ATE501251T1 - Zellbibliothek - Google Patents
ZellbibliothekInfo
- Publication number
- ATE501251T1 ATE501251T1 AT02709979T AT02709979T ATE501251T1 AT E501251 T1 ATE501251 T1 AT E501251T1 AT 02709979 T AT02709979 T AT 02709979T AT 02709979 T AT02709979 T AT 02709979T AT E501251 T1 ATE501251 T1 AT E501251T1
- Authority
- AT
- Austria
- Prior art keywords
- novel
- libraries
- host cells
- cell library
- discovery
- Prior art date
Links
- 230000014509 gene expression Effects 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000007876 drug discovery Methods 0.000 abstract 1
- 230000037353 metabolic pathway Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
Landscapes
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Eye Examination Apparatus (AREA)
- Holo Graphy (AREA)
- Aerials With Secondary Devices (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200100128 | 2001-01-25 | ||
| DKPA200100679 | 2001-05-01 | ||
| US30086301P | 2001-06-27 | 2001-06-27 | |
| PCT/DK2002/000056 WO2002059297A2 (en) | 2001-01-25 | 2002-01-25 | A library of a collection of cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE501251T1 true ATE501251T1 (de) | 2011-03-15 |
Family
ID=43646216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02709979T ATE501251T1 (de) | 2001-01-25 | 2002-01-25 | Zellbibliothek |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7838287B2 (https=) |
| EP (1) | EP1356037B1 (https=) |
| JP (2) | JP2004525624A (https=) |
| AT (1) | ATE501251T1 (https=) |
| AU (1) | AU2002227883A1 (https=) |
| CA (1) | CA2474172C (https=) |
| DE (1) | DE60239386D1 (https=) |
| DK (1) | DK1356037T3 (https=) |
| WO (1) | WO2002059297A2 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8008459B2 (en) | 2001-01-25 | 2011-08-30 | Evolva Sa | Concatemers of differentially expressed multiple genes |
| WO2002059297A2 (en) | 2001-01-25 | 2002-08-01 | Evolva Biotech A/S | A library of a collection of cells |
| EP1472349B1 (en) * | 2002-01-25 | 2008-10-29 | Evolva AG | Methods for multiple parameter screening and evolution of cells to produce small molecules with multiple functionalities |
| DK2314629T4 (da) | 2002-07-18 | 2023-02-06 | Merus Nv | Rekombinant produktion af blandinger af antistoffer |
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| WO2004016791A1 (en) * | 2002-08-01 | 2004-02-26 | Evolva Ltd | Methods of mixing large numbers of heterologous genes |
| WO2004106375A1 (en) | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| EP1737971B1 (en) * | 2004-01-20 | 2017-08-16 | Merus N.V. | Mixtures of binding proteins |
| CN103589650A (zh) | 2005-03-18 | 2014-02-19 | 米克罗比亚公司 | 产油酵母和真菌中类胡萝卜素的产生 |
| WO2008042338A2 (en) | 2006-09-28 | 2008-04-10 | Microbia, Inc. | Production of carotenoids in oleaginous yeast and fungi |
| CN102282155B (zh) | 2008-12-02 | 2017-06-09 | 日本波涛生命科学公司 | 磷原子修饰的核酸的合成方法 |
| KR101153866B1 (ko) | 2009-05-21 | 2012-06-27 | 대한민국 | 형질전환용 운반체, 이의 제조방법, 이를 이용한 형질전환방법 및 형질전환체 |
| RU2612521C2 (ru) | 2009-07-06 | 2017-03-09 | Онтории, Инк. | Новые пролекарства нуклеиновых кислот и способы их применения |
| WO2011146833A1 (en) | 2010-05-20 | 2011-11-24 | Evolva Inc. | Method of producing isoprenoid compounds in yeast |
| CN105671108A (zh) | 2010-06-02 | 2016-06-15 | 沃维公司 | 甜菊糖苷的重组生产 |
| JP5868324B2 (ja) | 2010-09-24 | 2016-02-24 | 株式会社Wave Life Sciences Japan | 不斉補助基 |
| CN103796657B (zh) | 2011-07-19 | 2017-07-11 | 波涛生命科学有限公司 | 合成官能化核酸的方法 |
| CN108396044A (zh) | 2011-08-08 | 2018-08-14 | 埃沃尔瓦公司 | 甜菊醇糖苷类的重组生产 |
| US9248181B2 (en) | 2012-04-20 | 2016-02-02 | Merus B.V. | Methods and means for the production of Ig-like molecules |
| US10829772B2 (en) | 2012-06-22 | 2020-11-10 | Monsanto Technology Llc | Unique modular vector design |
