JP2004521117A - メラノコルチン受容体アゴニストとしての置換ピペリジン／ピペラジン - Google Patents
メラノコルチン受容体アゴニストとしての置換ピペリジン／ピペラジン Download PDFInfo
- Publication number
- JP2004521117A JP2004521117A JP2002559409A JP2002559409A JP2004521117A JP 2004521117 A JP2004521117 A JP 2004521117A JP 2002559409 A JP2002559409 A JP 2002559409A JP 2002559409 A JP2002559409 A JP 2002559409A JP 2004521117 A JP2004521117 A JP 2004521117A
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- 0 C=*CC(C1)[*+]Cc2c1cccc2 Chemical compound C=*CC(C1)[*+]Cc2c1cccc2 0.000 description 14
- XSSWFYSBSGAYOD-UHFFFAOYSA-N CC(C)(C)OC(N1C(CC(O)=O)c2ccccc2C1)=O Chemical compound CC(C)(C)OC(N1C(CC(O)=O)c2ccccc2C1)=O XSSWFYSBSGAYOD-UHFFFAOYSA-N 0.000 description 2
- KZGANJFEUHORED-UHFFFAOYSA-N C=[Br]c1c(C=C(CC2)N3CCOCC3)c2ccc1 Chemical compound C=[Br]c1c(C=C(CC2)N3CCOCC3)c2ccc1 KZGANJFEUHORED-UHFFFAOYSA-N 0.000 description 1
- ZTXJCCMGHPXAGQ-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCN1c1c(cncc2)c2ccc1)=O Chemical compound CC(C)(C)OC(N(CC1)CCN1c1c(cncc2)c2ccc1)=O ZTXJCCMGHPXAGQ-UHFFFAOYSA-N 0.000 description 1
- ZAWPAGYWUKXQNK-VQCQRNETSA-N CC(C)(C)OC(N1C(CC(N[C@H](Cc(cc2)ccc2Cl)C(OC)=O)=O)c2ccccc2C1)=O Chemical compound CC(C)(C)OC(N1C(CC(N[C@H](Cc(cc2)ccc2Cl)C(OC)=O)=O)c2ccccc2C1)=O ZAWPAGYWUKXQNK-VQCQRNETSA-N 0.000 description 1
- WCSOQNUPONWLSG-UHFFFAOYSA-N CCOC(C(C1)NC(C)(C)c(cc2)c1cc2OC)=O Chemical compound CCOC(C(C1)NC(C)(C)c(cc2)c1cc2OC)=O WCSOQNUPONWLSG-UHFFFAOYSA-N 0.000 description 1
- RMKUIMTVLKSVEX-UHFFFAOYSA-N CCOC(C(Cc1c2)NC(C)(C)c1ccc2O)=O Chemical compound CCOC(C(Cc1c2)NC(C)(C)c1ccc2O)=O RMKUIMTVLKSVEX-UHFFFAOYSA-N 0.000 description 1
- YXOVIGZJPGLNGM-UHFFFAOYSA-N Cc1cccc2c1CCCC2 Chemical compound Cc1cccc2c1CCCC2 YXOVIGZJPGLNGM-UHFFFAOYSA-N 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N OS(C(F)(F)F)(=O)=O Chemical compound OS(C(F)(F)F)(=O)=O ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26359501P | 2001-01-23 | 2001-01-23 | |
| PCT/US2002/000516 WO2002059107A1 (en) | 2001-01-23 | 2002-01-23 | Substituted piperidines/piperazines as melanocortin receptor agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004521117A true JP2004521117A (ja) | 2004-07-15 |
| JP2004521117A5 JP2004521117A5 (https=) | 2005-12-22 |
Family
ID=23002443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002559409A Pending JP2004521117A (ja) | 2001-01-23 | 2002-01-23 | メラノコルチン受容体アゴニストとしての置換ピペリジン／ピペラジン |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7157463B2 (https=) |
| EP (1) | EP1368339A1 (https=) |
| JP (1) | JP2004521117A (https=) |
| CA (1) | CA2433025A1 (https=) |
| WO (1) | WO2002059107A1 (https=) |
Families Citing this family (99)
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| US7169777B2 (en) | 2001-01-23 | 2007-01-30 | Eli Lilly And Company | Melanocortin receptor agonists |
| WO2002059117A1 (en) | 2001-01-23 | 2002-08-01 | Eli Lilly And Company | Piperazine- and piperidine-derivatives as melanocortin receptor agonists |
| JP2004532838A (ja) | 2001-03-02 | 2004-10-28 | ブリストル−マイヤーズ スクイブ カンパニー | メラノコルチン受容体のモデュレーターとして有用な化合物及びそれを含む製薬組成物 |
| US6911447B2 (en) | 2001-04-25 | 2005-06-28 | The Procter & Gamble Company | Melanocortin receptor ligands |
| US7115607B2 (en) | 2001-07-25 | 2006-10-03 | Amgen Inc. | Substituted piperazinyl amides and methods of use |
| US6977264B2 (en) | 2001-07-25 | 2005-12-20 | Amgen Inc. | Substituted piperidines and methods of use |
| US7456184B2 (en) | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| US7354923B2 (en) | 2001-08-10 | 2008-04-08 | Palatin Technologies, Inc. | Piperazine melanocortin-specific compounds |
| WO2003061660A1 (en) | 2002-01-23 | 2003-07-31 | Eli Lilly And Company | Melanocortin receptor agonists |
| US7026335B2 (en) | 2002-04-30 | 2006-04-11 | The Procter & Gamble Co. | Melanocortin receptor ligands |
| US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
| AU2003268493A1 (en) | 2002-09-11 | 2004-04-30 | Merck & Co., Inc. | Piperazine urea derivatives as melanocortin-4 receptor agonists |
| TW200504033A (en) * | 2002-10-23 | 2005-02-01 | Procter & Gamble | Melanocortin receptor ligands |
