|
ES2165768B1
(es)
|
1999-07-14 |
2003-04-01 |
Almirall Prodesfarma Sa |
Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
|
|
AU6610001A
(en)
*
|
2000-06-27 |
2002-01-08 |
S A L V A T Lab Sa |
Carbamates derived from arylalkylamines
|
|
AU2002228015B2
(en)
|
2000-12-22 |
2007-08-23 |
Almirall, S.A. |
Quinuclidine carbamate derivatives and their use as M3 antagonists
|
|
SI1353919T1
(sl)
|
2000-12-28 |
2006-12-31 |
Almirall Prodesfarma Ag |
Novi derivati kinuklidina in medicinske zmesi, kijih vsebujejo.
|
|
NZ554913A
(en)
|
2001-12-14 |
2009-01-31 |
Targacept Inc |
Methods and compositions for the treatment of central nervous system disorders
|
|
WO2003053966A2
(en)
|
2001-12-20 |
2003-07-03 |
Laboratorios S.A.L.V.A.T., S.A. |
1-alkyl-1-azoniabicyclo [2.2.2] octane carbamate derivatives and their use as muscarinic receptor antagonists
|
|
ES2203327B1
(es)
*
|
2002-06-21 |
2005-06-16 |
Almirall Prodesfarma, S.A. |
Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen.
|
|
ES2204295B1
(es)
|
2002-07-02 |
2005-08-01 |
Almirall Prodesfarma, S.A. |
Nuevos derivados de quinuclidina-amida.
|
|
US7399779B2
(en)
*
|
2002-07-08 |
2008-07-15 |
Ranbaxy Laboratories Limited |
3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonists
|
|
TWI295669B
(en)
|
2002-10-30 |
2008-04-11 |
Theravance Inc |
Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
|
|
PE20040950A1
(es)
|
2003-02-14 |
2005-01-01 |
Theravance Inc |
DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
|
|
EP1618091A1
(en)
|
2003-04-09 |
2006-01-25 |
Ranbaxy Laboratories, Ltd. |
Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
|
|
EP1626957A1
(en)
|
2003-04-11 |
2006-02-22 |
Ranbaxy Laboratories Limited |
Azabicyclo derivatives as muscarinic receptor antagonists
|
|
TW200519106A
(en)
|
2003-05-02 |
2005-06-16 |
Novartis Ag |
Organic compounds
|
|
US7358244B2
(en)
|
2003-05-28 |
2008-04-15 |
Theravance, Inc. |
Azabicycloalkane compounds
|
|
JP2007524641A
(ja)
|
2003-07-11 |
2007-08-30 |
セラヴァンス, インコーポレーテッド |
置換4−アミノ−1−ベンジルピペリジン化合物
|
|
ATE435855T1
(de)
|
2003-11-21 |
2009-07-15 |
Theravance Inc |
Verbindungen mit agonistischer wirkung am beta2- adrenergen rezeptor und am muscarinischen rezeptor
|
|
GB0401334D0
(en)
|
2004-01-21 |
2004-02-25 |
Novartis Ag |
Organic compounds
|
|
EP1723112A1
(en)
|
2004-03-11 |
2006-11-22 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
US7560469B2
(en)
|
2004-03-11 |
2009-07-14 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
TW200538095A
(en)
|
2004-03-11 |
2005-12-01 |
Theravance Inc |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
US7524962B2
(en)
|
2004-03-11 |
2009-04-28 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
EP1723108A1
(en)
|
2004-03-11 |
2006-11-22 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
TWI341836B
(en)
|
2004-03-11 |
2011-05-11 |
Theravance Inc |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
JP2007528416A
(ja)
|
2004-03-11 |
2007-10-11 |
セラヴァンス, インコーポレーテッド |
ムスカリンレセプターアンタゴニストとしての有用なビフェニル化合物
|
|
EP1723109A1
(en)
|
2004-03-11 |
2006-11-22 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
GB0411056D0
(en)
|
2004-05-18 |
2004-06-23 |
Novartis Ag |
Organic compounds
|
|
ES2246170B1
(es)
*
|
2004-07-29 |
2007-04-01 |
Almirall Prodesfarma, S.A. |
Nuevo procedimiento para preparar derivados de carbamato de quinuclidinio.
