JP2004524032A5 - - Google Patents
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- Publication number
- JP2004524032A5 JP2004524032A5 JP2002571915A JP2002571915A JP2004524032A5 JP 2004524032 A5 JP2004524032 A5 JP 2004524032A5 JP 2002571915 A JP2002571915 A JP 2002571915A JP 2002571915 A JP2002571915 A JP 2002571915A JP 2004524032 A5 JP2004524032 A5 JP 2004524032A5
- Authority
- JP
- Japan
- Prior art keywords
- oligomer
- combination
- block
- linker
- blocks
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27454701P | 2001-03-09 | 2001-03-09 | |
| PCT/US2002/007050 WO2002072865A2 (en) | 2001-03-09 | 2002-03-09 | Methods, kits and compositions of combination oligomers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007095671A Division JP2007209346A (ja) | 2001-03-09 | 2007-03-30 | 組み合わせオリゴマーならびにそれらの調製のためのライブラリーに適する、方法、キット、および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004524032A JP2004524032A (ja) | 2004-08-12 |
| JP2004524032A5 true JP2004524032A5 (enExample) | 2005-07-07 |
| JP4408628B2 JP4408628B2 (ja) | 2010-02-03 |
Family
ID=23048654
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002571915A Expired - Fee Related JP4408628B2 (ja) | 2001-03-09 | 2002-03-09 | 組み合わせオリゴマーならびにそれらの調製のためのライブラリーに適する、方法、キット、および組成物 |
| JP2007095671A Pending JP2007209346A (ja) | 2001-03-09 | 2007-03-30 | 組み合わせオリゴマーならびにそれらの調製のためのライブラリーに適する、方法、キット、および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007095671A Pending JP2007209346A (ja) | 2001-03-09 | 2007-03-30 | 組み合わせオリゴマーならびにそれらの調製のためのライブラリーに適する、方法、キット、および組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (9) | US7256275B2 (enExample) |
| EP (2) | EP1412517B1 (enExample) |
| JP (2) | JP4408628B2 (enExample) |
| AT (2) | ATE346950T1 (enExample) |
| AU (1) | AU2002250262B9 (enExample) |
| CA (1) | CA2439750A1 (enExample) |
| DE (2) | DE60216468T2 (enExample) |
| DK (1) | DK1412517T3 (enExample) |
| WO (1) | WO2002072865A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60216468T2 (de) | 2001-03-09 | 2007-09-27 | Boston Probes, Inc., Bedford | Kombinationsoligomere betreffende verfahren, kits und zusammensetzungen |
| WO2004022578A2 (en) | 2002-09-08 | 2004-03-18 | Applera Corporation | Methods, compositions and libraries pertaining pna dimer and pna oligomer synthesis |
| JP4608483B2 (ja) * | 2003-02-18 | 2011-01-12 | アプライド バイオシステムズ, エルエルシー | ポリヌクレオチドの複合的分析のための組成物および方法 |
| EP1674581A1 (en) * | 2004-12-21 | 2006-06-28 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Twin probes, a tool for the detection of SNPs |
| US7892737B2 (en) * | 2005-06-30 | 2011-02-22 | Life Technologies Corporation | Compositions, kits and methods pertaining to stability modulation of PNA oligomer/nucleic acid complexes |
| GB2433591A (en) * | 2005-12-20 | 2007-06-27 | Sharp Kk | Method for functionalising a hydrophobic substrate |
| GB2433506A (en) * | 2005-12-20 | 2007-06-27 | Sharp Kk | A method of producing a multimeric capture agent |
| GB2433505A (en) * | 2005-12-20 | 2007-06-27 | Sharp Kk | Capture agents for binding a ligand |
| EP1994182B1 (en) * | 2006-03-15 | 2019-05-29 | Siemens Healthcare Diagnostics Inc. | Degenerate nucleobase analogs |
| CN101421420B (zh) * | 2006-08-08 | 2015-03-11 | 爱科来株式会社 | 突变的检测方法及用于该方法的试剂盒 |
| WO2008039367A1 (en) | 2006-09-22 | 2008-04-03 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Synthesis of trans-tert-butyl-2-aminocyclopentylcarbamate |
| GB0718255D0 (en) * | 2007-09-19 | 2007-10-31 | Univ Edinburgh | Nucleobase characterisation |
| JP2012502911A (ja) * | 2008-09-14 | 2012-02-02 | インサイター インコーポレイテッド | ナノスケール分子合成 |
