JP2004517081A - １−（２−ｍ−メタンスルホンアミドフェニルエチル）−４−（ｍ−トリフルオロメチルフェニル）ピペラジンならびにその医薬的に許容しうる塩および溶媒和物 - Google Patents

１−（２−ｍ−メタンスルホンアミドフェニルエチル）−４−（ｍ−トリフルオロメチルフェニル）ピペラジンならびにその医薬的に許容しうる塩および溶媒和物 Download PDF

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Publication number
JP2004517081A
JP2004517081A JP2002546529A JP2002546529A JP2004517081A JP 2004517081 A JP2004517081 A JP 2004517081A JP 2002546529 A JP2002546529 A JP 2002546529A JP 2002546529 A JP2002546529 A JP 2002546529A JP 2004517081 A JP2004517081 A JP 2004517081A
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JP
Japan
Prior art keywords
bladder
receptor agonist
urinary incontinence
receptor
patient
Prior art date
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Pending
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JP2002546529A
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English (en)
Japanese (ja)
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JP2004517081A5 (https=
Inventor
ジョン・メーナート・ショース
デニス・チャールズ・トンプソン
カール・ブルース・ソー
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Eli Lilly and Co
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Eli Lilly and Co
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Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JP2004517081A publication Critical patent/JP2004517081A/ja
Publication of JP2004517081A5 publication Critical patent/JP2004517081A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2002546529A 2000-11-29 2001-11-16 １−（２−ｍ−メタンスルホンアミドフェニルエチル）−４−（ｍ−トリフルオロメチルフェニル）ピペラジンならびにその医薬的に許容しうる塩および溶媒和物 Pending JP2004517081A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25020300P 2000-11-29 2000-11-29
PCT/US2001/042949 WO2002044159A2 (en) 2000-11-29 2001-11-16 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl)piperazine and pharmaceutically acceptable salts and solvates thereof and their use in the treatment of incontinence

Publications (2)

Publication Number Publication Date
JP2004517081A true JP2004517081A (ja) 2004-06-10
JP2004517081A5 JP2004517081A5 (https=) 2005-11-17

Family

ID=22946725

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002546529A Pending JP2004517081A (ja) 2000-11-29 2001-11-16 １−（２−ｍ−メタンスルホンアミドフェニルエチル）−４−（ｍ−トリフルオロメチルフェニル）ピペラジンならびにその医薬的に許容しうる塩および溶媒和物

Country Status (9)

Country Link
US (1) US6864262B2 (https=)
EP (1) EP1341777B1 (https=)
JP (1) JP2004517081A (https=)
AT (1) ATE374192T1 (https=)
AU (1) AU2002230411A1 (https=)
CA (1) CA2427098A1 (https=)
DE (1) DE60130677T2 (https=)
ES (1) ES2292636T3 (https=)
WO (1) WO2002044159A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2611376C2 (ru) 2010-10-15 2017-02-21 Контера Фарма Апс Фармацевтическая композиция для лечения, профилактики или облегчения двигательных расстройств и ее применение
NZ700474A (en) 2012-04-18 2016-10-28 Contera Pharma Aps Orally available pharmaceutical formulation suitable for improved management of movement disorders
AU2017297718B2 (en) 2016-07-11 2023-06-08 Contera Pharma A/S Pulsatile drug delivery system for treating morning akinesia

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB948766A (en) 1959-10-20 1964-02-05 May & Baker Ltd Trifluoromethylphenylpiperazine derivatives
BE755015A (fr) 1969-08-20 1971-02-01 Byk Gulden Lomberg Chem Fab Piperazinyl-alcoylamino-uraciles substitues par un groupe aryle, leurs ethers et thioethers, ainsi que leur procede de preparation
BE759371A (fr) 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
FR2362628A1 (fr) 1976-08-26 1978-03-24 Roussel Uclaf Nouveaux derives du piperidyl-indole et leurs sels, procede de preparation et application a titre de medicaments
US4423049A (en) 1981-12-28 1983-12-27 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines
DE3321969A1 (de) 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
AU577802B2 (en) 1983-10-17 1988-10-06 Duphar International Research B.V. Blood-pressure lowering piperazine derivatives
EP0303507B1 (en) 1987-08-13 1993-07-28 Glaxo Group Limited Indole derivatives
JPH03502701A (ja) 1988-12-15 1991-06-20 アボツト・ラボラトリーズ ５‐ｈｔ選択性物質
PT97888B (pt) 1990-06-07 1998-12-31 Zeneca Ltd Processo para a preparacao de compostos heterociclicos derivados de indol e de composicoes farmaceuticas que os contem
US5545644A (en) 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
SK278998B6 (sk) 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
PT533268E (pt) 1991-09-18 2002-02-28 Glaxo Group Ltd Derivados de benzanilida como antagonistas de 5-ht1d
CA2084531A1 (en) 1991-12-19 1993-06-20 David W. Smith Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines
SI9300097B (en) 1992-02-27 2001-12-31 Janssen Pharmaceutica Nv (benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines
US5521188A (en) 1993-09-16 1996-05-28 Bristol-Myers Squibb Company Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines
EP0733048A1 (en) 1993-12-07 1996-09-25 Smithkline Beecham Plc Heterocyclic biphenylylamides useful as 5ht1d antagonists
SE9504661D0 (sv) 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
AU736510B2 (en) * 1997-06-27 2001-07-26 Nippon Kayaku Kabushiki Kaisha Remedies/preventives for frequent urination/urinary incontinence and tropone derivatives
JP3441636B2 (ja) 1997-11-21 2003-09-02 株式会社エヌ・ティ・ティ・ドコモ チャネル推定値を求める装置および方法、受信装置ならびに伝送システム

Also Published As

Publication number Publication date
EP1341777A2 (en) 2003-09-10
WO2002044159A3 (en) 2002-08-22
WO2002044159A2 (en) 2002-06-06
EP1341777B1 (en) 2007-09-26
ES2292636T3 (es) 2008-03-16
ATE374192T1 (de) 2007-10-15
CA2427098A1 (en) 2002-06-06
DE60130677D1 (de) 2007-11-08
AU2002230411A1 (en) 2002-06-11
US6864262B2 (en) 2005-03-08
US20040067962A1 (en) 2004-04-08
WO2002044159A8 (en) 2003-11-20
DE60130677T2 (de) 2008-07-17

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