JP2004536617A - 核酸増幅方法 - Google Patents

核酸増幅方法 Download PDF

Info

Publication number
JP2004536617A
JP2004536617A JP2003517293A JP2003517293A JP2004536617A JP 2004536617 A JP2004536617 A JP 2004536617A JP 2003517293 A JP2003517293 A JP 2003517293A JP 2003517293 A JP2003517293 A JP 2003517293A JP 2004536617 A JP2004536617 A JP 2004536617A
Authority
JP
Japan
Prior art keywords
probe
amplification product
product
amplification
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003517293A
Other languages
English (en)
Japanese (ja)
Inventor
ランデグレン、ウルフ
グルベルグ、マティス
ニルソン、マティス
Original Assignee
バイオサイクリカ アクチボラゲット
ランデグレン ジーン テクノロジー アクチボラゲット
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by バイオサイクリカ アクチボラゲット, ランデグレン ジーン テクノロジー アクチボラゲット filed Critical バイオサイクリカ アクチボラゲット
Publication of JP2004536617A publication Critical patent/JP2004536617A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6848Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2003517293A 2001-08-03 2002-07-12 核酸増幅方法 Pending JP2004536617A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0118959A GB2378245A (en) 2001-08-03 2001-08-03 Nucleic acid amplification method
PCT/SE2002/001378 WO2003012119A2 (en) 2001-08-03 2002-07-12 Nucleic acid amplification method

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008316989A Division JP4559517B2 (ja) 2001-08-03 2008-12-12 核酸増幅方法

Publications (1)

Publication Number Publication Date
JP2004536617A true JP2004536617A (ja) 2004-12-09

Family

ID=9919749

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2003517293A Pending JP2004536617A (ja) 2001-08-03 2002-07-12 核酸増幅方法
JP2008316989A Expired - Lifetime JP4559517B2 (ja) 2001-08-03 2008-12-12 核酸増幅方法
JP2009230088A Expired - Lifetime JP4675424B2 (ja) 2001-08-03 2009-10-02 核酸増幅方法
JP2010125694A Expired - Lifetime JP5313204B2 (ja) 2001-08-03 2010-06-01 核酸増幅方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2008316989A Expired - Lifetime JP4559517B2 (ja) 2001-08-03 2008-12-12 核酸増幅方法
JP2009230088A Expired - Lifetime JP4675424B2 (ja) 2001-08-03 2009-10-02 核酸増幅方法
JP2010125694A Expired - Lifetime JP5313204B2 (ja) 2001-08-03 2010-06-01 核酸増幅方法

Country Status (7)

Country Link
US (3) US7320860B2 (https=)
EP (4) EP2224016A1 (https=)
JP (4) JP2004536617A (https=)
AU (1) AU2002314693A1 (https=)
CA (1) CA2455803A1 (https=)
GB (1) GB2378245A (https=)
WO (1) WO2003012119A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008522628A (ja) * 2004-12-11 2008-07-03 サイトジェニックス, インコーポレイテッド 高品質核酸のセルフリー生合成及びその使用
JP2009077735A (ja) * 2001-08-03 2009-04-16 Biocyclica Ab 核酸増幅方法
JP2011505161A (ja) * 2007-12-04 2011-02-24 ピエール、ファーブル、メディカマン 抗体ライブラリーを作製およびスクリーニングするための新規な方法

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0304371D0 (en) * 2003-02-26 2003-04-02 Solexa Ltd DNA Sequence analysis
US7385043B1 (en) * 2003-04-30 2008-06-10 The Public Health Research Institute Of The City Of New York, Inc. Homogeneous multiplex screening assays and kits
SE0401270D0 (sv) 2004-05-18 2004-05-18 Fredrik Dahl Method for amplifying specific nucleic acids in parallel
EP1756307A1 (en) * 2004-05-20 2007-02-28 Trillion Genomics Limited Use of mass labelled probes to detect target nucleic acids using mass spectrometry
US7972858B2 (en) * 2004-08-13 2011-07-05 President And Fellows Of Harvard College Ultra high-throughput opti-nanopore DNA readout platform
CA2615323A1 (en) 2005-06-06 2007-12-21 454 Life Sciences Corporation Paired end sequencing
JP5103398B2 (ja) * 2005-06-06 2012-12-19 454 ライフ サイエンシーズ コーポレイション 両末端配列決定(pairedendsequencing)
EP3257949A1 (en) 2005-06-15 2017-12-20 Complete Genomics Inc. Nucleic acid analysis by random mixtures of non-overlapping fragments
US8137936B2 (en) * 2005-11-29 2012-03-20 Macevicz Stephen C Selected amplification of polynucleotides
US8492098B2 (en) 2006-02-21 2013-07-23 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of reaction components that affect a reaction
SG170028A1 (en) 2006-02-24 2011-04-29 Callida Genomics Inc High throughput genome sequencing on dna arrays
US7910354B2 (en) 2006-10-27 2011-03-22 Complete Genomics, Inc. Efficient arrays of amplified polynucleotides
US20090111706A1 (en) 2006-11-09 2009-04-30 Complete Genomics, Inc. Selection of dna adaptor orientation by amplification
US7862999B2 (en) 2007-01-17 2011-01-04 Affymetrix, Inc. Multiplex targeted amplification using flap nuclease
US20100047792A1 (en) * 2007-04-10 2010-02-25 Szendroe Istvan Label-free optical detection method
US20080293589A1 (en) * 2007-05-24 2008-11-27 Affymetrix, Inc. Multiplex locus specific amplification
CN101889074A (zh) * 2007-10-04 2010-11-17 哈尔西恩莫尔丘勒公司 采用电子显微镜对核酸聚合物测序
US8415099B2 (en) 2007-11-05 2013-04-09 Complete Genomics, Inc. Efficient base determination in sequencing reactions
US8298768B2 (en) 2007-11-29 2012-10-30 Complete Genomics, Inc. Efficient shotgun sequencing methods
US8592150B2 (en) 2007-12-05 2013-11-26 Complete Genomics, Inc. Methods and compositions for long fragment read sequencing
WO2009097368A2 (en) 2008-01-28 2009-08-06 Complete Genomics, Inc. Methods and compositions for efficient base calling in sequencing reactions
US20090233809A1 (en) * 2008-03-04 2009-09-17 Affymetrix, Inc. Resequencing methods for identification of sequence variants
ES2637411T3 (es) 2008-12-01 2017-10-13 Laboratory Corporation Of America Holdings Métodos y ensayos para medir p95 Y/O p95 en una muestra y anticuerpos específicos para p95
JP2012515353A (ja) * 2009-01-15 2012-07-05 ラボラトリー コーポレイション オブ アメリカ ホールディングス Her−2発現の測定による患者の反応を判定する方法
EP2387711B1 (en) 2009-01-15 2015-04-22 Laboratory Corporation of America Holdings Methods of determining patient response by measurement of her-3
EP2425240A4 (en) 2009-04-30 2012-12-12 Good Start Genetics Inc METHOD AND COMPOSITION FOR EVALUATING GENETIC MARKERS
US12129514B2 (en) 2009-04-30 2024-10-29 Molecular Loop Biosolutions, Llc Methods and compositions for evaluating genetic markers
US9524369B2 (en) 2009-06-15 2016-12-20 Complete Genomics, Inc. Processing and analysis of complex nucleic acid sequence data
WO2011027966A2 (en) * 2009-09-03 2011-03-10 Seegene, Inc. Td probe and its uses
JP2013511991A (ja) * 2009-11-25 2013-04-11 クアンタライフ, インコーポレイテッド 遺伝子材料を検出する方法および組成物
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
CN103026232B (zh) 2010-03-01 2015-02-04 匡特里克斯公司 扩大用于检测分子或颗粒的测定法中的动态范围的方法和系统
EP2585593B1 (en) 2010-06-24 2017-03-01 Population Genetics Technologies Ltd. Methods for polynucleotide library production, immortalization and region of interest extraction
US10669569B2 (en) 2010-10-15 2020-06-02 Navinci Diagnostics Ab Dynamic range methods
CN101974638B (zh) * 2010-11-10 2012-10-03 华东医学生物技术研究所 连接反应偶联核酸侵入反应与切刻内切酶反应的核酸信号扩增检测方法
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
AU2012214312A1 (en) 2011-02-09 2013-08-22 Bio-Rad Laboratories, Inc. Analysis of nucleic acids
US9556473B2 (en) 2011-02-15 2017-01-31 Leica Biosystems Newcastle Ltd Methods for identifying nucleic acid sequences
CN103649331A (zh) 2011-02-15 2014-03-19 莱卡生物系统纽卡斯尔有限责任公司 用于mrna的定位的原位检测的方法
US8759036B2 (en) 2011-03-21 2014-06-24 Affymetrix, Inc. Methods for synthesizing pools of probes
GB201107863D0 (en) 2011-05-11 2011-06-22 Olink Ab Method and product
US10597701B2 (en) 2011-05-11 2020-03-24 Navinci Diagnostics Ab Unfolding proximity probes and methods for the use thereof
CA2852665A1 (en) 2011-10-17 2013-04-25 Good Start Genetics, Inc. Analysis methods
WO2013128281A1 (en) 2012-02-28 2013-09-06 Population Genetics Technologies Ltd Method for attaching a counter sequence to a nucleic acid sample
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
US8812422B2 (en) 2012-04-09 2014-08-19 Good Start Genetics, Inc. Variant database
US10227635B2 (en) 2012-04-16 2019-03-12 Molecular Loop Biosolutions, Llc Capture reactions
KR101922124B1 (ko) 2012-08-27 2018-11-26 삼성전자주식회사 시료 중 rna로부터 dna를 증폭하는 방법
EP2920324B1 (en) 2012-11-14 2017-12-27 Olink Bioscience AB Localised rca-based amplification method
US20160369321A1 (en) 2012-11-14 2016-12-22 Olink Ab RCA Reporter Probes and Their Use in Detecting Nucleic Acid Molecules
JP6112652B2 (ja) * 2012-11-29 2017-04-12 国立大学法人広島大学 標的dnaの特異的増幅方法
CA2901907C (en) * 2013-02-20 2023-06-20 Emory University Methods of sequencing nucleic acids in mixtures and compositions related thereto
CA2904181A1 (en) 2013-03-13 2014-10-09 Anahit Aghvanyan Sandwich immunoassay comprising anchoring reagent
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
EP2971159B1 (en) 2013-03-14 2019-05-08 Molecular Loop Biosolutions, LLC Methods for analyzing nucleic acids
US10202500B2 (en) 2013-03-15 2019-02-12 Lubrizol Advanced Materials, Inc. Heavy metal free CPVC compounds
WO2014197377A2 (en) 2013-06-03 2014-12-11 Good Start Genetics, Inc. Methods and systems for storing sequence read data
CN105555972B (zh) 2013-07-25 2020-07-31 伯乐生命医学产品有限公司 遗传测定
US9644232B2 (en) 2013-07-26 2017-05-09 General Electric Company Method and device for collection and amplification of circulating nucleic acids
US9217167B2 (en) 2013-07-26 2015-12-22 General Electric Company Ligase-assisted nucleic acid circularization and amplification
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
EP3058096A1 (en) 2013-10-18 2016-08-24 Good Start Genetics, Inc. Methods for assessing a genomic region of a subject
GB201320145D0 (en) 2013-11-14 2014-01-01 Olink Ab Localised RCA-based amplification method using a padlock-probe
GB201321123D0 (en) 2013-11-29 2014-01-15 Linea Ab Q Amplification of circular molecules
GB2520765A (en) 2013-12-02 2015-06-03 Vanadis Diagnostics Ab Multiplex detection of nucleic acids
US10112194B2 (en) 2014-04-14 2018-10-30 Q-Linea Ab Detection of microscopic objects
US11053548B2 (en) 2014-05-12 2021-07-06 Good Start Genetics, Inc. Methods for detecting aneuploidy
EP3143401A4 (en) 2014-05-15 2017-10-11 Meso Scale Technologies, LLC Improved assay methods
KR102535489B1 (ko) 2014-06-13 2023-05-22 큐-리네아 에이비 미생물 검출 방법 및 특성 규명 방법
GB201413718D0 (en) 2014-08-01 2014-09-17 Olink Ab Method for selecting a target nucleic acid sequence
GB201413717D0 (en) 2014-08-01 2014-09-17 Olink Ab Method for selecting a target nucleic acid sequence
WO2016025818A1 (en) 2014-08-15 2016-02-18 Good Start Genetics, Inc. Systems and methods for genetic analysis
WO2016040446A1 (en) 2014-09-10 2016-03-17 Good Start Genetics, Inc. Methods for selectively suppressing non-target sequences
JP2017536087A (ja) 2014-09-24 2017-12-07 グッド スタート ジェネティクス, インコーポレイテッド 遺伝子アッセイのロバストネスを増大させるためのプロセス制御
EP3209798B1 (en) 2014-10-23 2022-07-27 Ricardo Mancebo Reagents and methods for isothermal chain reaction
WO2016112073A1 (en) 2015-01-06 2016-07-14 Good Start Genetics, Inc. Screening for structural variants
GB201507026D0 (en) 2015-04-24 2015-06-10 Linea Ab Q Medical sample transportation container
EP4219532A3 (en) 2015-06-05 2023-08-16 Dana-Farber Cancer Institute, Inc. Compositions and methods for transient gene therapy with enhanced stability
EP3307908B1 (en) 2015-06-09 2019-09-11 Life Technologies Corporation Methods for molecular tagging
GB201511129D0 (en) 2015-06-24 2015-08-05 Linea Ab Q Method of determining antimicrobial susceptibility of a microorganism
WO2017020023A2 (en) 2015-07-29 2017-02-02 Progenity, Inc. Nucleic acids and methods for detecting chromosomal abnormalities
GB201518655D0 (en) 2015-10-21 2015-12-02 Olink Ab Method for generating proximity probes
WO2017087560A1 (en) 2015-11-16 2017-05-26 Progenity, Inc. Nucleic acids and methods for detecting methylation status
WO2017173279A1 (en) * 2016-03-31 2017-10-05 Arizona Board Of Regents On Behalf Of Arizona State University Probes and methods for measuring tandem repeats
GB2554767A (en) 2016-04-21 2018-04-11 Q Linea Ab Detecting and characterising a microorganism
US10655170B2 (en) 2016-07-06 2020-05-19 Takara Bio Usa, Inc. Coupling adaptors to a target nucleic acid
GB201614023D0 (en) 2016-08-16 2016-09-28 Olink Bioscience Ab Double-stranded circle probes
GB201621514D0 (en) 2016-12-16 2017-02-01 Q-Linea Ab Padlock probe detection method
EP3601610A1 (en) 2017-03-30 2020-02-05 Pioneer Hi-Bred International, Inc. Methods of identifying and characterizing gene editing variations in nucleic acids
AU2018251187B2 (en) * 2017-04-14 2024-03-28 Dana-Farber Cancer Institute, Inc. Compositions and methods for transient gene therapy with enhanced stability
US11459603B2 (en) * 2017-05-23 2022-10-04 Rutgers, The State University Of New Jersey Target mediated in situ signal amplification with dual interacting hairpin probes
JP2020532976A (ja) 2017-09-14 2020-11-19 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 環状一本鎖dnaライブラリーを生成するための新規な方法
WO2019053215A1 (en) 2017-09-15 2019-03-21 F. Hoffmann-La Roche Ag HYBRIDIZATION-EXTENSION-LIGATURE STRATEGY TO GENERATE CIRCULAR SINGLE-STRAND DNA BANKS
CN120210336A (zh) 2017-10-06 2025-06-27 10X基因组学有限公司 Rna模板化连接
EP3692166A1 (en) 2017-10-06 2020-08-12 H. Hoffnabb-La Roche Ag Circularization methods for single molecule sequencing sample preparation
WO2019086531A1 (en) 2017-11-03 2019-05-09 F. Hoffmann-La Roche Ag Linear consensus sequencing
CN111801427B (zh) 2018-02-05 2023-12-05 豪夫迈·罗氏有限公司 用于单分子的单链环状dna模板的产生
US11898204B2 (en) 2018-03-02 2024-02-13 Roche Sequencing Solutions, Inc. Generation of single-stranded circular DNA templates for single molecule sequencing
CN120905352A (zh) 2018-04-02 2025-11-07 埃努梅拉分子股份有限公司 用于对核酸分子进行计数的方法、系统和组合物
CN109444102B (zh) * 2018-12-18 2021-03-23 济南大学 一种检测赭曲霉毒素a的荧光生物传感器及其制备方法和应用
CN120098057A (zh) 2019-03-01 2025-06-06 中尺度技术有限责任公司 用于免疫方法的被电化学发光标记的探针、使用这类探针的方法和包含这类探针的试剂盒
EP3947718A4 (en) 2019-04-02 2022-12-21 Enumera Molecular, Inc. METHODS, SYSTEMS AND COMPOSITIONS FOR COUNTING NUCLEIC ACID MOLECULES
EP4069731A4 (en) 2019-12-03 2024-05-29 Alamar Biosciences, Inc. Nucleic acid linked immune-sandwich assay (nulisa)
GB201919029D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
GB201919032D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
US11492662B2 (en) 2020-08-06 2022-11-08 Singular Genomics Systems, Inc. Methods for in situ transcriptomics and proteomics
US11434525B2 (en) 2020-08-06 2022-09-06 Singular Genomics Systems, Inc. Spatial sequencing
WO2022056078A1 (en) * 2020-09-11 2022-03-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Rnase h-assisted detection assay for rna (radar)
AU2021345359A1 (en) 2020-09-21 2023-05-11 Enumera Molecular, Inc. Compositions and methods for isolation of cell-free dna
US12467081B2 (en) 2020-11-23 2025-11-11 Pleno, Inc. Encoded endonuclease assays
EP4334706A4 (en) 2021-05-05 2025-08-06 Singular Genomics Systems Inc MULTIOMICS ANALYSIS DEVICE AND METHODS OF USE THEREOF
GB202203185D0 (en) 2022-03-08 2022-04-20 Rarity Bioscience Ab Method for detecting nucleic acid amplification products
EP4720332A1 (en) 2023-06-01 2026-04-08 Singular Genomics Systems, Inc. Methods and probes for detecting polynucleotide sequences in cells and tissues
GB202310278D0 (en) 2023-07-05 2023-08-16 Navinci Diagnostics Ab Stabilisation of phi29 polymerase
CN120249442B (zh) * 2025-06-04 2025-09-26 北京航空航天大学杭州创新研究院 一种基于邻近核酸扩增信号放大的超灵敏免疫检测方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011769A (en) 1985-12-05 1991-04-30 Meiogenics U.S. Limited Partnership Methods for detecting nucleic acid sequences
US5403711A (en) 1987-11-30 1995-04-04 University Of Iowa Research Foundation Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
AU649066B2 (en) * 1990-07-25 1994-05-12 Syngene, Inc. Circular extension for generating multiple nucleic acid complements
JP3085409B2 (ja) 1991-03-29 2000-09-11 東洋紡績株式会社 標的核酸配列の検出方法およびそのための試薬キット
US5714320A (en) 1993-04-15 1998-02-03 University Of Rochester Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides
US6077668A (en) * 1993-04-15 2000-06-20 University Of Rochester Highly sensitive multimeric nucleic acid probes
WO1995014106A2 (en) 1993-11-17 1995-05-26 Id Biomedical Corporation Cycling probe cleavage detection of nucleic acid sequences
ES2185719T3 (es) 1994-12-23 2003-05-01 Dade Behring Inc Deteccion de acidos nucleicos por formacion de un producto catalizada por diana.
SE504798C2 (sv) 1995-06-16 1997-04-28 Ulf Landegren Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten
DK0862656T3 (da) 1995-11-21 2001-04-09 Univ Yale Unimolekylær segmentamplifikation og -detektering
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
ATE238434T1 (de) 1995-12-05 2003-05-15 Jorn Erland Koch Eine in kaskaden verlaufende vervielfältigungsreaktion von nukleinsäuren
US6124120A (en) 1997-10-08 2000-09-26 Yale University Multiple displacement amplification
AU3601599A (en) 1998-03-25 1999-10-18 Ulf Landegren Rolling circle replication of padlock probes
US6037130A (en) 1998-07-28 2000-03-14 The Public Health Institute Of The City Of New York, Inc. Wavelength-shifting probes and primers and their use in assays and kits
US6150112A (en) 1998-09-18 2000-11-21 Yale University Methods for identifying DNA sequences for use in comparison of DNA samples by their lack of polymorphism using Y shape adaptors
US6235502B1 (en) * 1998-09-18 2001-05-22 Molecular Staging Inc. Methods for selectively isolating DNA using rolling circle amplification
US6830884B1 (en) * 1998-12-15 2004-12-14 Molecular Staging Inc. Method of amplification
WO2000036141A1 (en) 1998-12-15 2000-06-22 Diatech Pty. Ltd. A method of amplification of a circularised nucleic acid probe
US6274320B1 (en) * 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
AU783841B2 (en) 1999-11-26 2005-12-15 454 Life Sciences Corporation Nucleic acid probe arrays
WO2001040516A2 (en) 1999-12-02 2001-06-07 Molecular Staging Inc. Generation of single-strand circular dna from linear self-annealing segments
US6221603B1 (en) * 2000-02-04 2001-04-24 Molecular Dynamics, Inc. Rolling circle amplification assay for nucleic acid analysis
US6291187B1 (en) 2000-05-12 2001-09-18 Molecular Staging, Inc. Poly-primed amplification of nucleic acid sequences
US6350580B1 (en) * 2000-10-11 2002-02-26 Stratagene Methods for detection of a target nucleic acid using a probe comprising secondary structure
US6573051B2 (en) * 2001-03-09 2003-06-03 Molecular Staging, Inc. Open circle probes with intramolecular stem structures
GB2378245A (en) * 2001-08-03 2003-02-05 Mats Nilsson Nucleic acid amplification method
SE0401270D0 (sv) 2004-05-18 2004-05-18 Fredrik Dahl Method for amplifying specific nucleic acids in parallel

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009077735A (ja) * 2001-08-03 2009-04-16 Biocyclica Ab 核酸増幅方法
JP2008522628A (ja) * 2004-12-11 2008-07-03 サイトジェニックス, インコーポレイテッド 高品質核酸のセルフリー生合成及びその使用
JP2011505161A (ja) * 2007-12-04 2011-02-24 ピエール、ファーブル、メディカマン 抗体ライブラリーを作製およびスクリーニングするための新規な方法

Also Published As

Publication number Publication date
GB0118959D0 (en) 2001-09-26
JP5313204B2 (ja) 2013-10-09
US20080131899A1 (en) 2008-06-05
JP4559517B2 (ja) 2010-10-06
US7790388B2 (en) 2010-09-07
JP4675424B2 (ja) 2011-04-20
EP2236622A3 (en) 2010-11-03
EP2251439B1 (en) 2013-09-11
EP2251439A1 (en) 2010-11-17
EP2236622B1 (en) 2017-09-06
EP2236622A2 (en) 2010-10-06
JP2009077735A (ja) 2009-04-16
US20050287526A1 (en) 2005-12-29
EP2224016A1 (en) 2010-09-01
WO2003012119A2 (en) 2003-02-13
GB2378245A (en) 2003-02-05
JP2009297045A (ja) 2009-12-24
EP1423532A2 (en) 2004-06-02
US7320860B2 (en) 2008-01-22
WO2003012119A3 (en) 2003-11-13
USRE44265E1 (en) 2013-06-04
EP1423532B1 (en) 2013-05-22
JP2010183916A (ja) 2010-08-26
CA2455803A1 (en) 2003-02-13
AU2002314693A1 (en) 2003-02-17

Similar Documents

Publication Publication Date Title
JP4559517B2 (ja) 核酸増幅方法
US20250263779A1 (en) Methods of detecting an analyte
EP2516679B1 (en) Tsg primer target detection
AU2010290277B2 (en) TD probe and its uses
CA2979858C (en) Detection of target nucleic acid sequences by pto cleavage and extension assay in a liquid phase
CA2790153C (en) Thd primer target detection
JPH02268683A (ja) 単一プライマーを用いる核酸の増幅
JP2019176867A (ja) 核酸プローブ及びゲノム断片検出方法
JP3909010B2 (ja) 高度ダイナミックレンジを有する定量的多重pcr
KR102672338B1 (ko) 분할된 t7 프로모터를 이용한 중증 급성 호흡기 증후군 코로나바이러스 2 검출 및/또는 이의 돌연변이 검출용 등온 단일 반응 프로브 세트 및 이의 용도
HK1245352A1 (en) Method for the simultaneous detection of multiple nucleic acid sequences in a sample

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050530

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080613

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080912

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080922

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20081014

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20081021

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20081112

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20081119

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20081128

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20081128

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090106

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090403

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090410

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090424

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20090522