| US9506057B2 (en) | 2010-03-26 | 2016-11-29 | Integrated Dna Technologies, Inc. | Modifications for antisense compounds |
| AU2011230496B2 (en) | 2010-03-26 | 2015-09-17 | Integrated Dna Technologies, Inc. | Methods for enhancing nucleic acid hybridization |
| CA2809457C (en) | 2010-09-07 | 2019-07-30 | Integrated Dna Technologies, Inc. | Modifications for antisense compounds |
| KR101569479B1 (ko) * | 2011-03-29 | 2015-11-16 | 주식회사 씨젠 | Pto 절단 및 연장-의존적 절단에 의한 타겟 핵산서열의 검출 |
| WO2013103146A1 (ja) * | 2012-01-07 | 2013-07-11 | 株式会社ボナック | アミノ酸骨格を有する一本鎖核酸分子 |
| RU2620955C2 (ru) * | 2012-03-05 | 2017-05-30 | Сиджен, Инк. | Детекция нуклеотидной вариации в нуклеиновокислотной последовательности-мишени в анализе с расщеплением и удлинением зондирующего и метящего олигонуклеотида (рто) |
| WO2013180038A1 (ja) | 2012-05-26 | 2013-12-05 | 株式会社ボナック | デリバリー機能を有する遺伝子発現制御用の一本鎖核酸分子 |
| WO2014021680A1 (ko) * | 2012-08-02 | 2014-02-06 | (주)바이오니아 | 신규 아조화합물, 이의 이용 및 이의제조방법 |
| GB201316644D0 (en) * | 2013-09-19 | 2013-11-06 | Kymab Ltd | Expression vector production & High-Throughput cell screening |
| US10612020B2 (en) | 2013-12-26 | 2020-04-07 | Tokyo Medical University | Artificial mimic miRNA for controlling gene expression, and use of same |
| CA2935022A1 (en) | 2013-12-27 | 2015-07-02 | Bonac Corporation | Artificial match-type mirna for controlling gene expression and use therefor |
| CA2971827A1 (en) | 2014-12-27 | 2016-06-30 | Bonac Corporation | Naturally occuring mirna for controlling gene expression, and use of same |
| US11142769B2 (en) | 2015-03-27 | 2021-10-12 | Bonac Corporation | Single-stranded nucleic acid molecule having delivery function and gene expression regulating ability |
| EP3416976A2 (en) | 2016-02-16 | 2018-12-26 | Yale University | Compositions for enhancing targeted gene editing and methods of use thereof |
| US20200113821A1 (en) | 2017-04-04 | 2020-04-16 | Yale University | Compositions and methods for in utero delivery |
| KR102403904B1 (ko) * | 2019-12-24 | 2022-06-02 | 주식회사 시선바이오머티리얼스 | 용액공정상 pna 올리고머의 제조방법 |
| JP2023542867A (ja) * | 2020-09-11 | 2023-10-12 | グリンプス バイオ, インコーポレイテッド | 疾患の検出/診断、病期分類、モニタリング及び処置のための生体外でのプロテアーゼ活性検出 |
| CN113322523B (zh) * | 2021-06-17 | 2024-03-19 | 翌圣生物科技(上海)股份有限公司 | Rna快速建库方法及其应用 |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| CA1284931C (en) | 1986-03-13 | 1991-06-18 | Henry A. Erlich | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
| US5252293A (en) | 1989-01-17 | 1993-10-12 | Vladimir Drbal | Analytical slide with porous filter membrane |
| DE3943522A1 (de) * | 1989-07-26 | 1991-02-07 | Boehringer Mannheim Gmbh | Heterobifunktionelle verbindungen |
| US5366860A (en) | 1989-09-29 | 1994-11-22 | Applied Biosystems, Inc. | Spectrally resolvable rhodamine dyes for nucleic acid sequence determination |
| US5188934A (en) | 1989-11-14 | 1993-02-23 | Applied Biosystems, Inc. | 4,7-dichlorofluorescein dyes as molecular probes |
| US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
| US5766855A (en) | 1991-05-24 | 1998-06-16 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity and sequence specificity |
| US5641625A (en) | 1992-05-22 | 1997-06-24 | Isis Pharmaceuticals, Inc. | Cleaving double-stranded DNA with peptide nucleic acids |
| US6451968B1 (en) | 1991-05-24 | 2002-09-17 | Isis Pharmaceuticals, Inc. | Peptide nucleic acids |
| DK51092D0 (da) | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5719262A (en) | 1993-11-22 | 1998-02-17 | Buchardt, Deceased; Ole | Peptide nucleic acids having amino acid side chains |
