JP4377221B2 - 銅含有アミン・オキシダーゼの炭素環ヒドラジノ阻害剤 - Google Patents
銅含有アミン・オキシダーゼの炭素環ヒドラジノ阻害剤 Download PDFInfo
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- JP4377221B2 JP4377221B2 JP2003511809A JP2003511809A JP4377221B2 JP 4377221 B2 JP4377221 B2 JP 4377221B2 JP 2003511809 A JP2003511809 A JP 2003511809A JP 2003511809 A JP2003511809 A JP 2003511809A JP 4377221 B2 JP4377221 B2 JP 4377221B2
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/10—Hydrazines
- C07C243/20—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/902,789 US6982286B2 (en) | 2001-07-12 | 2001-07-12 | Carbocyclic hydrazino inhibitors of copper-containing amine oxidases |
| PCT/FI2002/000630 WO2003006003A1 (en) | 2001-07-12 | 2002-07-11 | Carbocyclic hydrazino inhibitors of copper-containing amine oxidases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005501035A JP2005501035A (ja) | 2005-01-13 |
| JP2005501035A5 JP2005501035A5 (enExample) | 2009-05-14 |
| JP4377221B2 true JP4377221B2 (ja) | 2009-12-02 |
Family
ID=25416395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003511809A Expired - Fee Related JP4377221B2 (ja) | 2001-07-12 | 2002-07-11 | 銅含有アミン・オキシダーゼの炭素環ヒドラジノ阻害剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6982286B2 (enExample) |
| EP (1) | EP1414426B1 (enExample) |
| JP (1) | JP4377221B2 (enExample) |
| KR (1) | KR20040017289A (enExample) |
| CN (1) | CN1520290A (enExample) |
| AT (1) | ATE318589T1 (enExample) |
| CA (1) | CA2451569A1 (enExample) |
| DE (1) | DE60209504T2 (enExample) |
| ES (1) | ES2259379T3 (enExample) |
| HU (1) | HUP0401097A3 (enExample) |
| IL (1) | IL159205A0 (enExample) |
| NO (1) | NO20035139D0 (enExample) |
| RU (1) | RU2004103869A (enExample) |
| WO (1) | WO2003006003A1 (enExample) |
| ZA (1) | ZA200309112B (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6982286B2 (en) * | 2001-07-12 | 2006-01-03 | Biotie Therapies Corp. | Carbocyclic hydrazino inhibitors of copper-containing amine oxidases |
| FI20022007A0 (fi) * | 2002-11-08 | 2002-11-08 | Juvantia Pharma Ltd Oy | Oromukosaalinen valmiste ja menetelmä sen valmistamiseksi |
| US7125901B2 (en) * | 2003-01-27 | 2006-10-24 | Astellas Pharma Inc. | Thiazole derivatives |
| EP1608365B1 (en) * | 2003-03-31 | 2013-10-02 | R-Tech Ueno, Ltd. | Method for treating vascular hyperpermeable disease |
| CA2526675A1 (en) | 2003-05-26 | 2004-12-02 | Biotie Therapies Corporation | Crystalline vap-1 and uses thereof |
| FI20031927A0 (fi) * | 2003-12-31 | 2003-12-31 | Faron Pharmaceuticals Oy | Terapeuttisesti vaikuttavia aineita ja niiden käyttö |
| US8119651B2 (en) * | 2004-01-30 | 2012-02-21 | Biotie Therapies Corp. | Compositions useful especially for treatment or prevention of metabolic syndrome |
| ATE460935T1 (de) * | 2004-01-30 | 2010-04-15 | Faron Pharmaceuticals Oy | Besonders nützliche zusammensetzungen für die behandlung oder prävention des metabolischen syndroms |
| FI20040136A0 (fi) * | 2004-01-30 | 2004-01-30 | Faron Pharmaceuticals Oy | Erityisesti diabeetikoille soveltuvia koostumuksia |
| JP4140630B2 (ja) * | 2005-11-10 | 2008-08-27 | Ｔｄｋ株式会社 | 磁気ヘッドアセンブリ及び磁気ヘッドアセンブリの製造方法 |
| US8372399B2 (en) | 2006-08-31 | 2013-02-12 | Cardiac Pacemakers, Inc. | Bispecific antibodies and agents to enhance stem cell homing |
| US20080058922A1 (en) * | 2006-08-31 | 2008-03-06 | Cardiac Pacemakers, Inc. | Methods and devices employing vap-1 inhibitors |
| US8636995B2 (en) * | 2006-08-31 | 2014-01-28 | Cardiac Pacemakers, Inc. | Methods and devices to regulate stem cell homing |
| US20080207728A1 (en) * | 2006-12-15 | 2008-08-28 | Lars Wortmann | Bicyclic acyltryptophanols |
| WO2009061830A1 (en) * | 2007-11-06 | 2009-05-14 | Massachusetts Eye & Ear Infirmary | Methods and compositions for treating conditions associated with angiogenesis using a vascular adhesion protein-1 (vap-1) inhibitor |
| EP2357252A4 (en) | 2008-09-03 | 2012-05-16 | Univ Barcelona Autonoma | METHOD AND COMPOSITIONS FOR TREATING AND DIAGNOSIS OF A HEMORRHAGIC CONVERSION |
| WO2010033045A1 (en) * | 2008-09-16 | 2010-03-25 | Igor Anatolievich Pomytkin | Compositions and methods for prevention or treatment of beta amyloid deposition |
| ES2403633T3 (es) | 2008-12-04 | 2013-05-20 | Proximagen Limited | Compuestos de imidazopiridina |
| UA112154C2 (uk) | 2009-09-08 | 2016-08-10 | Біоті Терапіс Корп. | Застосування повністю людського анти-vap-1-антитіла для лікування фіброзних станів |
| GB201004311D0 (en) | 2010-03-15 | 2010-04-28 | Proximagen Ltd | New enzyme inhibitor compounds |
| FI20115234A0 (fi) | 2011-03-08 | 2011-03-08 | Biotie Therapies Corp | Uusia pyridatsinoni- ja pyridoniyhdisteitä |
| EA201490451A1 (ru) | 2011-09-14 | 2014-12-30 | Проксимаген Лимитед | Новые соединения - ингибиторы ферментов |
| GB201115853D0 (en) | 2011-09-14 | 2011-10-26 | Proximagen Ltd | New enzyme inhibitor compounds |
| GB201304527D0 (en) | 2013-03-13 | 2013-04-24 | Proximagen Ltd | New compounds |
| GB201304526D0 (en) | 2013-03-13 | 2013-04-24 | Proximagen Ltd | New compounds |
| AU2014279863A1 (en) | 2013-06-12 | 2016-01-28 | Proximagen Limited | New therapeutic uses of enzyme inhibitors |
| WO2015159112A1 (en) | 2014-04-15 | 2015-10-22 | Pécsi Tudományegyetem | Semicarbazide-sensitive amine oxidase inhibitors for use as analgesics in traumatic neuropathy and neurogenic inflammation |
| WO2015189534A1 (en) | 2014-06-12 | 2015-12-17 | Proximagen Limited | Vap-1 inhibitors for treating muscular dystrophy |
| GB201416446D0 (en) | 2014-09-17 | 2014-10-29 | Proximagen Ltd | New enzyme inhibitor compounds |
| GB201416444D0 (en) | 2014-09-17 | 2014-10-29 | Proximagen Ltd | New compounds |
| GB201521541D0 (en) * | 2015-12-07 | 2016-01-20 | Proximagen Ltd | New therapeutic uses of enzyme inhibitors |
| US20180360808A1 (en) | 2015-12-07 | 2018-12-20 | Benevolentai Cambridge Limited | Vap-1 inhibitors for treating pain |
| GB201709136D0 (en) * | 2017-06-08 | 2017-07-26 | Proximagen Ltd | New therapeutic uses of enzyme inhibitors |
| CN108033946A (zh) * | 2017-12-29 | 2018-05-15 | 佛山汉方中医医院有限公司 | 一种含金刚烷结构的ssao抑制剂、制备方法及其用途 |
| CN109988147A (zh) * | 2017-12-29 | 2019-07-09 | 佛山汉方中医医院有限公司 | 含金刚烷结构的ssao抑制剂、制备方法及其用途 |
| CN108129458A (zh) * | 2017-12-29 | 2018-06-08 | 佛山汉方中医医院有限公司 | 一种金刚烷和二甲胺吡啶结构衍生物、其制备方法及用途 |
| CN107935990A (zh) * | 2017-12-29 | 2018-04-20 | 佛山汉方中医医院有限公司 | 含金刚烷和烷氧吡啶结构化合物、其制备方法及用途 |
| CN107915719A (zh) * | 2017-12-29 | 2018-04-17 | 佛山汉方中医医院有限公司 | 一类甲基金刚烷和吡啶结构的ssao抑制剂及其用途 |
| CN108191823A (zh) * | 2017-12-29 | 2018-06-22 | 佛山汉方中医医院有限公司 | 一类烷基取代金刚烷ssao抑制剂、制备方法及其用途 |
| CN108191825A (zh) * | 2017-12-29 | 2018-06-22 | 佛山汉方中医医院有限公司 | 一种甲基金刚烷和硝基吡啶结构衍生物及其用途 |
| CN108033945A (zh) * | 2017-12-29 | 2018-05-15 | 佛山汉方中医医院有限公司 | 一种金刚烷和硝基吡啶结构化合物及用途 |
| CN107935993A (zh) * | 2017-12-29 | 2018-04-20 | 佛山汉方中医医院有限公司 | 甲基金刚烷和硝基吡啶结构衍生物、其制备方法及其用途 |
| CN107935992A (zh) * | 2017-12-29 | 2018-04-20 | 佛山汉方中医医院有限公司 | 一类含金刚烷和卤代吡啶结构化合物及用途 |
| CN108191824A (zh) * | 2017-12-29 | 2018-06-22 | 佛山汉方中医医院有限公司 | 一种甲基金刚烷和二甲胺吡啶结构衍生物、其制备方法及其用途 |
| CN108084154A (zh) * | 2017-12-29 | 2018-05-29 | 佛山汉方中医医院有限公司 | 一种金刚烷和胺基吡啶结构衍生物、其制备方法及用途 |
| CN108084155A (zh) * | 2017-12-29 | 2018-05-29 | 佛山汉方中医医院有限公司 | 甲基金刚烷和烷氧吡啶结构的ssao抑制剂及其用途 |
| CN107935989A (zh) * | 2017-12-29 | 2018-04-20 | 佛山汉方中医医院有限公司 | 金刚烷和腈基吡啶结构化合物、其制备方法及用途 |
| SE544131C2 (en) * | 2020-03-16 | 2022-01-04 | Pvac Medical Tech Ltd | Use of substance and pharmaceutical composition thereof, and medical treatments or uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3105849A (en) * | 1960-02-01 | 1963-10-01 | Ciba Geigy Corp | Bicyclic hydrazinium compounds |
| JP2002510300A (ja) | 1997-06-05 | 2002-04-02 | ヴィーナンティアス・リミテッド | インダン化合物及びそれらの医薬学的使用 |
| WO1998055447A1 (en) | 1997-06-05 | 1998-12-10 | Venantius Limited | 3-aminoindane derivatives, process for their preparation and pharmaceutical compositions containing them |
| AU8216301A (en) | 2000-07-05 | 2002-01-14 | Biotie Therapies Corp | Inhibitors of copper-containing amine oxidases |
| US6982286B2 (en) * | 2001-07-12 | 2006-01-03 | Biotie Therapies Corp. | Carbocyclic hydrazino inhibitors of copper-containing amine oxidases |
-
2001
- 2001-07-12 US US09/902,789 patent/US6982286B2/en not_active Expired - Fee Related
-
2002
- 2002-07-11 US US10/483,291 patent/US20040236108A1/en not_active Abandoned
- 2002-07-11 DE DE60209504T patent/DE60209504T2/de not_active Expired - Lifetime
- 2002-07-11 CN CNA028128915A patent/CN1520290A/zh active Pending
- 2002-07-11 ES ES02751224T patent/ES2259379T3/es not_active Expired - Lifetime
- 2002-07-11 IL IL15920502A patent/IL159205A0/xx unknown
- 2002-07-11 AT AT02751224T patent/ATE318589T1/de not_active IP Right Cessation
- 2002-07-11 KR KR10-2004-7000368A patent/KR20040017289A/ko not_active Withdrawn
- 2002-07-11 RU RU2004103869/04A patent/RU2004103869A/ru not_active Application Discontinuation
- 2002-07-11 EP EP02751224A patent/EP1414426B1/en not_active Expired - Lifetime
- 2002-07-11 WO PCT/FI2002/000630 patent/WO2003006003A1/en not_active Ceased
- 2002-07-11 HU HU0401097A patent/HUP0401097A3/hu unknown
- 2002-07-11 CA CA002451569A patent/CA2451569A1/en not_active Abandoned
- 2002-07-11 JP JP2003511809A patent/JP4377221B2/ja not_active Expired - Fee Related
-
2003
- 2003-11-19 NO NO20035139A patent/NO20035139D0/no not_active Application Discontinuation
- 2003-11-24 ZA ZA200309112A patent/ZA200309112B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1520290A (zh) | 2004-08-11 |
| DE60209504T2 (de) | 2006-10-12 |
| CA2451569A1 (en) | 2003-01-23 |
| US20030125360A1 (en) | 2003-07-03 |
| NO20035139D0 (no) | 2003-11-19 |
| US20040236108A1 (en) | 2004-11-25 |
| DE60209504D1 (de) | 2006-04-27 |
| ATE318589T1 (de) | 2006-03-15 |
| KR20040017289A (ko) | 2004-02-26 |
| US6982286B2 (en) | 2006-01-03 |
| HUP0401097A3 (en) | 2006-02-28 |
| ZA200309112B (en) | 2004-07-23 |
| JP2005501035A (ja) | 2005-01-13 |
| HUP0401097A2 (hu) | 2004-09-28 |
| IL159205A0 (en) | 2004-06-01 |
| RU2004103869A (ru) | 2005-03-27 |
| EP1414426B1 (en) | 2006-03-01 |
| WO2003006003A1 (en) | 2003-01-23 |
| ES2259379T3 (es) | 2006-10-01 |
| EP1414426A1 (en) | 2004-05-06 |
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