JP2004527213A5 - - Google Patents
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- JP2004527213A5 JP2004527213A5 JP2002518253A JP2002518253A JP2004527213A5 JP 2004527213 A5 JP2004527213 A5 JP 2004527213A5 JP 2002518253 A JP2002518253 A JP 2002518253A JP 2002518253 A JP2002518253 A JP 2002518253A JP 2004527213 A5 JP2004527213 A5 JP 2004527213A5
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- Prior art keywords
- polypeptide
- nucleic acid
- acid molecule
- antigen
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 description 41
- 229920001184 polypeptide Polymers 0.000 description 34
- 102000004196 processed proteins & peptides Human genes 0.000 description 34
- 150000007523 nucleic acids Chemical class 0.000 description 21
- 108020004707 nucleic acids Proteins 0.000 description 17
- 102000039446 nucleic acids Human genes 0.000 description 17
- 210000004027 cell Anatomy 0.000 description 14
- 238000000034 method Methods 0.000 description 12
- 239000000427 antigen Substances 0.000 description 10
- 102000036639 antigens Human genes 0.000 description 10
- 108091007433 antigens Proteins 0.000 description 10
- 230000004927 fusion Effects 0.000 description 9
- 108010006519 Molecular Chaperones Proteins 0.000 description 8
- 230000000890 antigenic effect Effects 0.000 description 7
- 239000013604 expression vector Substances 0.000 description 7
- 239000002245 particle Substances 0.000 description 7
- 108091028043 Nucleic acid sequence Proteins 0.000 description 6
- 210000000612 antigen-presenting cell Anatomy 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 102100021868 Calnexin Human genes 0.000 description 4
- 108010056891 Calnexin Proteins 0.000 description 4
- 102000004082 Calreticulin Human genes 0.000 description 4
- 108090000549 Calreticulin Proteins 0.000 description 4
- 102100028082 Tapasin Human genes 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 108010059434 tapasin Proteins 0.000 description 4
- 102100039328 Endoplasmin Human genes 0.000 description 3
- 102000043129 MHC class I family Human genes 0.000 description 3
- 108091054437 MHC class I family Proteins 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 230000028993 immune response Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 241000701806 Human papillomavirus Species 0.000 description 2
- 101000767631 Human papillomavirus type 16 Protein E7 Proteins 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 125000000539 amino acid group Chemical group 0.000 description 2
- 210000004443 dendritic cell Anatomy 0.000 description 2
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 2
- 108010017007 glucose-regulated proteins Proteins 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000013598 vector Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 101000793651 Homo sapiens Calreticulin Proteins 0.000 description 1
- 101000812663 Homo sapiens Endoplasmin Proteins 0.000 description 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 1
- 241000710960 Sindbis virus Species 0.000 description 1
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 description 1
- 210000001130 astrocyte Anatomy 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000009260 cross reactivity Effects 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical group [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 102000053922 human CALR Human genes 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 230000002601 intratumoral effect Effects 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 230000002101 lytic effect Effects 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 210000000274 microglia Anatomy 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 231100001221 nontumorigenic Toxicity 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22290200P | 2000-08-03 | 2000-08-03 | |
| US60/222,902 | 2000-08-03 | ||
| PCT/US2001/024134 WO2002012281A2 (en) | 2000-08-03 | 2001-08-02 | Molecular vaccine linking an endoplasmic reticulum chaperone polypeptide to an antigen |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008197856A Division JP2009017883A (ja) | 2000-08-03 | 2008-07-31 | 抗原に小胞体シャペロンポリペプチドを連結した分子ワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004527213A JP2004527213A (ja) | 2004-09-09 |