| US5700922A (en) | 1991-12-24 | 1997-12-23 | Isis Pharmaceuticals, Inc. | PNA-DNA-PNA chimeric macromolecules |
| GB9211979D0 (en) | 1992-06-05 | 1992-07-15 | Buchard Ole | Uses of nucleic acid analogues |
| US5527675A (en) | 1993-08-20 | 1996-06-18 | Millipore Corporation | Method for degradation and sequencing of polymers which sequentially eliminate terminal residues |
| DE4331012A1 (de) | 1993-09-13 | 1995-03-16 | Bayer Ag | Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik |
| GB2284209A (en) | 1993-11-25 | 1995-05-31 | Ole Buchardt | Nucleic acid analogue-induced transcription of RNA from a double-stranded DNA template |
| GB2289677A (en) | 1993-12-06 | 1995-11-29 | Pna Diagnostics As | Labelling of nucleic acid analogue-peptide chimerae |
| DK145493D0 (da) | 1993-12-23 | 1993-12-23 | Dako As | Antistof |
| US5539083A (en) | 1994-02-23 | 1996-07-23 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid combinatorial libraries and improved methods of synthesis |
| US5705333A (en) | 1994-08-05 | 1998-01-06 | The Regents Of The University Of California | Peptide-based nucleic acid mimics(PENAMS) |
| US6280964B1 (en) | 1995-04-14 | 2001-08-28 | The Regents Of The University Of California | Binding sites for phosphotyrosine binding domains |
| JP2001518054A (ja) * | 1995-06-07 | 2001-10-09 | パーセプティブ バイオシステムズ,インコーポレーテッド | Pna−dnaキメラと、このキメラ合成用のpnaシントン |
| DE19532553A1 (de) | 1995-09-04 | 1997-03-06 | Hoechst Ag | Verfahren zur Herstellung substituierter N-Ethyl-Glycinderivate |
| US6020481A (en) | 1996-04-01 | 2000-02-01 | The Perkin-Elmer Corporation | Asymmetric benzoxanthene dyes |
| US5847162A (en) | 1996-06-27 | 1998-12-08 | The Perkin Elmer Corporation | 4, 7-Dichlororhodamine dyes |
| SE506700C2 (sv) | 1996-05-31 | 1998-02-02 | Mikael Kubista | Sond och förfaranden för analys av nukleinsyra |
| US6110676A (en) | 1996-12-04 | 2000-08-29 | Boston Probes, Inc. | Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays |
| EP0857791B1 (en) * | 1996-12-21 | 2004-03-31 | PNA Diagnostics A/S | Method of analysis using signal amplification |
| CA2218440A1 (en) | 1996-12-21 | 1998-06-21 | Boehringer Mannheim Gmbh | Method of analysis using signal amplification |
| US6080418A (en) | 1997-04-07 | 2000-06-27 | 3M Innovative Properties Company | Suspensions of microcapsules containing biologically active ingredients and adhesive microspheres |
| US6107470A (en) | 1997-05-29 | 2000-08-22 | Nielsen; Peter E. | Histidine-containing peptide nucleic acids |
| WO1998056807A1 (en) | 1997-06-13 | 1998-12-17 | Gryphon Sciences | Solid phase native chemical ligation of unprotected or n-terminal cysteine protected peptides in aqueous solution |
| DK0897991T3 (da) | 1997-08-22 | 2005-07-25 | Pna Diagnostics Aps | Små triplexdannende PNA-oligoer |
| US6008379A (en) | 1997-10-01 | 1999-12-28 | The Perkin-Elmer Corporation | Aromatic-substituted xanthene dyes |
| US6485901B1 (en) * | 1997-10-27 | 2002-11-26 | Boston Probes, Inc. | Methods, kits and compositions pertaining to linear beacons |
| EP1025120B1 (en) | 1997-10-27 | 2010-08-18 | Boston Probes, Inc. | Methods, kits and compositions pertaining to pna molecular beacons |
| US5936087A (en) | 1997-11-25 | 1999-08-10 | The Perkin-Elmer Corporation | Dibenzorhodamine dyes |
| US6080868A (en) | 1998-01-23 | 2000-06-27 | The Perkin-Elmer Corporation | Nitro-substituted non-fluorescent asymmetric cyanine dye compounds |
