JP2004526730A5 - - Google Patents
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- Publication number
- JP2004526730A5 JP2004526730A5 JP2002572914A JP2002572914A JP2004526730A5 JP 2004526730 A5 JP2004526730 A5 JP 2004526730A5 JP 2002572914 A JP2002572914 A JP 2002572914A JP 2002572914 A JP2002572914 A JP 2002572914A JP 2004526730 A5 JP2004526730 A5 JP 2004526730A5
- Authority
- JP
- Japan
- Prior art keywords
- propofol
- formulation
- sae
- pharmaceutical
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 24
- OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical compound CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 claims 20
- 229960004134 propofol Drugs 0.000 claims 20
- 238000009472 formulation Methods 0.000 claims 18
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 8
- 239000012669 liquid formulation Substances 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 6
- 239000007788 liquid Substances 0.000 claims 5
- 229920000858 Cyclodextrin Polymers 0.000 claims 4
- 238000002360 preparation method Methods 0.000 claims 4
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 4
- 125000004964 sulfoalkyl group Chemical group 0.000 claims 4
- 239000007924 injection Substances 0.000 claims 3
- 238000002347 injection Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000003755 preservative agent Substances 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000008344 egg yolk phospholipid Substances 0.000 claims 2
- 229960004194 lidocaine Drugs 0.000 claims 2
- 239000003589 local anesthetic agent Substances 0.000 claims 2
- 239000003921 oil Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 229940124531 pharmaceutical excipient Drugs 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 claims 1
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 1
- BFUUJUGQJUTPAF-UHFFFAOYSA-N 2-(3-amino-4-propoxybenzoyl)oxyethyl-diethylazanium;chloride Chemical compound [Cl-].CCCOC1=CC=C(C(=O)OCC[NH+](CC)CC)C=C1N BFUUJUGQJUTPAF-UHFFFAOYSA-N 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims 1
- YQKAVWCGQQXBGW-UHFFFAOYSA-N Piperocaine Chemical compound CC1CCCCN1CCCOC(=O)C1=CC=CC=C1 YQKAVWCGQQXBGW-UHFFFAOYSA-N 0.000 claims 1
- 239000002535 acidifier Substances 0.000 claims 1
- 230000003113 alkalizing effect Effects 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000002518 antifoaming agent Substances 0.000 claims 1
- 239000003429 antifungal agent Substances 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 229960005274 benzocaine Drugs 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 229960003150 bupivacaine Drugs 0.000 claims 1
- -1 cation compound Chemical class 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 229960001747 cinchocaine Drugs 0.000 claims 1
- PUFQVTATUTYEAL-UHFFFAOYSA-N cinchocaine Chemical compound C1=CC=CC2=NC(OCCCC)=CC(C(=O)NCCN(CC)CC)=C21 PUFQVTATUTYEAL-UHFFFAOYSA-N 0.000 claims 1
- 230000009918 complex formation Effects 0.000 claims 1
- 230000000536 complexating effect Effects 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 229910001882 dioxygen Inorganic materials 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- WBZKQQHYRPRKNJ-UHFFFAOYSA-L disulfite Chemical compound [O-]S(=O)S([O-])(=O)=O WBZKQQHYRPRKNJ-UHFFFAOYSA-L 0.000 claims 1
- 239000003792 electrolyte Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 230000000004 hemodynamic effect Effects 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000002960 lipid emulsion Substances 0.000 claims 1
