RU2296122C2 - Производные 2-пирролидона в качестве простаноидных агонистов и фармацевтическая композиция - Google Patents
Производные 2-пирролидона в качестве простаноидных агонистов и фармацевтическая композиция Download PDFInfo
- Publication number
- RU2296122C2 RU2296122C2 RU2004104627/04A RU2004104627A RU2296122C2 RU 2296122 C2 RU2296122 C2 RU 2296122C2 RU 2004104627/04 A RU2004104627/04 A RU 2004104627/04A RU 2004104627 A RU2004104627 A RU 2004104627A RU 2296122 C2 RU2296122 C2 RU 2296122C2
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- Prior art keywords
- oxopyrrolidin
- enyl
- acid
- hydroxyoct
- derivatives
- Prior art date
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- 0 ***BON(C(*C(*)(*)O)C(*)(*)C1(*)*)C1=O Chemical compound ***BON(C(*C(*)(*)O)C(*)(*)C1(*)*)C1=O 0.000 description 1
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Vascular Medicine (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30576201P | 2001-07-16 | 2001-07-16 | |
| US60/305,762 | 2001-07-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2004104627A RU2004104627A (ru) | 2005-07-10 |
| RU2296122C2 true RU2296122C2 (ru) | 2007-03-27 |
Family
ID=23182225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004104627/04A RU2296122C2 (ru) | 2001-07-16 | 2002-07-11 | Производные 2-пирролидона в качестве простаноидных агонистов и фармацевтическая композиция |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6849657B2 (enExample) |
| EP (1) | EP1408961B1 (enExample) |
| JP (2) | JP4211605B2 (enExample) |
| KR (1) | KR100702368B1 (enExample) |
| CN (1) | CN100371322C (enExample) |
| AT (1) | ATE366571T1 (enExample) |
| AU (1) | AU2002328338C1 (enExample) |
| BR (1) | BR0211167A (enExample) |
| CA (1) | CA2451393C (enExample) |
| DE (1) | DE60221130T2 (enExample) |
| DK (1) | DK1408961T3 (enExample) |
| ES (1) | ES2289140T3 (enExample) |
| GT (1) | GT200200152A (enExample) |
| MX (1) | MXPA04000454A (enExample) |
| PA (1) | PA8550501A1 (enExample) |
| PE (1) | PE20030286A1 (enExample) |
| PL (1) | PL215425B1 (enExample) |
| PT (1) | PT1408961E (enExample) |
| RU (1) | RU2296122C2 (enExample) |
| WO (1) | WO2003007941A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2296122C2 (ru) * | 2001-07-16 | 2007-03-27 | Ф.Хоффманн-Ля Рош Аг | Производные 2-пирролидона в качестве простаноидных агонистов и фармацевтическая композиция |
| KR100826866B1 (ko) * | 2001-07-23 | 2008-05-06 | 오노 야꾸힝 고교 가부시키가이샤 | Ep4 아고니스트를 유효 성분으로 하는 골량 저하질환의 치료제 |
| CA2466751A1 (en) * | 2001-12-03 | 2003-06-12 | Merck And Co., Inc. | Ep4 receptor agonist, compositions and methods thereof |
| KR100704215B1 (ko) * | 2002-03-05 | 2007-04-10 | 오노 야꾸힝 고교 가부시키가이샤 | 8-아자프로스타글란딘 유도체 화합물 및 그 화합물을 유효성분으로서 함유하는 약제 |
| US6573294B1 (en) | 2002-05-14 | 2003-06-03 | Allergan, Inc. | 8-azaprostaglandin analogs as agents for lowering intraocular pressure |
| AU2003237520B2 (en) | 2002-06-10 | 2009-01-08 | Laboratoires Serono Sa | Gamma lactams as prostaglandin agonists and use thereof |
| AU2003292751A1 (en) | 2002-12-26 | 2004-07-22 | Dow Corning Toray Silicone Co., Ltd. | Hair care composition |
| JP2006515015A (ja) * | 2003-01-10 | 2006-05-18 | エフ.ホフマン−ラ ロシュ アーゲー | プロスタグランジンアゴニストとしての2−ピペリドン誘導体 |
| AU2004216857A1 (en) * | 2003-03-03 | 2004-09-16 | Laboratoires Serono Sa | G-lactam derivatives as prostaglandin agonists |
| US6734201B1 (en) | 2003-06-02 | 2004-05-11 | Allergan, Inc. | 8-Azaprostaglandin carbonate and thiocarbonate analogs as therapeutic agents |
| US6734206B1 (en) * | 2003-06-02 | 2004-05-11 | Allergan, Inc. | 3-oxa-8-azaprostaglandin analogs as agents for lowering intraocular pressure |
| CA2569464C (en) * | 2004-06-04 | 2012-10-23 | Allergan, Inc. | 5-thio-piperdinyl prostaglandin e analogs |
| EP1824819B1 (en) | 2004-12-06 | 2010-01-20 | Merck Serono SA | Pyrrolidin-2-one derivatives for use as dp1 receptor agonists |
| US7531533B2 (en) | 2005-01-27 | 2009-05-12 | Asahi Kasei Pharma Corporation | 6-Membered heterocyclic compound and use thereof |
| KR100890490B1 (ko) * | 2005-01-27 | 2009-03-26 | 아사히 가세이 파마 가부시키가이샤 | 헤테로 6원환 화합물 및 그의 용도 |
| US8524731B2 (en) * | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US8372912B2 (en) * | 2005-08-12 | 2013-02-12 | Eastman Chemical Company | Polyvinyl chloride compositions |
| WO2008027435A1 (en) * | 2006-08-30 | 2008-03-06 | Eastman Chemical Company | Terephthalates as plasticizers in vinyl acetate polymer compositions |
| CA2661173C (en) | 2006-08-30 | 2012-08-28 | Eastman Chemical Company | Sealant compositions having a novel plasticizer |
| MX2009012043A (es) | 2007-05-08 | 2010-02-18 | Nat Univ Corp Hamamatsu | Activador de celulas t citotoxicas que comprende agonista ep4. |
| US20120142684A1 (en) * | 2010-12-02 | 2012-06-07 | Allergan, Inc. | Compounds and methods for skin repair |
| AU2012290987B2 (en) | 2011-08-02 | 2017-04-20 | Ono Pharmaceutical Co., Ltd. | Left ventricular diastolic function improving agent |
| CN107802623B (zh) | 2012-07-19 | 2020-10-30 | 开曼化学股份有限公司 | 用于ep4介导的骨相关疾病和病症的二氟内酰胺组合物 |
| US9914725B2 (en) | 2013-03-15 | 2018-03-13 | Cayman Chemical Company, Inc. | Methods of synthesizing a difluorolactam analog |
| ES2635635T3 (es) | 2013-03-15 | 2017-10-04 | Cayman Chemical Company, Incorporated | Compuestos de difluorolactama como agonistas selectivos del receptor EP4 para su uso en el tratamiento de enfermedades y afecciones mediadas por EP4 |
| WO2014144610A1 (en) | 2013-03-15 | 2014-09-18 | Cayman Chemical Company, Inc. | Lactam compounds as ep4 receptor-selective agonists for use in the treatment of ep4-mediated diseases and conditions |
| EP3021879A2 (en) | 2013-07-19 | 2016-05-25 | Cayman Chemical Company, Incorporated | Methods, systems, and compositions for promoting bone growth |
| AU2018396402C1 (en) | 2017-12-25 | 2021-03-18 | Asahi Kasei Pharma Corporation | Nitrogen-containing 6-membered cyclic compound |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE841165A (fr) * | 1975-04-28 | 1976-10-27 | Derives d'acides 8-aza-prostanoiques et leur procede de preparation | |
| SU837321A3 (ru) * | 1976-03-31 | 1981-06-07 | Лябаз С.А. (Фирма) | Способ получени производныхпРОСТАглАНдиНА |
| US6211226B1 (en) * | 1998-12-17 | 2001-04-03 | Alcon Laboratories, Inc. | 11-Aza prostaglandins for the treatment of glaucoma and ocular hypertension |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3975399A (en) | 1974-08-06 | 1976-08-17 | E. I. Du Pont De Nemours And Company | 1,5-Disubstituted-2-pyrrolidinones, -3-pyrrolin-2-ones, and -4-pyrrolin-2-ones |
| US4113873A (en) | 1975-04-26 | 1978-09-12 | Tanabe Seiyaku Co. Ltd. | 8-azaprostanoic acid derivatives |
| DE2528664A1 (de) | 1975-06-27 | 1977-01-13 | Hoechst Ag | Pyrrolidone und verfahren zu ihrer herstellung |
| DE2556326A1 (de) | 1975-12-13 | 1977-06-23 | Hoechst Ag | Neue pyrrolidone und verfahren zu ihrer herstellung |
| DE2619638A1 (de) | 1976-05-04 | 1977-11-17 | Hoechst Ag | Pyrrolidone und verfahren zu ihrer herstellung |
| US4177346A (en) | 1976-08-06 | 1979-12-04 | Pfizer Inc. | 1,5-Disubstituted-2-pyrrolidones |
| US4320136A (en) | 1980-08-11 | 1982-03-16 | E. I. Du Pont De Nemours And Company | 8-Aza-16,16-difluoroprostanoids |
| JP2571250B2 (ja) * | 1987-01-19 | 1997-01-16 | 三共株式会社 | プロスタグランジン化合物 |
| SE9702681D0 (sv) * | 1997-07-10 | 1997-07-10 | Pharmacia & Upjohn Ab | Method and composition for treatment of impotence |
| TWI249520B (en) * | 1998-07-15 | 2006-02-21 | Ono Pharmaceutical Co | 5-Thia-omega-substituted phenyl prostaglandin E derivatives, method for producing the same and medicines containing the same as the active ingredient |
| CA2346038A1 (en) | 1998-10-15 | 2000-04-20 | Merck & Co., Inc. | Methods for inhibiting bone resorption |
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| EP1132086B1 (en) * | 2000-01-31 | 2006-05-31 | Pfizer Products Inc. | Use of prostaglandin (PGE2) receptor 4 (EP4) selective agonists for the treatment of acute and chronic renal failure |
| AU2001235990A1 (en) * | 2000-02-28 | 2001-09-03 | Fumie Sato | Prostaglandin e derivatives |
| AU2001290250A1 (en) | 2000-09-21 | 2002-04-02 | Ono Pharmaceutical Co. Ltd. | Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient |
| OA12533A (en) * | 2000-11-27 | 2006-06-05 | Pfizer Prod Inc | Ep4 receptor selective agonists in the treatment of osteoporosis. |
| RU2296122C2 (ru) * | 2001-07-16 | 2007-03-27 | Ф.Хоффманн-Ля Рош Аг | Производные 2-пирролидона в качестве простаноидных агонистов и фармацевтическая композиция |
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2002
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- 2002-07-11 CA CA2451393A patent/CA2451393C/en not_active Expired - Fee Related
- 2002-07-11 AU AU2002328338A patent/AU2002328338C1/en not_active Ceased
- 2002-07-11 PT PT02762347T patent/PT1408961E/pt unknown
- 2002-07-11 PL PL367696A patent/PL215425B1/pl not_active IP Right Cessation
- 2002-07-11 EP EP02762347A patent/EP1408961B1/en not_active Expired - Lifetime
- 2002-07-11 WO PCT/EP2002/007733 patent/WO2003007941A1/en not_active Ceased
- 2002-07-11 JP JP2003513549A patent/JP4211605B2/ja not_active Expired - Fee Related
- 2002-07-11 CN CNB028142675A patent/CN100371322C/zh not_active Expired - Fee Related
- 2002-07-11 ES ES02762347T patent/ES2289140T3/es not_active Expired - Lifetime
- 2002-07-11 DK DK02762347T patent/DK1408961T3/da active
- 2002-07-11 KR KR1020047000756A patent/KR100702368B1/ko not_active Expired - Fee Related
- 2002-07-11 BR BR0211167-5A patent/BR0211167A/pt not_active IP Right Cessation
- 2002-07-11 AT AT02762347T patent/ATE366571T1/de active
- 2002-07-11 MX MXPA04000454A patent/MXPA04000454A/es active IP Right Grant
- 2002-07-11 DE DE60221130T patent/DE60221130T2/de not_active Expired - Lifetime
- 2002-07-15 PA PA20028550501A patent/PA8550501A1/es unknown
- 2002-07-15 PE PE2002000629A patent/PE20030286A1/es not_active Application Discontinuation
- 2002-07-15 GT GT200200152A patent/GT200200152A/es unknown
- 2002-07-16 US US10/197,279 patent/US6849657B2/en not_active Expired - Lifetime
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| BE841165A (fr) * | 1975-04-28 | 1976-10-27 | Derives d'acides 8-aza-prostanoiques et leur procede de preparation | |
| SU837321A3 (ru) * | 1976-03-31 | 1981-06-07 | Лябаз С.А. (Фирма) | Способ получени производныхпРОСТАглАНдиНА |
| US6211226B1 (en) * | 1998-12-17 | 2001-04-03 | Alcon Laboratories, Inc. | 11-Aza prostaglandins for the treatment of glaucoma and ocular hypertension |
Also Published As
| Publication number | Publication date |
|---|---|
| US6849657B2 (en) | 2005-02-01 |
| PE20030286A1 (es) | 2003-03-25 |
| PT1408961E (pt) | 2007-10-10 |
| DE60221130D1 (de) | 2007-08-23 |
| DE60221130T2 (de) | 2008-03-13 |
| JP5003601B2 (ja) | 2012-08-15 |
| CA2451393C (en) | 2011-01-04 |
| KR20040017317A (ko) | 2004-02-26 |
| MXPA04000454A (es) | 2004-03-18 |
| WO2003007941A1 (en) | 2003-01-30 |
| PA8550501A1 (es) | 2003-06-30 |
| CN1529593A (zh) | 2004-09-15 |
| GT200200152A (es) | 2003-06-19 |
| PL367696A1 (en) | 2005-03-07 |
| EP1408961A1 (en) | 2004-04-21 |
| CA2451393A1 (en) | 2003-01-30 |
| KR100702368B1 (ko) | 2007-04-02 |
| ES2289140T3 (es) | 2008-02-01 |
| JP4211605B2 (ja) | 2009-01-21 |
| DK1408961T3 (da) | 2007-11-05 |
| CN100371322C (zh) | 2008-02-27 |
| AU2002328338C1 (en) | 2009-01-08 |
| RU2004104627A (ru) | 2005-07-10 |
| JP2008303222A (ja) | 2008-12-18 |
| ATE366571T1 (de) | 2007-08-15 |
| JP2004538280A (ja) | 2004-12-24 |
| PL215425B1 (pl) | 2013-12-31 |
| EP1408961B1 (en) | 2007-07-11 |
| AU2002328338B2 (en) | 2008-04-24 |
| US20030064964A1 (en) | 2003-04-03 |
| BR0211167A (pt) | 2004-08-10 |
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