| US6326479B1 (en) | 1998-01-27 | 2001-12-04 | Boston Probes, Inc. | Synthetic polymers and methods, kits or compositions for modulating the solubility of same |
| EP1053355B1 (en) | 1998-02-11 | 2001-11-14 | PE Corporation (NY) | Pna and dna conjugates and methods for preparation thereof |
| US6361942B1 (en) | 1998-03-24 | 2002-03-26 | Boston Probes, Inc. | Method, kits and compositions pertaining to detection complexes |
| EP1073767B1 (en) * | 1998-04-29 | 2009-11-25 | Boston Probes, Inc. | Methods, kits and compositions for detecting and quantitating target sequences |
| US6287772B1 (en) | 1998-04-29 | 2001-09-11 | Boston Probes, Inc. | Methods, kits and compositions for detecting and quantitating target sequences |
| ATE343586T1 (de) | 1998-07-09 | 2006-11-15 | Biocept Inc | Verfahren zur verwendung einer universellen bibliothek von peptid-nukleinsäuren zur optimierung der dns-hybridisierung |
| US6248884B1 (en) | 1999-06-03 | 2001-06-19 | The Perkin-Elmer Corporation | Extended rhodamine compounds useful as fluorescent labels |
| US6316230B1 (en) * | 1999-08-13 | 2001-11-13 | Applera Corporation | Polymerase extension at 3′ terminus of PNA-DNA chimera |
| US6140500A (en) | 1999-09-03 | 2000-10-31 | Pe Corporation | Red-emitting [8,9]benzophenoxazine nucleic acid dyes and methods for their use |
| US6297016B1 (en) | 1999-10-08 | 2001-10-02 | Applera Corporation | Template-dependent ligation with PNA-DNA chimeric probes |
| US6472153B1 (en) | 1999-10-26 | 2002-10-29 | Epoch Biosciences, Inc. | Hybridization-triggered fluorescent detection of nucleic acids |
| US6191278B1 (en) | 1999-11-03 | 2001-02-20 | Pe Corporation | Water-soluble rhodamine dyes and conjugates thereof |
| DE60216468T2 (de) * | 2001-03-09 | 2007-09-27 | Boston Probes, Inc., Bedford | Kombinationsoligomere betreffende verfahren, kits und zusammensetzungen |
-
2002
- 2002-03-09 DE DE60216468T patent/DE60216468T2/de not_active Expired - Lifetime
- 2002-03-09 EP EP02719163A patent/EP1412517B1/en not_active Expired - Lifetime
- 2002-03-09 DK DK02719163T patent/DK1412517T3/da active
- 2002-03-09 AT AT02719163T patent/ATE346950T1/de not_active IP Right Cessation
- 2002-03-09 CA CA002439750A patent/CA2439750A1/en not_active Abandoned
- 2002-03-09 WO PCT/US2002/007050 patent/WO2002072865A2/en not_active Ceased
- 2002-03-09 AU AU2002250262A patent/AU2002250262B9/en not_active Ceased
- 2002-03-09 JP JP2002571915A patent/JP4408628B2/ja not_active Expired - Fee Related
- 2002-03-09 DE DE60239020T patent/DE60239020D1/de not_active Expired - Lifetime
- 2002-03-09 AT AT06023675T patent/ATE496139T1/de not_active IP Right Cessation
- 2002-03-09 US US10/096,125 patent/US7256275B2/en not_active Expired - Fee Related
- 2002-03-09 EP EP06023675A patent/EP1748078B1/en not_active Expired - Lifetime
-
2006
- 2006-12-22 US US11/615,190 patent/US7638279B2/en not_active Expired - Fee Related
- 2006-12-22 US US11/615,374 patent/US7674585B2/en not_active Expired - Fee Related
- 2006-12-26 US US11/616,080 patent/US7605253B2/en not_active Expired - Fee Related
- 2006-12-26 US US11/616,123 patent/US7884053B2/en not_active Expired - Fee Related
- 2006-12-26 US US11/616,071 patent/US7566420B1/en not_active Expired - Fee Related
- 2006-12-26 US US11/616,141 patent/US7745126B2/en not_active Expired - Fee Related
- 2006-12-26 US US11/616,059 patent/US7851155B2/en not_active Expired - Fee Related
- 2006-12-26 US US11/616,110 patent/US20090163381A1/en not_active Abandoned
-
2007
- 2007-03-30 JP JP2007095671A patent/JP2007209346A/ja active Pending
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