JP2004525624A5 - - Google Patents
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- JP2004525624A5 JP2004525624A5 JP2002559584A JP2002559584A JP2004525624A5 JP 2004525624 A5 JP2004525624 A5 JP 2004525624A5 JP 2002559584 A JP2002559584 A JP 2002559584A JP 2002559584 A JP2002559584 A JP 2002559584A JP 2004525624 A5 JP2004525624 A5 JP 2004525624A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- ability
- nucleotide sequence
- library
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 30
- 239000002773 nucleotide Substances 0.000 claims 16
- 125000003729 nucleotide group Chemical group 0.000 claims 16
- 238000000034 method Methods 0.000 claims 8
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 7
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 239000013598 vector Substances 0.000 claims 5
- 108091034117 Oligonucleotide Proteins 0.000 claims 4
- 125000006850 spacer group Chemical group 0.000 claims 4
- 241000235648 Pichia Species 0.000 claims 3
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 3
- 108091028732 Concatemer Proteins 0.000 claims 2
- 241000235058 Komagataella pastoris Species 0.000 claims 2
- 241000081271 Phaffia rhodozyma Species 0.000 claims 2
- 241000235015 Yarrowia lipolytica Species 0.000 claims 2
- 210000004507 artificial chromosome Anatomy 0.000 claims 2
- 238000010367 cloning Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000003204 osmotic effect Effects 0.000 claims 2
- 108091008146 restriction endonucleases Proteins 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 210000005253 yeast cell Anatomy 0.000 claims 2
- 241000222178 Candida tropicalis Species 0.000 claims 1
- 201000007336 Cryptococcosis Diseases 0.000 claims 1
- 241000235646 Cyberlindnera jadinii Species 0.000 claims 1
- 241001465321 Eremothecium Species 0.000 claims 1
- 241001149669 Hanseniaspora Species 0.000 claims 1
- 108091092195 Intron Proteins 0.000 claims 1
- 241000235649 Kluyveromyces Species 0.000 claims 1
- 235000014663 Kluyveromyces fragilis Nutrition 0.000 claims 1
- 241001138401 Kluyveromyces lactis Species 0.000 claims 1
- 241000235650 Kluyveromyces marxianus Species 0.000 claims 1
- 241001489207 Lipomyces lipofer Species 0.000 claims 1
- 241000235048 Meyerozyma guilliermondii Species 0.000 claims 1
- 241000320412 Ogataea angusta Species 0.000 claims 1
- 101150053185 P450 gene Proteins 0.000 claims 1
- 241000235652 Pachysolen Species 0.000 claims 1
- 241000223252 Rhodotorula Species 0.000 claims 1
- 241000223253 Rhodotorula glutinis Species 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 1
- 235000018368 Saccharomyces fragilis Nutrition 0.000 claims 1
- 241000235343 Saccharomycetales Species 0.000 claims 1
- 241000235003 Saccharomycopsis Species 0.000 claims 1
- 241000192263 Scheffersomyces shehatae Species 0.000 claims 1
- 241000235060 Scheffersomyces stipitis Species 0.000 claims 1
- 241000383403 Solen Species 0.000 claims 1
- 241000192348 [Candida] palmioleophila Species 0.000 claims 1
- 229940031154 kluyveromyces marxianus Drugs 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 239000002574 poison Substances 0.000 claims 1
- 231100000614 poison Toxicity 0.000 claims 1
- 230000000644 propagated effect Effects 0.000 claims 1
- 229960002181 saccharomyces boulardii Drugs 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 230000003595 spectral effect Effects 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200100128 | 2001-01-25 | ||
