JP2005281257A - 美肌剤 - Google Patents
美肌剤 Download PDFInfo
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- JP2005281257A JP2005281257A JP2004101142A JP2004101142A JP2005281257A JP 2005281257 A JP2005281257 A JP 2005281257A JP 2004101142 A JP2004101142 A JP 2004101142A JP 2004101142 A JP2004101142 A JP 2004101142A JP 2005281257 A JP2005281257 A JP 2005281257A
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- sphingomyelin
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Abstract
【解決手段】 リン脂質であるスフィンゴミエリンを美肌剤の有効成分とする。また、スフィンゴミエリンを美肌用飲食品又は飼料の有効成分として配合する。本発明により、経口摂取することにより、皮膚の保湿、保護作用や肌荒れ防止・改善、しわ防止等の美容効果を示す美肌剤、美肌用飲食品又は飼料を提供することができる。
【選択図】 なし
Description
皮膚バリア機能の低下した角質層では、皮膚からの水分の消失が健康な状態に比べ激しいことが知られており、皮膚の水分蒸散量(Trans Epidermal Water Loss: TEWL)の増加が認められる。このTEWLは角質層のバリア機能や保湿機能と密接に関連しており、皮膚バリア機能の指標とされている。
従って皮膚の水分量を増加させたり、TEWLの増加を抑制させることで皮膚を健康な状態、すなわち美肌状態にすることができる。
また、動物、特にペットにおいては、アレルギー等の影響で皮膚状態が悪化することが近年問題になっており、皮膚の保湿、保護をすることで改善され、健康な皮膚状態とすることができる。
スフィンゴミエリンは、経口摂取した場合、小腸から血管に取り込まれることが報告されている(非特許文献2)。また、皮膚顆粒層のスフィンゴミエリンは、スフィンゴミエリナーゼの作用により加水分解され角質層のセラミドとして供給されることが知られている(非特許文献3)。
しかしながら、スフィンゴミエリンを経口摂取することによって、皮膚の保湿、保護作用や肌荒れ防止・改善、しわ防止等の美容効果を示すという報告はない。
本発明に用いることができるスフィンゴミエリンとしては、天然に由来するものであって、例えば、牛乳やヤギ乳等の乳由来のものや鶏卵等の卵黄由来のものを使用することが可能である。実際、牛乳由来のスフィンゴミエリン原料としては、スフィンゴミエリンの含量が25%以上と高濃度で安価なものが上市されているので、このような原料を用いるとよい。
本発明の美肌剤は、上記スフィンゴミエリンをそのまま美肌剤として用いることも可能であるが、スフィンゴミエリンの他に糖類や脂質、タンパク質、ビタミン類、ミネラル類、フレーバー等、他の医薬品、飲食品や飼料に通常使用する原材料等を混合して栄養組成物とすることや、さらに常法に従い粉末剤、顆粒剤、錠剤、カプセル剤、ドリンク剤などに製剤化した形態とすることも可能である。また、スフィンゴミエリンに加えて、他の美容効果を示す成分、例えば皮膚のコラーゲン産生を促進するコラーゲン、ビタミンCや鉄等とともに使用することも可能である。
本発明の美肌剤の有効量としては、後述するヌードマウスを用いた動物試験により、マウス体重1kgあたり、スフィンゴミエリンを2mg以上、好ましくは5mg以上経口摂取させることにより、皮膚の水分量が増加し、また、皮膚の水分蒸散量(TEWL)が低下することが分かった。したがって、通常、成人一人一日あたり、スフィンゴミエリンを2mg以上、好ましくは5mg以上摂取させることにより皮膚の保湿、保護作用や肌荒れ防止・改善、しわ防止等の美容効果が期待できるので、この必要量を確保できるようにすればよい。
また、本発明の美肌用飼料は、通常の飼料、例えば家畜用飼料やペットフード等にスフィンゴミエリンを配合すればよい。これらの飼料については、一日あたり、スフィンゴミエリンを2mg以上摂取させるためには、飼料100gあたりスフィンゴミエリンを0.1〜400mg配合することが好ましい。
本発明では、医薬品、飲食品や飼料の製造に通常使用される殺菌処理が可能であり、粉末状であっては乾熱殺菌も可能である。従って、本発明のスフィンゴミエリンを含有する液状、ゲル状、粉末状、顆粒状等様々な形態の医薬品、飲食品や飼料を製造することができる。
(飼料の調製)
スフィンゴミエリン含量10%のスフィンゴミエリン原料(Phospholac 500、NZMP社製)を表1に示したように脱イオン水に溶解し、50℃まで加熱後、ウルトラディスパーサー(ULTRA-TURRAX T-25;IKAジャパン社製)にて、9500rpmで20分間撹拌混合して、試験用飼料1〜3を調製した。
5週齢のCD-1(ICR)-nu/nuマウスを生理食塩水をマウス体重1kgあたり10g投与する群(A群)、試験用飼料1をマウス体重1kgあたり10g投与する群(B群)、試験用飼料2をマウス体重1kgあたり10g投与する群(C群)、試験用飼料3をマウス体重1kgあたり10g投与する群(D群)の4試験群(各群10匹ずつ)にわけ、それぞれを毎日1回ゾンデで経口投与して4週間飼育した。飼育開始時と飼育終了時にマウス尾尻部分の皮膚の水分量および水分蒸散量を測定し、飼育開始時のそれぞれの値を100としたときの飼育終了時の値(増加率)を算出した。皮膚の水分量および水分蒸散量は、それぞれCourage+Khazaka社製のCorneometerおよびTewameterを用いて測定した。その結果を表2に示す。
以下に、実施例を示して本発明を詳細に説明するが、これらは単に本発明の実施態様を例示するのみであり、本発明はこれらによって何ら限定されるものではない。
Claims (4)
- スフィンゴミエリンを有効成分とする美肌剤。
- スフィンゴミエリンが牛乳由来である請求項1に記載の美肌剤。
- スフィンゴミエリンを配合した美肌用飲食品又は飼料。
- スフィンゴミエリンが牛乳由来である請求項3に記載の美肌用飲食品又は飼料。
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
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JP2004101142A JP2005281257A (ja) | 2004-03-30 | 2004-03-30 | 美肌剤 |
ES05727923T ES2402299T3 (es) | 2004-03-30 | 2005-03-30 | Agente acondicionador de la piel |
CA2561729A CA2561729C (en) | 2004-03-30 | 2005-03-30 | Skin beautifier |
KR1020067021806A KR101094693B1 (ko) | 2004-03-30 | 2005-03-30 | 스킨 컨디셔닝제 |
CN200580010224XA CN1997376B (zh) | 2004-03-30 | 2005-03-30 | 美肤剂 |
PCT/JP2005/006030 WO2005094839A1 (ja) | 2004-03-30 | 2005-03-30 | 美肌剤 |
AU2005228742A AU2005228742B2 (en) | 2004-03-30 | 2005-03-30 | Skin conditioning agent |
PT57279234T PT1736159E (pt) | 2004-03-30 | 2005-03-30 | Agente de condicionamento da pele |
US10/594,661 US20080064664A1 (en) | 2004-03-30 | 2005-03-30 | Skin Beautifier |
DK05727923.4T DK1736159T3 (da) | 2004-03-30 | 2005-03-30 | Hudplejemiddel |
NZ550269A NZ550269A (en) | 2004-03-30 | 2005-03-30 | Skin conditioning agent containing sphingomyelin |
EP05727923A EP1736159B1 (en) | 2004-03-30 | 2005-03-30 | Skin conditioning agent |
HK07110734.3A HK1105361A1 (en) | 2004-03-30 | 2007-10-04 | Skin conditioning agent |
US12/947,891 US8920822B2 (en) | 2004-03-30 | 2010-11-17 | Skin beautifier |
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JP2004101142A JP2005281257A (ja) | 2004-03-30 | 2004-03-30 | 美肌剤 |
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JP2004101142A Pending JP2005281257A (ja) | 2004-03-30 | 2004-03-30 | 美肌剤 |
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US (2) | US20080064664A1 (ja) |
EP (1) | EP1736159B1 (ja) |
JP (1) | JP2005281257A (ja) |
KR (1) | KR101094693B1 (ja) |
CN (1) | CN1997376B (ja) |
AU (1) | AU2005228742B2 (ja) |
CA (1) | CA2561729C (ja) |
DK (1) | DK1736159T3 (ja) |
ES (1) | ES2402299T3 (ja) |
HK (1) | HK1105361A1 (ja) |
NZ (1) | NZ550269A (ja) |
PT (1) | PT1736159E (ja) |
WO (1) | WO2005094839A1 (ja) |
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WO2008093657A1 (ja) | 2007-01-30 | 2008-08-07 | Snow Brand Milk Products Co., Ltd. | 美肌剤 |
WO2010134384A1 (ja) * | 2009-05-20 | 2010-11-25 | よつ葉乳業株式会社 | 皮膚機能改善組成物 |
JP2011157328A (ja) * | 2010-02-03 | 2011-08-18 | Kao Corp | ミトコンドリア機能向上剤 |
JP2011157330A (ja) * | 2010-02-03 | 2011-08-18 | Kao Corp | 運動機能改善剤 |
WO2012090860A1 (ja) * | 2010-12-27 | 2012-07-05 | 雪印メグミルク株式会社 | ミルクセラミド含有食品及びその製造方法 |
JP2016094466A (ja) * | 2016-02-01 | 2016-05-26 | 花王株式会社 | 運動機能改善剤 |
KR20220123222A (ko) * | 2019-12-26 | 2022-09-06 | 마루하 니치로 가부시키가이샤 | 다가 불포화 지방산이 결합한 인지질을 포함하는 어란 지질 조성물 |
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CN101166429A (zh) * | 2005-04-13 | 2008-04-23 | 雪印乳业株式会社 | 营养组合物 |
AU2007279674B2 (en) * | 2006-08-04 | 2013-10-03 | Megmilk Snow Brand Co., Ltd. | Agent for preventing infection |
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Also Published As
Publication number | Publication date |
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NZ550269A (en) | 2010-05-28 |
HK1105361A1 (en) | 2008-02-15 |
KR101094693B1 (ko) | 2011-12-20 |
EP1736159A4 (en) | 2009-07-29 |
EP1736159A1 (en) | 2006-12-27 |
AU2005228742B2 (en) | 2011-07-28 |
KR20070002062A (ko) | 2007-01-04 |
PT1736159E (pt) | 2013-04-03 |
CN1997376A (zh) | 2007-07-11 |
CN1997376B (zh) | 2011-05-11 |
EP1736159B1 (en) | 2013-01-09 |
WO2005094839A1 (ja) | 2005-10-13 |
CA2561729C (en) | 2013-10-15 |
US20110065670A1 (en) | 2011-03-17 |
DK1736159T3 (da) | 2013-02-11 |
ES2402299T3 (es) | 2013-04-30 |
AU2005228742A1 (en) | 2005-10-13 |
CA2561729A1 (en) | 2005-10-13 |
US20080064664A1 (en) | 2008-03-13 |
US8920822B2 (en) | 2014-12-30 |
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