JP2004536046A5 - - Google Patents
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- Publication number
- JP2004536046A5 JP2004536046A5 JP2002578971A JP2002578971A JP2004536046A5 JP 2004536046 A5 JP2004536046 A5 JP 2004536046A5 JP 2002578971 A JP2002578971 A JP 2002578971A JP 2002578971 A JP2002578971 A JP 2002578971A JP 2004536046 A5 JP2004536046 A5 JP 2004536046A5
- Authority
- JP
- Japan
- Prior art keywords
- acne
- pharmaceutical composition
- tetracycline
- administered
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010000496 acne Diseases 0.000 claims 31
- 208000002874 Acne Vulgaris Diseases 0.000 claims 30
- 239000004098 Tetracycline Substances 0.000 claims 19
- 229960002180 tetracycline Drugs 0.000 claims 19
- 235000019364 tetracycline Nutrition 0.000 claims 19
- 229930101283 tetracycline Natural products 0.000 claims 19
- -1 bisphosphonate compound Chemical class 0.000 claims 17
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 11
- 230000003115 biocidal effect Effects 0.000 claims 6
- 210000002966 serum Anatomy 0.000 claims 6
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 claims 5
- 229960003722 doxycycline Drugs 0.000 claims 5
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 claims 4
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 4
- 229960004023 minocycline Drugs 0.000 claims 4
- 150000003522 tetracyclines Chemical class 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 230000001937 non-anti-biotic effect Effects 0.000 claims 3
- XCCHQGIGHCRZOS-KBKZQPOHSA-N (4as,5as,6s,12ar)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C1=CC=C2[C@@](C)(O)[C@@H](C[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)C3)(O)C3=O)C3=C(O)C2=C1O XCCHQGIGHCRZOS-KBKZQPOHSA-N 0.000 claims 2
- 229940122361 Bisphosphonate Drugs 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 2
- MWUTTXATIMURBN-VSAOOKSHSA-N (4aS,5aS,6S,12aR)-3,6,10,11-tetrahydroxy-6-methyl-1,12-dioxo-4a,5,5a,12a-tetrahydro-4H-tetracene-2-carboxamide Chemical compound C[C@]1(O)[C@H]2C[C@H]3CC(O)=C(C(N)=O)C(=O)[C@H]3C(=O)C2=C(O)c2c(O)cccc12 MWUTTXATIMURBN-VSAOOKSHSA-N 0.000 claims 1
- NBRQRXRBIHVLGI-OWXODZSWSA-N (4as,5ar,12ar)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=CC=CC(O)=C2C(O)=C(C2=O)[C@@H]1C[C@@H]1[C@@]2(O)C(O)=C(C(=O)N)C(=O)C1 NBRQRXRBIHVLGI-OWXODZSWSA-N 0.000 claims 1
- GUXHBMASAHGULD-SEYHBJAFSA-N (4s,4as,5as,6s,12ar)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1([C@H]2O)=C(Cl)C=CC(O)=C1C(O)=C1[C@@H]2C[C@H]2[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]2(O)C1=O GUXHBMASAHGULD-SEYHBJAFSA-N 0.000 claims 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- 208000003911 Acne Keloid Diseases 0.000 claims 1
- 206010000503 Acne cystic Diseases 0.000 claims 1
- 206010000513 Acne pustular Diseases 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- 208000001348 Chloracne Diseases 0.000 claims 1
- 206010011732 Cyst Diseases 0.000 claims 1
- FMTDIUIBLCQGJB-UHFFFAOYSA-N Demethylchlortetracyclin Natural products C1C2C(O)C3=C(Cl)C=CC(O)=C3C(=O)C2=C(O)C2(O)C1C(N(C)C)C(O)=C(C(N)=O)C2=O FMTDIUIBLCQGJB-UHFFFAOYSA-N 0.000 claims 1
- 206010051651 Dermatitis papillaris capillitii Diseases 0.000 claims 1
- 206010027026 Mechanical acne Diseases 0.000 claims 1
- 239000004100 Oxytetracycline Substances 0.000 claims 1
- 206010033733 Papule Diseases 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- 208000024780 Urticaria Diseases 0.000 claims 1
- 206010047623 Vitamin C deficiency Diseases 0.000 claims 1
- 210000001193 acne keloid Anatomy 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 claims 1
- CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 claims 1
- HISOCSRUFLPKDE-KLXQUTNESA-N cmt-2 Chemical compound C1=CC=C2[C@](O)(C)C3CC4C(N(C)C)C(O)=C(C#N)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O HISOCSRUFLPKDE-KLXQUTNESA-N 0.000 claims 1
- VCROZLOYPNVPSH-DCKQLXEASA-N cmt-5 Chemical compound N1N=C2C3=C(O)C=CC=C3[C@@](C)(O)C3C2=C1[C@]1(O)C(=O)C(C(N)=O)=C(O)CC1C3 VCROZLOYPNVPSH-DCKQLXEASA-N 0.000 claims 1
- BVFDLIAWTKFZQD-JXVDNWKRSA-N cmt-8 Chemical compound O=C1C2=C(O)C=CC=C2C(C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)C[C@@H]1C2O BVFDLIAWTKFZQD-JXVDNWKRSA-N 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 208000031513 cyst Diseases 0.000 claims 1
- 229960002398 demeclocycline Drugs 0.000 claims 1
- 239000003599 detergent Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 238000010255 intramuscular injection Methods 0.000 claims 1
- 239000007927 intramuscular injection Substances 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 229960000625 oxytetracycline Drugs 0.000 claims 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 claims 1
- 235000019366 oxytetracycline Nutrition 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 235000019260 propionic acid Nutrition 0.000 claims 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims 1
- 201000004700 rosacea Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000010233 scurvy Diseases 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28191601P | 2001-04-05 | 2001-04-05 | |
| PCT/US2002/010747 WO2002080932A1 (en) | 2001-04-05 | 2002-04-05 | Methods of treating acne |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009280436A Division JP2010053155A (ja) | 2001-04-05 | 2009-12-10 | ざ瘡の治療方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004536046A JP2004536046A (ja) | 2004-12-02 |
| JP2004536046A5 true JP2004536046A5 (https=) | 2005-12-22 |
Family
ID=23079310
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002578971A Pending JP2004536046A (ja) | 2001-04-05 | 2002-04-05 | ざ瘡の治療方法 |
| JP2009280436A Pending JP2010053155A (ja) | 2001-04-05 | 2009-12-10 | ざ瘡の治療方法 |
| JP2011115785A Pending JP2011168613A (ja) | 2001-04-05 | 2011-05-24 | ざ瘡の治療方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009280436A Pending JP2010053155A (ja) | 2001-04-05 | 2009-12-10 | ざ瘡の治療方法 |
| JP2011115785A Pending JP2011168613A (ja) | 2001-04-05 | 2011-05-24 | ざ瘡の治療方法 |
Country Status (12)
| Country | Link |
|---|---|
| EP (4) | EP1383508B1 (https=) |
| JP (3) | JP2004536046A (https=) |
| KR (1) | KR100926326B1 (https=) |
| AT (1) | ATE330615T1 (https=) |
| AU (1) | AU2002303250B2 (https=) |
| CA (2) | CA2719162C (https=) |
| DE (1) | DE60212613T2 (https=) |
| DK (1) | DK1383508T3 (https=) |
| ES (1) | ES2266499T3 (https=) |
| NZ (1) | NZ528197A (https=) |
| PT (1) | PT1383508E (https=) |
| WO (1) | WO2002080932A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2551708T3 (es) * | 2002-01-08 | 2015-11-23 | Paratek Pharmaceuticals, Inc. | Compuestos de 4-desdimetilamino tetraciclina |
| US8192749B2 (en) | 2003-04-16 | 2012-06-05 | Galderma Laboratories Inc. | Methods of simultaneously treating ocular rosacea and acne rosacea |
| EP1494681A4 (en) * | 2002-04-16 | 2008-08-06 | Collagenex Pharm Inc | PROCESS FOR THE SIMULTANEOUS TREATMENT OF OCULAR ROSACEA AND ACNE ROSACEA |
| WO2004091483A2 (en) | 2003-04-07 | 2004-10-28 | Shire Laboratories, Inc. | Once daily formulations of tetracyclines |
| AU2004261143B2 (en) | 2003-07-25 | 2009-11-05 | Allergan Pharmaceuticals International Limited | A doxycycline metal complex in a solid dosage form |
| EP1684768A4 (en) * | 2003-11-06 | 2007-06-06 | Univ New York State Res Found | METHOD FOR TREATING ECCEM |
| US7544373B2 (en) | 2007-04-02 | 2009-06-09 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| US7919483B2 (en) * | 2005-06-24 | 2011-04-05 | Medicis Pharmaceutical Corporation | Method for the treatment of acne |
| US8252776B2 (en) | 2007-04-02 | 2012-08-28 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| US7541347B2 (en) | 2007-04-02 | 2009-06-02 | Medicis Pharmaceutical Coropration | Minocycline oral dosage forms for the treatment of acne |
| US7704959B2 (en) * | 2006-10-03 | 2010-04-27 | Dow Pharmaceutical Sciences | Azithromycin for the treatment of nodular acne |
| KR20130137696A (ko) * | 2007-03-23 | 2013-12-17 | 몰레큘러 리서치 센터, 인크. | 테트라사이클린류를 함유하는 항염증성 조성물 및 이의 치료 용도 |
| WO2008121107A1 (en) * | 2007-04-02 | 2008-10-09 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| WO2009138516A1 (en) * | 2008-05-16 | 2009-11-19 | Galderma Research & Development | Therapy regimen for treating acne related diseases |
| WO2010017310A1 (en) | 2008-08-06 | 2010-02-11 | Medicis Pharmaceutical Corporation | Method for the treatment of acne and certain dosage forms thereof |
