DE60212613T2 - Doxycyclin zur behandlung von akne - Google Patents
Doxycyclin zur behandlung von akne Download PDFInfo
- Publication number
- DE60212613T2 DE60212613T2 DE60212613T DE60212613T DE60212613T2 DE 60212613 T2 DE60212613 T2 DE 60212613T2 DE 60212613 T DE60212613 T DE 60212613T DE 60212613 T DE60212613 T DE 60212613T DE 60212613 T2 DE60212613 T2 DE 60212613T2
- Authority
- DE
- Germany
- Prior art keywords
- acne
- use according
- administered
- administration
- tetracycline compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 229960003194 meglumine Drugs 0.000 description 1
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- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 229960002421 minocycline hydrochloride Drugs 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- ACTNHJDHMQSOGL-UHFFFAOYSA-N n',n'-dibenzylethane-1,2-diamine Chemical compound C=1C=CC=CC=1CN(CCN)CC1=CC=CC=C1 ACTNHJDHMQSOGL-UHFFFAOYSA-N 0.000 description 1
- 230000011242 neutrophil chemotaxis Effects 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229940127249 oral antibiotic Drugs 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 1
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- 235000019366 oxytetracycline Nutrition 0.000 description 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
- 229940046231 pamidronate Drugs 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 229940097158 periostat Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 230000008569 process Effects 0.000 description 1
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- 235000019260 propionic acid Nutrition 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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- 210000002374 sebum Anatomy 0.000 description 1
- VIDTVPHHDGRGAF-UHFFFAOYSA-N selenium sulfide Chemical compound [Se]=S VIDTVPHHDGRGAF-UHFFFAOYSA-N 0.000 description 1
- 229960005265 selenium sulfide Drugs 0.000 description 1
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- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
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- 208000009056 telangiectasis Diseases 0.000 description 1
- 229940063650 terramycin Drugs 0.000 description 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
- 229940019375 tiludronate Drugs 0.000 description 1
- 229940042129 topical gel Drugs 0.000 description 1
- 229940126702 topical medication Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000001720 vestibular Effects 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28191601P | 2001-04-05 | 2001-04-05 | |
| US281916P | 2001-04-05 | ||
| PCT/US2002/010747 WO2002080932A1 (en) | 2001-04-05 | 2002-04-05 | Methods of treating acne |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60212613D1 DE60212613D1 (de) | 2006-08-03 |
| DE60212613T2 true DE60212613T2 (de) | 2007-05-24 |
Family
ID=23079310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60212613T Expired - Lifetime DE60212613T2 (de) | 2001-04-05 | 2002-04-05 | Doxycyclin zur behandlung von akne |
Country Status (12)
| Country | Link |
|---|---|
| EP (4) | EP1383508B1 (https=) |
| JP (3) | JP2004536046A (https=) |
| KR (1) | KR100926326B1 (https=) |
| AT (1) | ATE330615T1 (https=) |
| AU (1) | AU2002303250B2 (https=) |
| CA (2) | CA2719162C (https=) |
| DE (1) | DE60212613T2 (https=) |
| DK (1) | DK1383508T3 (https=) |
| ES (1) | ES2266499T3 (https=) |
| NZ (1) | NZ528197A (https=) |
| PT (1) | PT1383508E (https=) |