| DKPA200100679 | 2001-05-01 | ||
| US30086301P | 2001-06-27 | 2001-06-27 | |
| PCT/DK2002/000056 WO2002059297A2 (en) | 2001-01-25 | 2002-01-25 | A library of a collection of cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009233636A Division JP4965625B2 (ja) | 2001-01-25 | 2009-10-07 | 細胞コレクションのライブラリー |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004525624A JP2004525624A (ja) | 2004-08-26 |
| JP2004525624A5 true JP2004525624A5 (https=) | 2005-12-22 |
Family
ID=43646216
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002559584A Withdrawn JP2004525624A (ja) | 2001-01-25 | 2002-01-25 | 細胞コレクションのライブラリー |
| JP2009233636A Expired - Fee Related JP4965625B2 (ja) | 2001-01-25 | 2009-10-07 | 細胞コレクションのライブラリー |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009233636A Expired - Fee Related JP4965625B2 (ja) | 2001-01-25 | 2009-10-07 | 細胞コレクションのライブラリー |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7838287B2 (https=) |
| EP (1) | EP1356037B1 (https=) |
| JP (2) | JP2004525624A (https=) |
| AT (1) | ATE501251T1 (https=) |
| AU (1) | AU2002227883A1 (https=) |
| CA (1) | CA2474172C (https=) |
| DE (1) | DE60239386D1 (https=) |
| DK (1) | DK1356037T3 (https=) |
| WO (1) | WO2002059297A2 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8008459B2 (en) | 2001-01-25 | 2011-08-30 | Evolva Sa | Concatemers of differentially expressed multiple genes |
| WO2002059297A2 (en) | 2001-01-25 | 2002-08-01 | Evolva Biotech A/S | A library of a collection of cells |
| EP1472349B1 (en) * | 2002-01-25 | 2008-10-29 | Evolva AG | Methods for multiple parameter screening and evolution of cells to produce small molecules with multiple functionalities |
| DK2314629T4 (da) | 2002-07-18 | 2023-02-06 | Merus Nv | Rekombinant produktion af blandinger af antistoffer |
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| WO2004016791A1 (en) * | 2002-08-01 | 2004-02-26 | Evolva Ltd | Methods of mixing large numbers of heterologous genes |
| WO2004106375A1 (en) | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| EP1737971B1 (en) * | 2004-01-20 | 2017-08-16 | Merus N.V. | Mixtures of binding proteins |
| CN103589650A (zh) | 2005-03-18 | 2014-02-19 | 米克罗比亚公司 | 产油酵母和真菌中类胡萝卜素的产生 |
| WO2008042338A2 (en) | 2006-09-28 | 2008-04-10 | Microbia, Inc. | Production of carotenoids in oleaginous yeast and fungi |
| CN102282155B (zh) | 2008-12-02 | 2017-06-09 | 日本波涛生命科学公司 | 磷原子修饰的核酸的合成方法 |
| KR101153866B1 (ko) | 2009-05-21 | 2012-06-27 | 대한민국 | 형질전환용 운반체, 이의 제조방법, 이를 이용한 형질전환방법 및 형질전환체 |
| RU2612521C2 (ru) | 2009-07-06 | 2017-03-09 | Онтории, Инк. | Новые пролекарства нуклеиновых кислот и способы их применения |
| WO2011146833A1 (en) | 2010-05-20 | 2011-11-24 | Evolva Inc. | Method of producing isoprenoid compounds in yeast |
| CN105671108A (zh) | 2010-06-02 | 2016-06-15 | 沃维公司 | 甜菊糖苷的重组生产 |
| JP5868324B2 (ja) | 2010-09-24 | 2016-02-24 | 株式会社Wave Life Sciences Japan | 不斉補助基 |
| CN103796657B (zh) | 2011-07-19 | 2017-07-11 | 波涛生命科学有限公司 | 合成官能化核酸的方法 |
| CN108396044A (zh) | 2011-08-08 | 2018-08-14 | 埃沃尔瓦公司 | 甜菊醇糖苷类的重组生产 |
| US9248181B2 (en) | 2012-04-20 | 2016-02-02 | Merus B.V. | Methods and means for the production of Ig-like molecules |
| US10829772B2 (en) | 2012-06-22 | 2020-11-10 | Monsanto Technology Llc | Unique modular vector design |
| KR102213609B1 (ko) | 2012-07-13 | 2021-02-08 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
| CA2879066C (en) | 2012-07-13 | 2019-08-13 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant |
| PL2872485T3 (pl) | 2012-07-13 | 2021-05-31 | Wave Life Sciences Ltd. | Asymetryczna grupa pomocnicza |
| US20150293076A1 (en) * | 2012-10-22 | 2015-10-15 | Bolt Threads, Inc. | Cellular Reprogramming for Product Optimization |
| SG11201505597SA (en) | 2013-02-06 | 2015-08-28 | Evolva Sa | Methods for improved production of rebaudioside d and rebaudioside m |
| CA2900882A1 (en) | 2013-02-11 | 2014-08-14 | Evolva Sa | Efficient production of steviol glycosides in recombinants hosts |
| CA2924343C (en) | 2013-09-17 | 2025-09-16 | Bolt Threads, Inc. | PROCESSES AND COMPOSITIONS FOR SYNTHESIZING IMPROVED SILK FIBERS |
| US9580758B2 (en) | 2013-11-12 | 2017-02-28 | Luc Montagnier | System and method for the detection and treatment of infection by a microbial agent associated with HIV infection |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| JPWO2015108047A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| US10322173B2 (en) | 2014-01-15 | 2019-06-18 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| BR112016016400A2 (pt) | 2014-01-16 | 2017-10-03 | Wave Life Sciences Ltd | Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos |
| AU2015303294A1 (en) | 2014-08-11 | 2017-02-02 | Evolva Sa. | Production of steviol glycosides in recombinant hosts |
| AU2015314251A1 (en) | 2014-09-09 | 2017-03-16 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| SG11201705606PA (en) | 2015-01-30 | 2017-08-30 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CA2979931A1 (en) | 2015-03-16 | 2016-09-22 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
| AU2016307066A1 (en) | 2015-08-07 | 2018-02-08 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| US10982249B2 (en) | 2016-04-13 | 2021-04-20 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| WO2017198682A1 (en) | 2016-05-16 | 2017-11-23 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| KR20190046993A (ko) | 2016-09-14 | 2019-05-07 | 볼트 쓰레즈, 인크. | 긴 균일한 재조합 단백질 섬유 |
| US11396669B2 (en) | 2016-11-07 | 2022-07-26 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| JP7212982B1 (ja) | 2022-10-05 | 2023-01-26 | 株式会社Logomix | 細胞ライブラリおよびその製造方法 |
| JP2025170455A (ja) * | 2022-10-05 | 2025-11-19 | 株式会社Logomix | 細胞ライブラリおよびその製造方法 |
| US20240209383A1 (en) * | 2022-12-21 | 2024-06-27 | Clara Foods Co. | Systems and methods for high yielding recombinant microorganisms and uses thereof |
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-
2002
- 2002-01-25 WO PCT/DK2002/000056 patent/WO2002059297A2/en not_active Ceased
- 2002-01-25 DE DE60239386T patent/DE60239386D1/de not_active Expired - Lifetime
- 2002-01-25 AU AU2002227883A patent/AU2002227883A1/en not_active Abandoned
- 2002-01-25 US US10/466,960 patent/US7838287B2/en not_active Expired - Fee Related
- 2002-01-25 EP EP02709979A patent/EP1356037B1/en not_active Expired - Lifetime
- 2002-01-25 DK DK02709979.5T patent/DK1356037T3/da active
- 2002-01-25 CA CA2474172A patent/CA2474172C/en not_active Expired - Fee Related
- 2002-01-25 AT AT02709979T patent/ATE501251T1/de not_active IP Right Cessation
- 2002-01-25 JP JP2002559584A patent/JP2004525624A/ja not_active Withdrawn
-
2009
- 2009-10-07 JP JP2009233636A patent/JP4965625B2/ja not_active Expired - Fee Related
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2010
- 2010-10-12 US US12/902,587 patent/US20120094870A1/en not_active Abandoned
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