| KR102213609B1 (ko) | 2012-07-13 | 2021-02-08 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
| CA2879066C (en) | 2012-07-13 | 2019-08-13 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant |
| PL2872485T3 (pl) | 2012-07-13 | 2021-05-31 | Wave Life Sciences Ltd. | Asymetryczna grupa pomocnicza |
| US20150293076A1 (en) * | 2012-10-22 | 2015-10-15 | Bolt Threads, Inc. | Cellular Reprogramming for Product Optimization |
| SG11201505597SA (en) | 2013-02-06 | 2015-08-28 | Evolva Sa | Methods for improved production of rebaudioside d and rebaudioside m |
| CA2900882A1 (en) | 2013-02-11 | 2014-08-14 | Evolva Sa | Efficient production of steviol glycosides in recombinants hosts |
| CA2924343C (en) | 2013-09-17 | 2025-09-16 | Bolt Threads, Inc. | PROCESSES AND COMPOSITIONS FOR SYNTHESIZING IMPROVED SILK FIBERS |
| US9580758B2 (en) | 2013-11-12 | 2017-02-28 | Luc Montagnier | System and method for the detection and treatment of infection by a microbial agent associated with HIV infection |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| JPWO2015108047A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| US10322173B2 (en) | 2014-01-15 | 2019-06-18 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| BR112016016400A2 (pt) | 2014-01-16 | 2017-10-03 | Wave Life Sciences Ltd | Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos |
| AU2015303294A1 (en) | 2014-08-11 | 2017-02-02 | Evolva Sa. | Production of steviol glycosides in recombinant hosts |
| AU2015314251A1 (en) | 2014-09-09 | 2017-03-16 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| SG11201705606PA (en) | 2015-01-30 | 2017-08-30 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CA2979931A1 (en) | 2015-03-16 | 2016-09-22 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
| AU2016307066A1 (en) | 2015-08-07 | 2018-02-08 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| US10982249B2 (en) | 2016-04-13 | 2021-04-20 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| WO2017198682A1 (en) | 2016-05-16 | 2017-11-23 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| KR20190046993A (ko) | 2016-09-14 | 2019-05-07 | 볼트 쓰레즈, 인크. | 긴 균일한 재조합 단백질 섬유 |
| US11396669B2 (en) | 2016-11-07 | 2022-07-26 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| JP7212982B1 (ja) | 2022-10-05 | 2023-01-26 | 株式会社Logomix | 細胞ライブラリおよびその製造方法 |
| JP2025170455A (ja) * | 2022-10-05 | 2025-11-19 | 株式会社Logomix | 細胞ライブラリおよびその製造方法 |
| US20240209383A1 (en) * | 2022-12-21 | 2024-06-27 | Clara Foods Co. | Systems and methods for high yielding recombinant microorganisms and uses thereof |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1341302C (en) | 1983-02-22 | 2001-10-09 | Rae Lyn Burke | Yeast expression systems with vectors having gapdh or pyk promoters and synthesis of foreign protein |
| AU3556789A (en) | 1988-04-22 | 1989-11-24 | Massachusetts Institute Of Technology | Process for forming and using microdroplets |
| WO1991000920A2 (en) | 1989-07-07 | 1991-01-24 | Unilever N.V. | Process for preparing a protein by a fungus transformed by multicopy integration of an expression vector |
| US5316922A (en) * | 1992-04-15 | 1994-05-31 | The United States Of America As Represented By Department Of Health And Human Services | Method for indentifying and expressing proteins that recognize and adhere to specific probes |
| US5482845A (en) | 1993-09-24 | 1996-01-09 | The Trustees Of Columbia University In The City Of New York | Method for construction of normalized cDNA libraries |
| CA2174354C (en) | 1993-10-27 | 2011-03-29 | Paul B. Fisher | Compositions of melanoma differentiation associated gene-7 (mda-7) in cancer diagnosis and treatment |
| US6268140B1 (en) * | 1994-02-03 | 2001-07-31 | Neugenesis | Combinatorial metabolic libraries |
