JP2004537284A5 - - Google Patents
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- Publication number
- JP2004537284A5 JP2004537284A5 JP2002576908A JP2002576908A JP2004537284A5 JP 2004537284 A5 JP2004537284 A5 JP 2004537284A5 JP 2002576908 A JP2002576908 A JP 2002576908A JP 2002576908 A JP2002576908 A JP 2002576908A JP 2004537284 A5 JP2004537284 A5 JP 2004537284A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- seq
- vke
- ppk
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004169 proteins and genes Human genes 0.000 claims 28
- 108090000623 proteins and genes Proteins 0.000 claims 28
- 238000000034 method Methods 0.000 claims 15
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 239000003112 inhibitor Substances 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 210000002919 epithelial cell Anatomy 0.000 claims 6
- 230000004936 stimulating effect Effects 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000007613 environmental effect Effects 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000002299 complementary DNA Substances 0.000 claims 3
- 210000000981 epithelium Anatomy 0.000 claims 3
- 230000002496 gastric effect Effects 0.000 claims 3
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 2
- 108020004511 Recombinant DNA Proteins 0.000 claims 2
- 230000010261 cell growth Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 230000012010 growth Effects 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 102000003839 Human Proteins Human genes 0.000 claims 1
- 108090000144 Human Proteins Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000010393 epithelial cell migration Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/821,726 US6734289B2 (en) | 2001-03-29 | 2001-03-29 | Gastrokines and derived peptides including inhibitors |
| PCT/US2002/009885 WO2002078640A2 (en) | 2001-03-29 | 2002-03-29 | Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007121196A Division JP2007217422A (ja) | 2001-03-29 | 2007-05-01 | ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004537284A JP2004537284A (ja) | 2004-12-16 |
| JP2004537284A5 true JP2004537284A5 (OSRAM) | 2005-08-18 |
| JP4281947B2 JP4281947B2 (ja) | 2009-06-17 |
Family
ID=25234151
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002576908A Expired - Fee Related JP4281947B2 (ja) | 2001-03-29 | 2002-03-29 | ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節 |
| JP2002589626A Expired - Fee Related JP4295516B2 (ja) | 2001-03-29 | 2002-03-29 | ガストロカインおよびインヒビターを含むその誘導ペプチド |
| JP2007121196A Pending JP2007217422A (ja) | 2001-03-29 | 2007-05-01 | ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002589626A Expired - Fee Related JP4295516B2 (ja) | 2001-03-29 | 2002-03-29 | ガストロカインおよびインヒビターを含むその誘導ペプチド |
| JP2007121196A Pending JP2007217422A (ja) | 2001-03-29 | 2007-05-01 | ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US6734289B2 (OSRAM) |
| EP (2) | EP1423409A4 (OSRAM) |
| JP (3) | JP4281947B2 (OSRAM) |
| AT (1) | ATE446510T1 (OSRAM) |
| AU (2) | AU2002303199B2 (OSRAM) |
| CA (2) | CA2442635A1 (OSRAM) |
| DE (1) | DE60234103D1 (OSRAM) |
| ES (1) | ES2332882T3 (OSRAM) |
| MX (2) | MXPA03008855A (OSRAM) |
| WO (2) | WO2002078640A2 (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7629317B2 (en) * | 2001-03-29 | 2009-12-08 | The University Of Chicago | Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors |
| US6734289B2 (en) * | 2001-03-29 | 2004-05-11 | The University Of Chicago | Gastrokines and derived peptides including inhibitors |
| DE102004047968A1 (de) * | 2004-10-01 | 2006-04-06 | B.R.A.H.M.S Ag | Bestimmung von Gastrokine 1 (GKN1) als Biomarker für Entzündungen und Infektionen |
| AU2006244080C1 (en) * | 2005-05-10 | 2012-02-02 | The University Of Chicago | Use of peptides derived from the growth factor AMP-18 for the treatment of mucositis |
| US8017576B2 (en) * | 2005-05-10 | 2011-09-13 | The University Of Chicago | Methods and compositions to treat mucositis |
| CA2643736C (en) * | 2005-05-10 | 2015-06-23 | The University Of Chicago | Methods and compositions to treat mucositis |
| KR101423344B1 (ko) * | 2006-01-04 | 2014-07-30 | 백스터 인터내셔널 인코포레이티드 | 올리고펩티드-무함유 세포 배양 배지를 이용하여 단백질을 발현시키는 방법 |
