ZA200309112B - Carbocyclic hydrazino inhibitors of copper-containing amine oxidases. - Google Patents
Carbocyclic hydrazino inhibitors of copper-containing amine oxidases. Download PDFInfo
- Publication number
- ZA200309112B ZA200309112B ZA200309112A ZA200309112A ZA200309112B ZA 200309112 B ZA200309112 B ZA 200309112B ZA 200309112 A ZA200309112 A ZA 200309112A ZA 200309112 A ZA200309112 A ZA 200309112A ZA 200309112 B ZA200309112 B ZA 200309112B
- Authority
- ZA
- South Africa
- Prior art keywords
- compound
- hydrogen
- formula
- optionally substituted
- indanol
- Prior art date
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- -1 (1R,2R)-2-(1-methylhydrazino)-1-indanol fumarate (1S, 2S)-2-(1-methylhydrazino)-1-indanol succinate (1R,2R)-2-(1-methylhydrazino)-1-indanol succinate (1R,2R)-2-(1-methylhydrazino)-1-indanol Chemical compound 0.000 claims description 23
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Classifications
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- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/10—Hydrazines
- C07C243/20—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of rings other than six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
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- Engineering & Computer Science (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/902,789 US6982286B2 (en) | 2001-07-12 | 2001-07-12 | Carbocyclic hydrazino inhibitors of copper-containing amine oxidases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200309112B true ZA200309112B (en) | 2004-07-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200309112A ZA200309112B (en) | 2001-07-12 | 2003-11-24 | Carbocyclic hydrazino inhibitors of copper-containing amine oxidases. |
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| Country | Link |
|---|---|
| US (2) | US6982286B2 (enExample) |
| EP (1) | EP1414426B1 (enExample) |
| JP (1) | JP4377221B2 (enExample) |
| KR (1) | KR20040017289A (enExample) |
| CN (1) | CN1520290A (enExample) |
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| RU (1) | RU2004103869A (enExample) |
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Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6982286B2 (en) * | 2001-07-12 | 2006-01-03 | Biotie Therapies Corp. | Carbocyclic hydrazino inhibitors of copper-containing amine oxidases |
| FI20022007A0 (fi) * | 2002-11-08 | 2002-11-08 | Juvantia Pharma Ltd Oy | Oromukosaalinen valmiste ja menetelmä sen valmistamiseksi |
| KR20120030601A (ko) * | 2003-01-27 | 2012-03-28 | 아스텔라스세이야쿠 가부시키가이샤 | 티아졸 유도체 및 ｖａｐ-1 저해제로서의 용도 |
| US20060229346A1 (en) * | 2003-03-31 | 2006-10-12 | Sucampo Ag | Method for treating vascular hyperpermeable disease |
| US7499847B2 (en) | 2003-05-26 | 2009-03-03 | Biotie Therapies Corporation | Crystalline VAP-1 and uses thereof |
| FI20031927A0 (fi) * | 2003-12-31 | 2003-12-31 | Faron Pharmaceuticals Oy | Terapeuttisesti vaikuttavia aineita ja niiden käyttö |
| JP2007519688A (ja) * | 2004-01-30 | 2007-07-19 | ファロン ファーマシューティカルズ オサケ ユキチュア | メタボリックシンドロームの治療または予防に特に有効な組成物 |
| FI20040136A0 (fi) * | 2004-01-30 | 2004-01-30 | Faron Pharmaceuticals Oy | Erityisesti diabeetikoille soveltuvia koostumuksia |
| US8119651B2 (en) * | 2004-01-30 | 2012-02-21 | Biotie Therapies Corp. | Compositions useful especially for treatment or prevention of metabolic syndrome |