| US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| US6309883B1 (en) * | 1994-02-17 | 2001-10-30 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| US6165793A (en) * | 1996-03-25 | 2000-12-26 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US6117679A (en) * | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| CA2219136A1 (en) * | 1995-04-24 | 1996-10-31 | Chromaxome Corp. | Methods for generating and screening novel metabolic pathways |
| US6030779A (en) * | 1995-07-18 | 2000-02-29 | Diversa Corporation | Screening for novel bioactivities |
| US6057103A (en) * | 1995-07-18 | 2000-05-02 | Diversa Corporation | Screening for novel bioactivities |
| US5958672A (en) * | 1995-07-18 | 1999-09-28 | Diversa Corporation | Protein activity screening of clones having DNA from uncultivated microorganisms |
| US6004788A (en) * | 1995-07-18 | 1999-12-21 | Diversa Corporation | Enzyme kits and libraries |
| US20010041333A1 (en) * | 1997-06-16 | 2001-11-15 | Short Jay M. | High throughput screening for a bioactivity or biomolecule |
| US20030215798A1 (en) | 1997-06-16 | 2003-11-20 | Diversa Corporation | High throughput fluorescence-based screening for novel enzymes |
| US6537776B1 (en) | 1999-06-14 | 2003-03-25 | Diversa Corporation | Synthetic ligation reassembly in directed evolution |
| US5939250A (en) * | 1995-12-07 | 1999-08-17 | Diversa Corporation | Production of enzymes having desired activities by mutagenesis |
| GB9603803D0 (en) * | 1996-02-22 | 1996-04-24 | Zeneca Ltd | Production of proteins, plasmids coding therefor and organisms containing such plasmids |
| US6025155A (en) | 1996-04-10 | 2000-02-15 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| US6242211B1 (en) | 1996-04-24 | 2001-06-05 | Terragen Discovery, Inc. | Methods for generating and screening novel metabolic pathways |
| US5783431A (en) * | 1996-04-24 | 1998-07-21 | Chromaxome Corporation | Methods for generating and screening novel metabolic pathways |
| WO1997044470A1 (en) | 1996-05-21 | 1997-11-27 | Novo Nordisk A/S | Novel yeast promoters suitable for expression cloning in yeast and heterologous expression of proteins in yeast |
| US5763239A (en) * | 1996-06-18 | 1998-06-09 | Diversa Corporation | Production and use of normalized DNA libraries |
| US6294325B1 (en) * | 1996-07-05 | 2001-09-25 | The Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of thermostable multi genes and proteins and uses thereof |
| CA2259158A1 (en) | 1996-07-09 | 1998-01-15 | The Government Of The United States Of America As Represented By The Sec Retary, Department Of Health And Human Services | Transformation-associated recombination cloning |
| US6326204B1 (en) | 1997-01-17 | 2001-12-04 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
| KR100570935B1 (ko) | 1997-01-17 | 2006-04-13 | 맥시겐, 인크. | 반복적 서열 재조합에 의한 전세포 및 유기체의 개량 방법 |
| CA2282658C (en) | 1997-02-27 | 2003-02-25 | Cellomics, Inc. | A system for cell-based screening |
| AU6571598A (en) | 1997-03-18 | 1998-10-12 | Chromaxome Corporation | Methods for screening compounds using encapsulated cells |
| DE69732378D1 (de) | 1997-05-27 | 2005-03-03 | Hanil Synthetic Fiber Co Ltd | Verfahren zur herstellung von rekombinanten eiweissen durch verwendung von hocheffizienten expressionsvektoren aus saccharomyces cerevisiae |
| GB9727512D0 (en) | 1997-12-31 | 1998-02-25 | Adprotech Plc | Fuzzy genes and their application in molecular adjuvants |
| CA2321930A1 (en) | 1998-03-04 | 1999-09-10 | Diversa Corporation | Production and use of normalized dna libraries |
| AU5217599A (en) | 1998-07-27 | 2000-02-21 | Genotypes, Inc. | Automatic eukaryotic artificial chromosome vector |
| WO2000008212A1 (en) | 1998-08-07 | 2000-02-17 | Cellay, Llc | Gel microdrops in genetic analysis |
