JP2004517151A5 - - Google Patents
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- Publication number
- JP2004517151A5 JP2004517151A5 JP2002559415A JP2002559415A JP2004517151A5 JP 2004517151 A5 JP2004517151 A5 JP 2004517151A5 JP 2002559415 A JP2002559415 A JP 2002559415A JP 2002559415 A JP2002559415 A JP 2002559415A JP 2004517151 A5 JP2004517151 A5 JP 2004517151A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryloyl
- alkanoyl
- compound according
- bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- 125000001589 carboacyl group Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- -1 α-naphthalenyl Chemical group 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 150000000463 2H-chromenes Chemical class 0.000 claims 1
- ZUDXUNPSRMREOJ-UHFFFAOYSA-N 3-(4-methoxyphenyl)-4-[[4-(2-piperidin-1-ylethoxy)phenyl]methyl]-2h-chromen-7-ol Chemical compound C1=CC(OC)=CC=C1C(COC1=CC(O)=CC=C11)=C1CC(C=C1)=CC=C1OCCN1CCCCC1 ZUDXUNPSRMREOJ-UHFFFAOYSA-N 0.000 claims 1
- 125000005330 8 membered heterocyclic group Chemical group 0.000 claims 1
- KYNSBQPICQTCGU-UHFFFAOYSA-N Benzopyrane Chemical compound C1=CC=C2C=CCOC2=C1 KYNSBQPICQTCGU-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940011871 estrogen Drugs 0.000 claims 1
- 239000000262 estrogen Substances 0.000 claims 1
- 125000000262 haloalkenyl group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01101521A EP1229036B1 (en) | 2001-01-24 | 2001-01-24 | 2H-1-benzopyran derivatives, processes for their preparation and pharmaceutical compositions thereof |
| EP01118682A EP1281710A1 (en) | 2001-08-03 | 2001-08-03 | 2H-1-benzopyran derivatives, processes for their preparation and pharmaceutical compositions thereof |
| PCT/EP2002/000567 WO2002059113A1 (en) | 2001-01-24 | 2002-01-21 | 2h-1-benzopyran derivatives, processes for their preparation and pharmaceutical compositions thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004517151A JP2004517151A (ja) | 2004-06-10 |
| JP2004517151A5 true JP2004517151A5 (enExample) | 2005-12-22 |
| JP4332349B2 JP4332349B2 (ja) | 2009-09-16 |
Family
ID=26076450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002559415A Expired - Fee Related JP4332349B2 (ja) | 2001-01-24 | 2002-01-21 | ２ｈ−１−ベンゾピラン誘導体、それらの製造法及びそれらの製薬学的組成物 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6951883B2 (enExample) |
| EP (1) | EP1355906B1 (enExample) |
| JP (1) | JP4332349B2 (enExample) |
| CN (1) | CN1261431C (enExample) |
| AT (1) | ATE286894T1 (enExample) |
| AU (1) | AU2002237282B2 (enExample) |
| BR (1) | BR0207066A (enExample) |
| CA (1) | CA2435775A1 (enExample) |
| CZ (1) | CZ20032014A3 (enExample) |
| DE (1) | DE60202590T2 (enExample) |
| DK (1) | DK1355906T3 (enExample) |
| DZ (1) | DZ3459A1 (enExample) |
| EA (1) | EA006158B1 (enExample) |
| ES (1) | ES2236485T3 (enExample) |
| HU (1) | HUP0401018A3 (enExample) |
| IL (2) | IL157065A0 (enExample) |
| MA (1) | MA26982A1 (enExample) |
| MX (1) | MXPA03006505A (enExample) |
| NO (1) | NO327808B1 (enExample) |
| NZ (1) | NZ527144A (enExample) |
| PL (1) | PL365062A1 (enExample) |
| PT (1) | PT1355906E (enExample) |
| SI (1) | SI1355906T1 (enExample) |
| SK (1) | SK287086B6 (enExample) |
| TN (1) | TNSN03043A1 (enExample) |
| WO (1) | WO2002059113A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8080675B2 (en) | 2004-09-21 | 2011-12-20 | Marshall Edwards, Inc. | Chroman derivatives, medicaments and use in therapy |
| NZ553834A (en) * | 2004-09-21 | 2010-03-26 | Novogen Res Pty Ltd | 7-hydroxy-3,4-diphenyl-chroman and chromene derivatives |
| EP1809618B1 (en) * | 2004-09-21 | 2013-07-17 | Marshall Edwards, Inc. | Chroman derivatives, medicaments and use in therapy |
| AU2005201855B2 (en) * | 2004-09-21 | 2012-03-29 | Marshall Edwards, Inc. | Chroman derived compounds and formulations thereof for use in therapy |
| JP4913056B2 (ja) * | 2004-09-21 | 2012-04-11 | マーシャル エドワーズ，インコーポレーテッド | 置換クロマン誘導体、医薬品、および治療における使用 |