| JP2004527213A5 true JP2004527213A5 (enExample) | 2008-09-18 |
| JP5087201B2 JP5087201B2 (ja) | 2012-12-05 |
Family
ID=22834209
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002518253A Expired - Lifetime JP5087201B2 (ja) | 2000-08-03 | 2001-08-02 | 抗原に小胞体シャペロンポリペプチドを連結した分子ワクチン |
| JP2008197856A Pending JP2009017883A (ja) | 2000-08-03 | 2008-07-31 | 抗原に小胞体シャペロンポリペプチドを連結した分子ワクチン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008197856A Pending JP2009017883A (ja) | 2000-08-03 | 2008-07-31 | 抗原に小胞体シャペロンポリペプチドを連結した分子ワクチン |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7342002B2 (enExample) |
| EP (1) | EP1363938B1 (enExample) |
| JP (2) | JP5087201B2 (enExample) |
| AU (1) | AU2001278117A1 (enExample) |
| CA (1) | CA2417214C (enExample) |
| DK (1) | DK1363938T3 (enExample) |
| ES (1) | ES2454640T3 (enExample) |
| WO (1) | WO2002012281A2 (enExample) |
Families Citing this family (44)
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| US20050100928A1 (en) * | 1999-09-16 | 2005-05-12 | Zycos Inc., A Delaware Corporation | Nucleic acids encoding polyepitope polypeptides |
| US8128922B2 (en) | 1999-10-20 | 2012-03-06 | Johns Hopkins University | Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen |
| AU2001290520A1 (en) * | 2000-08-01 | 2002-02-13 | The Johns Hokpins University | Intercellular transport protein linked to an antigen as a molecular vaccine |
| WO2002012281A2 (en) | 2000-08-03 | 2002-02-14 | Johns Hopkins University | Molecular vaccine linking an endoplasmic reticulum chaperone polypeptide to an antigen |
| AU2002242016A1 (en) | 2001-02-01 | 2002-08-12 | The Johns Hopkins University | Nucleic acid derived vaccine that encodes an antigen linked to a polypeptide that promotes antigen presentation |
| US20070026501A1 (en) * | 2003-04-18 | 2007-02-01 | Joe Chiba | Immunogen, composition for immulogical use and process for producing antibody using the same |
| US9701725B2 (en) * | 2003-05-05 | 2017-07-11 | The Johns Hopkins University | Anti-cancer DNA vaccine employing plasmids encoding signal sequence, mutant oncoprotein antigen, and heat shock protein |
| ES2427641T3 (es) | 2003-05-22 | 2013-10-31 | Ibio, Inc. | Molécula vehículo recombinante para la expresión, el suministro y la purificación de polipéptidos diana |
| WO2005081716A2 (en) * | 2003-11-24 | 2005-09-09 | The Johns Hopkins University | DNA VACCINES TARGETING ANTIGENS OF THE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS (SARS-CoV) |
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| US9085638B2 (en) | 2007-03-07 | 2015-07-21 | The Johns Hopkins University | DNA vaccine enhancement with MHC class II activators |
| US20080260765A1 (en) * | 2007-03-15 | 2008-10-23 | Johns Hopkins University | HPV DNA Vaccines and Methods of Use Thereof |
| US20100291683A1 (en) * | 2007-03-27 | 2010-11-18 | Lung-Ji Chang | Modified Antigen Presenting Cells and Methods of Use |
| WO2009009759A2 (en) * | 2007-07-11 | 2009-01-15 | Fraunhofer Usa, Inc. | Yersinia pestis antigens, vaccine compositions, and related methods |
| KR20110011595A (ko) * | 2008-01-28 | 2011-02-08 | 탭이뮨, 인크. | 면역 반응 증진을 위한 타파신 증대 |
| EP2752193B1 (en) | 2008-03-03 | 2017-01-11 | The University of Miami | Allogeneic cancer cell-based immunotherapy |
| WO2009117116A2 (en) | 2008-03-20 | 2009-09-24 | University Of Miami | Heat shock protein gp96 vaccination and methods of using same |
| US20090285861A1 (en) * | 2008-04-17 | 2009-11-19 | Tzyy-Choou Wu | Tumor cell-based cancer immunotherapeutic compositions and methods |
| WO2010030861A2 (en) * | 2008-09-11 | 2010-03-18 | Calretex, Llc | Compositions and methods for purifying calreticulin |
| WO2010037046A1 (en) | 2008-09-28 | 2010-04-01 | Fraunhofer Usa, Inc. | Humanized neuraminidase antibody and methods of use thereof |
| CA2776144C (en) | 2009-09-29 | 2020-10-27 | Fraunhofer Usa, Inc. | Influenza hemagglutinin antibodies, compositions, and related methods |
