |
| FI20040136A0 (fi) * | 2004-01-30 | 2004-01-30 | Faron Pharmaceuticals Oy | Erityisesti diabeetikoille soveltuvia koostumuksia |
| JP2007519688A (ja) * | 2004-01-30 | 2007-07-19 | ファロン ファーマシューティカルズ オサケ ユキチュア | メタボリックシンドロームの治療または予防に特に有効な組成物 |
| JP4140630B2 (ja) * | 2005-11-10 | 2008-08-27 | Ｔｄｋ株式会社 | 磁気ヘッドアセンブリ及び磁気ヘッドアセンブリの製造方法 |
| US8372399B2 (en) | 2006-08-31 | 2013-02-12 | Cardiac Pacemakers, Inc. | Bispecific antibodies and agents to enhance stem cell homing |
| US8636995B2 (en) * | 2006-08-31 | 2014-01-28 | Cardiac Pacemakers, Inc. | Methods and devices to regulate stem cell homing |
| US20080058922A1 (en) * | 2006-08-31 | 2008-03-06 | Cardiac Pacemakers, Inc. | Methods and devices employing vap-1 inhibitors |
| US20080207728A1 (en) * | 2006-12-15 | 2008-08-28 | Lars Wortmann | Bicyclic acyltryptophanols |
| US20090170770A1 (en) * | 2007-11-06 | 2009-07-02 | Ali Hafezi-Moghadam | Methods and compositions for treating conditions associated with angiogenesis using a vascular adhesion protein-1 (vap 1) inhibitor |
| US8906642B2 (en) | 2008-09-03 | 2014-12-09 | Universitat Autonoma De Barcelona | Methods and compositions for the treatment and diagnosis of haemorrhagic conversion |
| WO2010033045A1 (en) * | 2008-09-16 | 2010-03-25 | Igor Anatolievich Pomytkin | Compositions and methods for prevention or treatment of beta amyloid deposition |
| DK2376490T3 (da) | 2008-12-04 | 2013-04-15 | Proximagen Ltd | Imidazopyridinforbindelser |
| UA112154C2 (uk) | 2009-09-08 | 2016-08-10 | Біоті Терапіс Корп. | Застосування повністю людського анти-vap-1-антитіла для лікування фіброзних станів |
| GB201004311D0 (en) | 2010-03-15 | 2010-04-28 | Proximagen Ltd | New enzyme inhibitor compounds |
| FI20115234A0 (fi) | 2011-03-08 | 2011-03-08 | Biotie Therapies Corp | Uusia pyridatsinoni- ja pyridoniyhdisteitä |
| CA2847193A1 (en) | 2011-09-14 | 2013-03-21 | Proximagen Limited | New enzyme inhibitor compounds |
| GB201115853D0 (en) | 2011-09-14 | 2011-10-26 | Proximagen Ltd | New enzyme inhibitor compounds |
| GB201304527D0 (en) | 2013-03-13 | 2013-04-24 | Proximagen Ltd | New compounds |
| GB201304526D0 (en) | 2013-03-13 | 2013-04-24 | Proximagen Ltd | New compounds |
| US20160113893A1 (en) | 2013-06-12 | 2016-04-28 | Proximagen Limited | New therapeutic uses of enzyme inhibitors |
| HUE042625T2 (hu) | 2014-04-15 | 2019-07-29 | Pecsi Tudomanyegyetem | Szemikarbazid-szenzitiv amin-oxidáz gátlók fájdalomcsillapítóként való alkalmazásra traumás neuropátiában és neurogén gyulladásban |
| WO2015189534A1 (en) | 2014-06-12 | 2015-12-17 | Proximagen Limited | Vap-1 inhibitors for treating muscular dystrophy |
| GB201416446D0 (en) | 2014-09-17 | 2014-10-29 | Proximagen Ltd | New enzyme inhibitor compounds |
| GB201416444D0 (en) | 2014-09-17 | 2014-10-29 | Proximagen Ltd | New compounds |
| GB201521541D0 (en) * | 2015-12-07 | 2016-01-20 | Proximagen Ltd | New therapeutic uses of enzyme inhibitors |
| WO2017098236A1 (en) | 2015-12-07 | 2017-06-15 | Proximagen Limited | Vap-1 inhibitors for treating pain |
| GB201709136D0 (en) * | 2017-06-08 | 2017-07-26 | Proximagen Ltd | New therapeutic uses of enzyme inhibitors |
| CN107935992A (zh) * | 2017-12-29 | 2018-04-20 | 佛山汉方中医医院有限公司 | 一类含金刚烷和卤代吡啶结构化合物及用途 |
| CN108191823A (zh) * | 2017-12-29 | 2018-06-22 | 佛山汉方中医医院有限公司 | 一类烷基取代金刚烷ssao抑制剂、制备方法及其用途 |
| CN108191824A (zh) * | 2017-12-29 | 2018-06-22 | 佛山汉方中医医院有限公司 | 一种甲基金刚烷和二甲胺吡啶结构衍生物、其制备方法及其用途 |
| CN108084154A (zh) * | 2017-12-29 | 2018-05-29 | 佛山汉方中医医院有限公司 | 一种金刚烷和胺基吡啶结构衍生物、其制备方法及用途 |
| CN107935993A (zh) * | 2017-12-29 | 2018-04-20 | 佛山汉方中医医院有限公司 | 甲基金刚烷和硝基吡啶结构衍生物、其制备方法及其用途 |
| CN107935989A (zh) * | 2017-12-29 | 2018-04-20 | 佛山汉方中医医院有限公司 | 金刚烷和腈基吡啶结构化合物、其制备方法及用途 |
| CN109988147A (zh) * | 2017-12-29 | 2019-07-09 | 佛山汉方中医医院有限公司 | 含金刚烷结构的ssao抑制剂、制备方法及其用途 |
| CN108084155A (zh) * | 2017-12-29 | 2018-05-29 | 佛山汉方中医医院有限公司 | 甲基金刚烷和烷氧吡啶结构的ssao抑制剂及其用途 |
| CN108191825A (zh) * | 2017-12-29 | 2018-06-22 | 佛山汉方中医医院有限公司 | 一种甲基金刚烷和硝基吡啶结构衍生物及其用途 |
| CN108033946A (zh) * | 2017-12-29 | 2018-05-15 | 佛山汉方中医医院有限公司 | 一种含金刚烷结构的ssao抑制剂、制备方法及其用途 |
| CN107935990A (zh) * | 2017-12-29 | 2018-04-20 | 佛山汉方中医医院有限公司 | 含金刚烷和烷氧吡啶结构化合物、其制备方法及用途 |
| CN107915719A (zh) * | 2017-12-29 | 2018-04-17 | 佛山汉方中医医院有限公司 | 一类甲基金刚烷和吡啶结构的ssao抑制剂及其用途 |
| CN108033945A (zh) * | 2017-12-29 | 2018-05-15 | 佛山汉方中医医院有限公司 | 一种金刚烷和硝基吡啶结构化合物及用途 |
| CN108129458A (zh) * | 2017-12-29 | 2018-06-08 | 佛山汉方中医医院有限公司 | 一种金刚烷和二甲胺吡啶结构衍生物、其制备方法及用途 |
| SE544131C2 (en) * | 2020-03-16 | 2022-01-04 | Pvac Medical Tech Ltd | Use of substance and pharmaceutical composition thereof, and medical treatments or uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3105849A (en) * | 1960-02-01 | 1963-10-01 | Ciba Geigy Corp | Bicyclic hydrazinium compounds |
| WO1998055439A1 (en) | 1997-06-05 | 1998-12-10 | Venantius Limited | Indane compounds and their pharmaceutical use |
| WO1998055447A1 (en) | 1997-06-05 | 1998-12-10 | Venantius Limited | 3-aminoindane derivatives, process for their preparation and pharmaceutical compositions containing them |
| PL360374A1 (en) | 2000-07-05 | 2004-09-06 | Biotie Therapies Corporation | Inhibitors of copper-containing amine oxidases |
| US6982286B2 (en) * | 2001-07-12 | 2006-01-03 | Biotie Therapies Corp. | Carbocyclic hydrazino inhibitors of copper-containing amine oxidases |
-
2001
- 2001-07-12 US US09/902,789 patent/US6982286B2/en not_active Expired - Fee Related
-
2002
- 2002-07-11 RU RU2004103869/04A patent/RU2004103869A/ru not_active Application Discontinuation
- 2002-07-11 HU HU0401097A patent/HUP0401097A3/hu unknown
- 2002-07-11 KR KR10-2004-7000368A patent/KR20040017289A/ko not_active Withdrawn
- 2002-07-11 JP JP2003511809A patent/JP4377221B2/ja not_active Expired - Fee Related
- 2002-07-11 IL IL15920502A patent/IL159205A0/xx unknown
- 2002-07-11 CA CA002451569A patent/CA2451569A1/en not_active Abandoned
- 2002-07-11 DE DE60209504T patent/DE60209504T2/de not_active Expired - Lifetime
- 2002-07-11 ES ES02751224T patent/ES2259379T3/es not_active Expired - Lifetime
- 2002-07-11 EP EP02751224A patent/EP1414426B1/en not_active Expired - Lifetime
- 2002-07-11 US US10/483,291 patent/US20040236108A1/en not_active Abandoned
- 2002-07-11 CN CNA028128915A patent/CN1520290A/zh active Pending
- 2002-07-11 AT AT02751224T patent/ATE318589T1/de not_active IP Right Cessation
- 2002-07-11 WO PCT/FI2002/000630 patent/WO2003006003A1/en not_active Ceased
-
2003
- 2003-11-19 NO NO20035139A patent/NO20035139D0/no not_active Application Discontinuation
- 2003-11-24 ZA ZA200309112A patent/ZA200309112B/en unknown
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