JP2004530691A5 - - Google Patents
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- Publication number
- JP2004530691A5 JP2004530691A5 JP2002589473A JP2002589473A JP2004530691A5 JP 2004530691 A5 JP2004530691 A5 JP 2004530691A5 JP 2002589473 A JP2002589473 A JP 2002589473A JP 2002589473 A JP2002589473 A JP 2002589473A JP 2004530691 A5 JP2004530691 A5 JP 2004530691A5
- Authority
- JP
- Japan
- Prior art keywords
- thiocarbonyl
- alkyl
- group
- substituted
- carbocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 claims 180
- 125000000217 alkyl group Chemical group 0.000 claims 138
- 125000000623 heterocyclic group Chemical group 0.000 claims 80
- 125000004452 carbocyclyl group Chemical group 0.000 claims 72
- 150000001875 compounds Chemical class 0.000 claims 57
- 125000005884 carbocyclylalkyl group Chemical group 0.000 claims 47
- 125000003545 alkoxy group Chemical group 0.000 claims 40
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 40
- 125000003342 alkenyl group Chemical group 0.000 claims 38
- 150000003839 salts Chemical class 0.000 claims 37
- 125000004432 carbon atom Chemical group C* 0.000 claims 28
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 24
- 229910052799 carbon Inorganic materials 0.000 claims 23
- 125000000753 cycloalkyl group Chemical group 0.000 claims 22
- 229910052736 halogen Inorganic materials 0.000 claims 22
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 20
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 20
- 125000005120 alkyl cycloalkyl alkyl group Chemical group 0.000 claims 20
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 20
- 125000004103 aminoalkyl group Chemical group 0.000 claims 20
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 20
- 125000006517 heterocyclyl carbonyl group Chemical group 0.000 claims 20
- 125000000304 alkynyl group Chemical group 0.000 claims 16
- 125000005843 halogen group Chemical group 0.000 claims 12
- 125000004093 cyano group Chemical group *C#N 0.000 claims 11
- 150000002367 halogens Chemical class 0.000 claims 11
- -1 alkoxycarbocyclyl Chemical group 0.000 claims 10
- 125000001424 substituent group Chemical group 0.000 claims 10
- 125000001188 haloalkyl group Chemical group 0.000 claims 5
- 125000004438 haloalkoxy group Chemical group 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 2
- 125000003678 cyclohexadienyl group Chemical group C1(=CC=CCC1)* 0.000 claims 2
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims 2
- 125000000058 cyclopentadienyl group Chemical group C1(=CC=CC1)* 0.000 claims 2
- 125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 claims 2
- ZSWFCLXCOIISFI-UHFFFAOYSA-N endo-cyclopentadiene Natural products C1C=CC=C1 ZSWFCLXCOIISFI-UHFFFAOYSA-N 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000001620 monocyclic carbocycle group Chemical group 0.000 claims 1
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 1
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 1
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 0 C=NC(C(*ON)=O)(N)I(Ic(cc1)ccc1NN)(=O)=O Chemical compound C=NC(C(*ON)=O)(N)I(Ic(cc1)ccc1NN)(=O)=O 0.000 description 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29037501P | 2001-05-11 | 2001-05-11 | |
| PCT/US2002/015257 WO2002092588A2 (en) | 2001-05-11 | 2002-05-10 | Aromatic sulfone hydroxamates and their use as protease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004530691A JP2004530691A (ja) | 2004-10-07 |
| JP2004530691A5 true JP2004530691A5 (enExample) | 2006-01-05 |
Family
ID=23115707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002589473A Withdrawn JP2004530691A (ja) | 2001-05-11 | 2002-05-10 | 芳香族スルホンヒドロキサメートおよびプロテアーゼ阻害剤としてのそれらの使用 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US6689794B2 (enExample) |
| EP (1) | EP1385836A2 (enExample) |
| JP (1) | JP2004530691A (enExample) |
| KR (1) | KR20040018368A (enExample) |
| CN (1) | CN1764655A (enExample) |
| AP (1) | AP2003002908A0 (enExample) |
| AR (1) | AR040928A1 (enExample) |
| BG (1) | BG108285A (enExample) |
| BR (1) | BR0209525A (enExample) |
| CA (1) | CA2446586A1 (enExample) |
| CO (1) | CO5540386A2 (enExample) |
| CR (1) | CR7146A (enExample) |
| CZ (1) | CZ20032913A3 (enExample) |
| EA (1) | EA200301116A1 (enExample) |
| EC (1) | ECSP034839A (enExample) |
| HR (1) | HRP20030901A2 (enExample) |
| HU (1) | HUP0304069A2 (enExample) |
| IL (1) | IL158454A0 (enExample) |
| IS (1) | IS7003A (enExample) |
| MX (1) | MXPA03010326A (enExample) |
| NO (1) | NO20034995L (enExample) |
| OA (1) | OA12602A (enExample) |
| PL (1) | PL367487A1 (enExample) |
| WO (1) | WO2002092588A2 (enExample) |
| YU (1) | YU85403A (enExample) |
| ZA (1) | ZA200308525B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2306460A1 (en) * | 1997-11-14 | 1999-05-27 | G.D. Searle & Co. | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
| GB9901147D0 (en) * | 1999-01-19 | 1999-03-10 | Merck Sharp & Dohme | Therapeutic agents |
| US6683093B2 (en) * | 2000-05-12 | 2004-01-27 | Pharmacia Corporation | Aromatic sulfone hydroxamic acids and their use as protease inhibitors |
| US20040024024A1 (en) * | 2001-05-11 | 2004-02-05 | Freskos John N. | Aromatic sulfone hydroxamates and their use as protease inhibitors |
| US20050209278A1 (en) * | 2002-04-25 | 2005-09-22 | Mcdonald Joseph J | Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors |
| BR0309671A (pt) * | 2002-04-25 | 2005-05-03 | Pharmacia Corp | ácidos de piperidinil- e piperazinil-sulfonilmetil hidroxâmicos e seu uso como inibidores de protease |
| JP2006502980A (ja) * | 2002-06-25 | 2006-01-26 | ファルマシア・コーポレーション | アリールスルホニルヒドロキサム酸およびアミド誘導体、ならびにプロテアーゼ阻害薬としてのそれらの使用 |
| US8088737B2 (en) | 2003-04-04 | 2012-01-03 | Incyte Corporation | Compositions, methods and kits relating to Her-2 cleavage |
| EP1638544B1 (en) | 2003-05-07 | 2007-12-05 | The University Court of The University of Aberdeen | Ketones and reduced ketones as therapeutic agents for the treatment of bone conditions |
| RU2006125441A (ru) * | 2003-12-15 | 2008-01-27 | Джапан Тобакко Инк. (Jp) | Производные циклопропана и их фармацевтическое применение |
| WO2005061448A1 (en) * | 2003-12-24 | 2005-07-07 | Monash University | Compositions and methods for treating vascular conditions |
| US20050250789A1 (en) * | 2004-04-20 | 2005-11-10 | Burns David M | Hydroxamic acid derivatives as metalloprotease inhibitors |
| US7709516B2 (en) * | 2005-06-17 | 2010-05-04 | Endorecherche, Inc. | Helix 12 directed non-steroidal antiandrogens |
| SG177221A1 (en) | 2006-12-15 | 2012-01-30 | Abbott Lab | Novel oxadiazole compounds |
| ES2779748T3 (es) | 2012-08-23 | 2020-08-19 | Janssen Biopharma Inc | Compuestos para el tratamiento de infecciones víricas por paramixovirus |