| PL2591114T3 (pl) * | 2010-07-06 | 2017-08-31 | Glaxosmithkline Biologicals Sa | Immunizacja dużych ssaków małymi dawkami rna |
| KR20140045341A (ko) * | 2011-02-23 | 2014-04-16 | 유니버시티 오브 마이애미 | Siv/hiv로부터의 보호를 위한 조합된 세포 기반의 gp96-ig-siv/hiv, 재조합 gp120 단백질 백신접종 |
| LT3892295T (lt) | 2011-05-24 | 2023-07-10 | BioNTech SE | Individualizuotos vakcinos nuo vėžio |
| EP2752112B1 (en) * | 2011-09-02 | 2016-04-27 | Kaneka Corporation | Transgenic bird expressing foreign gene using endoplasmic reticulum chaperone promoter |
| WO2013093629A2 (en) * | 2011-12-20 | 2013-06-27 | Netherlands Cancer Institute | Modular vaccines, methods and compositions related thereto |
| JP6484558B2 (ja) | 2012-11-28 | 2019-03-13 | バイオエヌテック エールエヌアー ファーマシューティカルズ ゲーエムベーハーBiontech Rna Pharmaceuticals Gmbh | 癌ワクチンの組み合せ物 |
| WO2014164727A1 (en) * | 2013-03-12 | 2014-10-09 | Wisconsin Alumni Research Foundation | A method of treating fungal infection |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| WO2017155981A1 (en) * | 2016-03-07 | 2017-09-14 | Massachusetts Institute Of Technology | Protein-chaperoned t-cell vaccines |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| WO2018224166A1 (en) | 2017-06-09 | 2018-12-13 | Biontech Rna Pharmaceuticals Gmbh | Methods for predicting the usefulness of disease specific amino acid modifications for immunotherapy |
| SG11201911430PA (en) | 2017-07-04 | 2020-01-30 | Curevac Ag | Novel nucleic acid molecules |
| CN109182339A (zh) * | 2018-09-06 | 2019-01-11 | 青岛农业大学 | 一种许氏平鮋钙网蛋白基因及应用 |
| CA3161800A1 (en) | 2019-11-18 | 2021-05-27 | Janssen Biotech, Inc. | Vaccines based on mutant calr and jak2 and their uses |
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| CN100335121C (zh) * | 2001-07-20 | 2007-09-05 | 得克萨斯大学体系董事会 | 涉及hpv相关的癌前期的和癌的生长(包括cin)的方法和组合物 |
| US20060040262A1 (en) | 2002-12-27 | 2006-02-23 | Morris David W | Novel compositions and methods in cancer |
| AU2003224732A1 (en) | 2002-03-25 | 2003-10-13 | The Trustees Of Boston University | Method of using anti-apoptotic factors in gene expression |
| DK1553966T3 (da) | 2002-10-03 | 2012-09-17 | Wyeth Corp | Fusionspeptider omfattende human papillomavirus E7- og E6- polypeptider samt immunogene sammensætninger deraf |
| US20070026076A1 (en) * | 2003-02-24 | 2007-02-01 | Tzyy-Choou Wu | Molecular vaccines employing nucleic acid encoding anti-apoptotic proteins |
| US9701725B2 (en) | 2003-05-05 | 2017-07-11 | The Johns Hopkins University | Anti-cancer DNA vaccine employing plasmids encoding signal sequence, mutant oncoprotein antigen, and heat shock protein |
| WO2005081716A2 (en) | 2003-11-24 | 2005-09-09 | The Johns Hopkins University | DNA VACCINES TARGETING ANTIGENS OF THE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS (SARS-CoV) |
| AU2005322960A1 (en) | 2005-01-06 | 2006-07-13 | The Johns Hopkins University | RNA interference that blocks expression of pro-apoptotic proteins potentiates immunity induced by DNA and transfected dendritic cell vaccines |
| EP1846026A4 (en) | 2005-01-26 | 2008-07-02 | Univ Johns Hopkins | ANTIBODY DNA VACCINE WITH PLASMIDES FOR CODING A MUTATED ONCOPROTEIN ANTIGEN AND CALRETICULIN |
-
2001
- 2001-08-02 WO PCT/US2001/024134 patent/WO2002012281A2/en not_active Ceased
- 2001-08-02 US US10/343,448 patent/US7342002B2/en not_active Expired - Lifetime
- 2001-08-02 CA CA2417214A patent/CA2417214C/en not_active Expired - Lifetime
- 2001-08-02 ES ES01956081.2T patent/ES2454640T3/es not_active Expired - Lifetime
- 2001-08-02 DK DK01956081.2T patent/DK1363938T3/en active
- 2001-08-02 JP JP2002518253A patent/JP5087201B2/ja not_active Expired - Lifetime
- 2001-08-02 EP EP01956081.2A patent/EP1363938B1/en not_active Expired - Lifetime
- 2001-08-02 AU AU2001278117A patent/AU2001278117A1/en not_active Abandoned
-
2008
- 2008-01-15 US US12/014,541 patent/US8007781B2/en not_active Expired - Fee Related
- 2008-07-31 JP JP2008197856A patent/JP2009017883A/ja active Pending
-
2012
- 2012-05-03 US US13/463,250 patent/US20130203961A1/en not_active Abandoned
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