| WO (1) | WO2002080932A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2551708T3 (es) * | 2002-01-08 | 2015-11-23 | Paratek Pharmaceuticals, Inc. | Compuestos de 4-desdimetilamino tetraciclina |
| US8192749B2 (en) | 2003-04-16 | 2012-06-05 | Galderma Laboratories Inc. | Methods of simultaneously treating ocular rosacea and acne rosacea |
| EP1494681A4 (en) * | 2002-04-16 | 2008-08-06 | Collagenex Pharm Inc | PROCESS FOR THE SIMULTANEOUS TREATMENT OF OCULAR ROSACEA AND ACNE ROSACEA |
| WO2004091483A2 (en) | 2003-04-07 | 2004-10-28 | Shire Laboratories, Inc. | Once daily formulations of tetracyclines |
| AU2004261143B2 (en) | 2003-07-25 | 2009-11-05 | Allergan Pharmaceuticals International Limited | A doxycycline metal complex in a solid dosage form |
| EP1684768A4 (en) * | 2003-11-06 | 2007-06-06 | Univ New York State Res Found | METHOD FOR TREATING ECCEM |
| US7544373B2 (en) | 2007-04-02 | 2009-06-09 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| US7919483B2 (en) * | 2005-06-24 | 2011-04-05 | Medicis Pharmaceutical Corporation | Method for the treatment of acne |
| US8252776B2 (en) | 2007-04-02 | 2012-08-28 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| US7541347B2 (en) | 2007-04-02 | 2009-06-02 | Medicis Pharmaceutical Coropration | Minocycline oral dosage forms for the treatment of acne |
| US7704959B2 (en) * | 2006-10-03 | 2010-04-27 | Dow Pharmaceutical Sciences | Azithromycin for the treatment of nodular acne |
| KR20130137696A (ko) * | 2007-03-23 | 2013-12-17 | 몰레큘러 리서치 센터, 인크. | 테트라사이클린류를 함유하는 항염증성 조성물 및 이의 치료 용도 |
| WO2008121107A1 (en) * | 2007-04-02 | 2008-10-09 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| WO2009138516A1 (en) * | 2008-05-16 | 2009-11-19 | Galderma Research & Development | Therapy regimen for treating acne related diseases |
| WO2010017310A1 (en) | 2008-08-06 | 2010-02-11 | Medicis Pharmaceutical Corporation | Method for the treatment of acne and certain dosage forms thereof |
| US9561241B1 (en) | 2011-06-28 | 2017-02-07 | Medicis Pharmaceutical Corporation | Gastroretentive dosage forms for minocycline |
| KR20140146095A (ko) * | 2012-04-19 | 2014-12-24 | 갈데르마 소시에떼아노님 | 여드름의 치료 방법 |
| RU2557991C1 (ru) * | 2014-05-19 | 2015-07-27 | Вячеслав Владимирович Чеботарёв | Способ лечения больных вульгарными угрями (акне), страдающих дисплазией соединительной ткани |
| CO2017001953A1 (es) * | 2017-02-27 | 2018-08-31 | Corporacion Univ Lasallista | Método de encapsulación de tetraciclinas |
| CN111343991A (zh) * | 2017-07-21 | 2020-06-26 | 阿尔米雷尔有限责任公司 | 非炎性病变的治疗 |
| JP7561029B2 (ja) | 2018-01-07 | 2024-10-03 | ドクター レディズ ラボラトリーズ リミテッド | 炎症性皮膚状態を処置するためのミノサイクリン |
| WO2020142350A1 (en) * | 2019-01-04 | 2020-07-09 | Dermata Therapeutics, Llc | Compositions and methods for the treatment of skin conditions |
| WO2021215405A1 (ja) * | 2020-04-20 | 2021-10-28 | 国立大学法人大阪大学 | 免疫賦活化剤、及び治療又は予防用組成物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3278457D1 (en) * | 1981-08-27 | 1988-06-16 | Soft Sheen Products Inc | Use of carbamide peroxide for the manufacture of a medicament for treatment of acne vulgaris |
| US5122519A (en) * | 1989-06-27 | 1992-06-16 | American Cyanamid Company | Stable, cosmetically acceptable topical gel formulation and method of treatment for acne |
| WO1992003133A1 (en) * | 1990-08-16 | 1992-03-05 | Bloom, Leonard | Topical treatment of blepharitis |
| US5674539A (en) * | 1994-12-09 | 1997-10-07 | Tomas; Robert E. | Method of treating skin and composition |
| FR2730930B1 (fr) * | 1995-02-27 | 1997-04-04 | Oreal | Utilisation d'inhibiteurs de no-synthase pour diminuer l'effet irritant cutane de produits utilises dans le domaine cosmetique ou pharmaceutique |
| US5827840A (en) * | 1996-08-01 | 1998-10-27 | The Research Foundation Of State University Of New York | Promotion of wound healing by chemically-modified tetracyclines |
| US5789395A (en) * | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
| US5908838A (en) * | 1998-02-19 | 1999-06-01 | Medics Pharmaceutical Corporation | Method for the treatment of acne |
| US6432934B1 (en) * | 1998-08-06 | 2002-08-13 | Advanced Vision Research | Methods and compositions for topical treatment of eye surface inflammation and related dry eye disease |
| US6015804A (en) * | 1998-09-11 | 2000-01-18 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds to enhance interleukin-10 production |
| US5998390A (en) * | 1998-09-28 | 1999-12-07 | The Research Foundation Of State University Of New York | Combination of bisphosphonate and tetracycline |
| CA2343038A1 (en) * | 1998-09-28 | 2000-04-06 | Maria Emanuel Ryan | A novel inhibitor of cataract formation |
| DE69932846T2 (de) * | 1998-11-18 | 2007-03-15 | Collagenex Pharmaceuticals, Inc. | Neue 4-dedimethylaminotetracyclinderivate |
| JP2001072660A (ja) * | 1999-09-08 | 2001-03-21 | Welfide Corp | ＴＮＦ−α産生抑制剤および／またはＩＬ−１０産生促進剤 |
-
2002
- 2002-04-05 EP EP02731267A patent/EP1383508B1/en not_active Expired - Lifetime
- 2002-04-05 EP EP06076250A patent/EP1716856A3/en not_active Withdrawn
- 2002-04-05 WO PCT/US2002/010747 patent/WO2002080932A1/en not_active Ceased
- 2002-04-05 CA CA2719162A patent/CA2719162C/en not_active Expired - Lifetime
- 2002-04-05 DK DK02731267T patent/DK1383508T3/da active
- 2002-04-05 CA CA2440472A patent/CA2440472C/en not_active Expired - Lifetime
- 2002-04-05 NZ NZ528197A patent/NZ528197A/en not_active IP Right Cessation
- 2002-04-05 PT PT02731267T patent/PT1383508E/pt unknown
- 2002-04-05 EP EP10159154A patent/EP2221056A1/en not_active Withdrawn
- 2002-04-05 AU AU2002303250A patent/AU2002303250B2/en not_active Expired
- 2002-04-05 EP EP06076249A patent/EP1712236A3/en not_active Withdrawn
- 2002-04-05 DE DE60212613T patent/DE60212613T2/de not_active Expired - Lifetime
- 2002-04-05 ES ES02731267T patent/ES2266499T3/es not_active Expired - Lifetime
- 2002-04-05 KR KR1020037012965A patent/KR100926326B1/ko not_active Expired - Lifetime
- 2002-04-05 AT AT02731267T patent/ATE330615T1/de active
- 2002-04-05 JP JP2002578971A patent/JP2004536046A/ja active Pending
-
2009
- 2009-12-10 JP JP2009280436A patent/JP2010053155A/ja active Pending
-
2011
- 2011-05-24 JP JP2011115785A patent/JP2011168613A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1716856A2 (en) | 2006-11-02 |
| EP1712236A2 (en) | 2006-10-18 |
| EP1716856A3 (en) | 2009-02-18 |
| CA2440472A1 (en) | 2002-10-17 |
| DE60212613D1 (de) | 2006-08-03 |
| CA2719162A1 (en) | 2002-10-17 |
| AU2002303250B2 (en) | 2006-05-25 |
| PT1383508E (pt) | 2006-11-30 |
| DK1383508T3 (da) | 2006-12-27 |
| KR100926326B1 (ko) | 2009-11-12 |
| EP1712236A3 (en) | 2008-05-28 |
| JP2004536046A (ja) | 2004-12-02 |
| KR20040007488A (ko) | 2004-01-24 |
| JP2010053155A (ja) | 2010-03-11 |
| EP1383508A1 (en) | 2004-01-28 |
| CA2719162C (en) | 2014-12-23 |
| CA2440472C (en) | 2011-01-18 |
| EP1383508B1 (en) | 2006-06-21 |
| EP1383508A4 (en) | 2005-07-06 |
| EP2221056A1 (en) | 2010-08-25 |
| JP2011168613A (ja) | 2011-09-01 |
| WO2002080932A1 (en) | 2002-10-17 |
| ATE330615T1 (de) | 2006-07-15 |
| ES2266499T3 (es) | 2007-03-01 |
| NZ528197A (en) | 2007-04-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |