JP2004535189A5 - - Google Patents
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- Publication number
- JP2004535189A5 JP2004535189A5 JP2003502199A JP2003502199A JP2004535189A5 JP 2004535189 A5 JP2004535189 A5 JP 2004535189A5 JP 2003502199 A JP2003502199 A JP 2003502199A JP 2003502199 A JP2003502199 A JP 2003502199A JP 2004535189 A5 JP2004535189 A5 JP 2004535189A5
- Authority
- JP
- Japan
- Prior art keywords
- recombinant protein
- host cell
- expression
- level
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 13
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 12
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 12
- 238000000034 method Methods 0.000 claims 11
- 230000014509 gene expression Effects 0.000 claims 9
- 239000013598 vector Substances 0.000 claims 8
- 230000035897 transcription Effects 0.000 claims 6
- 238000013518 transcription Methods 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 230000013595 glycosylation Effects 0.000 claims 2
- 238000006206 glycosylation reaction Methods 0.000 claims 2
- 239000012679 serum free medium Substances 0.000 claims 2
- 101000756632 Homo sapiens Actin, cytoplasmic 1 Proteins 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 238000011031 large-scale manufacturing process Methods 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 238000004114 suspension culture Methods 0.000 claims 1
- 230000002459 sustained effect Effects 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29596101P | 2001-06-04 | 2001-06-04 | |
| US33362001P | 2001-11-26 | 2001-11-26 | |
| US35240402P | 2002-01-29 | 2002-01-29 | |
| PCT/US2002/017763 WO2002099089A1 (en) | 2001-06-04 | 2002-06-04 | Compositions and methods for high-level, large-scale production of recombinant proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004535189A JP2004535189A (ja) | 2004-11-25 |
| JP2004535189A5 true JP2004535189A5 (cg-RX-API-DMAC7.html) | 2006-01-05 |
Family
ID=27404392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003502199A Pending JP2004535189A (ja) | 2001-06-04 | 2002-06-04 | 組換えタンパク質の高レベルの大規模生成のための組成物および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20040161817A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1402006A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2004535189A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20040032105A (cg-RX-API-DMAC7.html) |
| CN (1) | CN1533432A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2002310321A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2463310A1 (cg-RX-API-DMAC7.html) |
| WO (2) | WO2002099089A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7812148B2 (en) | 2001-04-05 | 2010-10-12 | Millipore Corporation | Vectors comprising CpG islands without position effect varigation and having increased expression |
| WO2004056986A2 (en) | 2002-12-20 | 2004-07-08 | Chromagenics B.V. | Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors |
| ES2345335T3 (es) | 2003-02-01 | 2010-09-21 | Millipore Corporation | Elementos geneticos mejorados que proporcionan altos niveles de expresion. |
| US7824907B2 (en) * | 2003-03-11 | 2010-11-02 | Merck Serono Sa | Expression vectors comprising the mCMV IE2 promoter |
| US20060195935A1 (en) | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| US8039230B2 (en) | 2004-11-08 | 2011-10-18 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| SI1809750T1 (sl) | 2004-11-08 | 2012-08-31 | Chromagenics Bv | Izbira gostiteljskih celic, ki imajo visok nivo izraĹľanja proteina |
| US8999667B2 (en) | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| JP5291341B2 (ja) | 2004-11-08 | 2013-09-18 | クロマジェニックス ベー ヴェー | タンパク質を高レベルで発現する宿主細胞の選定 |
| JP4642865B2 (ja) * | 2005-03-05 | 2011-03-02 | ミリポア・コーポレイション | 新規制御エレメントを含むベクター |
| GB0504587D0 (en) * | 2005-03-05 | 2005-04-13 | Ml Lab Plc | Vectors comprising guinea pig CMV regulatory elements |
| GB0509965D0 (en) * | 2005-05-17 | 2005-06-22 | Ml Lab Plc | Improved expression elements |
| EP1739179A1 (en) * | 2005-06-30 | 2007-01-03 | Octapharma AG | Serum-free stable transfection and production of recombinant human proteins in human cell lines |
| EP1996705B1 (en) | 2006-03-20 | 2011-08-31 | ChromaGenics B.V. | Expression augmenting dna fragments, use thereof, and methods for finding thereof |
| WO2010085251A1 (en) | 2009-01-22 | 2010-07-29 | Momenta Pharmaceuticals, Inc. | Galactose-alpha-1, 3-galactose-containing n-glycans in glycoprotein products derived from cho cells |
| JP2016500255A (ja) | 2012-12-11 | 2016-01-12 | アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ | ハイスループットなレセプター：リガンド同定の方法 |
| WO2014134412A1 (en) | 2013-03-01 | 2014-09-04 | Regents Of The University Of Minnesota | Talen-based gene correction |
| CN104341505A (zh) * | 2013-07-29 | 2015-02-11 | 西藏海思科药业集团股份有限公司 | 对蒙古人种和高加索人种低免疫原性的、抗egfr的人鼠嵌合抗体 |
| CN104341503A (zh) * | 2013-07-29 | 2015-02-11 | 西藏海思科药业集团股份有限公司 | 对蒙古人种和高加索人种低免疫原性的、抗cd20的人抗体 |
| KR102488477B1 (ko) * | 2014-01-21 | 2023-01-13 | 앨버트 아인슈타인 컬리지 오브 메디신 | 신속하고 포괄적인 t-세포 면역 모니터링을 위한 세포 플랫폼 |
| US11505591B2 (en) | 2016-05-18 | 2022-11-22 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| KR20190044029A (ko) | 2016-05-18 | 2019-04-29 | 알버트 아인슈타인 컬리지 오브 메디슨, 인크. | 변이체 pd-l1 폴리펩타이드, t-세포 조절 다량체 폴리펩타이드 및 이들의 사용 방법 |
| DK3558339T5 (da) | 2016-12-22 | 2024-09-02 | Cue Biopharma Inc | T-celle-modulerende multimere polypeptider og fremgangsmåder til anvendelse deraf |
| EP3565829A4 (en) | 2017-01-09 | 2021-01-27 | Cue Biopharma, Inc. | T-CELL-MODULATING MULTIMERIC POLYPEPTIDES AND METHOD OF USING THEREOF |
| US20200010528A1 (en) | 2017-03-15 | 2020-01-09 | Cue Biopharma, Inc. | Methods for modulating an immune response |
| CN111886241A (zh) | 2018-01-09 | 2020-11-03 | 库尔生物制药有限公司 | 多聚体t细胞调节多肽及其使用方法 |
| CA3099955A1 (en) | 2018-05-24 | 2019-11-28 | National University Corporation Hokkaido University | Novel vector and use thereof |
| IL296209A (en) | 2020-05-12 | 2022-11-01 | Cue Biopharma Inc | Multimeric t-cell modulatory polypeptides and methods of using them |
| EP4211149A4 (en) | 2020-09-09 | 2024-10-09 | Cue Biopharma, Inc. | MULTIMERIC POLYPEPTIDES MODULATING MHC CLASS II T CELLS FOR THE TREATMENT OF TYPE 1 DIABETES MELLITUS (T1D) AND METHODS OF USE THEREOF |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO162160C (no) * | 1987-01-09 | 1989-11-15 | Medi Cult As | Serumfritt vekstmedium, samt anvendelse derav. |
| IL87737A (en) * | 1987-09-11 | 1993-08-18 | Genentech Inc | Method for culturing polypeptide factor dependent vertebrate recombinant cells |
| SE9303601D0 (sv) * | 1993-11-01 | 1993-11-01 | Kabi Pharmacia Ab | Improved cell cultivation method and medium |
| CN100365127C (zh) * | 1998-07-21 | 2008-01-30 | 密理博公司 | 具有遍在染色质开放表达元件(ucoe)的聚核苷酸 |
-
2002
- 2002-06-04 KR KR10-2003-7015872A patent/KR20040032105A/ko not_active Withdrawn
- 2002-06-04 JP JP2003502199A patent/JP2004535189A/ja active Pending
- 2002-06-04 CA CA002463310A patent/CA2463310A1/en not_active Abandoned
- 2002-06-04 EP EP02734688A patent/EP1402006A4/en not_active Withdrawn
- 2002-06-04 WO PCT/US2002/017763 patent/WO2002099089A1/en not_active Ceased
- 2002-06-04 WO PCT/US2002/017770 patent/WO2002099070A2/en not_active Ceased
- 2002-06-04 US US10/163,863 patent/US20040161817A1/en not_active Abandoned
- 2002-06-04 AU AU2002310321A patent/AU2002310321A1/en not_active Abandoned
- 2002-06-04 CN CNA028143825A patent/CN1533432A/zh active Pending
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