| CA2506843A1 (en) * | 2002-11-22 | 2004-06-10 | Novo-Nordisk A/S | 2,5-diketopiperazines for the treatment of obesity |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| PL378754A1 (pl) | 2003-03-03 | 2006-05-15 | F.Hoffmann-La Roche Ag | 2,5- i 2,6-Podstawione tetrahydroizochinoliny do stosowania jako modulatory 5-HT6 |
| WO2004078717A1 (en) | 2003-03-03 | 2004-09-16 | Merck & Co., Inc. | Acylated piperazine derivatives as melanocortin-4 receptor agonists |
| EP1468999A1 (en) * | 2003-03-20 | 2004-10-20 | MyoContract Ltd. | Substituted piperidine and piperazine derivatives as melanocortin-4 receptor modulators |
| CA2519939A1 (en) | 2003-03-26 | 2004-10-14 | Merck & Co., Inc. | Bicyclic piperidine derivatives as melanocortin-4 receptor agonists |
| AU2004274309B2 (en) | 2003-09-22 | 2010-04-08 | Msd K.K. | Novel piperidine derivative |
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| CA2609388C (en) | 2005-05-30 | 2013-08-06 | Banyu Pharmaceutical Co., Ltd. | Novel piperidine derivative |
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| AU2022209657B2 (en) * | 2021-01-21 | 2025-06-05 | Lg Chem, Ltd. | Uses of melanocortin-4 receptor agonist |
| EP4299572A4 (en) * | 2021-02-26 | 2024-07-31 | Lg Chem, Ltd. | MELANOCORTIN RECEPTOR 4 AGONIST |
| US20240239783A1 (en) * | 2021-05-06 | 2024-07-18 | Lg Chem, Ltd. | Crystal form vii of melanocortin receptor agonist compound and method for preparing same |
| US20240228473A1 (en) * | 2021-05-06 | 2024-07-11 | Lg Chem, Ltd. | Crystalline form v of melanocortin receptor agonist compound, and method for preparing same |
| CN117242063A (zh) * | 2021-05-07 | 2023-12-15 | 株式会社Lg化学 | 黑皮质素受体激动剂化合物与香兰素的共晶及其制备方法 |
| AU2022271120A1 (en) * | 2021-05-07 | 2023-11-09 | Lg Chem, Ltd. | Crystal form iv of organic acid salts of melanocortin receptor agonist compound, and preparation method thereof |
| BR112023022334A2 (pt) * | 2021-05-07 | 2023-12-26 | Lg Chemical Ltd | Formas cristalinas de sulfato do composto agonista do receptor de melanocortina, seus métodos de preparação, seus usos, e composições farmacêuticas compreendendo as mesmas |
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|---|---|---|---|---|
| NZ258412A (en) | 1992-12-11 | 1997-01-29 | Merck & Co Inc | Spiro-fused piperidine derivatives and pharmaceutical compositions |
| AU3768799A (en) | 1998-04-28 | 1999-11-16 | Trega Biosciences, Inc. | Isoquinoline compound melanocortin receptor ligands and methods of using same |
| AU742425B2 (en) | 1998-06-11 | 2002-01-03 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
| US6294534B1 (en) * | 1998-06-11 | 2001-09-25 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
| WO2000074679A1 (en) * | 1999-06-04 | 2000-12-14 | Merck & Co., Inc. | Substituted piperidines as melanocortin-4 receptor agonists |
| AU4929601A (en) | 2000-03-23 | 2001-10-03 | Merck & Co Inc | Substituted piperidines as melanocortin receptor agonists |
| EP1268000A4 (en) | 2000-03-23 | 2004-12-29 | Merck & Co Inc | SPIROPIPERID DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS |
| AU2001288285B2 (en) * | 2000-08-23 | 2005-09-29 | Merck & Co., Inc. | Substituted piperidines as melanocortin receptor agonists |
| US7169777B2 (en) | 2001-01-23 | 2007-01-30 | Eli Lilly And Company | Melanocortin receptor agonists |
| WO2002059117A1 (en) | 2001-01-23 | 2002-08-01 | Eli Lilly And Company | Piperazine- and piperidine-derivatives as melanocortin receptor agonists |
| JP2004532838A (ja) | 2001-03-02 | 2004-10-28 | ブリストル−マイヤーズ スクイブ カンパニー | メラノコルチン受容体のモデュレーターとして有用な化合物及びそれを含む製薬組成物 |
-
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- 2002-01-23 WO PCT/US2002/000516 patent/WO2002059107A1/en not_active Ceased
- 2002-01-23 JP JP2002559409A patent/JP2004521117A/ja active Pending
- 2002-01-23 CA CA002433025A patent/CA2433025A1/en not_active Abandoned
- 2002-01-23 EP EP02701923A patent/EP1368339A1/en not_active Withdrawn
- 2002-01-23 US US10/466,249 patent/US7157463B2/en not_active Expired - Fee Related
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| WO2002059107A1 (en) | 2002-08-01 |
| EP1368339A1 (en) | 2003-12-10 |
| US7157463B2 (en) | 2007-01-02 |
| CA2433025A1 (en) | 2002-08-01 |
| WO2002059107A8 (en) | 2003-11-06 |
| US20040058936A1 (en) | 2004-03-25 |
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