| EP2082674A1 (en) | 2008-01-22 | 2009-07-29 | Trelleborg Building Systems AB | Waterproof sealing profile |
| US20100331827A1 (en) * | 2008-02-18 | 2010-12-30 | Koninklijke Philips Electronics N.V. | Administration of drugs to a patient |
| EP2943211A4 (en) | 2012-12-19 | 2017-01-25 | David Boone | Uses of a gastrokine protein |
| JP7438757B2 (ja) * | 2017-02-06 | 2024-02-27 | バイオテンプト・ベー・フェー | 治療用途のためのヒトｃペプチドとヒトエラスチン受容体との相互作用のペプチドモジュレーター |
| KR102590757B1 (ko) * | 2020-12-11 | 2023-10-17 | 가톨릭대학교 산학협력단 | GKN1(Gastrokine 1) 특이적 항체 및 이의 용도 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5476922A (en) | 1987-06-24 | 1995-12-19 | Arch Development Corporation | Methods and compositions for the preparation and use of autocrine growth factors |
| US5135856A (en) | 1987-06-24 | 1992-08-04 | Arch Development Corp. | Production of autocrine growth factors |
| US5102870A (en) | 1989-04-14 | 1992-04-07 | Schering Ag | Treatment and prevention of oral mucositis with growth factors |
| JP2938129B2 (ja) | 1989-05-02 | 1999-08-23 | 武田薬品工業株式会社 | 虚血性腎疾患の予防・治療剤 |
| US5644026A (en) * | 1994-05-03 | 1997-07-01 | La Jolla Cancer Research Foundation | Epitaxin, a cell motility factor |
| JPH08231413A (ja) | 1994-12-29 | 1996-09-10 | Mochida Pharmaceut Co Ltd | 臓器障害に基づく疾患の予防・治療剤 |
| JP3859710B2 (ja) | 1995-04-21 | 2006-12-20 | 三菱化学株式会社 | 虚血性疾患の予防及び／又は治療剤 |
| AU6229098A (en) * | 1997-02-21 | 1998-09-09 | Takara Shuzo Co., Ltd. | Cancer-associated genes |
| US20030068623A1 (en) * | 1997-06-16 | 2003-04-10 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| JP2003516709A (ja) * | 1997-08-06 | 2003-05-20 | ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー | 分泌蛋白およびそれらをコードするポリヌクレオチド |
| CA2331386A1 (en) | 1998-06-26 | 2000-01-06 | Incyte Pharmaceuticals, Inc. | Human signal peptide-containing proteins |
| ATE322681T1 (de) | 1999-01-21 | 2006-04-15 | Metamorphix Inc | Inhibitoren für wachstumdifferenzierungsfaktor und ihre anwendungen |
| AU3774300A (en) * | 1999-06-02 | 2000-12-18 | Genentech Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| ES2287020T3 (es) * | 1999-06-02 | 2007-12-16 | Genentech, Inc. | Procedimiento y composiciones para inhibir el crecimiento de celulas neoplasicas. |
| US7629317B2 (en) | 2001-03-29 | 2009-12-08 | The University Of Chicago | Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors |
| US6734289B2 (en) | 2001-03-29 | 2004-05-11 | The University Of Chicago | Gastrokines and derived peptides including inhibitors |
| US8017576B2 (en) | 2005-05-10 | 2011-09-13 | The University Of Chicago | Methods and compositions to treat mucositis |
-
2001
- 2001-03-29 US US09/821,726 patent/US6734289B2/en not_active Expired - Lifetime
-
2002
- 2002-03-29 MX MXPA03008855A patent/MXPA03008855A/es active IP Right Grant
- 2002-03-29 AU AU2002303199A patent/AU2002303199B2/en not_active Ceased
- 2002-03-29 CA CA002442635A patent/CA2442635A1/en not_active Abandoned
- 2002-03-29 EP EP02731209A patent/EP1423409A4/en not_active Withdrawn
- 2002-03-29 JP JP2002576908A patent/JP4281947B2/ja not_active Expired - Fee Related
- 2002-03-29 WO PCT/US2002/009885 patent/WO2002078640A2/en not_active Ceased
- 2002-03-29 EP EP02728619A patent/EP1415154B1/en not_active Expired - Lifetime
- 2002-03-29 JP JP2002589626A patent/JP4295516B2/ja not_active Expired - Fee Related
- 2002-03-29 MX MXPA03008861A patent/MXPA03008861A/es active IP Right Grant
- 2002-03-29 ES ES02728619T patent/ES2332882T3/es not_active Expired - Lifetime
- 2002-03-29 DE DE60234103T patent/DE60234103D1/de not_active Expired - Lifetime
- 2002-03-29 US US10/473,524 patent/US7557083B2/en not_active Expired - Fee Related
- 2002-03-29 AU AU2002258663A patent/AU2002258663B2/en not_active Ceased
- 2002-03-29 WO PCT/US2002/010148 patent/WO2002092758A2/en not_active Ceased
- 2002-03-29 US US10/473,571 patent/US8278269B2/en not_active Expired - Fee Related
- 2002-03-29 CA CA2442684A patent/CA2442684C/en not_active Expired - Fee Related
- 2002-03-29 AT AT02728619T patent/ATE446510T1/de not_active IP Right Cessation
-
2007
- 2007-05-01 JP JP2007121196A patent/JP2007217422A/ja active Pending
-
2012
- 2012-08-30 US US13/599,417 patent/US8791068B2/en not_active Expired - Fee Related
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