JP2005524622A5 - - Google Patents
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- Publication number
- JP2005524622A5 JP2005524622A5 JP2003558038A JP2003558038A JP2005524622A5 JP 2005524622 A5 JP2005524622 A5 JP 2005524622A5 JP 2003558038 A JP2003558038 A JP 2003558038A JP 2003558038 A JP2003558038 A JP 2003558038A JP 2005524622 A5 JP2005524622 A5 JP 2005524622A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- compound according
- different
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 36
- 150000001413 amino acids Chemical class 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 241000192125 Firmicutes Species 0.000 claims 8
- -1 amidino, carboxy, guanidino, hydroxy, sulfanyl Chemical group 0.000 claims 8
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 6
- 125000003710 aryl alkyl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 150000002431 hydrogen Chemical group 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 229920006395 saturated elastomer Polymers 0.000 claims 4
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 3
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical group NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical group OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims 3
- 125000003368 amide group Chemical group 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims 3
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 2
- 241000233866 Fungi Species 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 230000000845 anti-microbial effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 238000007910 systemic administration Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45371002P | 2002-01-03 | 2002-01-03 | |
| PCT/US2003/000158 WO2003057724A1 (en) | 2002-01-03 | 2003-01-02 | Dab9 DERIVATIVES OF LIPOPEPTIDE ANTIBIOTICS AND METHODS OF MAKING AND USING THE SAME |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005524622A JP2005524622A (ja) | 2005-08-18 |
| JP2005524622A5 true JP2005524622A5 (https=) | 2006-02-16 |
| JP4402463B2 JP4402463B2 (ja) | 2010-01-20 |
Family
ID=33131662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003558038A Expired - Fee Related JP4402463B2 (ja) | 2002-01-03 | 2003-01-02 | リポペプチド抗生物質のＤａｂ９誘導体およびそれを製造および使用する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US7125844B2 (https=) |
| EP (1) | EP1481005A1 (https=) |
| JP (1) | JP4402463B2 (https=) |
| AU (1) | AU2003202878B2 (https=) |
| CA (1) | CA2471458A1 (https=) |
| WO (1) | WO2003057724A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4402463B2 (ja) * | 2002-01-03 | 2010-01-20 | マイジェニックス インコーポレイテッド | リポペプチド抗生物質のＤａｂ９誘導体およびそれを製造および使用する方法 |
| CN1839150A (zh) | 2003-07-17 | 2006-09-27 | 麦根克斯有限公司 | 脂肽抗菌衍生物组合物及其应用方法 |
| WO2007092632A2 (en) * | 2006-02-09 | 2007-08-16 | Elevance Renawable Sciences, Inc. | Surface coating compositions and methods |
| RU2008132757A (ru) * | 2006-02-09 | 2010-03-20 | Елевансе Реневал Сайенсез, Инк. (US) | Антибактериальные составы, способы и системы |
| GB0821540D0 (en) | 2008-11-25 | 2008-12-31 | Merlion Pharmaceuticals Pte Ltd | Lipopeptide compounds and their use |
| US9504756B2 (en) * | 2012-05-15 | 2016-11-29 | Seattle Genetics, Inc. | Self-stabilizing linker conjugates |
| TWI851531B (zh) | 2016-08-09 | 2024-08-11 | 美商思進公司 | 具有改善之生理化學性質之具自我穩定連接子之藥物結合物 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB923544A (en) | 1959-07-21 | 1963-04-10 | Takeda Pharmaceutical | A new antibiotic-glumamycin |
| US3057779A (en) | 1960-03-14 | 1962-10-09 | American Cyanamid Co | Antibiotic and production thereof |
| US3639582A (en) | 1967-04-14 | 1972-02-01 | Zaidan Hojin Biseibutsu | Antibiotic laspartomycin |
| DE1800363A1 (de) | 1967-10-04 | 1969-07-03 | Shionogi & Co | Tsushimycin und seine Herstellung |
| FR2124060B1 (https=) | 1971-02-02 | 1974-04-12 | Rhone Poulenc Sa | |
| US4524135A (en) | 1982-05-21 | 1985-06-18 | Eli Lilly And Company | A-21978C cyclic peptides |
| ZA883887B (en) | 1987-06-10 | 1990-02-28 | Lilly Co Eli | Chromatographic purification process |
| US5039789A (en) | 1988-04-11 | 1991-08-13 | Eli Lilly And Company | A54145 cyclic peptides |
| US5028590A (en) | 1988-04-11 | 1991-07-02 | Eli Lilly And Company | Derivatives of A54145 cyclic peptides |
| US4977083A (en) | 1988-04-11 | 1990-12-11 | Eli Lilly And Company | Processes for preparing A54145 compounds |
| US4994270A (en) | 1988-04-11 | 1991-02-19 | Eli Lilly And Company | A54145 antibiotics and process for their production |
| TW455591B (en) | 1993-06-08 | 2001-09-21 | Hoechst Ag | Lipopeptides from actinoplanes sp. with pharmacological action, process for their production and the use thereof |
| DE4411025A1 (de) | 1994-03-30 | 1995-10-05 | Hoechst Ag | Lipopeptid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| EP1666587A1 (en) | 1996-06-13 | 2006-06-07 | Astellas Pharma Inc. | Cyclic lipopeptide acylase |
| DE19807972A1 (de) | 1998-02-25 | 1999-08-26 | Hoechst Marion Roussel De Gmbh | Lipopeptidantibiotika-Calciumsalze, Verfahren zu ihrer Herstellung und Verwendung |
| US6750199B2 (en) * | 2000-07-17 | 2004-06-15 | Micrologix Biotech Inc. | Antimicrobial sulfonamide derivatives of lipopeptide antibiotics |
| WO2002005837A1 (en) | 2000-07-17 | 2002-01-24 | Intrabiotics Pharmaceuticals, Inc. | Antimicrobial sulfonamide derivatives of lipopeptide antibiotics |
| US6716962B2 (en) | 2000-07-17 | 2004-04-06 | Micrologix Biotech Inc. | Extractive purification of lipopeptide antibiotics |
| JP4402463B2 (ja) * | 2002-01-03 | 2010-01-20 | マイジェニックス インコーポレイテッド | リポペプチド抗生物質のＤａｂ９誘導体およびそれを製造および使用する方法 |
-
2003
- 2003-01-02 JP JP2003558038A patent/JP4402463B2/ja not_active Expired - Fee Related
- 2003-01-02 US US10/336,641 patent/US7125844B2/en not_active Expired - Fee Related
- 2003-01-02 WO PCT/US2003/000158 patent/WO2003057724A1/en not_active Ceased
- 2003-01-02 EP EP03701990A patent/EP1481005A1/en not_active Withdrawn
- 2003-01-02 AU AU2003202878A patent/AU2003202878B2/en not_active Ceased
- 2003-01-02 CA CA002471458A patent/CA2471458A1/en not_active Abandoned
-
2006
- 2006-10-05 US US11/539,139 patent/US7655623B2/en not_active Expired - Fee Related
-
2010
- 2010-02-01 US US12/697,937 patent/US20100137199A1/en not_active Abandoned
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