JP2004524297A5 - - Google Patents
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- JP2004524297A5 JP2004524297A5 JP2002559397A JP2002559397A JP2004524297A5 JP 2004524297 A5 JP2004524297 A5 JP 2004524297A5 JP 2002559397 A JP2002559397 A JP 2002559397A JP 2002559397 A JP2002559397 A JP 2002559397A JP 2004524297 A5 JP2004524297 A5 JP 2004524297A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- compound
- formula
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 0 CC(*)(C(C(C1)=C2)=CC(C)(*)C=C2O*)NC1C(O*)=O Chemical compound CC(*)(C(C(C1)=C2)=CC(C)(*)C=C2O*)NC1C(O*)=O 0.000 description 13
- XSSWFYSBSGAYOD-UHFFFAOYSA-N CC(C)(C)OC(N(C1)C(CC(O)=O)c2c1cccc2)=O Chemical compound CC(C)(C)OC(N(C1)C(CC(O)=O)c2c1cccc2)=O XSSWFYSBSGAYOD-UHFFFAOYSA-N 0.000 description 2
- CSFSUNBQORKLSC-UHFFFAOYSA-N CCN(CC)C(C(c(cccc1)c1F)N1CCNCC1)=O Chemical compound CCN(CC)C(C(c(cccc1)c1F)N1CCNCC1)=O CSFSUNBQORKLSC-UHFFFAOYSA-N 0.000 description 2
- FUXMOFPWLDVQTM-UHFFFAOYSA-N C=C(c1ccccc1)N Chemical compound C=C(c1ccccc1)N FUXMOFPWLDVQTM-UHFFFAOYSA-N 0.000 description 1
- QSCDWOFJWMHEII-UHFFFAOYSA-N CC(C)(C)OC(N(C1)C(CC(OC)=O)c(cc2)c1cc2OC)=O Chemical compound CC(C)(C)OC(N(C1)C(CC(OC)=O)c(cc2)c1cc2OC)=O QSCDWOFJWMHEII-UHFFFAOYSA-N 0.000 description 1
- AKOIDFWMLPBRNP-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCN1C(CC1CCCCC1)C=N)=O Chemical compound CC(C)(C)OC(N(CC1)CCN1C(CC1CCCCC1)C=N)=O AKOIDFWMLPBRNP-UHFFFAOYSA-N 0.000 description 1
- YQFLEDGFNLINGI-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCN1C(CN(C(c1c2cccc1)=O)C2=O)C1CCCCC1)=O Chemical compound CC(C)(C)OC(N(CC1)CCN1C(CN(C(c1c2cccc1)=O)C2=O)C1CCCCC1)=O YQFLEDGFNLINGI-UHFFFAOYSA-N 0.000 description 1
- MZBJCRNZEDCXLB-UHFFFAOYSA-N CC(C)(C)OC(N1C(CC(OC)=O)c2ccccc2C1)=O Chemical compound CC(C)(C)OC(N1C(CC(OC)=O)c2ccccc2C1)=O MZBJCRNZEDCXLB-UHFFFAOYSA-N 0.000 description 1
- SMRCOUQENXQAGT-VQHVLOKHSA-N CC(C)(C)OC(NCc1c(/C=C/C(OC)=O)ccc(OC)c1)=O Chemical compound CC(C)(C)OC(NCc1c(/C=C/C(OC)=O)ccc(OC)c1)=O SMRCOUQENXQAGT-VQHVLOKHSA-N 0.000 description 1
- MECGBIWOIPWJAE-MDZDMXLPSA-N CC(C)(C)OC(NCc1ccccc1/C=C/C(OC)=O)=O Chemical compound CC(C)(C)OC(NCc1ccccc1/C=C/C(OC)=O)=O MECGBIWOIPWJAE-MDZDMXLPSA-N 0.000 description 1
- XZRYUQXRTMRYPL-DHNZSJTASA-N CC(C)(c1c(C2)cccc1)NC2C(N[C@H](Cc(cc1)ccc1Cl)C(N(CC1)CCN1C(CNS(C)(=O)=O)C1CCCCC1)=O)=O Chemical compound CC(C)(c1c(C2)cccc1)NC2C(N[C@H](Cc(cc1)ccc1Cl)C(N(CC1)CCN1C(CNS(C)(=O)=O)C1CCCCC1)=O)=O XZRYUQXRTMRYPL-DHNZSJTASA-N 0.000 description 1
- QSBQKYZVHHKLRC-UHFFFAOYSA-N CC(C)C(CN(C(c1c2cccc1)=O)C2=O)C(CCCC1)CCN1C(OC(C)(C)C)=O Chemical compound CC(C)C(CN(C(c1c2cccc1)=O)C2=O)C(CCCC1)CCN1C(OC(C)(C)C)=O QSBQKYZVHHKLRC-UHFFFAOYSA-N 0.000 description 1
- SOFCEPXLSUWJQY-UHFFFAOYSA-N CC(C)C(NCC(c1ccccc1F)N(CC1)CCN1C(C(Cc(cc1)ccc1Cl)NC(C(C1)NCc2c1cccc2)=O)=O)=O Chemical compound CC(C)C(NCC(c1ccccc1F)N(CC1)CCN1C(C(Cc(cc1)ccc1Cl)NC(C(C1)NCc2c1cccc2)=O)=O)=O SOFCEPXLSUWJQY-UHFFFAOYSA-N 0.000 description 1
- SRPGFJDOALJGMR-UHFFFAOYSA-N CC(C)CC(C(OC)=O)Br Chemical compound CC(C)CC(C(OC)=O)Br SRPGFJDOALJGMR-UHFFFAOYSA-N 0.000 description 1
- AMJQHOGLKIZODY-UHFFFAOYSA-N CC(C)CC(C1)NCc2c1cccc2 Chemical compound CC(C)CC(C1)NCc2c1cccc2 AMJQHOGLKIZODY-UHFFFAOYSA-N 0.000 description 1
- YKLSFUIBCYZBIO-UHFFFAOYSA-N CC(C)CC(C1CCCCC1)N(CC1)CCN1C(C(Cc(cc1)ccc1Cl)NC(CC1NCc2ccccc12)=O)=O Chemical compound CC(C)CC(C1CCCCC1)N(CC1)CCN1C(C(Cc(cc1)ccc1Cl)NC(CC1NCc2ccccc12)=O)=O YKLSFUIBCYZBIO-UHFFFAOYSA-N 0.000 description 1
- GEFXPJCTTJTVBZ-UHFFFAOYSA-N CC(C)CN(CC(C1CCCCC1)N(CC1)CCN1C(C(CC1=CCC(C)(C)C=C1)NC(CC1NCc2ccccc12)=O)=O)S(C)(=O)=O Chemical compound CC(C)CN(CC(C1CCCCC1)N(CC1)CCN1C(C(CC1=CCC(C)(C)C=C1)NC(CC1NCc2ccccc12)=O)=O)S(C)(=O)=O GEFXPJCTTJTVBZ-UHFFFAOYSA-N 0.000 description 1
- XOCZBVCLNSGCJC-UHFFFAOYSA-N CC(C)CN(CC(C1CCCCC1)N1CCNCC1)S(C)(=O)=O Chemical compound CC(C)CN(CC(C1CCCCC1)N1CCNCC1)S(C)(=O)=O XOCZBVCLNSGCJC-UHFFFAOYSA-N 0.000 description 1
- FSPLHTOFIXAJDL-ZDUSSCGKSA-N CC(C)C[C@@H](C1)NCC2=C1C=CCC2 Chemical compound CC(C)C[C@@H](C1)NCC2=C1C=CCC2 FSPLHTOFIXAJDL-ZDUSSCGKSA-N 0.000 description 1
- AMJQHOGLKIZODY-CYBMUJFWSA-N CC(C)C[C@H](C1)NCc2c1cccc2 Chemical compound CC(C)C[C@H](C1)NCc2c1cccc2 AMJQHOGLKIZODY-CYBMUJFWSA-N 0.000 description 1
- HKYBMMQXLYYHDT-BPNDJBKRSA-N CCC1=CCC(C[C@H](C(OC)=O)NC(CC(C)(c2ccccc2C2)N2C(OC(C)(C)C)=O)=O)C=C1 Chemical compound CCC1=CCC(C[C@H](C(OC)=O)NC(CC(C)(c2ccccc2C2)N2C(OC(C)(C)C)=O)=O)C=C1 HKYBMMQXLYYHDT-BPNDJBKRSA-N 0.000 description 1
- URVFLPYBZIHIPL-UHFFFAOYSA-N CCN(CC(C1CCCC1)N1CCNCC1)S(C)(=O)=O Chemical compound CCN(CC(C1CCCC1)N1CCNCC1)S(C)(=O)=O URVFLPYBZIHIPL-UHFFFAOYSA-N 0.000 description 1
- YFKPLZMYGVVNJJ-UHFFFAOYSA-N CCN(CC(C1CCCCC1)N1CCNCC1)C(C)=O Chemical compound CCN(CC(C1CCCCC1)N1CCNCC1)C(C)=O YFKPLZMYGVVNJJ-UHFFFAOYSA-N 0.000 description 1
- OFCYIMPWTBTUHN-UHFFFAOYSA-N CCN(CC(C1CCCCC1)N1CCNCC1)S(C)(=O)=O Chemical compound CCN(CC(C1CCCCC1)N1CCNCC1)S(C)(=O)=O OFCYIMPWTBTUHN-UHFFFAOYSA-N 0.000 description 1
- ZQWFUYSVIYOKTN-GAXAPSDUSA-N CCN(CC)C(C(C1CCCCC1)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O)=O Chemical compound CCN(CC)C(C(C1CCCCC1)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2c1cccc2)=O)=O)=O ZQWFUYSVIYOKTN-GAXAPSDUSA-N 0.000 description 1
- WZVLKUBGAPFRIO-UHFFFAOYSA-N CCN(CC)C(C(C1CCCCC1)N1CCNCC1)=O Chemical compound CCN(CC)C(C(C1CCCCC1)N1CCNCC1)=O WZVLKUBGAPFRIO-UHFFFAOYSA-N 0.000 description 1
- ZKDMBVHANOCHEU-UHFFFAOYSA-N CCN(CC)C(C(CC(C)C)N(CC1)CCN1C(OC(C)(C)C)=O)=O Chemical compound CCN(CC)C(C(CC(C)C)N(CC1)CCN1C(OC(C)(C)C)=O)=O ZKDMBVHANOCHEU-UHFFFAOYSA-N 0.000 description 1
- MLYLSCXBZJWKRE-KWRHIPAJSA-N CCN(CC)CC(C1CCCCC1)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(c1ncc(cccc2)c2c1)=O)=O Chemical compound CCN(CC)CC(C1CCCCC1)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(c1ncc(cccc2)c2c1)=O)=O MLYLSCXBZJWKRE-KWRHIPAJSA-N 0.000 description 1
- QLNOYTUKDZUEOD-UHFFFAOYSA-N CCN(CC)CC(c1ccccc1Cl)N(CC1)CCN1C(C(Cc(cc1)ccc1Cl)NC(CC1NCc2ccccc12)=O)=O Chemical compound CCN(CC)CC(c1ccccc1Cl)N(CC1)CCN1C(C(Cc(cc1)ccc1Cl)NC(CC1NCc2ccccc12)=O)=O QLNOYTUKDZUEOD-UHFFFAOYSA-N 0.000 description 1
- HUEPPPNHLOEYBI-UHFFFAOYSA-N CCOC(C(c1ccccn1)N(CC1)CCN1C(OC(C)(C)C)=O)=O Chemical compound CCOC(C(c1ccccn1)N(CC1)CCN1C(OC(C)(C)C)=O)=O HUEPPPNHLOEYBI-UHFFFAOYSA-N 0.000 description 1
- CFILESISCTXYFT-UHFFFAOYSA-N CCOC(CC(C)(c1ccccc1C1)N1C(OC(C)(C)C)=O)=O Chemical compound CCOC(CC(C)(c1ccccc1C1)N1C(OC(C)(C)C)=O)=O CFILESISCTXYFT-UHFFFAOYSA-N 0.000 description 1
- JIUDIUCVHFEZBW-UHFFFAOYSA-N CN1C(CC(NC(Cc(cc2)ccc2Cl)C(O)=O)=O)c2ccccc2C1 Chemical compound CN1C(CC(NC(Cc(cc2)ccc2Cl)C(O)=O)=O)c2ccccc2C1 JIUDIUCVHFEZBW-UHFFFAOYSA-N 0.000 description 1
- VAJNXYXOWIDURP-UHFFFAOYSA-N COC(CC1NCc2cc(OC)ccc12)=O Chemical compound COC(CC1NCc2cc(OC)ccc12)=O VAJNXYXOWIDURP-UHFFFAOYSA-N 0.000 description 1
- KDZSUIDMNNNLEF-GXUDPACQSA-O C[S+](NCC(C1CCCCC1)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2ccccc12)=O)=O)O Chemical compound C[S+](NCC(C1CCCCC1)N(CC1)CCN1C([C@@H](Cc(cc1)ccc1Cl)NC(CC1NCc2ccccc12)=O)=O)O KDZSUIDMNNNLEF-GXUDPACQSA-O 0.000 description 1
- KNHRAGXSNLNBSI-QYEGGPJFSA-N O=C(CC1NCc2ccccc12)N[C@H](Cc(cc1)ccc1Cl)C(N(CC1)CCN1C(CC(N1CCCC1)=O)C1CCCCC1)=O Chemical compound O=C(CC1NCc2ccccc12)N[C@H](Cc(cc1)ccc1Cl)C(N(CC1)CCN1C(CC(N1CCCC1)=O)C1CCCCC1)=O KNHRAGXSNLNBSI-QYEGGPJFSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26338001P | 2001-01-23 | 2001-01-23 | |
| PCT/US2002/000518 WO2002059095A1 (en) | 2001-01-23 | 2002-01-23 | Melanocortin receptor agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004524297A JP2004524297A (ja) | 2004-08-12 |
| JP2004524297A5 true JP2004524297A5 (https=) | 2006-08-17 |
Family
ID=23001546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002559397A Pending JP2004524297A (ja) | 2001-01-23 | 2002-01-23 | メラノコルチン受容体アゴニスト |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7169777B2 (https=) |
| EP (1) | EP1358163A1 (https=) |
| JP (1) | JP2004524297A (https=) |
| CA (1) | CA2432988A1 (https=) |
| WO (1) | WO2002059095A1 (https=) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2247298T3 (es) | 2001-01-23 | 2006-03-01 | Eli Lilly And Company | Derivados de piperazina y piperidina como agonistas del receptor de melanocortina. |
| EP1368339A1 (en) | 2001-01-23 | 2003-12-10 | Eli Lilly & Company | Substituted piperidines/piperazines as melanocortin receptor agonists |
| US6911447B2 (en) * | 2001-04-25 | 2005-06-28 | The Procter & Gamble Company | Melanocortin receptor ligands |
| US6977264B2 (en) | 2001-07-25 | 2005-12-20 | Amgen Inc. | Substituted piperidines and methods of use |
| US7115607B2 (en) | 2001-07-25 | 2006-10-03 | Amgen Inc. | Substituted piperazinyl amides and methods of use |
| US7456184B2 (en) | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| US7354923B2 (en) | 2001-08-10 | 2008-04-08 | Palatin Technologies, Inc. | Piperazine melanocortin-specific compounds |
| EP1465867A1 (en) * | 2001-10-09 | 2004-10-13 | Neurocrine Biosciences, Inc. | Ligands of melanocortin receptors and compositions and methods related thereto |
| WO2003061660A1 (en) | 2002-01-23 | 2003-07-31 | Eli Lilly And Company | Melanocortin receptor agonists |
| US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
| WO2004024720A1 (en) | 2002-09-11 | 2004-03-25 | Merck & Co., Inc. | Piperazine urea derivatives as melanocortin-4 receptor agonists |
| TW200504033A (en) * | 2002-10-23 | 2005-02-01 | Procter & Gamble | Melanocortin receptor ligands |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| WO2004078717A1 (en) | 2003-03-03 | 2004-09-16 | Merck & Co., Inc. | Acylated piperazine derivatives as melanocortin-4 receptor agonists |
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| BRPI0610580B8 (pt) | 2005-05-30 | 2021-05-25 | Banyu Pharma Co Ltd | composto derivado de piperidina |
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| WO2018069532A1 (en) | 2016-10-14 | 2018-04-19 | Tes Pharma S.R.L. | Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase |
| US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| EP3558298B1 (en) | 2016-12-20 | 2026-03-11 | Merck Sharp & Dohme LLC | Antidiabetic spirochroman compounds |
| JOP20190245A1 (ar) | 2017-04-20 | 2019-10-15 | Novartis Ag | أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط |
| TW202027794A (zh) | 2018-10-03 | 2020-08-01 | 瑞士商諾華公司 | 血管生成素樣３多肽之持續遞送 |
| AR117122A1 (es) | 2018-11-20 | 2021-07-14 | Tes Pharma S R L | INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA |
| WO2023219152A1 (ja) * | 2022-05-13 | 2023-11-16 | 中外製薬株式会社 | リチウム塩の析出工程を含む、アミノ酸の塩若しくはペプチド化合物の塩又はこれらの溶媒和物の製造方法 |
| CN116396151B (zh) * | 2022-12-06 | 2023-11-03 | 如东众意化工有限公司 | 一种1-(4-氯苯基)-2-环丙基-1-丙酮的合成方法 |
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| WO1994013696A1 (en) | 1992-12-11 | 1994-06-23 | Merck & Co., Inc. | Spiro piperidines and homologs which promote release of growth hormone |
| EP1076649A4 (en) | 1998-04-28 | 2010-06-02 | Trega Biosciences Inc | ISOQUINOLINE-BASED COMPOUNDS IN PLACE OF MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USE |
| US6294534B1 (en) * | 1998-06-11 | 2001-09-25 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
| WO1999064002A1 (en) * | 1998-06-11 | 1999-12-16 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
| CA2377369A1 (en) | 1999-06-04 | 2000-12-14 | Merck & Co., Inc. | Substituted piperidines as melanocortin-4 receptor agonists |
| JP2003527444A (ja) | 2000-03-23 | 2003-09-16 | メルク エンド カムパニー インコーポレーテッド | メラノコルチン受容体アゴニストとして作用するスピロピペリジン誘導体 |
| WO2001070708A1 (en) | 2000-03-23 | 2001-09-27 | Merck & Co., Inc. | Substituted piperidines as melanocortin receptor agonists |
| JP2004506687A (ja) | 2000-08-23 | 2004-03-04 | メルク エンド カムパニー インコーポレーテッド | メラノコルチン受容体作働薬としての置換ピペリジン類 |
| EP1368339A1 (en) | 2001-01-23 | 2003-12-10 | Eli Lilly & Company | Substituted piperidines/piperazines as melanocortin receptor agonists |
| ES2247298T3 (es) | 2001-01-23 | 2006-03-01 | Eli Lilly And Company | Derivados de piperazina y piperidina como agonistas del receptor de melanocortina. |
| CA2438272A1 (en) | 2001-03-02 | 2002-10-10 | John Macor | Compounds useful as modulators of melanocortin receptors and pharmaceutical compositions comprising same |
-
2002
- 2002-01-23 CA CA002432988A patent/CA2432988A1/en not_active Abandoned
- 2002-01-23 WO PCT/US2002/000518 patent/WO2002059095A1/en not_active Ceased
- 2002-01-23 JP JP2002559397A patent/JP2004524297A/ja active Pending
- 2002-01-23 EP EP02701924A patent/EP1358163A1/en not_active Withdrawn
- 2002-01-23 US US10/466,250 patent/US7169777B2/en not_active Expired - Fee Related
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