AU2015336008B2 - Promoting epithelial regeneration post tonsillectomy using heparin binding epidermal growth factor like growth factor - Google Patents

Promoting epithelial regeneration post tonsillectomy using heparin binding epidermal growth factor like growth factor Download PDF

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Publication number
AU2015336008B2
AU2015336008B2 AU2015336008A AU2015336008A AU2015336008B2 AU 2015336008 B2 AU2015336008 B2 AU 2015336008B2 AU 2015336008 A AU2015336008 A AU 2015336008A AU 2015336008 A AU2015336008 A AU 2015336008A AU 2015336008 B2 AU2015336008 B2 AU 2015336008B2
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AU
Australia
Prior art keywords
egf
wound
tonsillectomy
subject
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2015336008A
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English (en)
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AU2015336008A1 (en
Inventor
Daniel BESWICK
Robson CAPASSO
Chloe DOMVILLE-LEWIS
Peter Luke Santa Maria
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
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Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of AU2015336008A1 publication Critical patent/AU2015336008A1/en
Application granted granted Critical
Publication of AU2015336008B2 publication Critical patent/AU2015336008B2/en
Priority to AU2019272030A priority Critical patent/AU2019272030A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2015336008A 2014-10-21 2015-10-21 Promoting epithelial regeneration post tonsillectomy using heparin binding epidermal growth factor like growth factor Ceased AU2015336008B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2019272030A AU2019272030A1 (en) 2014-10-21 2019-11-29 Promoting epithelial regeneration post tonsillectomy using heparin binding epidermal growth factor like growth factor

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462066564P 2014-10-21 2014-10-21
US62/066,564 2014-10-21
PCT/US2015/056651 WO2016064998A1 (en) 2014-10-21 2015-10-21 Promoting epithelial regeneration post tonsillectomy using heparin binding epidermal growth factor like growth factor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2019272030A Division AU2019272030A1 (en) 2014-10-21 2019-11-29 Promoting epithelial regeneration post tonsillectomy using heparin binding epidermal growth factor like growth factor

Publications (2)

Publication Number Publication Date
AU2015336008A1 AU2015336008A1 (en) 2017-05-25
AU2015336008B2 true AU2015336008B2 (en) 2019-11-21

Family

ID=55761476

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2015336008A Ceased AU2015336008B2 (en) 2014-10-21 2015-10-21 Promoting epithelial regeneration post tonsillectomy using heparin binding epidermal growth factor like growth factor
AU2019272030A Abandoned AU2019272030A1 (en) 2014-10-21 2019-11-29 Promoting epithelial regeneration post tonsillectomy using heparin binding epidermal growth factor like growth factor

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2019272030A Abandoned AU2019272030A1 (en) 2014-10-21 2019-11-29 Promoting epithelial regeneration post tonsillectomy using heparin binding epidermal growth factor like growth factor

Country Status (6)

Country Link
US (2) US20170232065A1 (https=)
EP (1) EP3209322A4 (https=)
JP (1) JP2017537067A (https=)
AU (2) AU2015336008B2 (https=)
CA (1) CA2964378A1 (https=)
WO (1) WO2016064998A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210138036A1 (en) * 2014-10-21 2021-05-13 The Board Of Trustees Of The Leland Stanford Junior University Method for Treating or Preventing Radiotherapy-and Chemotherapy-Associated Oral Mucositis Using Locally Administered Heparin Binding Epidermal Growth Factor Like Growth Factor (HB-EGF)
WO2019231860A1 (en) * 2018-05-27 2019-12-05 The Board Of Trustees Of The Leland Stanford Junior University Method for treating or preventing radiotherapy- and chemotherapy-associated oral mucositis using locally administered heparin binding epidermal growth factor like growth factor (hb-egf)
US11980613B2 (en) * 2018-07-12 2024-05-14 The Board Of Trustees Of The Leland Stanford Junior University Methods for reversing HIV latency using BAF complex modulating compounds
WO2020243607A1 (en) * 2019-05-31 2020-12-03 The Board Of Trustees Of The Leland Stanford Junior University Mucoadhesive microgel compositions and methods for using the same
EP4247964A4 (en) * 2020-12-18 2025-07-23 Univ Duke COMPOSITIONS AND METHODS FOR ENHANCING SPINAL CORD TISSUE REGENERATION

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811393A (en) * 1990-10-16 1998-09-22 The Childrens Medical Center Corp. Heparin binding mitogen with homology to epidermal growth factor (EGF)
WO2007061411A2 (en) * 2005-11-21 2007-05-31 Kevin Todd Kotecki A method for developing and marketing a post operative home recovery kit for use by a patient after discharge from a hospital and for recuperation at home
WO2008008389A2 (en) * 2006-07-10 2008-01-17 Sinexus, Inc. Implantable sustained drug delivery device for releasing active agents to the osteomeatal complex
US20130165376A1 (en) * 2007-04-30 2013-06-27 Nationwide Children's Hospital Inc. Heparin Binding Epidermal Growth Factor (HB-EGF) for Use in Methods of Treating and Preventing Intestinal Injury Related to Hemorrhagic Shock and Resuscitation
US20140154236A1 (en) * 2009-04-27 2014-06-05 Intersect Ent, Inc. Devices and methods for treating pain associated with tonsillectomies

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112620A (en) * 1990-09-20 1992-05-12 Mikkur, Inc. Polyethylene glycol ointment for apthous ulcers
US6682501B1 (en) * 1996-02-23 2004-01-27 Gyrus Ent, L.L.C. Submucosal tonsillectomy apparatus and method
US8912165B2 (en) * 1999-03-12 2014-12-16 Biotec Pharmacon Asa Methods of skin treatment and use of water-soluble β-(1,3) glucans as active agents for producing therapeutic skin treatment agents
WO2007014167A2 (en) * 2005-07-22 2007-02-01 Five Prime Therapeutics, Inc. Compositions for and methods of treating epithelial diseases with growth factors
US10058631B2 (en) * 2014-07-09 2018-08-28 Cook Medical Technologies Llc Tonsillectomy sponge
EP3573697A4 (en) * 2017-01-27 2020-11-11 The UAB Research Foundation PROLONGED INTRA-TONSILLARY DRUG ADMINISTRATION WITH NEEDLE NETWORK

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811393A (en) * 1990-10-16 1998-09-22 The Childrens Medical Center Corp. Heparin binding mitogen with homology to epidermal growth factor (EGF)
WO2007061411A2 (en) * 2005-11-21 2007-05-31 Kevin Todd Kotecki A method for developing and marketing a post operative home recovery kit for use by a patient after discharge from a hospital and for recuperation at home
WO2008008389A2 (en) * 2006-07-10 2008-01-17 Sinexus, Inc. Implantable sustained drug delivery device for releasing active agents to the osteomeatal complex
US20130165376A1 (en) * 2007-04-30 2013-06-27 Nationwide Children's Hospital Inc. Heparin Binding Epidermal Growth Factor (HB-EGF) for Use in Methods of Treating and Preventing Intestinal Injury Related to Hemorrhagic Shock and Resuscitation
US20140154236A1 (en) * 2009-04-27 2014-06-05 Intersect Ent, Inc. Devices and methods for treating pain associated with tonsillectomies

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JM KIM ET AL, "Effects of HB-EGF and epiregulin on wound healing of gingival cells in vitro: Roles of HB-EGF and epiregulin in wound healing", ORAL DISEASES, GB, (2011-07-19), vol. 17, no. 8, pages 785 - 793 *
VAIMAN et al., "Oxycodone and Dexamethasone for pain management after tonsillectomy: A placebo-controlled EMG assessed clinical trial.", Med Sci Monit, (2011-10-01) *

Also Published As

Publication number Publication date
US20210038690A1 (en) 2021-02-11
WO2016064998A1 (en) 2016-04-28
JP2017537067A (ja) 2017-12-14
US20170232065A1 (en) 2017-08-17
EP3209322A1 (en) 2017-08-30
AU2019272030A1 (en) 2019-12-19
EP3209322A4 (en) 2018-07-18
AU2015336008A1 (en) 2017-05-25
CA2964378A1 (en) 2016-04-28

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired