JP2020127419A5 - - Google Patents
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- Publication number
- JP2020127419A5 JP2020127419A5 JP2020081545A JP2020081545A JP2020127419A5 JP 2020127419 A5 JP2020127419 A5 JP 2020127419A5 JP 2020081545 A JP2020081545 A JP 2020081545A JP 2020081545 A JP2020081545 A JP 2020081545A JP 2020127419 A5 JP2020127419 A5 JP 2020127419A5
- Authority
- JP
- Japan
- Prior art keywords
- analog
- seq
- shk
- analog according
- toxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 239000003053 toxin Substances 0.000 claims 6
- 231100000765 toxin Toxicity 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 208000023275 Autoimmune disease Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000010367 cloning Methods 0.000 claims 2
- 239000013599 cloning vector Substances 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 101100330292 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) cys-12 gene Proteins 0.000 claims 1
- 101100498071 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) cys-17 gene Proteins 0.000 claims 1
- 101100386053 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) cys-3 gene Proteins 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2014903189A AU2014903189A0 (en) | 2014-08-15 | Novel potassium channel blockers | |
| AU2014903189 | 2014-08-15 | ||
| JP2017508102A JP6847828B2 (ja) | 2014-08-15 | 2015-08-14 | 新規なカリウムチャネルブロッカー及び自己免疫疾患の治療におけるそれらの使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017508102A Division JP6847828B2 (ja) | 2014-08-15 | 2015-08-14 | 新規なカリウムチャネルブロッカー及び自己免疫疾患の治療におけるそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020127419A JP2020127419A (ja) | 2020-08-27 |
| JP2020127419A5 true JP2020127419A5 (OSRAM) | 2020-11-12 |
| JP6953579B2 JP6953579B2 (ja) | 2021-10-27 |
Family
ID=55303691
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017508102A Active JP6847828B2 (ja) | 2014-08-15 | 2015-08-14 | 新規なカリウムチャネルブロッカー及び自己免疫疾患の治療におけるそれらの使用 |
| JP2020081545A Active JP6953579B2 (ja) | 2014-08-15 | 2020-05-01 | 新規なカリウムチャネルブロッカー及び自己免疫疾患の治療におけるそれらの使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017508102A Active JP6847828B2 (ja) | 2014-08-15 | 2015-08-14 | 新規なカリウムチャネルブロッカー及び自己免疫疾患の治療におけるそれらの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10246496B2 (OSRAM) |
| EP (1) | EP3180365B1 (OSRAM) |
| JP (2) | JP6847828B2 (OSRAM) |
| AU (1) | AU2015303825B2 (OSRAM) |
| WO (1) | WO2016023072A1 (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6847828B2 (ja) * | 2014-08-15 | 2021-03-24 | モナッシュ ユニバーシティ | 新規なカリウムチャネルブロッカー及び自己免疫疾患の治療におけるそれらの使用 |
| KR102533290B1 (ko) * | 2022-04-14 | 2023-05-16 | 한국해양과학기술원 | 전압개폐 칼륨이온채널 억제 활성능을 갖는 펩타이드 |
| KR102553070B1 (ko) * | 2022-06-16 | 2023-07-07 | 한국해양과학기술원 | 전압개폐 칼륨이온채널 억제 활성능을 갖는 작은상자해파리 기원 펩타이드 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3090753A1 (en) * | 2004-10-07 | 2016-11-09 | The Regents of The University of California | Analogs of shk toxin and their uses in selective inhibition of kv1.3 potassium channels |
| TW200833840A (en) * | 2006-10-25 | 2008-08-16 | Amgen Inc | Toxin peptide therapeutic agents |
| CA2686216C (en) * | 2007-05-14 | 2016-04-12 | Universidad Nacional Autonoma De Mexico | Vm23 and vm24, two scorpion peptides that block human t-lymphocyte potassium channels (sub-type kv1.3) with high selectivity and decrease the in vivo dth-responses in rats |
| JP2012521360A (ja) * | 2009-03-20 | 2012-09-13 | アムジエン・インコーポレーテツド | Ｋｖ１．３の選択的かつ強力なペプチド阻害剤 |
| CA2838474A1 (en) * | 2011-06-06 | 2012-12-13 | Kineta One, Llc | Shk-based pharmaceutical compositions and methods of manufacturing and using the same |
| WO2014116937A1 (en) * | 2013-01-25 | 2014-07-31 | Janssen Biotech, Inc. | Kv1.3 antagonists and methods of use |
| JP6847828B2 (ja) * | 2014-08-15 | 2021-03-24 | モナッシュ ユニバーシティ | 新規なカリウムチャネルブロッカー及び自己免疫疾患の治療におけるそれらの使用 |
-
2015
- 2015-08-14 JP JP2017508102A patent/JP6847828B2/ja active Active
- 2015-08-14 US US15/503,841 patent/US10246496B2/en active Active
- 2015-08-14 EP EP15832619.9A patent/EP3180365B1/en active Active
- 2015-08-14 WO PCT/AU2015/000487 patent/WO2016023072A1/en not_active Ceased
- 2015-08-14 AU AU2015303825A patent/AU2015303825B2/en active Active
-
2020
- 2020-05-01 JP JP2020081545A patent/JP6953579B2/ja active Active
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