- 239000008297 liquid dosage form Substances 0.000 claims 1
- 229960005015 local anesthetics Drugs 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 229940067082 pentetate Drugs 0.000 claims 1
- 229960001045 piperocaine Drugs 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 229960001807 prilocaine Drugs 0.000 claims 1
- MVFGUOIZUNYYSO-UHFFFAOYSA-N prilocaine Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C MVFGUOIZUNYYSO-UHFFFAOYSA-N 0.000 claims 1
- 229960004919 procaine Drugs 0.000 claims 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 claims 1
- 229960003981 proparacaine Drugs 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 229960001549 ropivacaine Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000008247 solid mixture Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 229960002372 tetracaine Drugs 0.000 claims 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27730501P | 2001-03-20 | 2001-03-20 | |
| PCT/US2002/008596 WO2002074200A1 (en) | 2001-03-20 | 2002-03-19 | Formulations containing propofol and a sulfoalkyl ether cyclodextrin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004526730A JP2004526730A (ja) | 2004-09-02 |
| JP2004526730A5 true JP2004526730A5 (enExample) | 2005-12-22 |
| JP4334229B2 JP4334229B2 (ja) | 2009-09-30 |
Family
ID=23060281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002572914A Expired - Fee Related JP4334229B2 (ja) | 2001-03-20 | 2002-03-19 | プロポフォール及びスルホアルキルエーテルシクロデキストリン含有製剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20030055023A1 (enExample) |
| EP (1) | EP1383445A4 (enExample) |
| JP (1) | JP4334229B2 (enExample) |
| AU (1) | AU2002254309B2 (enExample) |
| CA (1) | CA2441744C (enExample) |
| WO (1) | WO2002074200A1 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1105096B1 (en) | 1998-08-19 | 2003-10-29 | Skyepharma Canada Inc. | Injectable aqueous dispersions of propofol |
| US6468989B1 (en) * | 2000-07-13 | 2002-10-22 | Dow Pharmaceutical Sciences | Gel compositions containing metronidazole |
| US7034013B2 (en) * | 2001-03-20 | 2006-04-25 | Cydex, Inc. | Formulations containing propofol and a sulfoalkyl ether cyclodextrin |
| DE60305438T2 (de) * | 2002-02-01 | 2006-12-21 | Shimoda Biotech (Pty.) Ltd., Mill Park | Lyophilisierte pharmazeutische zusammensetzung von propofol |
| US7550155B2 (en) | 2002-07-29 | 2009-06-23 | Transform Pharmaceuticals Inc. | Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses |
| AU2003261274C1 (en) | 2002-07-29 | 2009-02-12 | Transform Pharmaceuticals, Inc. | Aqueous 2,6-diisopropylphenol pharmaceutical compositions |
| US7089927B2 (en) * | 2002-10-23 | 2006-08-15 | New York University | System and method for guidance of anesthesia, analgesia and amnesia |
| JP2006514923A (ja) * | 2002-10-25 | 2006-05-18 | ファイザー・プロダクツ・インク | 注射可能な新規なデポ製剤 |
| AU2003267763A1 (en) * | 2002-10-25 | 2004-05-13 | Pfizer Products Inc. | Depot formulations of arylheterocyclic active agents in the form of a suspension |
| CA2503956A1 (en) * | 2002-10-29 | 2004-05-13 | Transform Pharmaceuticals, Inc. | Propofol with cysteine |
| MXPA03009945A (es) | 2002-11-05 | 2007-04-16 | Lg Electronics Inc | Montaje para montar una pantalla de toque para un monitor con pantalla de cristal liquido. |
| AU2003260943A1 (en) * | 2003-06-10 | 2005-01-04 | Shashikant Prabhudas Kurani | Improved novel, clear, painless preparation of propofol |
| KR20060113737A (ko) * | 2003-12-22 | 2006-11-02 | 쉐링 코포레이션 | 약제학적 조성물 |
| US20070020299A1 (en) | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
