JP2004520377A5 - - Google Patents

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Publication number
JP2004520377A5
JP2004520377A5 JP2002559400A JP2002559400A JP2004520377A5 JP 2004520377 A5 JP2004520377 A5 JP 2004520377A5 JP 2002559400 A JP2002559400 A JP 2002559400A JP 2002559400 A JP2002559400 A JP 2002559400A JP 2004520377 A5 JP2004520377 A5 JP 2004520377A5
Authority
JP
Japan
Prior art keywords
methyl
phenyl
thiazol
trifluoromethyl
sulfanyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2002559400A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004520377A (ja
JP4234431B2 (ja
Filing date
Publication date
Priority claimed from GBGB0031103.5A external-priority patent/GB0031103D0/en
Application filed filed Critical
Publication of JP2004520377A publication Critical patent/JP2004520377A/ja
Publication of JP2004520377A5 publication Critical patent/JP2004520377A5/ja
Application granted granted Critical
Publication of JP4234431B2 publication Critical patent/JP4234431B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2002559400A 2000-12-20 2001-12-19 ヒトペルオキシソーム増殖因子活性化受容体の活性化剤としてのチアゾール及びオキサゾール誘導体 Expired - Fee Related JP4234431B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0031103.5A GB0031103D0 (en) 2000-12-20 2000-12-20 Chemical compounds
PCT/US2001/051056 WO2002059098A1 (en) 2000-12-20 2001-12-19 Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors

Publications (3)

Publication Number Publication Date
JP2004520377A JP2004520377A (ja) 2004-07-08
JP2004520377A5 true JP2004520377A5 (https=) 2005-12-22
JP4234431B2 JP4234431B2 (ja) 2009-03-04

Family

ID=9905490

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002559400A Expired - Fee Related JP4234431B2 (ja) 2000-12-20 2001-12-19 ヒトペルオキシソーム増殖因子活性化受容体の活性化剤としてのチアゾール及びオキサゾール誘導体

Country Status (9)

