JP2004538280A5 - - Google Patents

Download PDF

Info

Publication number
JP2004538280A5
JP2004538280A5 JP2003513549A JP2003513549A JP2004538280A5 JP 2004538280 A5 JP2004538280 A5 JP 2004538280A5 JP 2003513549 A JP2003513549 A JP 2003513549A JP 2003513549 A JP2003513549 A JP 2003513549A JP 2004538280 A5 JP2004538280 A5 JP 2004538280A5
Authority
JP
Japan
Prior art keywords
hydrogen
alkyl
nso
tetrazol
remainder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2003513549A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004538280A (ja
JP4211605B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2002/007733 external-priority patent/WO2003007941A1/en
Publication of JP2004538280A publication Critical patent/JP2004538280A/ja
Publication of JP2004538280A5 publication Critical patent/JP2004538280A5/ja
Application granted granted Critical
Publication of JP4211605B2 publication Critical patent/JP4211605B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2003513549A 2001-07-16 2002-07-11 プロスタノイドアゴニストとしての２ピロリドン誘導体 Expired - Fee Related JP4211605B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30576201P 2001-07-16 2001-07-16
PCT/EP2002/007733 WO2003007941A1 (en) 2001-07-16 2002-07-11 2 pyrrolidone derivatives as prostanoid agonists

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008155799A Division JP5003601B2 (ja) 2001-07-16 2008-06-13 プロスタノイドアゴニストとしての２ピロリドン誘導体

Publications (3)

Publication Number Publication Date
JP2004538280A JP2004538280A (ja) 2004-12-24
JP2004538280A5 true JP2004538280A5 (enExample) 2008-10-30
JP4211605B2 JP4211605B2 (ja) 2009-01-21

Family

ID=23182225

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2003513549A Expired - Fee Related JP4211605B2 (ja) 2001-07-16 2002-07-11 プロスタノイドアゴニストとしての２ピロリドン誘導体
JP2008155799A Expired - Fee Related JP5003601B2 (ja) 2001-07-16 2008-06-13 プロスタノイドアゴニストとしての２ピロリドン誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008155799A Expired - Fee Related JP5003601B2 (ja) 2001-07-16 2008-06-13 プロスタノイドアゴニストとしての２ピロリドン誘導体

Country Status (20)

Country Link
US (1) US6849657B2 (enExample)
EP (1) EP1408961B1 (enExample)
JP (2) JP4211605B2 (enExample)
KR (1) KR100702368B1 (enExample)
CN (1) CN100371322C (enExample)
AT (1) ATE366571T1 (enExample)
AU (1) AU2002328338C1 (enExample)
BR (1) BR0211167A (enExample)
CA (1) CA2451393C (enExample)
DE (1) DE60221130T2 (enExample)
DK (1) DK1408961T3 (enExample)
ES (1) ES2289140T3 (enExample)
GT (1) GT200200152A (enExample)
MX (1) MXPA04000454A (enExample)
PA (1) PA8550501A1 (enExample)
PE (1) PE20030286A1 (enExample)
PL (1) PL215425B1 (enExample)
PT (1) PT1408961E (enExample)
RU (1) RU2296122C2 (enExample)
WO (1) WO2003007941A1 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1408961B1 (en) * 2001-07-16 2007-07-11 F. Hoffmann-La Roche Ag 2 pyrrolidone derivatives as prostanoid agonists
CN101921220B (zh) 2001-07-23 2013-05-22 小野药品工业株式会社 治疗与骨质损失有关的疾病的含有ep4激动剂作为活性成分的药物组合物
CA2466751A1 (en) * 2001-12-03 2003-06-12 Merck And Co., Inc. Ep4 receptor agonist, compositions and methods thereof
EP1481976B1 (en) 2002-03-05 2012-11-07 Ono Pharmaceutical Co., Ltd. 8-azaprostaglandin derivative compounds and drugs containing the compounds as the active ingredient
US6573294B1 (en) 2002-05-14 2003-06-03 Allergan, Inc. 8-azaprostaglandin analogs as agents for lowering intraocular pressure
CA2483555A1 (en) 2002-06-10 2003-12-18 Applied Research Systems Ars Holding N.V. Gamma lactams as prostaglandin agonists and use thereof
US8114391B2 (en) 2002-12-26 2012-02-14 Dow Corning Toray Company, Ltd. Hair care composition
BRPI0406717A (pt) 2003-01-10 2005-12-20 Hoffmann La Roche Composto, composição farmacêutica que compreende o mesmo, método de tratamento de uma enfermidade em um mamìfero, utilização do composto e processo para a sua produção
CA2513652A1 (en) * 2003-03-03 2004-09-16 Applied Research Systems Ars Holding N.V. G-lactam derivatives as prostaglandin agonists
US6734206B1 (en) * 2003-06-02 2004-05-11 Allergan, Inc. 3-oxa-8-azaprostaglandin analogs as agents for lowering intraocular pressure
US6734201B1 (en) 2003-06-02 2004-05-11 Allergan, Inc. 8-Azaprostaglandin carbonate and thiocarbonate analogs as therapeutic agents
WO2005121086A2 (en) * 2004-06-04 2005-12-22 Allergan, Inc. Piperidinyl prostaglandin analogs as ocular hypotensive agents
ES2336933T3 (es) 2004-12-06 2010-04-19 Merck Serono Sa Derivados de pirrolidin-2-ona para usar como antagonistas del receptor dp1.
US7531533B2 (en) 2005-01-27 2009-05-12 Asahi Kasei Pharma Corporation 6-Membered heterocyclic compound and use thereof
KR100890490B1 (ko) * 2005-01-27 2009-03-26 아사히 가세이 파마 가부시키가이샤 헤테로 6원환 화합물 및 그의 용도
US8524731B2 (en) * 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8372912B2 (en) * 2005-08-12 2013-02-12 Eastman Chemical Company Polyvinyl chloride compositions
CN101511958B (zh) * 2006-08-30 2012-09-05 伊士曼化工公司 乙酸乙烯酯聚合物组合物中作为增塑剂的对苯二甲酸酯
US8784989B2 (en) 2006-08-30 2014-07-22 Eastman Chemical Company Sealant compositions having a novel plasticizer
AU2008246579A1 (en) 2007-05-08 2008-11-13 National University Corporation, Hamamatsu University School Of Medicine Cytotoxic T cell activator comprising EP4 agonist
US20120142684A1 (en) * 2010-12-02 2012-06-07 Allergan, Inc. Compounds and methods for skin repair
SG2014007603A (en) 2011-08-02 2014-03-28 Ono Pharmaceutical Co Left ventricular diastolic function improving agent
HUE031885T2 (en) 2012-07-19 2017-08-28 Cayman Chemical Co Inc Difluoro lactam preparations for EP4-mediated osteo-related diseases and conditions
WO2014144500A2 (en) 2013-03-15 2014-09-18 Cayman Chemical Company, Inc. Methods of synthesizing a difluorolactam analog
US9676712B2 (en) 2013-03-15 2017-06-13 Cayman Chemical Company, Inc. Lactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions
ES2635635T3 (es) 2013-03-15 2017-10-04 Cayman Chemical Company, Incorporated Compuestos de difluorolactama como agonistas selectivos del receptor EP4 para su uso en el tratamiento de enfermedades y afecciones mediadas por EP4
KR20160048054A (ko) 2013-07-19 2016-05-03 카이맨 케미칼 컴파니 인코포레이티드 골 성장의 촉진을 위한 방법, 시스템 및 조성물
US10988468B2 (en) 2017-12-25 2021-04-27 Asahi Kasei Pharma Corporation Nitrogen-containing 6-membered cyclic compound

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3975399A (en) * 1974-08-06 1976-08-17 E. I. Du Pont De Nemours And Company 1,5-Disubstituted-2-pyrrolidinones, -3-pyrrolin-2-ones, and -4-pyrrolin-2-ones
US4113873A (en) * 1975-04-26 1978-09-12 Tanabe Seiyaku Co. Ltd. 8-azaprostanoic acid derivatives
NL7604330A (nl) * 1975-04-28 1976-11-01 Syntex Inc Werkwijze voor de bereiding van 8-azaprostaan- zuurderivaten.
DE2528664A1 (de) 1975-06-27 1977-01-13 Hoechst Ag Pyrrolidone und verfahren zu ihrer herstellung
DE2556326A1 (de) 1975-12-13 1977-06-23 Hoechst Ag Neue pyrrolidone und verfahren zu ihrer herstellung
IL49325A (en) * 1976-03-31 1979-11-30 Labaz 8-aza-11-deoxy-pge1 derivatives,their preparation and pharmaceutical compositions containing them
DE2619638A1 (de) 1976-05-04 1977-11-17 Hoechst Ag Pyrrolidone und verfahren zu ihrer herstellung
US4177346A (en) * 1976-08-06 1979-12-04 Pfizer Inc. 1,5-Disubstituted-2-pyrrolidones
US4320136A (en) * 1980-08-11 1982-03-16 E. I. Du Pont De Nemours And Company 8-Aza-16,16-difluoroprostanoids
JP2571250B2 (ja) * 1987-01-19 1997-01-16 三共株式会社 プロスタグランジン化合物
SE9702681D0 (sv) * 1997-07-10 1997-07-10 Pharmacia & Upjohn Ab Method and composition for treatment of impotence
TWI249520B (en) * 1998-07-15 2006-02-21 Ono Pharmaceutical Co 5-Thia-omega-substituted phenyl prostaglandin E derivatives, method for producing the same and medicines containing the same as the active ingredient
AU6427599A (en) 1998-10-15 2000-05-01 Merck & Co., Inc. Methods for stimulating bone formation
CA2346038A1 (en) 1998-10-15 2000-04-20 Merck & Co., Inc. Methods for inhibiting bone resorption
US6211226B1 (en) * 1998-12-17 2001-04-03 Alcon Laboratories, Inc. 11-Aza prostaglandins for the treatment of glaucoma and ocular hypertension
TWI247606B (en) * 1999-11-24 2006-01-21 Ono Pharmaceutical Co Treating agent for osteopenic diseases
PL356662A1 (en) 1999-12-22 2004-06-28 Pfizer Products Inc. Ep4 receptor selective agonists in the treatment of osteoporosis
PT1132086E (pt) * 2000-01-31 2006-09-29 Pfizer Prod Inc Utilizacao de agonistas selectivos para o receptor da prostaglandina (pge2) 4 (ep4) para o tratamento de falha renal aguda e cronica
AU2001235990A1 (en) * 2000-02-28 2001-09-03 Fumie Sato Prostaglandin e derivatives
AU2001290250A1 (en) 2000-09-21 2002-04-02 Ono Pharmaceutical Co. Ltd. Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient
NZ525164A (en) * 2000-11-27 2005-04-29 Pfizer Prod Inc EP4 receptor selective agonists in the treatment of osteoporosis
EP1408961B1 (en) * 2001-07-16 2007-07-11 F. Hoffmann-La Roche Ag 2 pyrrolidone derivatives as prostanoid agonists

Similar Documents

Publication Publication Date Title
JPH1180090A5 (enExample)
JP2007510619A5 (enExample)
JP2002060340A5 (enExample)
JP2003510305A5 (enExample)
JP2003530368A5 (enExample)
JP2007503487A5 (enExample)
JP2003531118A5 (enExample)
JP2007503405A5 (enExample)
JP2002541233A5 (enExample)
JP2000086767A5 (enExample)
JP2003508388A5 (enExample)
JP2002332234A5 (enExample)
JP2002518384A5 (enExample)
JP2006514114A5 (enExample)
CA2153979A1 (en) Compounds having both potent calcium antagonist and antioxidant activity and use thereof as cytoprotective agents
JP2001523712A5 (enExample)
JP2003199728A5 (enExample)
JP2003534359A5 (enExample)
JP2003508534A5 (enExample)
JP2006503143A5 (enExample)
JP2005533904A5 (enExample)
JP2003506447A5 (enExample)
EP1236744A3 (en) Guanidin-group containing polymer, cosmetic employing same and method of preparing same
JP2001510866A5 (enExample)
RU94019411A (ru) Эфиры хинук лидина, промежуточные соединения для их синтеза, фармацевтическая композиция и способ лечения