| JP4140630B2 (ja) * | 2005-11-10 | 2008-08-27 | Ｔｄｋ株式会社 | 磁気ヘッドアセンブリ及び磁気ヘッドアセンブリの製造方法 |
| US20080058922A1 (en) * | 2006-08-31 | 2008-03-06 | Cardiac Pacemakers, Inc. | Methods and devices employing vap-1 inhibitors |
| US8372399B2 (en) | 2006-08-31 | 2013-02-12 | Cardiac Pacemakers, Inc. | Bispecific antibodies and agents to enhance stem cell homing |
| US8636995B2 (en) * | 2006-08-31 | 2014-01-28 | Cardiac Pacemakers, Inc. | Methods and devices to regulate stem cell homing |
| US20080207728A1 (en) * | 2006-12-15 | 2008-08-28 | Lars Wortmann | Bicyclic acyltryptophanols |
| US20090170770A1 (en) * | 2007-11-06 | 2009-07-02 | Ali Hafezi-Moghadam | Methods and compositions for treating conditions associated with angiogenesis using a vascular adhesion protein-1 (vap 1) inhibitor |
| US8906642B2 (en) | 2008-09-03 | 2014-12-09 | Universitat Autonoma De Barcelona | Methods and compositions for the treatment and diagnosis of haemorrhagic conversion |
| WO2010033045A1 (en) * | 2008-09-16 | 2010-03-25 | Igor Anatolievich Pomytkin | Compositions and methods for prevention or treatment of beta amyloid deposition |
| US20120010188A1 (en) | 2008-12-04 | 2012-01-12 | Promimagen Ltd. | Imidazopyridine Compounds |
| UA112154C2 (uk) * | 2009-09-08 | 2016-08-10 | Біоті Терапіс Корп. | Застосування повністю людського анти-vap-1-антитіла для лікування фіброзних станів |
| GB201004311D0 (en) | 2010-03-15 | 2010-04-28 | Proximagen Ltd | New enzyme inhibitor compounds |
| FI20115234A0 (fi) | 2011-03-08 | 2011-03-08 | Biotie Therapies Corp | Uusia pyridatsinoni- ja pyridoniyhdisteitä |
| GB201115853D0 (en) | 2011-09-14 | 2011-10-26 | Proximagen Ltd | New enzyme inhibitor compounds |
| CN103889983B (zh) | 2011-09-14 | 2015-12-09 | 普罗克西梅根有限公司 | 酶抑制剂化合物 |
| GB201304526D0 (en) | 2013-03-13 | 2013-04-24 | Proximagen Ltd | New compounds |
| GB201304527D0 (en) | 2013-03-13 | 2013-04-24 | Proximagen Ltd | New compounds |
| AU2014279863A1 (en) | 2013-06-12 | 2016-01-28 | Proximagen Limited | New therapeutic uses of enzyme inhibitors |
| ES2714125T3 (es) | 2014-04-15 | 2019-05-27 | Pecsi Tudomanyegyetem | Inhibidores de la amino oxidasa sensible a la semicarbazida para uso como analgésicos en una neuropatía traumática y una inflamación neurogénica |
| WO2015189534A1 (en) | 2014-06-12 | 2015-12-17 | Proximagen Limited | Vap-1 inhibitors for treating muscular dystrophy |
| GB201416446D0 (en) | 2014-09-17 | 2014-10-29 | Proximagen Ltd | New enzyme inhibitor compounds |
| GB201416444D0 (en) | 2014-09-17 | 2014-10-29 | Proximagen Ltd | New compounds |
| GB201521541D0 (en) * | 2015-12-07 | 2016-01-20 | Proximagen Ltd | New therapeutic uses of enzyme inhibitors |
| HK1256174A1 (zh) | 2015-12-07 | 2019-09-13 | Benevolentai Cambridge Limited | 用於治疗疼痛的 vap-1 抑制剂 |
| GB201709136D0 (en) * | 2017-06-08 | 2017-07-26 | Proximagen Ltd | New therapeutic uses of enzyme inhibitors |
| CN108191823A (zh) * | 2017-12-29 | 2018-06-22 | 佛山汉方中医医院有限公司 | 一类烷基取代金刚烷ssao抑制剂、制备方法及其用途 |
| CN107935990A (zh) * | 2017-12-29 | 2018-04-20 | 佛山汉方中医医院有限公司 | 含金刚烷和烷氧吡啶结构化合物、其制备方法及用途 |
| CN108129458A (zh) * | 2017-12-29 | 2018-06-08 | 佛山汉方中医医院有限公司 | 一种金刚烷和二甲胺吡啶结构衍生物、其制备方法及用途 |
| CN107935992A (zh) * | 2017-12-29 | 2018-04-20 | 佛山汉方中医医院有限公司 | 一类含金刚烷和卤代吡啶结构化合物及用途 |