|
|
GT200500281A
(es)
|
2004-10-22 |
2006-04-24 |
Novartis Ag |
Compuestos organicos.
|
|
GB0424284D0
(en)
|
2004-11-02 |
2004-12-01 |
Novartis Ag |
Organic compounds
|
|
GB0426164D0
(en)
|
2004-11-29 |
2004-12-29 |
Novartis Ag |
Organic compounds
|
|
US7629336B2
(en)
|
2005-03-10 |
2009-12-08 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
US7659403B2
(en)
|
2005-03-10 |
2010-02-09 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
TW200714587A
(en)
|
2005-03-10 |
2007-04-16 |
Theravance Inc |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
EP1866284A1
(en)
|
2005-03-10 |
2007-12-19 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
WO2006099031A1
(en)
|
2005-03-10 |
2006-09-21 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
GB0507577D0
(en)
|
2005-04-14 |
2005-05-18 |
Novartis Ag |
Organic compounds
|
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
|
WO2006138218A1
(en)
|
2005-06-13 |
2006-12-28 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
BRPI0614874A2
(pt)
|
2005-08-22 |
2011-04-19 |
Targacept Inc |
diazatricicloalcanos substituìdos com heteroarila, métodos para sua preparação e uso dos mesmos
|
|
CA2625664C
(en)
|
2005-10-21 |
2016-01-05 |
Novartis Ag |
Human antibodies against il13 and therapeutic uses
|
|
WO2007110782A1
(en)
*
|
2005-12-30 |
2007-10-04 |
Ranbaxy Laboratories Limited |
Muscarinic receptor antagonists
|
|
GB0601951D0
(en)
|
2006-01-31 |
2006-03-15 |
Novartis Ag |
Organic compounds
|
|
GB0602778D0
(en)
|
2006-02-10 |
2006-03-22 |
Glaxo Group Ltd |
Novel compound
|
|
HRP20120494T1
(hr)
|
2006-04-21 |
2012-08-31 |
Novartis Ag |
Derivati purina za uporabu kao agonista adenozin a2a receptora
|
|
ES2298049B1
(es)
|
2006-07-21 |
2009-10-20 |
Laboratorios Almirall S.A. |
Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano.
|
|
EP1882691A1
(en)
*
|
2006-07-26 |
2008-01-30 |
CHIESI FARMACEUTICI S.p.A. |
Quinuclidine derivatives as M3 antagonists
|
|
CN101516885A
(zh)
|
2006-09-29 |
2009-08-26 |
诺瓦提斯公司 |
作为pi3k脂质激酶抑制剂的吡唑并嘧啶类化合物
|
|
TW200825084A
(en)
*
|
2006-11-14 |
2008-06-16 |
Astrazeneca Ab |
New compounds 521
|
|
NZ577939A
(en)
|
2007-01-10 |
2011-03-31 |
Irm Llc |
Compounds and compositions as channel activating protease inhibitors
|
|
AU2008212171A1
(en)
*
|
2007-02-09 |
2008-08-14 |
Astellas Pharma Inc. |
Aza-bridged-ring compound
|
|
US20090010923A1
(en)
*
|
2007-04-24 |
2009-01-08 |
University Of Maryland, Baltimore |
Treatment of cancer with anti-muscarinic receptor agents
|
|
KR20100005730A
(ko)
|
2007-05-07 |
2010-01-15 |
노파르티스 아게 |
유기 화합물
|
|
SA08290475B1
(ar)
|
2007-08-02 |
2013-06-22 |
Targacept Inc |
(2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
|
|
CN101883771A
(zh)
|
2007-10-01 |
2010-11-10 |
科门蒂斯公司 |
作为α7-烟碱乙酰胆碱受体配体用于治疗阿尔茨海默氏病的奎宁环-4-基甲基1H-吲哚-3-甲酸酯衍生物
|
|
EP2065385A1
(en)
*
|
2007-11-28 |
2009-06-03 |
Laboratorios SALVAT, S.A. |
Stable crystalline salt of (R)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabiciyclo [2.2.2]oct-3-yl ester
|
|
EA017919B1
(ru)
|
2007-12-10 |
2013-04-30 |
Новартис Аг |
Производные пиразин-2-карбоксамида для лечения заболеваний, которые поддаются лечению путем блокирования эпителиальных натриевых каналов
|
|
PT2231642E
(pt)
|
2008-01-11 |
2014-03-12 |
Novartis Ag |
Pirimidinas como inibidores de quinase
|
|
EP2080507A1
(en)
*
|
2008-01-15 |
2009-07-22 |
CHIESI FARMACEUTICI S.p.A. |
Pharmaceutical formulations comprising an anticholinergic drug
|
|
HRP20130749T1
(en)
|
2008-02-13 |
2013-10-11 |
Targacept, Inc. |
Combination of alpha 7 nicotinic agonists and antipsychotics
|
|
US20100055045A1
(en)
*
|
2008-02-26 |
2010-03-04 |
William Gerhart |
Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations
|
|
AU2009241628A1
(en)
*
|
2008-02-26 |
2009-11-05 |
Elevation Pharmaceuticals, Inc. |
Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations
|
|
EP2100598A1
(en)
|
2008-03-13 |
2009-09-16 |
Laboratorios Almirall, S.A. |
Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
|
|
EP2100599A1
(en)
|
2008-03-13 |
2009-09-16 |
Laboratorios Almirall, S.A. |
Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
|
|
US8268834B2
(en)
|
2008-03-19 |
2012-09-18 |
Novartis Ag |
Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
|
|
US8236808B2
(en)
|
2008-06-10 |
2012-08-07 |
Novartis Ag |
Pyrazine derivatives as ENAC blockers
|
|
EP2154136A1
(en)
|
2008-08-08 |
2010-02-17 |
CHIESI FARMACEUTICI S.p.A. |
Quinuclidine carbonate derivatives and medicinal compositions thereof
|
|
WO2010045633A2
(en)
*
|
2008-10-17 |
2010-04-22 |
National Jewish Health |
Measurement and analysis of leukotrienes
|
|
EP2206712A1
(en)
|
2008-12-23 |
2010-07-14 |
CHIESI FARMACEUTICI S.p.A. |
"Alkaloid aminoester derivatives and medicinal composition thereof"
|
|
TW201031664A
(en)
|
2009-01-26 |
2010-09-01 |
Targacept Inc |
Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
|
|
WO2010088335A1
(en)
|
2009-01-29 |
2010-08-05 |
Novartis Ag |
Substituted benzimidazoles for the treatment of astrocytomas
|
|
US8389526B2
(en)
|
2009-08-07 |
2013-03-05 |
Novartis Ag |
3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
|
|
EP2464649A1
(en)
|
2009-08-12 |
2012-06-20 |
Novartis AG |
Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation
|
|
DK2467141T3
(en)
|
2009-08-17 |
2019-02-18 |
Intellikine Llc |
HETEROCYCLIC COMPOUNDS AND APPLICATIONS THEREOF
|
|
BR112012008061A2
(pt)
|
2009-08-20 |
2016-03-01 |
Novartis Ag |
compostos de oxima heterocíclica
|
|
WO2011050325A1
(en)
|
2009-10-22 |
2011-04-28 |
Vertex Pharmaceuticals Incorporated |
Compositions for treatment of cystic fibrosis and other chronic diseases
|
|
US8247436B2
(en)
|
2010-03-19 |
2012-08-21 |
Novartis Ag |
Pyridine and pyrazine derivative for the treatment of CF
|
|
PH12012502404A1
(en)
|
2010-06-22 |
2013-02-18 |
Chiesi Farm Spa |
Dry powder formulation comprising an antimuscarinic drug
|
|
WO2011160918A1
(en)
|
2010-06-22 |
2011-12-29 |
Chiesi Farmaceutici S.P.A. |
Alkaloid aminoester derivatives and medicinal composition thereof
|
|
RU2567548C2
(ru)
*
|
2010-06-22 |
2015-11-10 |
КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. |
Производные сложного аминоэфира алкалоида и их лекарственные композиции
|
|
CA2803459A1
(en)
*
|
2010-06-22 |
2011-12-29 |
Chiesi Farmaceutici S.P.A. |
Alkaloid aminoester derivatives and medicinal compositions thereof
|
|
UY33597A
(es)
|
2010-09-09 |
2012-04-30 |
Irm Llc |
Compuestos y composiciones como inhibidores de la trk
|
|
WO2012034095A1
(en)
|
2010-09-09 |
2012-03-15 |
Irm Llc |
Compounds and compositions as trk inhibitors
|
|
US8372845B2
(en)
|
2010-09-17 |
2013-02-12 |
Novartis Ag |
Pyrazine derivatives as enac blockers
|
|
RU2585767C2
(ru)
*
|
2010-11-26 |
2016-06-10 |
КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. |
Производные глицина и их применение в качестве антагонистов мускариновых рецепторов
|
|
KR101928505B1
(ko)
*
|
2011-01-28 |
2018-12-12 |
에스케이바이오팜 주식회사 |
피리돈 유도체 및 이를 포함하는 약학적 조성물
|
|
JP2014505088A
(ja)
|
2011-02-10 |
2014-02-27 |
ノバルティス アーゲー |
C−METチロシンキナーゼ阻害剤としての[1,2,4]トリアゾロ[4,3−b]ピリダジン化合物
|
|
US20120220557A1
(en)
|
2011-02-17 |
2012-08-30 |
Chiesi Farmaceutici S.P.A. |
Liquid propellant-free formulation comprising an antimuscarinic drug
|
|
EP2678016B1
(en)
|
2011-02-23 |
2016-08-10 |
Intellikine, LLC |
Heterocyclic compounds and uses thereof
|
|
PH12013501758A1
(en)
|
2011-02-25 |
2013-10-14 |
Irm Llc |
Pyrazolo [1,5-a] pyridines as trk inhibitors
|
|
PT2685986T
(pt)
*
|
2011-03-18 |
2020-03-05 |
Genzyme Corp |
Inibidor de glicosilceramida-sintase
|
|
EP2510928A1
(en)
|
2011-04-15 |
2012-10-17 |
Almirall, S.A. |
Aclidinium for use in improving the quality of sleep in respiratory patients
|
|
BR112013025682A2
(pt)
*
|
2011-04-29 |
2017-01-03 |
Chiesi Farm Spa |
Compostos, composição farmacêutica, uso de um composto, combinação e dispositivo
|
|
UY34305A
(es)
|
2011-09-01 |
2013-04-30 |
Novartis Ag |
Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar
|
|
MX339302B
(es)
|
2011-09-15 |
2016-05-19 |
Novartis Ag |
3-(quinolin-6-il-tio)-[1,2,4]-triazolo-[4,3-a]-piridinas 6-sustituidas como cinasas de tirosina.
|
|
ES2558457T3
(es)
|
2011-09-16 |
2016-02-04 |
Novartis Ag |
Compuestos heterocíclicos para el tratamiento de fibrosis quística
|
|
WO2013038381A1
(en)
|
2011-09-16 |
2013-03-21 |
Novartis Ag |
Pyridine/pyrazine amide derivatives
|
|
WO2013038378A1
(en)
|
2011-09-16 |
2013-03-21 |
Novartis Ag |
Pyridine amide derivatives
|
|
WO2013038373A1
(en)
|
2011-09-16 |
2013-03-21 |
Novartis Ag |
Pyridine amide derivatives
|
|
EP2755652B1
(en)
|
2011-09-16 |
2021-06-02 |
Novartis AG |
N-substituted heterocyclyl carboxamides
|
|
JP6130391B2
(ja)
|
2011-11-23 |
2017-05-17 |
インテリカイン, エルエルシー |
Mtor阻害剤を使用する強化された治療レジメン
|
|
WO2013098145A1
(en)
|
2011-12-30 |
2013-07-04 |
Chiesi Farmaceutici S.P.A. |
Quinuclidine esters of 1-azaheterocyclylacetic acid as antimuscarinic agents, process for their preparation and medicinal compositions thereof
|
|
US8809340B2
(en)
|
2012-03-19 |
2014-08-19 |
Novartis Ag |
Crystalline form
|
|
EP3964513A1
(en)
|
2012-04-03 |
2022-03-09 |
Novartis AG |
Combination products with tyrosine kinase inhibitors and their use
|
|
JOP20130273B1
(ar)
|
2012-09-11 |
2021-08-17 |
Genzyme Corp |
مثبطات انزيم (سينثاز) غلوكوسيل سيراميد
|
|
US9073921B2
(en)
|
2013-03-01 |
2015-07-07 |
Novartis Ag |
Salt forms of bicyclic heterocyclic derivatives
|
|
JP2016512835A
(ja)
|
2013-03-15 |
2016-05-09 |
インテリカイン, エルエルシー |
キナーゼ阻害剤の組み合わせ及びそれらの使用
|
|
WO2015084804A1
(en)
|
2013-12-03 |
2015-06-11 |
Novartis Ag |
Combination of mdm2 inhibitor and braf inhibitor and their use
|
|
BR112016023967A2
(pt)
|
2014-04-24 |
2017-08-15 |
Novartis Ag |
derivados de pirazina como inibidores de fosfatidilinositol 3-cinase
|
|
EP3134396B1
(en)
|
2014-04-24 |
2019-09-18 |
Novartis AG |
Amino pyridine derivatives as phosphatidylinositol 3-kinase inhibitors
|
|
JP6433509B2
(ja)
|
2014-04-24 |
2018-12-05 |
ノバルティス アーゲー |
ホスファチジルイノシトール3−キナーゼ阻害薬としてのアミノピラジン誘導体
|
|
WO2016007630A1
(en)
|
2014-07-11 |
2016-01-14 |
Alpharmagen, Llc |
Quinuclidine compounds for modulating alpha7 -nicotinic acetylcholine receptor activity
|
|
WO2016011658A1
(en)
|
2014-07-25 |
2016-01-28 |
Novartis Ag |
Combination therapy
|
|
CA2954862A1
(en)
|
2014-07-31 |
2016-02-04 |
Novartis Ag |
Combination therapy
|
|
US9724340B2
(en)
|
2015-07-31 |
2017-08-08 |
Attenua, Inc. |
Antitussive compositions and methods
|
|
EP3980121A1
(en)
|
2019-06-10 |
2022-04-13 |
Novartis AG |
Pyridine and pyrazine derivative for the treatment of cf, copd, and bronchiectasis
|
|
AU2020338971B2
(en)
|
2019-08-28 |
2023-11-23 |
Novartis Ag |
Substituted 1,3-phenyl heteroaryl derivatives and their use in the treatment of disease
|
|
TW202140550A
(zh)
|
2020-01-29 |
2021-11-01 |
瑞士商諾華公司 |
使用抗tslp抗體治療炎性或阻塞性氣道疾病之方法
|
|
US12083115B2
(en)
|
2020-02-03 |
2024-09-10 |
Genzyme Corporation |
Methods for treating neurological symptoms associated with lysosomal storage diseases
|
|
BR112023000798A2
(pt)
|
2020-07-24 |
2023-02-07 |
Genzyme Corp |
Composições farmacêuticas compreendendo venglustat
|