| EP4306173A3 (en) | 2014-06-12 | 2024-04-10 | Cedars-Sinai Medical Center | Compositions and methods for treating cancers |
| CN104292180A (zh) * | 2014-10-12 | 2015-01-21 | 湖南华腾制药有限公司 | 一种恶二唑衍生物的制备方法 |
| ES3011633T3 (en) * | 2017-08-31 | 2025-04-07 | Ahammune Biosciences Private Ltd | Thiophene compounds, process for synthesis and use thereof for the treatment of autoimmune disorders |
| KR102533605B1 (ko) * | 2018-01-10 | 2023-05-17 | 주식회사 라이조테크 | 신규한 페닐설포닐 옥사졸 유도체 및 이의 용도 |
| EP4377321A1 (en) * | 2021-07-28 | 2024-06-05 | University of KwaZulu-Natal | Metallo-?-lactamase inhibitors |
| CN117800921B (zh) * | 2024-02-28 | 2024-06-11 | 南京市鸿舜医药科技有限公司 | 一种咪唑烷二酮类hdac抑制剂、制备方法及应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4595700A (en) | 1984-12-21 | 1986-06-17 | G. D. Searle & Co. | Thiol based collagenase inhibitors |
| US4882434A (en) | 1986-10-29 | 1989-11-21 | Takeda Chemical Industries, Ltd. | Gamma-lactonecarboxylic acid derivatives and their use as antibacterial agents or intermediates |
| GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| JP3122161B2 (ja) | 1991-05-16 | 2001-01-09 | 武田薬品工業株式会社 | γ−ラクトン免疫抑制剤 |
| JP3348725B2 (ja) | 1992-04-07 | 2002-11-20 | ブリティッシュ バイオテック ファーマシューティカルズ リミテッド | ヒドロキサム酸ベースのコラゲナーゼとサイトカイン阻害剤 |
| US5376664A (en) | 1992-07-27 | 1994-12-27 | The Du Pont Merck Pharmaceutical Company | Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents |
| US5455258A (en) | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| GB9307956D0 (en) | 1993-04-17 | 1993-06-02 | Walls Alan J | Hydroxamic acid derivatives |
| GB9320660D0 (en) | 1993-10-07 | 1993-11-24 | British Bio Technology | Inhibition of cytokine production |
| GB9323165D0 (en) | 1993-11-10 | 1994-01-05 | Chiros Ltd | Compounds |
| WO1995029892A1 (en) | 1994-04-28 | 1995-11-09 | The Du Pont Merck Pharmaceutical Company | Hydroxamic acid and amino acid derivatives and their use as anti-arthritic agents |
| GB9416897D0 (en) | 1994-08-20 | 1994-10-12 | British Biotech Pharm | Metalloproteinase inhibitors |
| CN1193978A (zh) | 1994-10-05 | 1998-09-23 | 奇罗斯恩有限公司 | 肽基化合物和它们作为金属蛋白酶抑制剂的医疗用途 |
| EA003294B1 (ru) | 1995-12-08 | 2003-04-24 | Агурон Фармасьютикалс, Инк. | Ингибиторы металлопротеиназы, фармацевтические композиции, их содержащие, и их фармацевтические применения |
| DK0780386T3 (da) | 1995-12-20 | 2003-02-03 | Hoffmann La Roche | Matrixmetalloproteaseinhibitorer |
| JP4358908B2 (ja) | 1996-01-02 | 2009-11-04 | アヴェンティス ファーマシューティカルズ インコーポレイテッド | 置換（アリール、ヘテロアリール、アリールメチル又はヘテロアリールメチル）ヒドロキサム酸化合物 |
| EP0994104A4 (en) | 1996-06-27 | 2001-09-12 | Ono Pharmaceutical Co | ARYL SULFIDE, SULFOXIDE AND SULPHONE DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THEM AS AN ACTIVE INGREDIENT |
| RU2221781C2 (ru) | 1996-07-22 | 2004-01-20 | Монсанто Компани | Тиолсульфоновые соединения в качестве ингибитора матриксной металлопротеазы и способы лечения |
| EP0973512B1 (en) | 1997-02-27 | 2004-04-07 | Wyeth Holdings Corporation | N-hydroxy-2-(alkyl, aryl or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors |
| US6300514B1 (en) | 1997-06-25 | 2001-10-09 | Ono Pharmaceutical Co., Ltd. | Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient |
| US6576664B1 (en) | 1997-08-18 | 2003-06-10 | Bristol-Myers Squibb Pharma Company | Inhibitors of aggrecanase and matrix metalloproteinases for the treatment of arthritis |
| US20010039287A1 (en) | 1997-11-14 | 2001-11-08 | Thomas E Barta | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
| CA2306460A1 (en) | 1997-11-14 | 1999-05-27 | G.D. Searle & Co. | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
| US6750228B1 (en) * | 1997-11-14 | 2004-06-15 | Pharmacia Corporation | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
| IL127496A0 (en) | 1997-12-19 | 1999-10-28 | Pfizer Prod Inc | The use of MMP inhibitors for the treatment of ocular angiogenesis |
| JP2002503717A (ja) | 1998-02-19 | 2002-02-05 | アメリカン・サイアナミド・カンパニー | マトリクス金属プロテイナーゼ阻害薬としてのｎ−ヒドロキシ−２−（アルキル、アリールまたはヘテロアリールスルファニル、スルフィニルまたはスルホニル）−３−置換−アルキル、アリールまたはヘテロアリールアミド |
| AU775701B2 (en) | 1999-02-08 | 2004-08-12 | G.D. Searle & Co. | Sulfamato hydroxamic acid metalloprotease inhibitor |
| WO2000059874A1 (en) | 1999-04-02 | 2000-10-12 | Du Pont Pharmaceuticals Company | NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE |
| EP1081137A1 (en) | 1999-08-12 | 2001-03-07 | Pfizer Products Inc. | Selective inhibitors of aggrecanase in osteoarthritis treatment |
| US6683093B2 (en) | 2000-05-12 | 2004-01-27 | Pharmacia Corporation | Aromatic sulfone hydroxamic acids and their use as protease inhibitors |
-
2002
- 2002-05-10 YU YU85403A patent/YU85403A/sh unknown
- 2002-05-10 WO PCT/US2002/015257 patent/WO2002092588A2/en not_active Ceased
- 2002-05-10 AR ARP020101724A patent/AR040928A1/es unknown
- 2002-05-10 BR BR0209525-4A patent/BR0209525A/pt not_active IP Right Cessation
- 2002-05-10 CZ CZ20032913A patent/CZ20032913A3/cs unknown
- 2002-05-10 EA EA200301116A patent/EA200301116A1/ru unknown
- 2002-05-10 PL PL02367487A patent/PL367487A1/xx unknown
- 2002-05-10 US US10/142,737 patent/US6689794B2/en not_active Expired - Fee Related
- 2002-05-10 CA CA002446586A patent/CA2446586A1/en not_active Abandoned
- 2002-05-10 OA OA1200300293A patent/OA12602A/en unknown
- 2002-05-10 HU HU0304069A patent/HUP0304069A2/hu unknown
- 2002-05-10 CN CNA02809672XA patent/CN1764655A/zh active Pending
- 2002-05-10 JP JP2002589473A patent/JP2004530691A/ja not_active Withdrawn
- 2002-05-10 MX MXPA03010326A patent/MXPA03010326A/es unknown
- 2002-05-10 HR HR20030901A patent/HRP20030901A2/hr not_active Application Discontinuation
- 2002-05-10 EP EP02729204A patent/EP1385836A2/en not_active Withdrawn
- 2002-05-10 IL IL15845402A patent/IL158454A0/xx unknown
- 2002-05-10 KR KR10-2003-7014663A patent/KR20040018368A/ko not_active Withdrawn
- 2002-05-10 AP APAP/P/2003/002908A patent/AP2003002908A0/en unknown
-
2003
- 2003-01-31 ZA ZA200308525A patent/ZA200308525B/en unknown
- 2003-09-05 US US10/657,034 patent/US6890928B2/en not_active Expired - Fee Related
- 2003-10-23 BG BG108285A patent/BG108285A/bg unknown
- 2003-10-29 IS IS7003A patent/IS7003A/is unknown
- 2003-11-10 CO CO03099304A patent/CO5540386A2/es not_active Application Discontinuation
- 2003-11-10 NO NO20034995A patent/NO20034995L/no not_active Application Discontinuation
- 2003-11-11 CR CR7146A patent/CR7146A/es not_active Application Discontinuation
- 2003-11-11 EC EC2003004839A patent/ECSP034839A/es unknown
-
2004
- 2004-11-17 US US10/992,483 patent/US20050101641A1/en not_active Abandoned
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