| US9561241B1 (en) | 2011-06-28 | 2017-02-07 | Medicis Pharmaceutical Corporation | Gastroretentive dosage forms for minocycline |
| KR20140146095A (ko) * | 2012-04-19 | 2014-12-24 | 갈데르마 소시에떼아노님 | 여드름의 치료 방법 |
| RU2557991C1 (ru) * | 2014-05-19 | 2015-07-27 | Вячеслав Владимирович Чеботарёв | Способ лечения больных вульгарными угрями (акне), страдающих дисплазией соединительной ткани |
| CO2017001953A1 (es) * | 2017-02-27 | 2018-08-31 | Corporacion Univ Lasallista | Método de encapsulación de tetraciclinas |
| CN111343991A (zh) * | 2017-07-21 | 2020-06-26 | 阿尔米雷尔有限责任公司 | 非炎性病变的治疗 |
| JP7561029B2 (ja) | 2018-01-07 | 2024-10-03 | ドクター レディズ ラボラトリーズ リミテッド | 炎症性皮膚状態を処置するためのミノサイクリン |
| WO2020142350A1 (en) * | 2019-01-04 | 2020-07-09 | Dermata Therapeutics, Llc | Compositions and methods for the treatment of skin conditions |
| WO2021215405A1 (ja) * | 2020-04-20 | 2021-10-28 | 国立大学法人大阪大学 | 免疫賦活化剤、及び治療又は予防用組成物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3278457D1 (en) * | 1981-08-27 | 1988-06-16 | Soft Sheen Products Inc | Use of carbamide peroxide for the manufacture of a medicament for treatment of acne vulgaris |
| US5122519A (en) * | 1989-06-27 | 1992-06-16 | American Cyanamid Company | Stable, cosmetically acceptable topical gel formulation and method of treatment for acne |
| WO1992003133A1 (en) * | 1990-08-16 | 1992-03-05 | Bloom, Leonard | Topical treatment of blepharitis |
| US5674539A (en) * | 1994-12-09 | 1997-10-07 | Tomas; Robert E. | Method of treating skin and composition |
| FR2730930B1 (fr) * | 1995-02-27 | 1997-04-04 | Oreal | Utilisation d'inhibiteurs de no-synthase pour diminuer l'effet irritant cutane de produits utilises dans le domaine cosmetique ou pharmaceutique |
| US5827840A (en) * | 1996-08-01 | 1998-10-27 | The Research Foundation Of State University Of New York | Promotion of wound healing by chemically-modified tetracyclines |
| US5789395A (en) * | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
| US5908838A (en) * | 1998-02-19 | 1999-06-01 | Medics Pharmaceutical Corporation | Method for the treatment of acne |
| US6432934B1 (en) * | 1998-08-06 | 2002-08-13 | Advanced Vision Research | Methods and compositions for topical treatment of eye surface inflammation and related dry eye disease |
| US6015804A (en) * | 1998-09-11 | 2000-01-18 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds to enhance interleukin-10 production |
| US5998390A (en) * | 1998-09-28 | 1999-12-07 | The Research Foundation Of State University Of New York | Combination of bisphosphonate and tetracycline |
| CA2343038A1 (en) * | 1998-09-28 | 2000-04-06 | Maria Emanuel Ryan | A novel inhibitor of cataract formation |
| DE69932846T2 (de) * | 1998-11-18 | 2007-03-15 | Collagenex Pharmaceuticals, Inc. | Neue 4-dedimethylaminotetracyclinderivate |
| JP2001072660A (ja) * | 1999-09-08 | 2001-03-21 | Welfide Corp | ＴＮＦ−α産生抑制剤および／またはＩＬ−１０産生促進剤 |
-
2002
- 2002-04-05 EP EP02731267A patent/EP1383508B1/en not_active Expired - Lifetime
- 2002-04-05 EP EP06076250A patent/EP1716856A3/en not_active Withdrawn
- 2002-04-05 WO PCT/US2002/010747 patent/WO2002080932A1/en not_active Ceased
- 2002-04-05 CA CA2719162A patent/CA2719162C/en not_active Expired - Lifetime
- 2002-04-05 DK DK02731267T patent/DK1383508T3/da active
- 2002-04-05 CA CA2440472A patent/CA2440472C/en not_active Expired - Lifetime
- 2002-04-05 NZ NZ528197A patent/NZ528197A/en not_active IP Right Cessation
- 2002-04-05 PT PT02731267T patent/PT1383508E/pt unknown
- 2002-04-05 EP EP10159154A patent/EP2221056A1/en not_active Withdrawn
- 2002-04-05 AU AU2002303250A patent/AU2002303250B2/en not_active Expired
- 2002-04-05 EP EP06076249A patent/EP1712236A3/en not_active Withdrawn
- 2002-04-05 DE DE60212613T patent/DE60212613T2/de not_active Expired - Lifetime
- 2002-04-05 ES ES02731267T patent/ES2266499T3/es not_active Expired - Lifetime
- 2002-04-05 KR KR1020037012965A patent/KR100926326B1/ko not_active Expired - Lifetime
- 2002-04-05 AT AT02731267T patent/ATE330615T1/de active
- 2002-04-05 JP JP2002578971A patent/JP2004536046A/ja active Pending
-
2009
- 2009-12-10 JP JP2009280436A patent/JP2010053155A/ja active Pending
-
2011
- 2011-05-24 JP JP2011115785A patent/JP2011168613A/ja active Pending
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