| WO2000012680A1 (en) | 1998-08-31 | 2000-03-09 | Maxygen, Inc. | Transformation, selection, and screening of sequence-shuffled polynucleotides for development and optimization of plant phenotypes |
| EP1114320A2 (en) | 1998-09-18 | 2001-07-11 | Cellomics, Inc. | A system for cell-based screening |
| AU3879300A (en) | 1999-03-09 | 2000-09-28 | Diversa Corporation | End selection in directed evolution |
| AU4039400A (en) | 1999-03-26 | 2000-10-16 | Diversa Corporation | Exonuclease-mediated nucleic acid reassembly in directed evolution |
| GB9908814D0 (en) * | 1999-04-16 | 1999-06-09 | Celltech Therapeutics Ltd | Process |
| AU7646000A (en) | 1999-11-05 | 2001-05-14 | Novozymes A/S | Methods to screen microorganisms or gene libraries for products secreted from a cell |
| US20010049104A1 (en) * | 2000-03-24 | 2001-12-06 | Stemmer Willem P.C. | Methods for modulating cellular and organismal phenotypes |
| CA2474161C (en) | 2001-01-25 | 2012-03-27 | Evolva Ltd. | Concatemers of differentially expressed multiple genes |
| WO2002059290A2 (en) | 2001-01-25 | 2002-08-01 | Evolva Biotech A/S | A method for evolving a cell having desired phenotype and envolved cells |
| WO2002059297A2 (en) | 2001-01-25 | 2002-08-01 | Evolva Biotech A/S | A library of a collection of cells |
| WO2002059330A2 (en) | 2001-01-25 | 2002-08-01 | Evolva Biotech A/S | Artificial chromosomes comprising concatemers of expressible nucleotide sequences |
| US8008459B2 (en) * | 2001-01-25 | 2011-08-30 | Evolva Sa | Concatemers of differentially expressed multiple genes |
| EP1472349B1 (en) * | 2002-01-25 | 2008-10-29 | Evolva AG | Methods for multiple parameter screening and evolution of cells to produce small molecules with multiple functionalities |
| DE60319259T2 (de) | 2002-06-14 | 2009-03-05 | Dyax Corp., Cambridge | Rekombination von nukleinsäurebibliotheksmitgliedern |
| US20030235823A1 (en) * | 2002-06-24 | 2003-12-25 | The University Of Alabama | Nucleotide sequences that code for torsin genes, torsin proteins, and methods of using the same to treat protein-aggregation |
| WO2004016791A1 (en) | 2002-08-01 | 2004-02-26 | Evolva Ltd | Methods of mixing large numbers of heterologous genes |
-
2002
- 2002-01-25 WO PCT/DK2002/000056 patent/WO2002059297A2/en not_active Ceased
- 2002-01-25 DE DE60239386T patent/DE60239386D1/de not_active Expired - Lifetime
- 2002-01-25 AU AU2002227883A patent/AU2002227883A1/en not_active Abandoned
- 2002-01-25 US US10/466,960 patent/US7838287B2/en not_active Expired - Fee Related
- 2002-01-25 EP EP02709979A patent/EP1356037B1/en not_active Expired - Lifetime
- 2002-01-25 DK DK02709979.5T patent/DK1356037T3/da active
- 2002-01-25 CA CA2474172A patent/CA2474172C/en not_active Expired - Fee Related
- 2002-01-25 AT AT02709979T patent/ATE501251T1/de not_active IP Right Cessation
- 2002-01-25 JP JP2002559584A patent/JP2004525624A/ja not_active Withdrawn
-
2009
- 2009-10-07 JP JP2009233636A patent/JP4965625B2/ja not_active Expired - Fee Related
-
2010
- 2010-10-12 US US12/902,587 patent/US20120094870A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002227883A1 (en) | 2002-08-06 |
| WO2002059297A3 (en) | 2003-04-10 |
| JP4965625B2 (ja) | 2012-07-04 |
| CA2474172A1 (en) | 2002-08-01 |
| JP2004525624A (ja) | 2004-08-26 |
| US7838287B2 (en) | 2010-11-23 |
| DE60239386D1 (de) | 2011-04-21 |
| US20040241672A1 (en) | 2004-12-02 |
| EP1356037A2 (en) | 2003-10-29 |
| WO2002059297A8 (en) | 2004-04-15 |
| JP2010043108A (ja) | 2010-02-25 |
| US20120094870A1 (en) | 2012-04-19 |
| DK1356037T3 (da) | 2011-06-27 |
| WO2002059297A2 (en) | 2002-08-01 |
| CA2474172C (en) | 2012-07-10 |
| EP1356037B1 (en) | 2011-03-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |