JP2004523529A - メラノコルチンレセプターアゴニスト - Google Patents
メラノコルチンレセプターアゴニスト Download PDFInfo
- Publication number
- JP2004523529A JP2004523529A JP2002559410A JP2002559410A JP2004523529A JP 2004523529 A JP2004523529 A JP 2004523529A JP 2002559410 A JP2002559410 A JP 2002559410A JP 2002559410 A JP2002559410 A JP 2002559410A JP 2004523529 A JP2004523529 A JP 2004523529A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- formula
- cycloalkyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 0 C[C@](*)c(cccc1)c1N1CCNCC1 Chemical compound C[C@](*)c(cccc1)c1N1CCNCC1 0.000 description 19
- XHBQEXHISRGXOF-UHFFFAOYSA-N C(CC1)CCC1c(cccc1)c1N1CCNCC1 Chemical compound C(CC1)CCC1c(cccc1)c1N1CCNCC1 XHBQEXHISRGXOF-UHFFFAOYSA-N 0.000 description 1
- FNKMFCHUSVUYQT-UHFFFAOYSA-N CC(C)(C)C(NCc(cccc1)c1N1CCNCC1)=O Chemical compound CC(C)(C)C(NCc(cccc1)c1N1CCNCC1)=O FNKMFCHUSVUYQT-UHFFFAOYSA-N 0.000 description 1
- QPPVJYFVJCJKTP-WOJBJXKFSA-N CC(C)(C)OC(N(Cc1c(C2)cccc1)[C@H]2C(N[C@H](Cc(cc1)ccc1Cl)C(O)=O)=O)=O Chemical compound CC(C)(C)OC(N(Cc1c(C2)cccc1)[C@H]2C(N[C@H](Cc(cc1)ccc1Cl)C(O)=O)=O)=O QPPVJYFVJCJKTP-WOJBJXKFSA-N 0.000 description 1
- FFRYJJHJNRQBMO-MRVPVSSYSA-N CC(C)(c(c(C1)c2)cc(O)c2O)N[C@H]1C(O)=O Chemical compound CC(C)(c(c(C1)c2)cc(O)c2O)N[C@H]1C(O)=O FFRYJJHJNRQBMO-MRVPVSSYSA-N 0.000 description 1
- KHYYALVVXGNZBG-PLYLYKGUSA-N CC(C)(c1c(C2)cccc1)NC2C(N[C@H](Cc(cc1)ccc1Cl)C(N(CC1)CCN1c(cccc1)c1NS(C)(=O)=O)=O)=O Chemical compound CC(C)(c1c(C2)cccc1)NC2C(N[C@H](Cc(cc1)ccc1Cl)C(N(CC1)CCN1c(cccc1)c1NS(C)(=O)=O)=O)=O KHYYALVVXGNZBG-PLYLYKGUSA-N 0.000 description 1
- BVXIGXOFNZDYCU-LLVKDONJSA-N CC(C)(c1ccccc1C1)N[C@H]1C(OC)=O Chemical compound CC(C)(c1ccccc1C1)N[C@H]1C(OC)=O BVXIGXOFNZDYCU-LLVKDONJSA-N 0.000 description 1
- WJUICTUIEHPGCS-UHFFFAOYSA-N CCCCN(C1)C(CC(OC)=O)c2c1cccc2 Chemical compound CCCCN(C1)C(CC(OC)=O)c2c1cccc2 WJUICTUIEHPGCS-UHFFFAOYSA-N 0.000 description 1
- FECOKXYSVFVXRX-VOTSOKGWSA-N COC(/C=C/c1ccccc1C=O)=O Chemical compound COC(/C=C/c1ccccc1C=O)=O FECOKXYSVFVXRX-VOTSOKGWSA-N 0.000 description 1
- SBTPNLFSCKSEDO-UHFFFAOYSA-N COC(CC1N(Cc2ccccc2)Cc2c1cccc2)=O Chemical compound COC(CC1N(Cc2ccccc2)Cc2c1cccc2)=O SBTPNLFSCKSEDO-UHFFFAOYSA-N 0.000 description 1
- JVKJKADJNQEXEA-MRVPVSSYSA-N COC([C@@H](C1)NCc(cc2O)c1cc2O)=O Chemical compound COC([C@@H](C1)NCc(cc2O)c1cc2O)=O JVKJKADJNQEXEA-MRVPVSSYSA-N 0.000 description 1
- GMKMISTTZYJZKC-IXCJQBJRSA-N CS(Nc(cccc1)c1N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC[C@@H](C1)NCc2c1cccc2)=O)(=O)=O Chemical compound CS(Nc(cccc1)c1N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC[C@@H](C1)NCc2c1cccc2)=O)(=O)=O GMKMISTTZYJZKC-IXCJQBJRSA-N 0.000 description 1
- HBZDOJHKUXRMEL-GJJMEYSYSA-N C[C@@H](c(cccc1)c1N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC([C@@H](C1)NCc2c1cccc2)=O)=O)O Chemical compound C[C@@H](c(cccc1)c1N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC([C@@H](C1)NCc2c1cccc2)=O)=O)O HBZDOJHKUXRMEL-GJJMEYSYSA-N 0.000 description 1
- WTDRDQBEARUVNC-ZCFIWIBFSA-N N[C@H](Cc(cc1)cc(O)c1O)C(O)=O Chemical compound N[C@H](Cc(cc1)cc(O)c1O)C(O)=O WTDRDQBEARUVNC-ZCFIWIBFSA-N 0.000 description 1
- SMNBUGUJCJUCKY-MRXNPFEDSA-N N[C@H](Cc(cc1)ccc1Cl)C(N(CC1)CCN1c(cccc1)c1S(N)(=O)=O)=O Chemical compound N[C@H](Cc(cc1)ccc1Cl)C(N(CC1)CCN1c(cccc1)c1S(N)(=O)=O)=O SMNBUGUJCJUCKY-MRXNPFEDSA-N 0.000 description 1
- FHWDVOTTYDDYFF-FQLXRVMXSA-N O=C([C@@H](Cc(cc1)ccc1Cl)NC([C@@H](C1)NCc2c1ccc(F)c2)=O)N(CC1)CCN1c1ccccc1C[n]1ncnc1 Chemical compound O=C([C@@H](Cc(cc1)ccc1Cl)NC([C@@H](C1)NCc2c1ccc(F)c2)=O)N(CC1)CCN1c1ccccc1C[n]1ncnc1 FHWDVOTTYDDYFF-FQLXRVMXSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Gynecology & Obstetrics (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Pregnancy & Childbirth (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26347101P | 2001-01-23 | 2001-01-23 | |
| PCT/US2002/000517 WO2002059108A1 (en) | 2001-01-23 | 2002-01-23 | Melanocortin receptor agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004523529A true JP2004523529A (ja) | 2004-08-05 |
| JP2004523529A5 JP2004523529A5 (https=) | 2008-10-02 |
Family
ID=23001925
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002559410A Pending JP2004523529A (ja) | 2001-01-23 | 2002-01-23 | メラノコルチンレセプターアゴニスト |
| JP2002559419A Pending JP2004523530A (ja) | 2001-01-23 | 2002-01-23 | メラノコルチン受容体アゴニストとしてのピペラジンおよびピペリジン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002559419A Pending JP2004523530A (ja) | 2001-01-23 | 2002-01-23 | メラノコルチン受容体アゴニストとしてのピペラジンおよびピペリジン誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7186715B2 (https=) |
| EP (2) | EP1368340B1 (https=) |
| JP (2) | JP2004523529A (https=) |
| AT (2) | ATE301652T1 (https=) |
| CA (2) | CA2431996A1 (https=) |
| DE (2) | DE60205465T2 (https=) |
| ES (2) | ES2246390T3 (https=) |
| WO (2) | WO2002059117A1 (https=) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006068058A1 (ja) * | 2004-12-20 | 2006-06-29 | Eisai R & D Management Co., Ltd. | １－シクロプロピルメチル－４－［２－（３，３，５，５－テトラメチルシクロヘキシル）フェニル］ピペラジンの塩および結晶 |
| WO2006134955A1 (ja) * | 2005-06-14 | 2006-12-21 | Eisai R & D Management Co., Ltd. | １，２－ジ（環式基）置換ベンゼン誘導体 |
| US7410971B2 (en) | 2003-12-26 | 2008-08-12 | Eisai R&D Management Co., Ltd. | 1,2-di(cyclic)substituted benzene compounds |
| JP2023501620A (ja) * | 2019-11-13 | 2023-01-18 | リブラ・セラピューティクス・インコーポレイテッド | 複素環式ｔｒｐｍｌ１アゴニスト |
| JP2023508930A (ja) * | 2019-12-19 | 2023-03-06 | カスマ セラピューティクス， インコーポレイテッド | Ｔｒｐｍｌモジュレーター |
Families Citing this family (128)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9904723D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission II |
| SE9904724D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission I |
| USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
| WO2002059107A1 (en) | 2001-01-23 | 2002-08-01 | Eli Lilly And Company | Substituted piperidines/piperazines as melanocortin receptor agonists |
| US7169777B2 (en) | 2001-01-23 | 2007-01-30 | Eli Lilly And Company | Melanocortin receptor agonists |
| WO2002059117A1 (en) | 2001-01-23 | 2002-08-01 | Eli Lilly And Company | Piperazine- and piperidine-derivatives as melanocortin receptor agonists |
| JP2004532838A (ja) | 2001-03-02 | 2004-10-28 | ブリストル−マイヤーズ スクイブ カンパニー | メラノコルチン受容体のモデュレーターとして有用な化合物及びそれを含む製薬組成物 |
| US6911447B2 (en) | 2001-04-25 | 2005-06-28 | The Procter & Gamble Company | Melanocortin receptor ligands |
| US6977264B2 (en) * | 2001-07-25 | 2005-12-20 | Amgen Inc. | Substituted piperidines and methods of use |
| US7115607B2 (en) | 2001-07-25 | 2006-10-03 | Amgen Inc. | Substituted piperazinyl amides and methods of use |
| CA2462200A1 (en) | 2001-08-10 | 2003-02-20 | Palatin Technologies, Inc. | Peptidomimetics of biologically active metallopeptides |
| US7354923B2 (en) | 2001-08-10 | 2008-04-08 | Palatin Technologies, Inc. | Piperazine melanocortin-specific compounds |
| US7456184B2 (en) | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| UA81749C2 (uk) * | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| WO2003061660A1 (en) * | 2002-01-23 | 2003-07-31 | Eli Lilly And Company | Melanocortin receptor agonists |
| US7026335B2 (en) | 2002-04-30 | 2006-04-11 | The Procter & Gamble Co. | Melanocortin receptor ligands |
| JP2005534632A (ja) * | 2002-05-10 | 2005-11-17 | ニューロクライン バイオサイエンセズ， インコーポレイテッド | メラノコルチンレセプターリガンドとしての置換ピペラジン |
| US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
| AU2003268493A1 (en) | 2002-09-11 | 2004-04-30 | Merck & Co., Inc. | Piperazine urea derivatives as melanocortin-4 receptor agonists |
| TW200504033A (en) * | 2002-10-23 | 2005-02-01 | Procter & Gamble | Melanocortin receptor ligands |
| WO2004081643A1 (en) * | 2002-12-20 | 2004-09-23 | Kaiser Aerospace & Electronics Corp. | Lenslet array with polarization conversion |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| WO2004078717A1 (en) | 2003-03-03 | 2004-09-16 | Merck & Co., Inc. | Acylated piperazine derivatives as melanocortin-4 receptor agonists |
| WO2004081005A1 (en) * | 2003-03-07 | 2004-09-23 | Neurocrine Biosciences, Inc. | Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto |
| CA2517291C (en) | 2003-03-19 | 2012-05-08 | Exelixis, Inc. | Ortho-substituted aryl and heteroaryl tie-2 modulators and methods of use |
| EP1460069A1 (en) * | 2003-03-20 | 2004-09-22 | MyoContract Ltd. | Substituted cyclohexyl and piperidinyl derivatives as melanocortin-4 receptor modulators |
| EP1468999A1 (en) * | 2003-03-20 | 2004-10-20 | MyoContract Ltd. | Substituted piperidine and piperazine derivatives as melanocortin-4 receptor modulators |
| CA2519939A1 (en) | 2003-03-26 | 2004-10-14 | Merck & Co., Inc. | Bicyclic piperidine derivatives as melanocortin-4 receptor agonists |
| EP1644347A1 (en) * | 2003-06-20 | 2006-04-12 | Arena Pharmaceuticals, Inc. | N-PHENYL-PIPERAZINE DERIVATIVES AND METHODS OF PROPHYLAXIS OR TREATMENT OF 5HT sb 2C /sb RECEPTOR ASSOCIATED DISEASES |
| AU2004274309B2 (en) | 2003-09-22 | 2010-04-08 | Msd K.K. | Novel piperidine derivative |
| US20050192286A1 (en) * | 2003-10-22 | 2005-09-01 | Neurocrine Biosciences, Inc. | Ligands of melanocortin receptors and compositions and methods related thereto |
| US20050119252A1 (en) * | 2003-10-22 | 2005-06-02 | Neurocrine Biosciences, Inc. | Ligands of melanocortin receptors and compositions and methods related thereto |
| EP1538159A1 (en) * | 2003-12-05 | 2005-06-08 | Santhera Pharmaceuticals (Schweiz) GmbH | Substituted N-benzyl-lactam derivatives as melanocortin-4 receptor agonists |
| CN100526301C (zh) * | 2003-12-26 | 2009-08-12 | 卫材R&D管理有限公司 | 1,2-二(环式基)取代苯化合物 |
| MY140489A (en) * | 2003-12-26 | 2009-12-31 | Eisai R&D Man Co Ltd | 1,2-di (cyclic) substituted benzene compounds |
| US20060276465A1 (en) * | 2003-12-26 | 2006-12-07 | Eisai R&D Management Co., Ltd. | 1,2-di(cyclic) substituted benzene compounds |
| US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
| SE0401465D0 (sv) | 2004-06-08 | 2004-06-08 | Carlsson A Research Ab | New substituted piperdines as modulators of dopamine neurotransmission |
| DE602005021641D1 (de) | 2004-06-08 | 2010-07-15 | Nsab, Filial Af Neurosearch Sweden Ab | Neue disubstituierte phenylpiperidine und piperazine als modulatoren der dopamin-neurotransmission |
| RU2366654C2 (ru) * | 2004-06-08 | 2009-09-10 | ЭнЭсЭйБи, ФИЛИАЛ АФ НЕУРОСЕРЧ СВИДЕН АБ, СВЕРИЙЕ | Новые дизамещенные фенилпиперидины/пиперазины в качестве модуляторов допаминовой нейротрансмиссии |
| US7851629B2 (en) | 2004-06-08 | 2010-12-14 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission |
| JP2008501749A (ja) * | 2004-06-08 | 2008-01-24 | ニューロサーチ スウェーデン アクチボラゲット | ドーパミン及びセロトニン神経伝達のモジュレーターとしての新規なジ置換フェニルピペリジン |
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- 2002-01-23 EP EP02714719A patent/EP1368340B1/en not_active Expired - Lifetime
- 2002-01-23 ES ES02714719T patent/ES2246390T3/es not_active Expired - Lifetime
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- 2002-01-23 JP JP2002559410A patent/JP2004523529A/ja active Pending
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- 2002-01-23 JP JP2002559419A patent/JP2004523530A/ja active Pending
- 2002-01-23 US US10/466,121 patent/US7291619B2/en not_active Expired - Fee Related
- 2002-01-23 WO PCT/US2002/000517 patent/WO2002059108A1/en not_active Ceased
- 2002-01-23 EP EP02701922A patent/EP1370558B1/en not_active Expired - Lifetime
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| US7410971B2 (en) | 2003-12-26 | 2008-08-12 | Eisai R&D Management Co., Ltd. | 1,2-di(cyclic)substituted benzene compounds |
| WO2006068058A1 (ja) * | 2004-12-20 | 2006-06-29 | Eisai R & D Management Co., Ltd. | １－シクロプロピルメチル－４－［２－（３，３，５，５－テトラメチルシクロヘキシル）フェニル］ピペラジンの塩および結晶 |
| JPWO2006068058A1 (ja) * | 2004-12-20 | 2008-06-12 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | １−シクロプロピルメチル−４−［２−（３，３，５，５−テトラメチルシクロヘキシル）フェニル］ピペラジンの塩および結晶 |
| US7910734B2 (en) | 2004-12-20 | 2011-03-22 | Eisai R&D Management Co., Ltd. | Crystal and salt of 1-cyclopropylmethyl-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine |
| WO2006134955A1 (ja) * | 2005-06-14 | 2006-12-21 | Eisai R & D Management Co., Ltd. | １，２－ジ（環式基）置換ベンゼン誘導体 |
| JP2023501620A (ja) * | 2019-11-13 | 2023-01-18 | リブラ・セラピューティクス・インコーポレイテッド | 複素環式ｔｒｐｍｌ１アゴニスト |
| JP2023508930A (ja) * | 2019-12-19 | 2023-03-06 | カスマ セラピューティクス， インコーポレイテッド | Ｔｒｐｍｌモジュレーター |
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| US7291619B2 (en) | 2007-11-06 |
| CA2432985A1 (en) | 2002-08-01 |
| DE60205727D1 (de) | 2005-09-29 |
| DE60205465T2 (de) | 2006-04-20 |
| EP1368340B1 (en) | 2005-08-10 |
| ES2247298T3 (es) | 2006-03-01 |
| US20040082590A1 (en) | 2004-04-29 |
| JP2004523530A (ja) | 2004-08-05 |
| CA2431996A1 (en) | 2002-08-01 |
| WO2002059117A8 (en) | 2003-11-06 |
| WO2002059117A1 (en) | 2002-08-01 |
| US20040092507A1 (en) | 2004-05-13 |
| ES2246390T3 (es) | 2006-02-16 |
| ATE301652T1 (de) | 2005-08-15 |
| DE60205465D1 (de) | 2005-09-15 |
| EP1368340A1 (en) | 2003-12-10 |
| ATE302773T1 (de) | 2005-09-15 |
| EP1370558A1 (en) | 2003-12-17 |
| US7186715B2 (en) | 2007-03-06 |
| WO2002059108A1 (en) | 2002-08-01 |
| EP1370558B1 (en) | 2005-08-24 |
| DE60205727T2 (de) | 2006-06-29 |
| WO2002059108A8 (en) | 2003-11-06 |
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