JP2005119983A - 栄養組成物 - Google Patents
栄養組成物 Download PDFInfo
- Publication number
- JP2005119983A JP2005119983A JP2003353893A JP2003353893A JP2005119983A JP 2005119983 A JP2005119983 A JP 2005119983A JP 2003353893 A JP2003353893 A JP 2003353893A JP 2003353893 A JP2003353893 A JP 2003353893A JP 2005119983 A JP2005119983 A JP 2005119983A
- Authority
- JP
- Japan
- Prior art keywords
- collagen
- iron
- vitamin
- nutritional composition
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 80
- 230000000050 nutritive effect Effects 0.000 title abstract 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 155
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 114
- 229910052742 iron Inorganic materials 0.000 claims abstract description 79
- 102000008186 Collagen Human genes 0.000 claims abstract description 72
- 108010035532 Collagen Proteins 0.000 claims abstract description 72
- 229920001436 collagen Polymers 0.000 claims abstract description 72
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 50
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 50
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 50
- 239000011718 vitamin C Substances 0.000 claims abstract description 50
- 239000003814 drug Substances 0.000 claims abstract description 14
- 102000014171 Milk Proteins Human genes 0.000 claims abstract description 7
- 108010011756 Milk Proteins Proteins 0.000 claims abstract description 7
- 235000021239 milk protein Nutrition 0.000 claims abstract description 7
- 235000016709 nutrition Nutrition 0.000 claims description 52
- 230000037319 collagen production Effects 0.000 claims description 35
- 230000001737 promoting effect Effects 0.000 claims description 35
- 238000002360 preparation method Methods 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 6
- 230000035764 nutrition Effects 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 3
- 210000000988 bone and bone Anatomy 0.000 abstract description 22
- 235000013305 food Nutrition 0.000 abstract description 17
- 239000003795 chemical substances by application Substances 0.000 abstract description 14
- 239000004480 active ingredient Substances 0.000 abstract description 5
- 230000032683 aging Effects 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 206010057178 Osteoarthropathies Diseases 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 16
- 241000700159 Rattus Species 0.000 description 14
- 210000003491 skin Anatomy 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 239000008367 deionised water Substances 0.000 description 13
- 229910021641 deionized water Inorganic materials 0.000 description 13
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 9
- 230000037396 body weight Effects 0.000 description 9
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 9
- 229960002591 hydroxyproline Drugs 0.000 description 9
- 239000000843 powder Substances 0.000 description 9
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 9
- 229940079593 drug Drugs 0.000 description 8
- 229960005070 ascorbic acid Drugs 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- LCWXJXMHJVIJFK-UHFFFAOYSA-N Hydroxylysine Natural products NCC(O)CC(N)CC(O)=O LCWXJXMHJVIJFK-UHFFFAOYSA-N 0.000 description 6
- 208000001132 Osteoporosis Diseases 0.000 description 6
- YSMODUONRAFBET-UHFFFAOYSA-N delta-DL-hydroxylysine Natural products NCC(O)CCC(N)C(O)=O YSMODUONRAFBET-UHFFFAOYSA-N 0.000 description 6
- YSMODUONRAFBET-UHNVWZDZSA-N erythro-5-hydroxy-L-lysine Chemical compound NC[C@H](O)CC[C@H](N)C(O)=O YSMODUONRAFBET-UHNVWZDZSA-N 0.000 description 6
- QJHBJHUKURJDLG-UHFFFAOYSA-N hydroxy-L-lysine Natural products NCCCCC(NO)C(O)=O QJHBJHUKURJDLG-UHFFFAOYSA-N 0.000 description 6
- 108090000765 processed proteins & peptides Proteins 0.000 description 6
- 235000020183 skimmed milk Nutrition 0.000 description 6
- 230000009759 skin aging Effects 0.000 description 6
- 150000001413 amino acids Chemical class 0.000 description 5
- 235000013361 beverage Nutrition 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- -1 vitamin C Chemical compound 0.000 description 5
- 206010017076 Fracture Diseases 0.000 description 4
- 208000012659 Joint disease Diseases 0.000 description 4
- 239000002211 L-ascorbic acid Substances 0.000 description 4
- 235000000069 L-ascorbic acid Nutrition 0.000 description 4
- 206010003246 arthritis Diseases 0.000 description 4
- 210000004207 dermis Anatomy 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 description 4
- 239000011707 mineral Substances 0.000 description 4
- 235000010755 mineral Nutrition 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 239000011668 ascorbic acid Substances 0.000 description 3
- 235000010323 ascorbic acid Nutrition 0.000 description 3
- 235000019606 astringent taste Nutrition 0.000 description 3
- 229960005069 calcium Drugs 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 3
- 239000011755 sodium-L-ascorbate Substances 0.000 description 3
- 235000019187 sodium-L-ascorbate Nutrition 0.000 description 3
- 229940088594 vitamin Drugs 0.000 description 3
- 229930003231 vitamin Natural products 0.000 description 3
- 235000013343 vitamin Nutrition 0.000 description 3
- 239000011782 vitamin Substances 0.000 description 3
- 150000003722 vitamin derivatives Chemical class 0.000 description 3
- 208000020084 Bone disease Diseases 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- PLKYGPRDCKGEJH-UHFFFAOYSA-N azane;2-hydroxypropane-1,2,3-tricarboxylic acid;iron Chemical compound N.[Fe].OC(=O)CC(O)(C(O)=O)CC(O)=O PLKYGPRDCKGEJH-UHFFFAOYSA-N 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 239000011706 ferric diphosphate Substances 0.000 description 2
- 235000007144 ferric diphosphate Nutrition 0.000 description 2
- CADNYOZXMIKYPR-UHFFFAOYSA-B ferric pyrophosphate Chemical compound [Fe+3].[Fe+3].[Fe+3].[Fe+3].[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O CADNYOZXMIKYPR-UHFFFAOYSA-B 0.000 description 2
- 229940036404 ferric pyrophosphate Drugs 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 150000003278 haem Chemical class 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 229940082629 iron antianemic preparations Drugs 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 201000008482 osteoarthritis Diseases 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- WVXRAFOPTSTNLL-NKWVEPMBSA-N 2',3'-dideoxyadenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1CC[C@@H](CO)O1 WVXRAFOPTSTNLL-NKWVEPMBSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 208000010392 Bone Fractures Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 108090000317 Chymotrypsin Proteins 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 102000008857 Ferritin Human genes 0.000 description 1
- 108050000784 Ferritin Proteins 0.000 description 1
- 238000008416 Ferritin Methods 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 150000000996 L-ascorbic acids Chemical class 0.000 description 1
- 108010063045 Lactoferrin Proteins 0.000 description 1
- 102000010445 Lactoferrin Human genes 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 240000003394 Malpighia glabra Species 0.000 description 1
- 235000014837 Malpighia glabra Nutrition 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 108010073771 Soybean Proteins Proteins 0.000 description 1
- 244000300264 Spinacia oleracea Species 0.000 description 1
- 235000009337 Spinacia oleracea Nutrition 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- 238000010306 acid treatment Methods 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000037182 bone density Effects 0.000 description 1
- 210000002805 bone matrix Anatomy 0.000 description 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 1
- 239000001527 calcium lactate Substances 0.000 description 1
- 235000011086 calcium lactate Nutrition 0.000 description 1
- 229960002401 calcium lactate Drugs 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229960002376 chymotrypsin Drugs 0.000 description 1
- 230000036570 collagen biosynthesis Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 235000008504 concentrate Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000011790 ferrous sulphate Substances 0.000 description 1
- 235000003891 ferrous sulphate Nutrition 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 235000014106 fortified food Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 1
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 1
- 235000021242 lactoferrin Nutrition 0.000 description 1
- 229940078795 lactoferrin Drugs 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000009245 menopause Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 235000020124 milk-based beverage Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 238000009806 oophorectomy Methods 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 230000003349 osteoarthritic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229940001941 soy protein Drugs 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- JHYAVWJELFKHLM-UHFFFAOYSA-H tetrasodium;2-hydroxypropane-1,2,3-tricarboxylate;iron(2+) Chemical compound [Na+].[Na+].[Na+].[Na+].[Fe+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O JHYAVWJELFKHLM-UHFFFAOYSA-H 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 229960001322 trypsin Drugs 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 235000021119 whey protein Nutrition 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
【解決手段】 ビタミンC、鉄剤及びコラーゲンを有効成分として含有させることにより、皮膚や骨等の生体内におけるコラーゲン産生を促進させるとともに、鉄剤を使用する場合に、乳蛋白質を含有させることで、鉄剤を含有する組成物に安定性を付与することが可能となる。
【選択図】 なし
Description
ハーパー・生化学、原書24版、上代淑人監訳、丸善(株)、315頁、1997年 浅野隆司外2名、BIO INDUSTRY、シーエムシー出版、 Vol.18、No.4、11頁、2001年 石見佳子外2名、Osteoporosis Japan 、ライフサイエンス出版、Vol.11、No.2、34頁、2003年
また、骨中のコラーゲンの生合成を促進させることにより、骨粗鬆症等の骨関節疾患を予防または治療でき、しかも安全性の高いコラーゲン産生促進用栄養組成物、及び、そのような栄養組成物を配合した飲食品、飼料、医薬を提供することを課題とする。
さらに、ビタミンC等のように鉄を遊離させ、さらに還元する作用を有する物質と鉄剤を混合することによって生ずる鉄の収斂味や沈殿の発生を減じたコラーゲン産生促進用栄養組成物、及び、そのような栄養組成物を配合した飲食品、飼料、医薬を提供することを課題とする。
ビタミンCとしては、L-アスコルビン酸、L-アスコルビン酸ナトリウム等のアスコルビン酸誘導体、また、アスコルビン酸を乳化剤等でコーティングしたアスコルビン酸製剤等を使用することが可能であり、これらのビタミンC類の2以上を任意の割合で配合した混合物であってもよい。また、例えば、アセロラ、レモン等のビタミンCを含有する天然物を使用することもできる。
本発明のコラーゲン産生促進用栄養組成物は、常法に従い、粉末剤、顆粒剤、錠剤、カプセル剤、ドリンク剤等に製剤化して用いることが出来る。また、これらを製剤化した後、これを栄養剤やヨーグルト、乳飲料、ウエハース等の飲食品、飼料及び医薬に配合することも可能である。
皮膚のコラーゲン量については、ラットの真皮をNimniらの方法(M.E.Nimniら、Arch. Biochem. Biophys.、122号、292頁、1967年参照。)に準じて処理した後、可溶性画分に含まれるヒドロキシプロリン量を測定した。ヒドロキシプロリンは、コラーゲンのみに含まれる特殊なアミノ酸で、コラーゲンを構成する全アミノ酸の約10%を占めることから、ヒドロキシプロリン量を測定することによりコラーゲン量を推定することができる(浅野隆司ら、BIO INDUSTRY、 Vol.18、No.4、12頁、2001年参照)。その結果を表1に示す。
Claims (4)
- ビタミンC、鉄剤及びコラーゲンを含有するコラーゲン産生促進用栄養組成物。
- 鉄剤が乳蛋白質を含有させたものである請求項1に記載の栄養組成物。
- 飲食品や飼料、医薬に通常用いられる原材料等を混合してなる請求項1乃至2に記載の栄養組成物。
- 請求項1乃至3のいずれかに記載の栄養組成物を配合した飲食品、飼料及び医薬。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003353893A JP4596513B2 (ja) | 2003-10-14 | 2003-10-14 | 栄養組成物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003353893A JP4596513B2 (ja) | 2003-10-14 | 2003-10-14 | 栄養組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005119983A true JP2005119983A (ja) | 2005-05-12 |
JP4596513B2 JP4596513B2 (ja) | 2010-12-08 |
Family
ID=34612046
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003353893A Expired - Fee Related JP4596513B2 (ja) | 2003-10-14 | 2003-10-14 | 栄養組成物 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP4596513B2 (ja) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006112012A1 (ja) * | 2005-04-13 | 2006-10-26 | Snow Brand Milk Products Co., Ltd. | 栄養組成物 |
WO2006114840A1 (ja) * | 2005-04-08 | 2006-11-02 | Snow Brand Milk Products Co., Ltd. | 乳蛋白質を含有する鉄組成物 |
FR2891138A1 (fr) * | 2005-09-23 | 2007-03-30 | Gattefosse Sas Soc Par Actions | Utilisation du fer comme stimulant de la synthese du collagene par les fibrolastes cutanes |
JP2007161688A (ja) * | 2005-12-16 | 2007-06-28 | Hiroshima Univ | 軟骨生成促進剤 |
WO2008146907A1 (ja) * | 2007-06-01 | 2008-12-04 | Kyowa Hakko Bio Co., Ltd. | 経口組成物 |
KR101055153B1 (ko) * | 2008-10-15 | 2011-08-08 | (주)더페이스샵 | 가수분해 콜라겐 펩타이드를 안정화한 나노리포좀과 비타민c를 함유하는 피부 노화 방지용 화장료 조성물 |
JP2012062248A (ja) * | 2010-09-14 | 2012-03-29 | Taisho Pharmaceutical Co Ltd | イプリフラボン可溶化組成物 |
JP2013060476A (ja) * | 2007-08-28 | 2013-04-04 | Unitika Ltd | コラーゲン産生促進剤 |
WO2013176054A1 (ja) * | 2012-05-25 | 2013-11-28 | ライオン株式会社 | アスコルビン酸誘導体を含む剤およびその用途 |
JP2013245194A (ja) * | 2012-05-25 | 2013-12-09 | Lion Corp | 経口投与組成物 |
JP2014001201A (ja) * | 2012-05-25 | 2014-01-09 | Lion Corp | 骨粗鬆症予防および/または改善剤 |
JP2015189700A (ja) * | 2014-03-28 | 2015-11-02 | 雪印メグミルク株式会社 | 光老化予防剤又は改善剤 |
CN105686005A (zh) * | 2016-02-19 | 2016-06-22 | 苏州微科天成生物技术有限公司 | 一种胶原蛋白制剂及其生产方法 |
KR20220131813A (ko) * | 2021-03-22 | 2022-09-29 | 주식회사 리앤씨바이오 | 콜라겐 펩타이드 및 생약 추출물을 포함하는 빈혈 예방 및 개선용 조성물 |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07278012A (ja) * | 1994-04-11 | 1995-10-24 | Sunstar Inc | 新陳代謝促進剤およびそれを配合した食品 |
JP2000281586A (ja) * | 1999-03-31 | 2000-10-10 | Snow Brand Milk Prod Co Ltd | 骨強化剤 |
JP2000300194A (ja) * | 1999-04-21 | 2000-10-31 | Otsuka Pharmaceut Factory Inc | 栄養粥 |
JP2001139447A (ja) * | 1999-11-12 | 2001-05-22 | Iwase Cosfa Kk | 水溶性i型コラーゲンおよびビタミンc誘導体を配合した皮膚化粧料 |
JP2002173445A (ja) * | 2000-12-06 | 2002-06-21 | Fancl Corp | 創傷治癒剤 |
JP2002238497A (ja) * | 2001-02-19 | 2002-08-27 | Fancl Corp | 食品組成物 |
JP2002529387A (ja) * | 1998-11-10 | 2002-09-10 | カラー アクセス,インコーポレイティド | 乳清タンパク質を含む局所用組成物 |
JP2002293731A (ja) * | 2001-03-23 | 2002-10-09 | L'oreal Sa | 皮膚の老化に対抗するための、繊維を含む組成物 |
JP2003144095A (ja) * | 2001-11-08 | 2003-05-20 | Snow Brand Milk Prod Co Ltd | 美肌剤 |
-
2003
- 2003-10-14 JP JP2003353893A patent/JP4596513B2/ja not_active Expired - Fee Related
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07278012A (ja) * | 1994-04-11 | 1995-10-24 | Sunstar Inc | 新陳代謝促進剤およびそれを配合した食品 |
JP2002529387A (ja) * | 1998-11-10 | 2002-09-10 | カラー アクセス,インコーポレイティド | 乳清タンパク質を含む局所用組成物 |
JP2000281586A (ja) * | 1999-03-31 | 2000-10-10 | Snow Brand Milk Prod Co Ltd | 骨強化剤 |
JP2000300194A (ja) * | 1999-04-21 | 2000-10-31 | Otsuka Pharmaceut Factory Inc | 栄養粥 |
JP2001139447A (ja) * | 1999-11-12 | 2001-05-22 | Iwase Cosfa Kk | 水溶性i型コラーゲンおよびビタミンc誘導体を配合した皮膚化粧料 |
JP2002173445A (ja) * | 2000-12-06 | 2002-06-21 | Fancl Corp | 創傷治癒剤 |
JP2002238497A (ja) * | 2001-02-19 | 2002-08-27 | Fancl Corp | 食品組成物 |
JP2002293731A (ja) * | 2001-03-23 | 2002-10-09 | L'oreal Sa | 皮膚の老化に対抗するための、繊維を含む組成物 |
JP2003144095A (ja) * | 2001-11-08 | 2003-05-20 | Snow Brand Milk Prod Co Ltd | 美肌剤 |
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006114840A1 (ja) * | 2005-04-08 | 2006-11-02 | Snow Brand Milk Products Co., Ltd. | 乳蛋白質を含有する鉄組成物 |
WO2006112012A1 (ja) * | 2005-04-13 | 2006-10-26 | Snow Brand Milk Products Co., Ltd. | 栄養組成物 |
FR2891138A1 (fr) * | 2005-09-23 | 2007-03-30 | Gattefosse Sas Soc Par Actions | Utilisation du fer comme stimulant de la synthese du collagene par les fibrolastes cutanes |
WO2007036667A1 (fr) * | 2005-09-23 | 2007-04-05 | Gattefosse S.A.S. | Utilisation du fer sous forme d'un extrait de pierre comme stimulant de la synthese du collagene par les fibroblastes cutanes |
JP2007161688A (ja) * | 2005-12-16 | 2007-06-28 | Hiroshima Univ | 軟骨生成促進剤 |
WO2008146907A1 (ja) * | 2007-06-01 | 2008-12-04 | Kyowa Hakko Bio Co., Ltd. | 経口組成物 |
US9492494B2 (en) | 2007-06-01 | 2016-11-15 | Kyowa Hakko Bio Co., Ltd. | Oral composition |
JP2013060476A (ja) * | 2007-08-28 | 2013-04-04 | Unitika Ltd | コラーゲン産生促進剤 |
JP5259601B2 (ja) * | 2007-08-28 | 2013-08-07 | ユニチカ株式会社 | コラーゲン産生促進剤 |
KR101055153B1 (ko) * | 2008-10-15 | 2011-08-08 | (주)더페이스샵 | 가수분해 콜라겐 펩타이드를 안정화한 나노리포좀과 비타민c를 함유하는 피부 노화 방지용 화장료 조성물 |
JP2012062248A (ja) * | 2010-09-14 | 2012-03-29 | Taisho Pharmaceutical Co Ltd | イプリフラボン可溶化組成物 |
WO2013176054A1 (ja) * | 2012-05-25 | 2013-11-28 | ライオン株式会社 | アスコルビン酸誘導体を含む剤およびその用途 |
JP2013245194A (ja) * | 2012-05-25 | 2013-12-09 | Lion Corp | 経口投与組成物 |
JP2014001201A (ja) * | 2012-05-25 | 2014-01-09 | Lion Corp | 骨粗鬆症予防および/または改善剤 |
JP2015189700A (ja) * | 2014-03-28 | 2015-11-02 | 雪印メグミルク株式会社 | 光老化予防剤又は改善剤 |
CN105686005A (zh) * | 2016-02-19 | 2016-06-22 | 苏州微科天成生物技术有限公司 | 一种胶原蛋白制剂及其生产方法 |
KR20220131813A (ko) * | 2021-03-22 | 2022-09-29 | 주식회사 리앤씨바이오 | 콜라겐 펩타이드 및 생약 추출물을 포함하는 빈혈 예방 및 개선용 조성물 |
KR102492549B1 (ko) * | 2021-03-22 | 2023-01-27 | 주식회사 리앤씨바이오 | 콜라겐 펩타이드 및 생약 추출물을 포함하는 빈혈 예방 및 개선용 조성물 |
Also Published As
Publication number | Publication date |
---|---|
JP4596513B2 (ja) | 2010-12-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR101361379B1 (ko) | 영양 조성물 | |
Khora | Marine fish-derived bioactive peptides and proteins for human therapeutics | |
JP4596513B2 (ja) | 栄養組成物 | |
TWI483684B (zh) | 肌肉增強劑 | |
WO2011108692A1 (ja) | 筋肉萎縮防止剤 | |
KR20100014572A (ko) | 오스테오칼신 함유 추출물의 제조방법 | |
JPH04183371A (ja) | 骨強化食品、飼料及び医薬 | |
JP2009167646A (ja) | 肝機能保護剤 | |
JP3393560B2 (ja) | 水溶性キトサンを含有するカルシウム吸収促進性組成物およびカルシウム吸収促進用添加剤 | |
JP2024063783A (ja) | フッ化物及びトリメチルアミン含量の低い海洋タンパク質加水分解物 | |
JP2009159983A (ja) | 食品組成物 | |
Pérez et al. | Nutritional Properties of Fish Bones: Potential Applications in the Food Industry | |
NZ578722A (en) | Skin-beautifying agent | |
KR20120134935A (ko) | 칼슘흡수율을 높이는 오징어 껍질의 콜라겐 조성물을 추출하는 방법 및 상기 콜라겐 조성물을 함유하는 전두부 | |
JP3397258B2 (ja) | カルシウム吸収促進性水溶性画分、それを含有する組成物およびカルシウム吸収促進用添加剤 | |
Kim et al. | Fish and bone as a calcium source | |
JP5311760B2 (ja) | 美白剤 | |
JPH09132531A (ja) | 流動食添加用組成物及び流動食 | |
Sandhu et al. | Conversion of Bone to Edible Products | |
JP2011084485A (ja) | 脂肪蓄積抑制剤 | |
NZ562350A (en) | Nutrient composition for promoting collagen production comprising vitamin C, an iron-saturated lactoferrin, collagen and a milk product containing a milk protein | |
JP2003063970A (ja) | 抗骨粗鬆症組成物 | |
JP2004081137A (ja) | 栄養補助食品 | |
BG113268A (bg) | Състав на хранителна добавка, съдържаща продукти от охлюви | |
JPH04120022A (ja) | 骨の健康増強剤及びその製造法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20061003 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20091117 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100115 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20100223 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100524 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100722 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20100727 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20100826 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100830 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20100915 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20100917 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 4596513 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20131001 Year of fee payment: 3 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313111 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20131001 Year of fee payment: 3 |
|
R371 | Transfer withdrawn |
Free format text: JAPANESE INTERMEDIATE CODE: R371 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20131001 Year of fee payment: 3 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313111 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20131001 Year of fee payment: 3 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |