JP2004527586A5 - - Google Patents
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- Publication number
- JP2004527586A5 JP2004527586A5 JP2003502070A JP2003502070A JP2004527586A5 JP 2004527586 A5 JP2004527586 A5 JP 2004527586A5 JP 2003502070 A JP2003502070 A JP 2003502070A JP 2003502070 A JP2003502070 A JP 2003502070A JP 2004527586 A5 JP2004527586 A5 JP 2004527586A5
- Authority
- JP
- Japan
- Prior art keywords
- polymer
- composition
- amino acid
- poly
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920000642 polymer Polymers 0.000 claims 11
- 150000002632 lipids Chemical class 0.000 claims 4
- 239000000178 monomer Substances 0.000 claims 4
- 229940024606 amino acid Drugs 0.000 claims 3
- 235000001014 amino acid Nutrition 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 2
- 150000003862 amino acid derivatives Chemical class 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 230000002209 hydrophobic effect Effects 0.000 claims 2
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 claims 1
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims 1
- 229930186217 Glycolipid Natural products 0.000 claims 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 150000001299 aldehydes Chemical class 0.000 claims 1
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 claims 1
- 235000008206 alpha-amino acids Nutrition 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 150000003975 aryl alkyl amines Chemical class 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
- 229940106189 ceramide Drugs 0.000 claims 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 125000005265 dialkylamine group Chemical group 0.000 claims 1
- 230000007774 longterm Effects 0.000 claims 1
- QEFRNWWLZKMPFJ-UHFFFAOYSA-N methionine S-oxide Chemical compound CS(=O)CCC(N)C(O)=O QEFRNWWLZKMPFJ-UHFFFAOYSA-N 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims 1
- JHCLUTILJRJUHZ-UHFFFAOYSA-N pentatriacontan-18-amine Chemical compound CCCCCCCCCCCCCCCCCC(N)CCCCCCCCCCCCCCCCC JHCLUTILJRJUHZ-UHFFFAOYSA-N 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 229920001308 poly(aminoacid) Polymers 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01202107 | 2001-06-01 | ||
| PCT/EP2002/006783 WO2002098952A1 (en) | 2001-06-01 | 2002-06-03 | Lipid-polymer-conjugates compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004527586A JP2004527586A (ja) | 2004-09-09 |
| JP2004527586A5 true JP2004527586A5 (enExample) | 2006-01-05 |
Family
ID=8180408
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003502070A Pending JP2004527586A (ja) | 2001-06-01 | 2002-06-03 | 脂質−ポリマー結合体組成物 |
| JP2003502069A Pending JP2004527585A (ja) | 2001-06-01 | 2002-06-03 | 脂質−ポリマー結合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003502069A Pending JP2004527585A (ja) | 2001-06-01 | 2002-06-03 | 脂質−ポリマー結合体 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US20040254352A1 (enExample) |
| EP (2) | EP1392755B1 (enExample) |
| JP (2) | JP2004527586A (enExample) |
| KR (2) | KR100874847B1 (enExample) |
| CN (2) | CN1308375C (enExample) |
| AT (2) | ATE416214T1 (enExample) |
| BR (2) | BR0209695A (enExample) |
| CA (2) | CA2448858A1 (enExample) |
| CZ (2) | CZ20033480A3 (enExample) |
| DE (2) | DE60218154T2 (enExample) |
| EE (2) | EE200300596A (enExample) |
| ES (2) | ES2318027T3 (enExample) |
| HR (2) | HRP20030975A2 (enExample) |
| HU (2) | HUP0400174A2 (enExample) |
| MX (2) | MXPA03011050A (enExample) |
| NO (2) | NO20035264D0 (enExample) |
| PL (2) | PL367479A1 (enExample) |
| SK (2) | SK15982003A3 (enExample) |
| WO (2) | WO2002098952A1 (enExample) |
| ZA (2) | ZA200308937B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60218154T2 (de) * | 2001-06-01 | 2007-10-31 | Astellas Pharma Europe B.V. | Lipid-polymer konjugaten |
| FR2840614B1 (fr) | 2002-06-07 | 2004-08-27 | Flamel Tech Sa | Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques |
| EP1393720A1 (en) * | 2002-08-27 | 2004-03-03 | Universiteit Utrecht | Vesicle-encapsulated corticosteroids for treatment of cancer |
| SG113442A1 (en) * | 2002-11-29 | 2005-08-29 | Agency Science Tech & Res | Improved temperature sensitive micelles |
| FR2855521B1 (fr) | 2003-05-28 | 2005-08-05 | Flamel Tech Sa | Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques. |
| EP1481683A1 (en) * | 2003-05-30 | 2004-12-01 | Yamanouchi Pharmaceutical Co. Ltd. | P-selectin targeting ligand and compositions thereof |
| SE527505C2 (sv) * | 2003-06-10 | 2006-03-28 | Anna Imberg | Komposita material och partiklar |
| FR2860516B1 (fr) * | 2003-10-03 | 2006-01-13 | Flamel Tech Sa | Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques |
| JP5331967B2 (ja) * | 2006-05-09 | 2013-10-30 | 国立大学法人大阪大学 | コレステロールアミン導入ポリ−γ−グルタミン酸誘導体 |
| JP4936312B2 (ja) * | 2006-07-20 | 2012-05-23 | 株式会社島津製作所 | 新規な両親媒性物質、それを用いた薬剤搬送システム及び分子イメージングシステム |
| JP5258189B2 (ja) * | 2006-11-09 | 2013-08-07 | 学校法人 関西大学 | 柔軟性生分解性ポリマー |
| ITRM20070327A1 (it) * | 2007-06-11 | 2008-12-12 | Univ Palermo | Vettori colloidali a struttura poliamminoacidica per il rilascio orale di peptidi e proteine e relativo metodo di produzione. |
| US20090285882A1 (en) * | 2008-04-22 | 2009-11-19 | Jochen Weiss | Stabilized Liposome Compositions and Related Methods of Use |
| KR101695836B1 (ko) * | 2010-04-13 | 2017-01-16 | (주)아모레퍼시픽 | 경피흡수용 고분자-리포좀 나노복합체 조성물 및 그 제조방법 |
| ES2385995B2 (es) * | 2011-01-10 | 2013-05-21 | Universidade De Santiago De Compostela | Nanocápsulas con cubierta polimérica |
| US9993427B2 (en) * | 2013-03-14 | 2018-06-12 | Biorest Ltd. | Liposome formulation and manufacture |
| WO2019172362A1 (ja) * | 2018-03-07 | 2019-09-12 | 公益財団法人川崎市産業振興財団 | 刺激応答性ポリマー |
| JPWO2023282296A1 (enExample) * | 2021-07-07 | 2023-01-12 | ||
| WO2024232832A1 (en) * | 2023-05-11 | 2024-11-14 | Agency For Science, Technology And Research | A compound for preparing lipid nanoparticles encapsulating an agent, nanoparticle composition comprising said compound and related methods thereof |
| WO2025021942A1 (en) | 2023-07-27 | 2025-01-30 | Bracco Suisse Sa | Ultrasound responsive vesicles containing lipid-polyamino acid conjugates |
| WO2025031991A1 (en) * | 2023-08-04 | 2025-02-13 | Polypeptide Therapeutic Solutions, S.L. | Stealth-stabilized sulfur-containing lipo/polyamino acids |
| WO2025080209A1 (en) * | 2023-10-10 | 2025-04-17 | Agency For Science, Technology And Research | A compound for preparing lipid nanoparticles encapsulating an agent, nanoparticle composition comprising said compound and related methods thereof |
| WO2025090023A1 (en) * | 2023-10-24 | 2025-05-01 | Agency For Science, Technology And Research | A compound for preparing lipid nanoparticles encapsulating an agent, nanoparticle composition comprising said compound, and related methods thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0657722B2 (ja) * | 1986-05-27 | 1994-08-03 | 三菱化成株式会社 | 水溶性ポリマ−組成物 |
| US5149794A (en) * | 1990-11-01 | 1992-09-22 | State Of Oregon | Covalent lipid-drug conjugates for drug targeting |
| US5395619A (en) * | 1993-03-03 | 1995-03-07 | Liposome Technology, Inc. | Lipid-polymer conjugates and liposomes |
| US6333021B1 (en) * | 1994-11-22 | 2001-12-25 | Bracco Research S.A. | Microcapsules, method of making and their use |
| US5972379A (en) * | 1995-02-14 | 1999-10-26 | Sequus Pharmaceuticals, Inc. | Liposome composition and method for administering a quinolone |
| US6197332B1 (en) * | 1997-08-13 | 2001-03-06 | Chiron Corporation | Lipid-conjugated polyamide compounds and related compositions and methods thereof |
| GB9811059D0 (en) * | 1998-05-23 | 1998-07-22 | Univ Strathclyde | Polyamino acid vesicles |
| DE60218154T2 (de) * | 2001-06-01 | 2007-10-31 | Astellas Pharma Europe B.V. | Lipid-polymer konjugaten |
-
2002
- 2002-06-03 DE DE60218154T patent/DE60218154T2/de not_active Expired - Fee Related
- 2002-06-03 WO PCT/EP2002/006783 patent/WO2002098952A1/en not_active Ceased
- 2002-06-03 US US10/479,319 patent/US20040254352A1/en not_active Abandoned
- 2002-06-03 CA CA002448858A patent/CA2448858A1/en not_active Abandoned
- 2002-06-03 MX MXPA03011050A patent/MXPA03011050A/es unknown
- 2002-06-03 DE DE60230137T patent/DE60230137D1/de not_active Expired - Fee Related
- 2002-06-03 HU HU0400174A patent/HUP0400174A2/hu unknown
- 2002-06-03 WO PCT/EP2002/006432 patent/WO2002098951A2/en not_active Ceased
- 2002-06-03 CZ CZ20033480A patent/CZ20033480A3/cs unknown
- 2002-06-03 KR KR1020037015720A patent/KR100874847B1/ko not_active Expired - Fee Related
- 2002-06-03 SK SK1598-2003A patent/SK15982003A3/sk unknown
- 2002-06-03 KR KR1020037015722A patent/KR100894852B1/ko not_active Expired - Fee Related
- 2002-06-03 PL PL02367479A patent/PL367479A1/xx not_active Application Discontinuation
- 2002-06-03 HU HU0400171A patent/HUP0400171A2/hu unknown
- 2002-06-03 HR HR20030975A patent/HRP20030975A2/hr not_active Application Discontinuation
- 2002-06-03 HR HR20030976A patent/HRP20030976A2/hr not_active Application Discontinuation
- 2002-06-03 ES ES02748799T patent/ES2318027T3/es not_active Expired - Lifetime
- 2002-06-03 CN CNB028127358A patent/CN1308375C/zh not_active Expired - Fee Related
- 2002-06-03 CN CNB02812734XA patent/CN1271116C/zh not_active Expired - Fee Related
- 2002-06-03 AT AT02748799T patent/ATE416214T1/de not_active IP Right Cessation
- 2002-06-03 AT AT02754661T patent/ATE353927T1/de not_active IP Right Cessation
- 2002-06-03 EE EEP200300596A patent/EE200300596A/xx unknown
- 2002-06-03 JP JP2003502070A patent/JP2004527586A/ja active Pending
- 2002-06-03 BR BR0209695-1A patent/BR0209695A/pt not_active IP Right Cessation
- 2002-06-03 CA CA002448856A patent/CA2448856A1/en not_active Abandoned
- 2002-06-03 EP EP02748799A patent/EP1392755B1/en not_active Expired - Lifetime
- 2002-06-03 EP EP02754661A patent/EP1392756B1/en not_active Expired - Lifetime
- 2002-06-03 PL PL02369455A patent/PL369455A1/xx not_active Application Discontinuation
- 2002-06-03 SK SK1597-2003A patent/SK15972003A3/sk not_active Application Discontinuation
- 2002-06-03 JP JP2003502069A patent/JP2004527585A/ja active Pending
- 2002-06-03 BR BR0209699-4A patent/BR0209699A/pt not_active IP Right Cessation
- 2002-06-03 US US10/479,031 patent/US20040241222A1/en not_active Abandoned
- 2002-06-03 EE EEP200300598A patent/EE200300598A/xx unknown
- 2002-06-03 MX MXPA03011049A patent/MXPA03011049A/es unknown
- 2002-06-03 ES ES02754661T patent/ES2282439T3/es not_active Expired - Lifetime
- 2002-06-03 CZ CZ20033479A patent/CZ20033479A3/cs unknown
-
2003
- 2003-11-17 ZA ZA200308937A patent/ZA200308937B/en unknown
- 2003-11-17 ZA ZA200308938A patent/ZA200308938B/en unknown
- 2003-11-27 NO NO20035264A patent/NO20035264D0/no not_active Application Discontinuation
- 2003-11-27 NO NO20035263A patent/NO20035263D0/no not_active Application Discontinuation
-
2009
- 2009-07-06 US US12/498,080 patent/US20100145018A1/en not_active Abandoned
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