JP2017537067A5 - - Google Patents
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- JP2017537067A5 JP2017537067A5 JP2017521530A JP2017521530A JP2017537067A5 JP 2017537067 A5 JP2017537067 A5 JP 2017537067A5 JP 2017521530 A JP2017521530 A JP 2017521530A JP 2017521530 A JP2017521530 A JP 2017521530A JP 2017537067 A5 JP2017537067 A5 JP 2017537067A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- egf
- administered
- subject
- wound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims description 48
- 239000000203 mixture Substances 0.000 claims description 43
- 101000871708 Homo sapiens Proheparin-binding EGF-like growth factor Proteins 0.000 claims description 30
- 102100033762 Proheparin-binding EGF-like growth factor Human genes 0.000 claims description 30
- 208000002847 Surgical Wound Diseases 0.000 claims description 24
- 238000007483 tonsillectomy Methods 0.000 claims description 12
- 206010052428 Wound Diseases 0.000 claims description 11
- 208000027418 Wounds and injury Diseases 0.000 claims description 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 10
- 230000008556 epithelial cell proliferation Effects 0.000 claims description 8
- 230000004936 stimulating effect Effects 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 5
- 210000005081 epithelial layer Anatomy 0.000 claims description 4
- 230000035876 healing Effects 0.000 claims description 4
- 238000002347 injection Methods 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 238000005507 spraying Methods 0.000 claims description 4
- 238000013268 sustained release Methods 0.000 claims description 4
- 239000012730 sustained-release form Substances 0.000 claims description 4
- 241000021559 Dicerandra Species 0.000 claims description 2
- 101500025336 Homo sapiens Heparin-binding EGF-like growth factor Proteins 0.000 claims description 2
- 235000010654 Melissa officinalis Nutrition 0.000 claims description 2
- 206010029113 Neovascularisation Diseases 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 210000000981 epithelium Anatomy 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 239000000499 gel Substances 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 239000000865 liniment Substances 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims 3
- 229940035676 analgesics Drugs 0.000 claims 1
- 229940035674 anesthetics Drugs 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003193 general anesthetic agent Substances 0.000 claims 1
- 239000002324 mouth wash Substances 0.000 claims 1
- 229940051866 mouthwash Drugs 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 230000017423 tissue regeneration Effects 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
- 241000321096 Adenoides Species 0.000 description 9
- 210000002534 adenoid Anatomy 0.000 description 9
- 238000002271 resection Methods 0.000 description 9
- 230000001613 neoplastic effect Effects 0.000 description 3
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 210000003254 palate Anatomy 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 210000001184 pharyngeal muscle Anatomy 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 210000002105 tongue Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462066564P | 2014-10-21 | 2014-10-21 | |
| US62/066,564 | 2014-10-21 | ||
| PCT/US2015/056651 WO2016064998A1 (en) | 2014-10-21 | 2015-10-21 | Promoting epithelial regeneration post tonsillectomy using heparin binding epidermal growth factor like growth factor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017537067A JP2017537067A (ja) | 2017-12-14 |
| JP2017537067A5 true JP2017537067A5 (https=) | 2018-11-29 |
Family
ID=55761476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017521530A Pending JP2017537067A (ja) | 2014-10-21 | 2015-10-21 | ヘパリン結合性上皮成長因子様成長因子を用いた、扁桃摘出後の上皮再生促進の方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20170232065A1 (https=) |
| EP (1) | EP3209322A4 (https=) |
| JP (1) | JP2017537067A (https=) |
| AU (2) | AU2015336008B2 (https=) |
| CA (1) | CA2964378A1 (https=) |
| WO (1) | WO2016064998A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019231860A1 (en) * | 2018-05-27 | 2019-12-05 | The Board Of Trustees Of The Leland Stanford Junior University | Method for treating or preventing radiotherapy- and chemotherapy-associated oral mucositis using locally administered heparin binding epidermal growth factor like growth factor (hb-egf) |
| US20210138036A1 (en) * | 2014-10-21 | 2021-05-13 | The Board Of Trustees Of The Leland Stanford Junior University | Method for Treating or Preventing Radiotherapy-and Chemotherapy-Associated Oral Mucositis Using Locally Administered Heparin Binding Epidermal Growth Factor Like Growth Factor (HB-EGF) |
| US11980613B2 (en) * | 2018-07-12 | 2024-05-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for reversing HIV latency using BAF complex modulating compounds |
| WO2020243607A1 (en) * | 2019-05-31 | 2020-12-03 | The Board Of Trustees Of The Leland Stanford Junior University | Mucoadhesive microgel compositions and methods for using the same |
| WO2022132984A1 (en) * | 2020-12-18 | 2022-06-23 | Duke University | Compositions for and methods of enhancing spinal cord tissue regeneration |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5112620A (en) * | 1990-09-20 | 1992-05-12 | Mikkur, Inc. | Polyethylene glycol ointment for apthous ulcers |
| US5811393A (en) * | 1990-10-16 | 1998-09-22 | The Childrens Medical Center Corp. | Heparin binding mitogen with homology to epidermal growth factor (EGF) |
| US6682501B1 (en) * | 1996-02-23 | 2004-01-27 | Gyrus Ent, L.L.C. | Submucosal tonsillectomy apparatus and method |
| US8912165B2 (en) * | 1999-03-12 | 2014-12-16 | Biotec Pharmacon Asa | Methods of skin treatment and use of water-soluble β-(1,3) glucans as active agents for producing therapeutic skin treatment agents |
| WO2007014167A2 (en) * | 2005-07-22 | 2007-02-01 | Five Prime Therapeutics, Inc. | Compositions for and methods of treating epithelial diseases with growth factors |
| WO2007061411A2 (en) * | 2005-11-21 | 2007-05-31 | Kevin Todd Kotecki | A method for developing and marketing a post operative home recovery kit for use by a patient after discharge from a hospital and for recuperation at home |
| AU2007272986B2 (en) * | 2006-07-10 | 2013-10-03 | Intersect Ent, Inc. | Implantable sustained drug delivery device for releasing active agents to the osteomeatal complex |
| WO2008134635A1 (en) * | 2007-04-30 | 2008-11-06 | Nationwide Children's Hospital | Heparin binding epidermal growth factor (hb-egf) for use in methods of treating and preventing intestinal injury related to hemorrhagic shock and resuscitation |
| AU2010241740B9 (en) * | 2009-04-27 | 2015-10-01 | Intersect Ent, Inc. | Devices and methods for treating pain associated with tonsillectomies |
| US10058631B2 (en) * | 2014-07-09 | 2018-08-28 | Cook Medical Technologies Llc | Tonsillectomy sponge |
| US20200008825A1 (en) * | 2017-01-27 | 2020-01-09 | Southern Research Institute | Sustained intratonsillar drug delivery with needle array |
-
2015
- 2015-10-21 EP EP15853304.2A patent/EP3209322A4/en not_active Withdrawn
- 2015-10-21 WO PCT/US2015/056651 patent/WO2016064998A1/en not_active Ceased
- 2015-10-21 CA CA2964378A patent/CA2964378A1/en not_active Abandoned
- 2015-10-21 AU AU2015336008A patent/AU2015336008B2/en not_active Ceased
- 2015-10-21 JP JP2017521530A patent/JP2017537067A/ja active Pending
-
2017
- 2017-04-20 US US15/492,773 patent/US20170232065A1/en not_active Abandoned
-
2019
- 2019-11-29 AU AU2019272030A patent/AU2019272030A1/en not_active Abandoned
-
2020
- 2020-08-19 US US16/997,607 patent/US20210038690A1/en not_active Abandoned
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