JP2005500299A5 - - Google Patents
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- Publication number
- JP2005500299A5 JP2005500299A5 JP2003504976A JP2003504976A JP2005500299A5 JP 2005500299 A5 JP2005500299 A5 JP 2005500299A5 JP 2003504976 A JP2003504976 A JP 2003504976A JP 2003504976 A JP2003504976 A JP 2003504976A JP 2005500299 A5 JP2005500299 A5 JP 2005500299A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- steroid
- prodrug
- parent drug
- ramipril
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 29
- 150000003431 steroids Chemical class 0.000 claims 24
- 239000003814 drug Substances 0.000 claims 20
- 229940002612 prodrug Drugs 0.000 claims 18
- 239000000651 prodrug Substances 0.000 claims 18
- 229940079593 drug Drugs 0.000 claims 17
- 238000000034 method Methods 0.000 claims 8
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims 5
- 230000035515 penetration Effects 0.000 claims 5
- 229960003401 ramipril Drugs 0.000 claims 5
- HDACQVRGBOVJII-JBDAPHQKSA-N ramipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 HDACQVRGBOVJII-JBDAPHQKSA-N 0.000 claims 3
- DBAQBRAQKYAQEO-GBBGEASQSA-N (2s,3as,6as)-1-[(2s)-2-[[(2s)-1-methoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2h-cyclopenta[b]pyrrole-2-carboxylic acid Chemical compound C([C@@H](C(=O)OC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 DBAQBRAQKYAQEO-GBBGEASQSA-N 0.000 claims 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 2
- 239000005541 ACE inhibitor Substances 0.000 claims 2
- IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 claims 2
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229960005309 estradiol Drugs 0.000 claims 2
- 229930182833 estradiol Natural products 0.000 claims 2
- 239000004615 ingredient Substances 0.000 claims 2
- 229940053934 norethindrone Drugs 0.000 claims 2
- 229960001652 norethindrone acetate Drugs 0.000 claims 2
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 230000037317 transdermal delivery Effects 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- RFWTZQAOOLFXAY-ZZDGKJOTSA-N [(8r,9s,13s,14s)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] heptanoate Chemical compound C1CC2=CC(O)=CC=C2[C@@H]2[C@@H]1[C@@H]1CCC(OC(=O)CCCCCC)[C@@]1(C)CC2 RFWTZQAOOLFXAY-ZZDGKJOTSA-N 0.000 claims 1
- 239000003263 anabolic agent Substances 0.000 claims 1
- 229940070021 anabolic steroids Drugs 0.000 claims 1
- 230000001548 androgenic effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000003750 conditioning effect Effects 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- 239000000583 progesterone congener Substances 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- -1 steroid ester Chemical class 0.000 claims 1
- 238000013271 transdermal drug delivery Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29838101P | 2001-06-18 | 2001-06-18 | |
| US60/298,381 | 2001-06-18 | ||
| US94810701A | 2001-09-07 | 2001-09-07 | |
| US09/948,107 | 2001-09-07 | ||
| PCT/US2002/016579 WO2002102390A1 (en) | 2001-06-18 | 2002-06-18 | Enhanced drug delivery in transdermal systems |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005500299A JP2005500299A (ja) | 2005-01-06 |
| JP2005500299A5 true JP2005500299A5 (enExample) | 2006-01-05 |
| JP5506126B2 JP5506126B2 (ja) | 2014-05-28 |
Family
ID=26970627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003504976A Expired - Fee Related JP5506126B2 (ja) | 2001-06-18 | 2002-06-18 | 経皮システムにおける加速した医薬の送達 |
Country Status (22)
| Country | Link |
|---|---|
| US (6) | US7867986B2 (enExample) |
| EP (1) | EP1406633B1 (enExample) |
| JP (1) | JP5506126B2 (enExample) |
| KR (1) | KR100988542B1 (enExample) |
| CN (1) | CN100391462C (enExample) |
| AR (1) | AR034518A1 (enExample) |
| AT (1) | ATE526973T1 (enExample) |
| AU (1) | AU2002320038B2 (enExample) |
| BR (1) | BR0210516A (enExample) |
| CA (1) | CA2451043C (enExample) |
| CL (1) | CL2008000489A1 (enExample) |
| DK (1) | DK1406633T3 (enExample) |
| ES (1) | ES2375105T3 (enExample) |
| IL (2) | IL159415A0 (enExample) |
| MX (1) | MXPA03011910A (enExample) |
| NO (1) | NO335025B1 (enExample) |
| NZ (1) | NZ530227A (enExample) |
| PT (1) | PT1406633E (enExample) |
| RU (2) | RU2358699C2 (enExample) |
| SA (1) | SA02230192B1 (enExample) |
| TW (1) | TWI277418B (enExample) |
| WO (1) | WO2002102390A1 (enExample) |
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