JP2005343887A - エラスターゼ阻害剤 - Google Patents
エラスターゼ阻害剤 Download PDFInfo
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- JP2005343887A JP2005343887A JP2005126684A JP2005126684A JP2005343887A JP 2005343887 A JP2005343887 A JP 2005343887A JP 2005126684 A JP2005126684 A JP 2005126684A JP 2005126684 A JP2005126684 A JP 2005126684A JP 2005343887 A JP2005343887 A JP 2005343887A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q9/00—Preparations for removing hair or for aiding hair removal
- A61Q9/02—Shaving preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/011—Hydrolysed proteins; Derivatives thereof from plants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/018—Hydrolysed proteins; Derivatives thereof from animals from milk
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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Abstract
【解決手段】 タンパク加水分解物(但し、大豆及びアーモンドのタンパク加水分解物を除く)を有効成分とするエラスターゼ阻害剤。
【選択図】 なし
Description
しかしながら、斯かるタンパク加水分解物がエラスターゼ阻害作用を有することは知られていない。
酵素による加水分解は、通常、タンパク質として1〜35重量%、好ましくは5〜15重量%を含有する溶液とし、用いる酵素の作用pH域、作用温度域で、酵素を作用させればよい。
大日本製薬社より市販されている正常ヒト繊維芽細胞を10%牛胎児血清を含むDME培地で継代培養し、本試験に供した。ラバーポリスマンを用いてシャーレから剥がした細胞を、生理食塩水に浮遊させ、低速の遠心分離器を使って細胞を集め、生理食塩水で3回洗浄した。細胞は、0.1% Triton X-100/0.2M Tris-HCl buffer(pH8.0)に浮遊させ超音波破砕し、酵素液とした。酵素活性測定の基質には125mM N−Suc−(Ala)3−p−ニトロアニリドを用いた。酵素液に表1に示す各種タンパク加水分解物を最終濃度1%となるように添加し、37℃で1時間反応させ、5μLの酢酸を加えて反応を停止させた。分光光度計で405nmにおける吸光度を測定することにより、生成したp−ニトロアニリン量を求め、下記式に基づき、エラスターゼ活性抑制率(%)を算出した。その結果、タンパク加水分解物は、優れたエラスターゼ活性阻害作用を有していた(表1)。
エラスターゼ活性抑制率(%)=100−(タンパク加水分解物を添加した時のp−ニトロアニリン量/タンパク加水分解物を添加しない時のp−ニトロアニリン量)×100
Claims (6)
- タンパク加水分解物(但し、大豆及びアーモンドのタンパク加水分解物を除く)を有効成分とするエラスターゼ阻害剤。
- タンパク加水分解物が、乳タンパク、絹タンパク、小麦タンパク、米タンパク、エンドウマメタンパク、オーツタンパク、コラーゲン、エラスチン及びケラチンから選ばれるタンパク質の加水分解物である請求項1記載のエラスターゼ阻害剤。
- タンパク加水分解物(但し、大豆及びアーモンドのタンパク加水分解物を除く)を有効成分とする発毛抑制剤。
- 体毛除去処理の頻度を軽減するものである請求項3記載の発毛抑制剤。
- 体毛除去処理がカミソリ処理である請求項3記載の発毛抑制剤。
- タンパク加水分解物(但し、アーモンドのタンパク加水分解物を除く)を有効成分とする皮膚老化防止剤。
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US10/855,358 US20050265946A1 (en) | 2004-05-28 | 2004-05-28 | Elastase inhibitor |
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JP2010013442A (ja) * | 2008-06-04 | 2010-01-21 | Maruzen Pharmaceut Co Ltd | 抑毛剤及び抑毛用皮膚化粧料 |
JP2011116727A (ja) * | 2009-12-07 | 2011-06-16 | Maruzen Pharmaceut Co Ltd | 抑毛剤組成物 |
JP2011195542A (ja) * | 2010-03-23 | 2011-10-06 | Kose Corp | エラスターゼ活性阻害剤 |
JP2013523869A (ja) * | 2010-04-15 | 2013-06-17 | アイエスピー インヴェストメンツ インコーポレイテッド | エンドウペプチド加水分解物の保湿活性作用剤としての使用 |
WO2020138023A1 (ja) * | 2018-12-27 | 2020-07-02 | サントリーホールディングス株式会社 | 変性エラスチンの分解低下の抑制剤、正常なエラスチン線維の維持剤、エラスチン-エラフィン複合体形成抑制剤及びエラスチン-エラフィン複合体形成抑制作用を有する物質のスクリーニング方法 |
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Cited By (7)
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JP2010013442A (ja) * | 2008-06-04 | 2010-01-21 | Maruzen Pharmaceut Co Ltd | 抑毛剤及び抑毛用皮膚化粧料 |
JP2011116727A (ja) * | 2009-12-07 | 2011-06-16 | Maruzen Pharmaceut Co Ltd | 抑毛剤組成物 |
JP2011195542A (ja) * | 2010-03-23 | 2011-10-06 | Kose Corp | エラスターゼ活性阻害剤 |
JP2013523869A (ja) * | 2010-04-15 | 2013-06-17 | アイエスピー インヴェストメンツ インコーポレイテッド | エンドウペプチド加水分解物の保湿活性作用剤としての使用 |
JP2022188206A (ja) * | 2017-08-10 | 2022-12-20 | 共栄化学工業株式会社 | 皮膚外用組成物 |
WO2020138023A1 (ja) * | 2018-12-27 | 2020-07-02 | サントリーホールディングス株式会社 | 変性エラスチンの分解低下の抑制剤、正常なエラスチン線維の維持剤、エラスチン-エラフィン複合体形成抑制剤及びエラスチン-エラフィン複合体形成抑制作用を有する物質のスクリーニング方法 |
JPWO2020138023A1 (ja) * | 2018-12-27 | 2021-10-21 | サントリーホールディングス株式会社 | 変性エラスチンの分解低下の抑制剤、正常なエラスチン線維の維持剤、エラスチン−エラフィン複合体形成抑制剤及びエラスチン−エラフィン複合体形成抑制作用を有する物質のスクリーニング方法 |
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