| CN108191824A (zh) * | 2017-12-29 | 2018-06-22 | 佛山汉方中医医院有限公司 | 一种甲基金刚烷和二甲胺吡啶结构衍生物、其制备方法及其用途 |
| CN109988147A (zh) * | 2017-12-29 | 2019-07-09 | 佛山汉方中医医院有限公司 | 含金刚烷结构的ssao抑制剂、制备方法及其用途 |
| CN108084155A (zh) * | 2017-12-29 | 2018-05-29 | 佛山汉方中医医院有限公司 | 甲基金刚烷和烷氧吡啶结构的ssao抑制剂及其用途 |
| CN108191825A (zh) * | 2017-12-29 | 2018-06-22 | 佛山汉方中医医院有限公司 | 一种甲基金刚烷和硝基吡啶结构衍生物及其用途 |
| CN108084154A (zh) * | 2017-12-29 | 2018-05-29 | 佛山汉方中医医院有限公司 | 一种金刚烷和胺基吡啶结构衍生物、其制备方法及用途 |
| CN107915719A (zh) * | 2017-12-29 | 2018-04-17 | 佛山汉方中医医院有限公司 | 一类甲基金刚烷和吡啶结构的ssao抑制剂及其用途 |
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|---|---|---|---|---|
| US3105849A (en) | 1960-02-01 | 1963-10-01 | Ciba Geigy Corp | Bicyclic hydrazinium compounds |
| WO1998055439A1 (en) | 1997-06-05 | 1998-12-10 | Venantius Limited | Indane compounds and their pharmaceutical use |
| WO1998055447A1 (en) | 1997-06-05 | 1998-12-10 | Venantius Limited | 3-aminoindane derivatives, process for their preparation and pharmaceutical compositions containing them |
| WO2002002090A2 (en) | 2000-07-05 | 2002-01-10 | Biotie Therapies Corp. | Inhibitors of copper-containing amine oxidases |
| US6982286B2 (en) * | 2001-07-12 | 2006-01-03 | Biotie Therapies Corp. | Carbocyclic hydrazino inhibitors of copper-containing amine oxidases |
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2002
- 2002-07-11 ES ES02751224T patent/ES2259379T3/es not_active Expired - Lifetime
- 2002-07-11 HU HU0401097A patent/HUP0401097A3/hu unknown
- 2002-07-11 IL IL15920502A patent/IL159205A0/xx unknown
- 2002-07-11 CN CNA028128915A patent/CN1520290A/zh active Pending
- 2002-07-11 RU RU2004103869/04A patent/RU2004103869A/ru not_active Application Discontinuation
- 2002-07-11 DE DE60209504T patent/DE60209504T2/de not_active Expired - Lifetime
- 2002-07-11 EP EP02751224A patent/EP1414426B1/en not_active Expired - Lifetime
- 2002-07-11 CA CA002451569A patent/CA2451569A1/en not_active Abandoned
- 2002-07-11 US US10/483,291 patent/US20040236108A1/en not_active Abandoned
- 2002-07-11 JP JP2003511809A patent/JP4377221B2/ja not_active Expired - Fee Related
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- 2002-07-11 AT AT02751224T patent/ATE318589T1/de not_active IP Right Cessation
- 2002-07-11 WO PCT/FI2002/000630 patent/WO2003006003A1/en not_active Ceased
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- 2003-11-19 NO NO20035139A patent/NO20035139D0/no not_active Application Discontinuation
- 2003-11-24 ZA ZA200309112A patent/ZA200309112B/en unknown
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| WO2003006003A1 (en) | 2003-01-23 |
| RU2004103869A (ru) | 2005-03-27 |
| DE60209504D1 (de) | 2006-04-27 |
| JP2005501035A (ja) | 2005-01-13 |
| JP4377221B2 (ja) | 2009-12-02 |
| CA2451569A1 (en) | 2003-01-23 |
| HUP0401097A2 (hu) | 2004-09-28 |
| DE60209504T2 (de) | 2006-10-12 |
| ATE318589T1 (de) | 2006-03-15 |
| KR20040017289A (ko) | 2004-02-26 |
| NO20035139D0 (no) | 2003-11-19 |
| EP1414426B1 (en) | 2006-03-01 |
| US20040236108A1 (en) | 2004-11-25 |
| HUP0401097A3 (en) | 2006-02-28 |
| IL159205A0 (en) | 2004-06-01 |
| US6982286B2 (en) | 2006-01-03 |
| ES2259379T3 (es) | 2006-10-01 |
| EP1414426A1 (en) | 2004-05-06 |
| CN1520290A (zh) | 2004-08-11 |
| US20030125360A1 (en) | 2003-07-03 |
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