| JP4976649B2 (ja) * | 2004-09-21 | 2012-07-18 | マーシャル エドワーズ，インク． | 化合物 |
| CN101444499B (zh) * | 2007-11-26 | 2012-12-05 | 湘北威尔曼制药股份有限公司 | 一种化合物及其组合物的新用途 |
| ES2773732T3 (es) | 2010-11-01 | 2020-07-14 | Mei Pharma Inc | Composiciones de isoflavonoides y procedimientos para el tratamiento del cáncer |
| EA031077B1 (ru) | 2013-06-19 | 2018-11-30 | Серагон Фармасьютикалз, Инк. | Модулятор рецептора эстрогена и его применения |
| HUE054998T2 (hu) | 2015-02-02 | 2021-10-28 | Mei Pharma Inc | Kombinációs terápiák emlõrák kezelésében való alkalmazásra |
| CN109963848B (zh) * | 2016-11-17 | 2022-07-05 | 赛诺菲 | 取代的n-(3-氟丙基)-吡咯烷化合物、其制备方法以及其治疗用途 |
| US20200215025A1 (en) * | 2017-09-15 | 2020-07-09 | Norbio No. 1 Pty Ltd | Treatment of excitotoxicity |
| CN112225716A (zh) * | 2020-10-30 | 2021-01-15 | 陕西嘉禾生物科技股份有限公司 | 一种鹰嘴豆牙素a的合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3374245A (en) * | 1964-04-01 | 1968-03-19 | Ciba Geigy Corp | Unsaturated oxacycles |
| DE1518002C3 (de) * | 1965-01-02 | 1975-01-23 | Merck Patent Gmbh, 6100 Darmstadt | Isoflavane und Isoflavene und Verfahren zu Ihrer Herstellung sowie diese enthaltende Arzneimittel |
| US5280040A (en) * | 1993-03-11 | 1994-01-18 | Zymogenetics, Inc. | Methods for reducing bone loss using centchroman derivatives |
| US5985306A (en) * | 1996-10-28 | 1999-11-16 | Novo Nordisk A/S | (+)-enantiomers of cis-3,4-chroman derivatives useful in prevention or treatment of estrogen diseases or syndromes |
| CA2269936A1 (en) * | 1996-10-28 | 1998-05-07 | Lise Brown Christiansen | Novel trans-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes |
| JP3251946B2 (ja) * | 1996-12-13 | 2002-01-28 | 中外製薬株式会社 | 新規なベンゾピラン誘導体 |
| KR20000001793A (ko) | 1998-06-13 | 2000-01-15 | 이경하 | 신규한 벤조피란 또는 티오벤조피란 유도체 |
| WO2000039120A2 (en) | 1998-12-30 | 2000-07-06 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
-
2002
- 2002-01-21 US US10/466,118 patent/US6951883B2/en not_active Expired - Fee Related
- 2002-01-21 EP EP02703564A patent/EP1355906B1/en not_active Expired - Lifetime
- 2002-01-21 DZ DZ023459A patent/DZ3459A1/fr active
- 2002-01-21 SI SI200230096T patent/SI1355906T1/xx unknown
- 2002-01-21 DE DE60202590T patent/DE60202590T2/de not_active Expired - Lifetime
- 2002-01-21 EA EA200300727A patent/EA006158B1/ru not_active IP Right Cessation
- 2002-01-21 PL PL02365062A patent/PL365062A1/xx not_active IP Right Cessation
- 2002-01-21 MX MXPA03006505A patent/MXPA03006505A/es active IP Right Grant
- 2002-01-21 AU AU2002237282A patent/AU2002237282B2/en not_active Ceased
- 2002-01-21 PT PT02703564T patent/PT1355906E/pt unknown
- 2002-01-21 ES ES02703564T patent/ES2236485T3/es not_active Expired - Lifetime
- 2002-01-21 CA CA002435775A patent/CA2435775A1/en not_active Abandoned
- 2002-01-21 AT AT02703564T patent/ATE286894T1/de not_active IP Right Cessation
- 2002-01-21 BR BR0207066-9A patent/BR0207066A/pt not_active IP Right Cessation
- 2002-01-21 NZ NZ527144A patent/NZ527144A/en unknown
- 2002-01-21 DK DK02703564T patent/DK1355906T3/da active
- 2002-01-21 CZ CZ20032014A patent/CZ20032014A3/cs unknown
- 2002-01-21 CN CNB02804066XA patent/CN1261431C/zh not_active Expired - Fee Related
- 2002-01-21 HU HU0401018A patent/HUP0401018A3/hu unknown
- 2002-01-21 SK SK939-2003A patent/SK287086B6/sk not_active IP Right Cessation
- 2002-01-21 IL IL15706502A patent/IL157065A0/xx unknown
- 2002-01-21 JP JP2002559415A patent/JP4332349B2/ja not_active Expired - Fee Related
- 2002-01-21 WO PCT/EP2002/000567 patent/WO2002059113A1/en not_active Ceased
-
2003
- 2003-07-08 TN TNPCT/EP2002/000567A patent/TNSN03043A1/en unknown
- 2003-07-15 MA MA27236A patent/MA26982A1/fr unknown
- 2003-07-23 IL IL157065A patent/IL157065A/en not_active IP Right Cessation
- 2003-07-23 NO NO20033318A patent/NO327808B1/no not_active IP Right Cessation
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