RU2296122C2 - Производные 2-пирролидона в качестве простаноидных агонистов и фармацевтическая композиция - Google Patents

Производные 2-пирролидона в качестве простаноидных агонистов и фармацевтическая композиция Download PDF

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RU2296122C2
RU2296122C2 RU2004104627/04A RU2004104627A RU2296122C2 RU 2296122 C2 RU2296122 C2 RU 2296122C2 RU 2004104627/04 A RU2004104627/04 A RU 2004104627/04A RU 2004104627 A RU2004104627 A RU 2004104627A RU 2296122 C2 RU2296122 C2 RU 2296122C2
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oxopyrrolidin
enyl
acid
hydroxyoct
derivatives
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RU2004104627/04A
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Russian (ru)
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RU2004104627A (ru
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Тодд Ричард ЭЛУОРТИ (US)
Тодд Ричард ЭЛУОРТИ
Майкл Гаррет РОПЕЛ (US)
Майкл Гаррет РОПЕЛ
Дейвид Бернард СМИТ (US)
Дейвид Бернард СМИТ
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Ф.Хоффманн-Ля Рош Аг
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
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    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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RU2004104627/04A 2001-07-16 2002-07-11 Производные 2-пирролидона в качестве простаноидных агонистов и фармацевтическая композиция RU2296122C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30576201P 2001-07-16 2001-07-16
US60/305,762 2001-07-16

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RU2004104627A RU2004104627A (ru) 2005-07-10
RU2296122C2 true RU2296122C2 (ru) 2007-03-27

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US (1) US6849657B2 (enExample)
EP (1) EP1408961B1 (enExample)
JP (2) JP4211605B2 (enExample)
KR (1) KR100702368B1 (enExample)
CN (1) CN100371322C (enExample)
AT (1) ATE366571T1 (enExample)
AU (1) AU2002328338C1 (enExample)
BR (1) BR0211167A (enExample)
CA (1) CA2451393C (enExample)
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PE (1) PE20030286A1 (enExample)
PL (1) PL215425B1 (enExample)
PT (1) PT1408961E (enExample)
RU (1) RU2296122C2 (enExample)
WO (1) WO2003007941A1 (enExample)

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CA2661168C (en) * 2006-08-30 2011-11-08 Eastman Chemical Company Terephthalates as plasticizers in vinyl acetate polymer compositions
CN101686985A (zh) 2007-05-08 2010-03-31 国立大学法人浜松医科大学 含有ep4激动剂的细胞毒性t细胞的活化剂
US20120142684A1 (en) * 2010-12-02 2012-06-07 Allergan, Inc. Compounds and methods for skin repair
US9682065B2 (en) 2011-08-02 2017-06-20 Ono Pharmaceutical Co., Ltd. Left ventricular diastolic function improving agent
EP2875022B1 (en) 2012-07-19 2016-10-12 Cayman Chemical Company, Incorporated Difluorolactam compounds as ep4 receptor-selective agonists for use in the treatment of ep4-mediated disease and conditions
PT2989098T (pt) 2013-03-15 2017-08-16 Cayman Chemical Co Inc Compostos de lactama como agonistas selectivos do receptor ep4 para uso no tratamento de doenças e condições mediadas por ep4
WO2014144500A2 (en) 2013-03-15 2014-09-18 Cayman Chemical Company, Inc. Methods of synthesizing a difluorolactam analog
WO2014144610A1 (en) 2013-03-15 2014-09-18 Cayman Chemical Company, Inc. Lactam compounds as ep4 receptor-selective agonists for use in the treatment of ep4-mediated diseases and conditions
CN105392505A (zh) 2013-07-19 2016-03-09 开曼化学股份有限公司 用于促进骨生长的方法、系统和组合物
PL3733665T3 (pl) 2017-12-25 2023-02-06 Asahi Kasei Pharma Corporation Związki zawierające ugrupowanie 2-okso-1,3,4-tiadiazynan-3-ylowe mające aktywność agonisty receptora EP4
WO2025115896A1 (ja) 2023-11-28 2025-06-05 小野薬品工業株式会社 Ｅｐ４アゴニスト

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GT200200152A (es) 2003-06-19
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BR0211167A (pt) 2004-08-10
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JP2008303222A (ja) 2008-12-18
PE20030286A1 (es) 2003-03-25
PL367696A1 (en) 2005-03-07
JP2004538280A (ja) 2004-12-24
CN1529593A (zh) 2004-09-15
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PT1408961E (pt) 2007-10-10
US20030064964A1 (en) 2003-04-03
CA2451393C (en) 2011-01-04
ATE366571T1 (de) 2007-08-15
AU2002328338B2 (en) 2008-04-24
KR20040017317A (ko) 2004-02-26
AU2002328338C1 (en) 2009-01-08
JP5003601B2 (ja) 2012-08-15
KR100702368B1 (ko) 2007-04-02
CA2451393A1 (en) 2003-01-30
RU2004104627A (ru) 2005-07-10
PA8550501A1 (es) 2003-06-30
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US6849657B2 (en) 2005-02-01
EP1408961A1 (en) 2004-04-21

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