Country Link
EP (1) EP1349843B1 (https=)
JP (1) JP4234431B2 (https=)
AT (1) ATE293611T1 (https=)
DE (1) DE60110262T2 (https=)
DK (1) DK1349843T3 (https=)
ES (1) ES2240558T3 (https=)
GB (1) GB0031103D0 (https=)
PT (1) PT1349843E (https=)
WO (1) WO2002059098A1 (https=)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7041691B1 (en) 1999-06-30 2006-05-09 Amgen Inc. Compounds for the modulation of PPARγ activity
US20030171399A1 (en) 2000-06-28 2003-09-11 Tularik Inc. Quinolinyl and benzothiazolyl modulators
GB0031109D0 (en) 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
US7105551B2 (en) 2000-12-20 2006-09-12 Smithkline Beecham Corporation Thiazole derivatives for treating PPAR related disorders
ATE325608T1 (de) 2001-08-13 2006-06-15 Janssen Pharmaceutica Nv 2,4,5-trisubstituted thiazolyl derivative und deren antiinflammatorische wirkung
US7259175B2 (en) 2002-02-25 2007-08-21 Eli Lilly And Company Peroxisome proliferator activated receptor modulators
GB0214139D0 (en) * 2002-06-19 2002-07-31 Glaxo Group Ltd Chemical compounds
BR0314335A (pt) 2002-09-05 2005-07-26 Novo Nordisk As Composto, uso do mesmo, composição farmacêutica, e métodos para o tratamento e/ou prevenção de condições mediadas por receptores nucleares, e de diabetes de tipo i, diabetes de tipo ii, tolerância prejudicada à glicose, resistência à insulina ou obesidade
JP2005035966A (ja) * 2002-09-06 2005-02-10 Takeda Chem Ind Ltd フランまたはチオフェン誘導体およびその医薬用途
AU2003261935A1 (en) * 2002-09-06 2004-03-29 Takeda Pharmaceutical Company Limited Furan or thiophene derivative and medicinal use thereof
AU2003267297A1 (en) * 2002-09-19 2004-04-08 Smithkline Beecham Corporation Process for preparing substituted phenoxy-acetic acids from phenols
DE60332860D1 (de) 2002-10-28 2010-07-15 High Point Pharmaceuticals Llc Neue verbindungen, die sich f r die behandlung von durch ppar vermittelten krankheiten eignen
DE60333211D1 (de) 2002-10-28 2010-08-12 High Point Pharmaceuticals Llc Neue verbindungen und deren verwendung als ppar-modulatoren
US7129268B2 (en) 2002-10-28 2006-10-31 Novo Nordisk A/S Peroxisome proliferator activated receptor-active arylene acetic acid derivatives
US20050080115A1 (en) 2002-10-28 2005-04-14 Lone Jeppesen Novel compounds, their preparation and use
DE10308355A1 (de) * 2003-02-27 2004-12-23 Aventis Pharma Deutschland Gmbh Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
US7223761B2 (en) 2003-10-03 2007-05-29 Amgen Inc. Salts and polymorphs of a potent antidiabetic compound
ES2352085T3 (es) 2004-05-05 2011-02-15 High Point Pharmaceuticals, Llc Nuevos compuestos, su preparación y uso.
WO2005105736A1 (en) 2004-05-05 2005-11-10 Novo Nordisk A/S Novel compounds, their preparation and use
KR20080014075A (ko) * 2005-05-25 2008-02-13 닛뽕 케미파 가부시키가이샤 페록시좀 증식제 활성화 수용체의 활성화제
ATE529404T1 (de) 2005-06-30 2011-11-15 High Point Pharmaceuticals Llc Phenoxyessigsäuren als ppar-delta-aktivatoren
BRPI0620468A2 (pt) 2005-12-22 2011-11-08 Transtech Pharma, Inc. ácidos fenóxi acéticos como ativadores de ppar delta
JP2009132620A (ja) * 2006-03-07 2009-06-18 Astellas Pharma Inc フェニルチアゾール誘導体
WO2007101864A2 (en) 2006-03-09 2007-09-13 High Point Pharmaceuticals, Llc Compounds that modulate ppar activity, their preparation and use
CN101466687B (zh) 2006-04-18 2012-04-11 日本化学医药株式会社 过氧化物酶体增殖剂激活受体δ的激活剂
WO2008028914A1 (en) 2006-09-07 2008-03-13 Nycomed Gmbh Combination treatment for diabetes mellitus
FR2910893A1 (fr) * 2006-12-29 2008-07-04 Genfit Sa Derives de (phenylthiazolyl)-phenyl-propan-1-one et de (phenyloxazolyl)-phenyl-propan-1-one substitues, preparations et utilisations.
KR101560844B1 (ko) 2007-06-04 2015-10-15 벤-구리온 유니버시티 오브 더 네게브 리서치 앤드 디벨럽먼트 어쏘러티 트라이-아릴계 화합물 및 이를 포함하는 조성물
EP2277874B1 (en) 2008-04-15 2018-06-27 Nippon Chemiphar Co., Ltd. Activator for peroxisome proliferator-activated receptor
US20120094959A1 (en) 2010-10-19 2012-04-19 Bonnie Blazer-Yost Treatment of cystic diseases
US9688673B2 (en) 2011-03-08 2017-06-27 The Regents Of The University Of California Deoxycytidine kinase binding compounds
WO2015035171A1 (en) 2013-09-09 2015-03-12 High Point Pharmaceuticals, Llc Use of a ppar-delta agonist for treating muscle atrophy
MX2016005995A (es) 2013-11-05 2016-08-17 Ben-Gurion Univ Of The Negev Res And Dev Authority Compuestos para el tratamiento de diabetes y complicaciones de la enfermedad derivadas de la misma.
EP4075980B1 (en) 2019-12-18 2025-07-23 Stinginn LLC Substituted 1,2, 4-triazoles and methods of use
WO2022094409A1 (en) 2020-11-02 2022-05-05 Trethera Corporation Crystalline forms of a deoxycytidine kinase inhibitor and uses thereof
JP2024521048A (ja) * 2021-05-19 2024-05-28 スティンジン,インコーポレイテッド Stingシグナル伝達組成物の小分子阻害剤および使用の方法
WO2023147309A1 (en) 2022-01-25 2023-08-03 Reneo Pharmaceuticals, Inc. Use of ppar-delta agonists in the treatment of disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2204616C (en) * 1995-09-18 2002-12-17 Ranjan Mukherjee Ppar gamma antagonists for treating obesity
GB9817118D0 (en) * 1998-08-07 1998-10-07 Glaxo Group Ltd Pharmaceutical compounds
GB9914977D0 (en) * 1999-06-25 1999-08-25 Glaxo Group Ltd Chemical compounds
PE20011010A1 (es) * 1999-12-02 2001-10-18 Glaxo Group Ltd Oxazoles y tiazoles sustituidos como agonista del receptor activado por el proliferador de peroxisomas humano

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