JP4281947B2 - ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節 - Google Patents

ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節 Download PDF

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Publication number
JP4281947B2
JP4281947B2 JP2002576908A JP2002576908A JP4281947B2 JP 4281947 B2 JP4281947 B2 JP 4281947B2 JP 2002576908 A JP2002576908 A JP 2002576908A JP 2002576908 A JP2002576908 A JP 2002576908A JP 4281947 B2 JP4281947 B2 JP 4281947B2
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Japan
Prior art keywords
protein
peptide
cells
seq
cell
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Expired - Fee Related
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JP2002576908A
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English (en)
Japanese (ja)
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JP2004537284A5 (OSRAM
JP2004537284A (ja
Inventor
ゲーリー エフ． トバック，
テレンス イー． マーティン，
マーガレット ウォルシュ−レイツ，
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University of Chicago
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University of Chicago
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2002576908A 2001-03-29 2002-03-29 ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節 Expired - Fee Related JP4281947B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/821,726 US6734289B2 (en) 2001-03-29 2001-03-29 Gastrokines and derived peptides including inhibitors
PCT/US2002/009885 WO2002078640A2 (en) 2001-03-29 2002-03-29 Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007121196A Division JP2007217422A (ja) 2001-03-29 2007-05-01 ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節

Publications (3)

Publication Number Publication Date
JP2004537284A JP2004537284A (ja) 2004-12-16
JP2004537284A5 JP2004537284A5 (OSRAM) 2005-08-18
JP4281947B2 true JP4281947B2 (ja) 2009-06-17

Family

ID=25234151

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2002576908A Expired - Fee Related JP4281947B2 (ja) 2001-03-29 2002-03-29 ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節
JP2002589626A Expired - Fee Related JP4295516B2 (ja) 2001-03-29 2002-03-29 ガストロカインおよびインヒビターを含むその誘導ペプチド
JP2007121196A Pending JP2007217422A (ja) 2001-03-29 2007-05-01 ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2002589626A Expired - Fee Related JP4295516B2 (ja) 2001-03-29 2002-03-29 ガストロカインおよびインヒビターを含むその誘導ペプチド
JP2007121196A Pending JP2007217422A (ja) 2001-03-29 2007-05-01 ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節

Country Status (10)

Country Link
US (4) US6734289B2 (OSRAM)
EP (2) EP1423409A4 (OSRAM)
JP (3) JP4281947B2 (OSRAM)
AT (1) ATE446510T1 (OSRAM)
AU (2) AU2002303199B2 (OSRAM)
CA (2) CA2442635A1 (OSRAM)
DE (1) DE60234103D1 (OSRAM)
ES (1) ES2332882T3 (OSRAM)
MX (2) MXPA03008855A (OSRAM)
WO (2) WO2002078640A2 (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7629317B2 (en) * 2001-03-29 2009-12-08 The University Of Chicago Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors
US6734289B2 (en) * 2001-03-29 2004-05-11 The University Of Chicago Gastrokines and derived peptides including inhibitors
DE102004047968A1 (de) * 2004-10-01 2006-04-06 B.R.A.H.M.S Ag Bestimmung von Gastrokine 1 (GKN1) als Biomarker für Entzündungen und Infektionen
AU2006244080C1 (en) * 2005-05-10 2012-02-02 The University Of Chicago Use of peptides derived from the growth factor AMP-18 for the treatment of mucositis
US8017576B2 (en) * 2005-05-10 2011-09-13 The University Of Chicago Methods and compositions to treat mucositis
CA2643736C (en) * 2005-05-10 2015-06-23 The University Of Chicago Methods and compositions to treat mucositis
KR101423344B1 (ko) * 2006-01-04 2014-07-30 백스터 인터내셔널 인코포레이티드 올리고펩티드-무함유 세포 배양 배지를 이용하여 단백질을 발현시키는 방법
EP2082674A1 (en) 2008-01-22 2009-07-29 Trelleborg Building Systems AB Waterproof sealing profile
US20100331827A1 (en) * 2008-02-18 2010-12-30 Koninklijke Philips Electronics N.V. Administration of drugs to a patient
EP2943211A4 (en) 2012-12-19 2017-01-25 David Boone Uses of a gastrokine protein
JP7438757B2 (ja) * 2017-02-06 2024-02-27 バイオテンプト・ベー・フェー 治療用途のためのヒトｃペプチドとヒトエラスチン受容体との相互作用のペプチドモジュレーター
KR102590757B1 (ko) * 2020-12-11 2023-10-17 가톨릭대학교 산학협력단 GKN1(Gastrokine 1) 특이적 항체 및 이의 용도

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5476922A (en) 1987-06-24 1995-12-19 Arch Development Corporation Methods and compositions for the preparation and use of autocrine growth factors
US5135856A (en) 1987-06-24 1992-08-04 Arch Development Corp. Production of autocrine growth factors
US5102870A (en) 1989-04-14 1992-04-07 Schering Ag Treatment and prevention of oral mucositis with growth factors
JP2938129B2 (ja) 1989-05-02 1999-08-23 武田薬品工業株式会社 虚血性腎疾患の予防・治療剤
US5644026A (en) * 1994-05-03 1997-07-01 La Jolla Cancer Research Foundation Epitaxin, a cell motility factor
JPH08231413A (ja) 1994-12-29 1996-09-10 Mochida Pharmaceut Co Ltd 臓器障害に基づく疾患の予防・治療剤
JP3859710B2 (ja) 1995-04-21 2006-12-20 三菱化学株式会社 虚血性疾患の予防及び／又は治療剤
AU6229098A (en) * 1997-02-21 1998-09-09 Takara Shuzo Co., Ltd. Cancer-associated genes
US20030068623A1 (en) * 1997-06-16 2003-04-10 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
JP2003516709A (ja) * 1997-08-06 2003-05-20 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー 分泌蛋白およびそれらをコードするポリヌクレオチド
CA2331386A1 (en) 1998-06-26 2000-01-06 Incyte Pharmaceuticals, Inc. Human signal peptide-containing proteins
ATE322681T1 (de) 1999-01-21 2006-04-15 Metamorphix Inc Inhibitoren für wachstumdifferenzierungsfaktor und ihre anwendungen
AU3774300A (en) * 1999-06-02 2000-12-18 Genentech Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
ES2287020T3 (es) * 1999-06-02 2007-12-16 Genentech, Inc. Procedimiento y composiciones para inhibir el crecimiento de celulas neoplasicas.
US7629317B2 (en) 2001-03-29 2009-12-08 The University Of Chicago Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors
US6734289B2 (en) 2001-03-29 2004-05-11 The University Of Chicago Gastrokines and derived peptides including inhibitors
US8017576B2 (en) 2005-05-10 2011-09-13 The University Of Chicago Methods and compositions to treat mucositis

Also Published As

Publication number Publication date
US7557083B2 (en) 2009-07-07
CA2442684C (en) 2013-11-19
DE60234103D1 (de) 2009-12-03
US20030017548A1 (en) 2003-01-23
US20130086701A1 (en) 2013-04-04
ES2332882T3 (es) 2010-02-15
EP1423409A2 (en) 2004-06-02
WO2002092758A9 (en) 2004-06-24
JP4295516B2 (ja) 2009-07-15
EP1415154B1 (en) 2009-10-21
WO2002092758A2 (en) 2002-11-21
MXPA03008861A (es) 2004-10-15
US8278269B2 (en) 2012-10-02
US6734289B2 (en) 2004-05-11
ATE446510T1 (de) 2009-11-15
AU2002303199B2 (en) 2008-03-13
AU2002258663B2 (en) 2008-02-21
CA2442635A1 (en) 2002-11-21
WO2002092758A3 (en) 2004-04-01
JP2007217422A (ja) 2007-08-30
WO2002078640A3 (en) 2004-03-04
CA2442684A1 (en) 2002-10-10
US8791068B2 (en) 2014-07-29
JP2004537284A (ja) 2004-12-16
EP1415154A2 (en) 2004-05-06
US20050054564A1 (en) 2005-03-10
WO2002092758A8 (en) 2003-02-20
WO2002078640A2 (en) 2002-10-10
JP2004532037A (ja) 2004-10-21
MXPA03008855A (es) 2004-12-06
EP1415154A4 (en) 2004-12-22
US20050065328A1 (en) 2005-03-24
EP1423409A4 (en) 2005-12-07

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