| US20070020298A1 (en) * | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether gamma-cyclodextrin and corticosteroid |
| EP1704858A4 (en) * | 2004-01-14 | 2008-06-04 | Otsuka Pharma Co Ltd | PROPOFOL-CONTAINING FAT-EMULSION PREPARATION |
| PT1713504T (pt) * | 2004-01-30 | 2017-08-29 | Zoetis Services Llc | Conservantes antimicrobianos para obter uma formulação multidose utilizando beta-ciclodextrinas para formas galénicas líquidas |
| CN101098678A (zh) | 2004-04-23 | 2008-01-02 | 锡德克斯公司 | 含有磺基烷基醚环糊精的dpi制剂 |
| BRPI0515181A (pt) * | 2004-09-13 | 2008-07-22 | Bharat Serums & Vaccines Ltd | composição de óleo-em-água estéril para administração intravenosa, uso de um monoglicerìdeo e processo de preparação de uma composição para administração intravenosa |
| US20060198891A1 (en) | 2004-11-29 | 2006-09-07 | Francois Ravenelle | Solid formulations of liquid biologically active agents |
| JPWO2006112276A1 (ja) | 2005-04-13 | 2008-12-11 | 株式会社大塚製薬工場 | プロポフォール含有脂肪乳剤 |
| JP2009504634A (ja) * | 2005-08-12 | 2009-02-05 | ブハラット セルムズ アンド ヴァクシンズ リミテッド | プロポフォールを含む水性麻酔剤組成物 |
| US20100204178A1 (en) | 2006-10-02 | 2010-08-12 | James Cloyd | Novel parenteral carbamazepine formulation |
| US7629331B2 (en) | 2005-10-26 | 2009-12-08 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof |
| EP1965780B1 (en) * | 2005-12-19 | 2017-03-08 | The University Of Liverpool | Propofol derivatives as analgesics |
| JP2009524590A (ja) * | 2005-12-20 | 2009-07-02 | ティカ レーケメデル アーベー | 薬物動態学的プロフィールの向上を有するコルチコステロイドを送達するための方法およびシステム |
| US20090239942A1 (en) | 2006-09-15 | 2009-09-24 | Cloyd James C | Topiramate Compositions and Methods of Making and Using the Same |
| PL2146946T3 (pl) * | 2007-05-09 | 2011-04-29 | Pharmacofore Inc | (-)-Stereoizomer 2,6-di-sec-butylofenolu i jego analogi |
| CA2685813A1 (en) * | 2007-05-09 | 2008-11-20 | Pharmacofore, Inc. | Therapeutic compounds |
| US12370352B2 (en) | 2007-06-28 | 2025-07-29 | Cydex Pharmaceuticals, Inc. | Nasal and ophthalmic delivery of aqueous corticosteroid solutions |
| WO2009146024A1 (en) | 2008-03-31 | 2009-12-03 | The General Hospital Corporation | Etomidate analogues with improved pharmacokinetic and pharmacodynamic properties |
| EP2106786A1 (de) * | 2008-04-04 | 2009-10-07 | Roewer, Norbert, Univ.-Prof. Dr. med. | Pharmazeutische Zubereitung mit permethyliertem Cyclodextrin |
| US7635773B2 (en) | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
| MY188453A (en) * | 2008-11-15 | 2021-12-09 | Melinta Subsidiary Corp | Antimicrobial compositions |
| BRPI1014854A2 (pt) * | 2009-03-30 | 2016-05-03 | Cerulean Pharma Inc | "conjugados polímero-agente, partículas, composições, e métodos de uso relacionados" |
| WO2010114768A1 (en) * | 2009-03-30 | 2010-10-07 | Cerulean Pharma Inc. | Polymer-epothilone conjugates, particles, compositions, and related methods of use |
| WO2010114770A1 (en) * | 2009-03-30 | 2010-10-07 | Cerulean Pharma Inc. | Polymer-agent conjugates, particles, compositions, and related methods of use |
| US8492538B1 (en) | 2009-06-04 | 2013-07-23 | Jose R. Matos | Cyclodextrin derivative salts |
| CA2767112C (en) | 2009-07-10 | 2018-06-19 | The General Hospital Corporation | Etomidate analogues that do not inhibit adrenocortical steroid synthesis |
| DK2525798T3 (da) * | 2010-01-21 | 2017-11-20 | Drawbridge Pharmaceuticals Pty Ltd | Anæstetisk formulering |
| MX2013009007A (es) | 2011-02-02 | 2013-08-29 | Nestec Sa | Composiciones nutricionales altas en proteina y metodos para elaborar y utilizar las mismas. |
| EP2484350B1 (de) * | 2011-02-04 | 2016-04-20 | Roewer, Norbert, Univ.-Prof. Dr. med. | Pharmazeutische Zubereitung, enthaltend einen Komplex eines Propofolsalzes mit einem Cyclodextrin |
| BR112014017230A2 (pt) | 2012-01-13 | 2020-11-24 | The General Hospital Corporation | compostos anestésicos e métodos de uso relacionados |
| PL3702374T3 (pl) | 2012-02-15 | 2022-11-21 | Cydex Pharmaceuticals, Inc. | Sposób wytwarzania pochodnych cyklodekstryny |
| WO2013130666A1 (en) | 2012-02-28 | 2013-09-06 | Cydex Pharmaceuticals, Inc. | Alkylated cyclodextrin compositions and processes for preparing and using the same |
| KR101889121B1 (ko) * | 2012-03-01 | 2018-09-20 | 노르베르트 뢰베르 | 제약 제제 |
| US10004807B2 (en) * | 2012-03-19 | 2018-06-26 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising fatty acid esters |
| WO2014053560A1 (de) * | 2012-10-04 | 2014-04-10 | Fresenius Kabi Deutschland Gmbh | Applikationsanordnung mit einem arzneistofffluid |
| UA121095C2 (uk) | 2012-10-22 | 2020-04-10 | Сідекс Фармасьютікалс, Інк. | Композиції алкілованого циклодекстрину і способи їх одержання і застосування |
| CN104870001B (zh) | 2012-11-15 | 2019-01-18 | 赛博尔泰克股份公司 | 用作消炎或免疫抑制有效成分的飞燕草素络合物 |
| HK1215392A1 (zh) | 2012-12-11 | 2016-08-26 | 赛博尔泰克股份公司 | 用於对抗黑色素瘤细胞的飞燕草素 |
| EP3183295B1 (en) | 2014-08-22 | 2023-08-02 | CyDex Pharmaceuticals, Inc. | Fractionated alkylated cyclodextrin compositions and processes for preparing and using the same |
| EP3199150A4 (en) * | 2014-09-25 | 2017-08-09 | Fujifilm Corporation | Propofol-containing oil-in-water emulsion composition and method for producing same |
| WO2017127835A2 (en) * | 2016-01-22 | 2017-07-27 | The Medicines Company | Aqueous formulations and methods of preparation and use thereof |
| WO2017132243A1 (en) * | 2016-01-29 | 2017-08-03 | Cuda Anesthetics, Llc | Aqueous pharmaceutical formulation comprising propofol |
| EP3567059A1 (en) * | 2018-05-09 | 2019-11-13 | Biocydex | Substituted cyclodextrin-metal complexes and uses thereof |
| WO2020093256A1 (zh) * | 2018-11-07 | 2020-05-14 | 比卡生物科技（广州）有限公司 | 一种澄清丙泊酚注射液及其制备方法 |
| CN111150703A (zh) * | 2018-11-07 | 2020-05-15 | 比卡生物科技（广州）有限公司 | 一种澄清丙泊酚注射液及其制备方法 |
| WO2020232274A1 (en) * | 2019-05-15 | 2020-11-19 | Bexson Biomedical, Inc. | Ketamine formulation for subcutaneous injection |
| US20230102590A1 (en) * | 2020-02-03 | 2023-03-30 | Senju Pharmaceutical Co., Ltd. | Use of polyether compound |
| JP2023551145A (ja) | 2020-11-18 | 2023-12-07 | ベクソン バイオメディカル，インク． | 医薬化合物の錯化剤塩製剤 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993017711A1 (en) * | 1992-03-11 | 1993-09-16 | Australian Commercial Research & Development Limited | New cyclodextrins and new formulated drugs |
| ZA962214B (en) * | 1995-04-10 | 1996-10-07 | Farmarc Nederland Bv | Pharmaceutical composition |
| US6362234B1 (en) * | 2000-08-15 | 2002-03-26 | Vyrex Corporation | Water-soluble prodrugs of propofol for treatment of migrane |
-
2002
- 2002-03-19 WO PCT/US2002/008596 patent/WO2002074200A1/en not_active Ceased
- 2002-03-19 CA CA2441744A patent/CA2441744C/en not_active Expired - Lifetime
- 2002-03-19 EP EP02723536A patent/EP1383445A4/en not_active Withdrawn
- 2002-03-19 AU AU2002254309A patent/AU2002254309B2/en not_active Ceased
- 2002-03-19 US US10/102,049 patent/US20030055023A1/en not_active Abandoned
- 2002-03-19 JP JP2002572914A patent/JP4334229B2/ja not_active Expired - Fee Related
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